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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan JPK: Jurnal Proteksi Kesehatan COMMUNITY : Jurnal Pengabdian Kepada Masyarakat HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Ilmu Multidisplin Health Dynamics Folia Medica Indonesiana
Musholli Himmatun Nabilah
Poltekkes Kemenkes Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Correlation Glucose, Uric Acid, and Cholesterol Levels Towards Health Conditions in the Highlands: POCT Approach Arifa Mustika; Yetti Hernaningsih; Puspa Wardhani; Siti Khaerunnisa; Nastasya Nunki; Baiq Nasha Islaeli; Uli Mas'uliyah Indarwati; Musholli Himmatun Nabilah; Teguh Satrio; Alfino Validita Sidiq; Fita Triastuti; Mochammad Reza Desianto; Agil Saputra; Novi Ersanto; Widaninggar Rahma Putri; Desty Indah Sari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2203

Abstract

Degenerative diseases arise when age increases due to the weakening of the body's physiological condition. The purpose of this study was to measure glucose, uric acid, and cholesterol levels in residents of Segunung Village to improve lifestyles and quality of life. As many as 110 residents of Segunung Village were used as subjects in this cross-sectional study. Glucose, uric acid, and cholesterol levels were measured using Point of Care Testing (POCT). A cut-off value of <200 was used to define high cholesterol levels. Only cholesterol levels showed an increase when compared with reference values, while glucose and uric acid levels were normal. Interestingly glucose was significantly correlated with age (r=0.309, p=0.001). The approach using POCT describes the overall condition of Segunung villagers and can be used as a basis for glucose, uric acid, and cholesterol screening tests.
PERBEDAAN MORFOLOGI SEL DARAH PADA PEMERIKSAAN HAPUSAN DARAH TEPI DENGAN PEWARNAAN GIEMSA MENGGUNAKAN LARUTAN PENGENCER BUFFER PHOSPHAT DAN LARUTAN PENGENCER AQUABIDEST Museyaroh, Museyaroh; Nabilah, Musholli Himmatun; Endarini, Lully Hanni
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 2 (2024): JUNI
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i2.2060

Abstract

Pemeriksaan Hapusan darah tepi (HDT) merupakan pemeriksaan untuk melihat morfologi sel-sel darah secara mikroskopis. Salah satu metode pemeriksaan hapusan darah tepi yang sering digunakan adalah pewarnaan giemsa. Pengenceran larutan giemsa secara teoritis menggunakan larutan penyangga buffer phosphat. Pengenceran giemsa sering menggunakan larutan buffer phosphat karena buffer phosphat mudah didapatkan, namun harganya cukup mahal. Kandungan phosphat yang melebihi batas 2 mg/L juga dapat berpengaruh terhadap keseimbangan ekosistem perairan sehingga dapat mencemari lingkungan bila terus digunakan. Penelitian ini bertujuan untuk menganalisis perbedaan morfologi sel-sel darah pada pemeriksaan HDT dengan pewarnaan giemsa menggunakan larutan buffer dan aquabidest dalam upaya penentuan larutan alternatif yang bisa digunakan sebagai larutan pengencer giemsa yang lebih murah dan mudah didapatkan. Penelitian ini merupakan penelitian eksperimental dengan studi cross sectional yang membandingkan kualitas morfologi sel darah sediaan HDT dengan pewarna giemsa yang diencerkan dengan buffer phosphate dan aquabidest. Sampel diambil dari 1 orang koresponden penelitian, untuk kemudian dibuat sediaan HDT masing-masing sebanyak 17 buah (pengencer buffer phosphat), dan 22 buah (pengencer aquabidest), dan diamati dengan mikroskop perbesaran lensa objektif 100x. Kualitas sediaan HDT giemsa dengan pengencer buffer phosphat menunjukkan hasil “baik” sebanyak 13 buah (76,47%), dan hasil “kurang baik” sebanyak 4 buah (23,53%), sedangkan kualitas sediaan HDT giemsa dengan pengencer aquabidest menunjukkan hasil “baik” sebanyak 18 buah (81,82%), dan hasil “kurang baik” sebanyak 4 buah (18,18%). Berdasarkan uji Mann-Whitney U, didapatkan P-Value 0,222. Kualitas sediaan HDT pewarnaan giemsa dengan pengencer buffer phosphat tidak menunjukkan perbedaan yang signifikan dengan yang menggunakan pengencer aquabidest (p>0,05).
PEMBERDAYAAN DAN EDUKASI WALI MURID TAMAN KANAK-KANAK DHARMA WANITA PERSATUAN TROPODO TENTANG PENCEGAHAN WEIGHT FALTERING PADA AWAL KEJADIAN STUNTING MELALUI PEMBUATAN MEDIA EDUKASI Istanto, Wisnu; Arifin, Syamsul; Nabilah, Musholli Himmatun
COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/community.v5i2.7322

Abstract

Stunting and weight faltering remain public health challenges for Indonesia, including rural areas of the country. One of the most effective ways of helping people understand balanced and inexpensive supplementary feeding is by teaching parents. This community service project was carried out at Dharma Wanita Persatuan Dukuhtengah Kindergarten to assist and educate parents using educational materials such as booklets and videos. The methods of implementation consist of several components, including preparation of materials, design of educational media, implementation of a pre-test, interactive counseling, post-test, and statistical analysis. A total of 45 parents took part fully in the activity. Evaluation results indicated a significant improvement in knowledge from an average pre-test score of 54.2 to an average post-test score of 84.6. The t-test showed a t-value of t(44)=20.08, p<0.0001, indicating that there was a significant difference in the means between the pre-test and post-test scores. The effect size of the intervention was considered very large, with a Cohen's d value of 2.99. The post-test scores became more normally distributed, with a narrower range (70-95) than pre-test scores (40-75), suggesting that understanding was consistently improving. This finding supports the effectiveness of simple visual educational media in enhancing nutritional awareness among the parents. The resultant product of this activity is that PMT education using booklets and videos is a viable model for a sustainable school and posyandu-level intervention to strengthen a community-based stunting prevention program. ABSTRAKMasalah stunting dan weight faltering pada anak usia dini masih menjadi tantangan kesehatan masyarakat di Indonesia, termasuk di wilayah pedesaan. Edukasi kepada wali murid menjadi salah satu strategi penting dalam meningkatkan pemahaman tentang pemberian makanan tambahan (PMT) yang bergizi seimbang dan terjangkau. Kegiatan pengabdian kepada masyarakat ini dilaksanakan di TK Dharma Wanita Persatuan Dukuhtengah dengan fokus pada pemberdayaan dan edukasi wali murid melalui pemanfaatan media edukasi berupa booklet dan video. Metode pelaksanaan mencakup tahap persiapan materi, desain media edukasi, pre-test, penyuluhan interaktif, post-test, serta analisis statistik. Jumlah peserta sebanyak 45 wali murid yang mengikuti kegiatan secara penuh. Hasil evaluasi menunjukkan adanya peningkatan signifikan pada pengetahuan peserta, dengan skor rata-rata pre-test 54,2 meningkat menjadi 84,6 pada post-test. Analisis paired t-test menghasilkan nilai t(44) = 20,08 dengan p < 0,0001, yang berarti terdapat perbedaan signifikan antara skor sebelum dan sesudah intervensi. Efek intervensi sangat besar dengan nilai Cohen’s d = 2,99. Distribusi skor post-test lebih seragam dengan rentang yang lebih sempit (70–95) dibanding pre-test (40–75), menunjukkan peningkatan pemahaman yang konsisten. Temuan ini menegaskan bahwa media edukasi visual sederhana efektif dalam meningkatkan kesadaran gizi pada wali murid. Simpulan dari kegiatan ini adalah edukasi PMT berbasis booklet dan video layak dijadikan model intervensi berkelanjutan di sekolah maupun posyandu untuk mendukung program pencegahan stunting di tingkat komunitas.
STUDI SURVEI : GAMBARAN PENYAKIT MENULAR PADA WANITA DI KABUPATEN MAGETAN Riyanto, Digdo; Woelansari, Evy Diah; Nabilah, Musholli Himmatun
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 3 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i3.6793

Abstract

ABSTRACT Sexually Transmitted Infections (STIs) such as HIV, Hepatitis B, and Syphilis are serious public health problems, especially among high-risk groups like female sex workers. The Pasar Sayur Magetan area has a high potential for STI transmission due to nighttime entertainment activities and the presence of dimly lit establishments. This study aims to identify the presence of STIs among women in Magetan as a basis for planning prevention and education programs by the government and health authorities. This research uses an analytical cross-sectional survey design with venous blood samples collected in EDTA anticoagulant tubes from female sex workers at Pasar Sayur Magetan. Data were collected through Rapid Diagnostic Tests (RDT) using immunochromatographic methods to detect HIV, Hepatitis B, and Syphilis, along with questionnaires to identify risk factors and behaviors influencing STI transmission. The study found cases of HIV and Syphilis among female sex workers in Pasar Sayur Magetan. The main risk factors include unsafe sexual behavior, inconsistent condom use, frequent partner changes, and limited education and knowledge. Although all respondents practiced good genital hygiene, this did not fully prevent STIs transmitted through blood and bodily fluids. This survey reveals the prevalence of STIs and the main risk factors in Pasar Sayur Magetan. These findings serve as a foundation for the government and health services to design prevention, education, and early detection programs to reduce cases and increase awareness of safe sexual behavior. ABSTRAK Infeksi Menular Seksual (IMS) seperti HIV, Hepatitis B, dan Sifilis menjadi masalah kesehatan serius, terutama bagi kelompok berisiko tinggi seperti wanita pekerja seks. Kawasan Pasar Sayur Magetan berpotensi tinggi dalam penyebaran IMS karena aktivitas hiburan malam dan keberadaan warung remang-remang. Penelitian ini bertujuan untuk mengetahui adanya penyakit penyakit menular seksual pada wanita di daerah Magetan, agar dapat digunakan sebagai dasar dalam perencanaan program pencegahan dan edukasi oleh pemerintah dan dinas Kesehatan. Penelitian ini menggunakan desain survei analitik cross-sectional dengan menggunakan sampel darah vena antikoagulan EDTA pada wanita pekerja seks di Pasar Sayur Magetan. Data dikumpulkan dari hasil pemeriksaan Rapid Diagnostic Test (RDT) metode imunokromatografi untuk mendeteksi HIV, Hepatitis B, dan Sifilis, serta kuesioner untuk mengidentifikasi faktor risiko dan perilaku yang mempengaruhi penularan IMS. Penelitian ini menemukan adanya kasus HIV dan Sifilis di kalangan wanita pekerja seks di Pasar Sayur Magetan dengan faktor risiko utama berupa perilaku seksual tidak aman dan ketidakkonsistenan penggunaan kondom serta keterbatasan pendidikan dan pengetahuan. Kesimpulannya, meskipun praktik genital higiene baik, risiko penularan IMS tetap terjadi. Survei ini mengungkap tingkat penyebaran PMS di Pasar Sayur Magetan serta faktor risiko utama. Temuan ini menjadi dasar bagi pemerintah dan dinas kesehatan dalam merancang program pencegahan, edukasi, dan deteksi dini guna mengurangi kasus serta meningkatkan kesadaran akan perilaku seksual yang aman.
Insidensi Koinfeksi Treponema Pallidum Terhadap Pemeriksaan Viral Load Penderita Human Immunodeficiency Virus di Puskesmas Maospati Kabupaten Magetan Dwi Hidayah Septiana; Evy Diah Woelansari; Musholli Himmatun Nabilah; Kartika Rahayuningsih; Triasworo Nawangwulan
Jurnal Ilmu Multidisiplin Vol. 4 No. 3 (2025): Jurnal Ilmu Multidisplin (Agustus - September 2025)
Publisher : Green Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jim.v4i3.1132

Abstract

Infeksi Menular Seksual (IMS) merupakan masalah kesehatan global yang terus meningkat dengan lebih dari 374 juta kasus baru setiap tahunnya. Di antara IMS, infeksi Human Immunodeficiency Virus (HIV) menjadi salah satu yang paling signifikan, dengan 38 juta orang terinfeksi di seluruh dunia pada tahun 2022. Di Kabupaten Magetan, kasus HIV meningkat dari 44 menjadi 102 dalam satu tahun. Koinfeksi HIV dengan Treponema pallidum penyebab sifilis dapat memperburuk kesehatan dan meningkatkan viral load. Penelitian ini bertujuan untuk mengetahui adanya insidensi koinfeksi Treponema pallidum terhadap pemeriksaan viral load penderita Human Immunodeficiency Virus menggunakan Metode RPR (Rapid Plasma Reagin) sifilis. Jenis penelitian ini adalah observasional dengan pendekatan studi kohort dan metode pengambilan sampel menggunakan teknik purposive sampling. Sampel penelitian terdiri dari 36 penderita HIV dengan data nilai viral load yang diperoleh dari data rekam medis Puskesmas Maospati, Kabupaten Magetan. Dari 36 sampel yang diperiksa, terdapat 3 (8%) penderita HIV yang terinfeksi sifilis. Hasil uji statistik menunjukkan bahwa terdapat hubungan positif dengan korelasi sedang antara koinfeksi Treponema pallidum terhadap hasil pemeriksaan viral load penderita Human Immunodeficiency Virus di Puskesmas Maospati dengan nilai Sig. (2-tailed) yaitu 0,014 yang berarti nilai P < 0,05. Berlandaskan dengan temuan dari analisis tentang insidensi koinfeksi Treponema pallidum terhadap pemeriksaan viral load penderita Human Immunodeficiency Virus di Puskesmas Maospati Kabupaten Magetan, dapat disimpulkan bahwa terdapat korelasi positif antara koinfeksi Treponema pallidum terhadap hasil pemeriksaan viral load penderita Human Immunodeficiency Virus di Puskesmas Maospati.
Hemoglobin A1c (HbA1c) Levels from the Examination of Different Blood Proportions in K2EDTA Tubes using an Enzymatic Method , Museyaroh; Nabilah, Musholli Himmatun; Werdiningsih, Retno
Folia Medica Indonesiana Vol. 59, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. Research on the effect of blood volume proportion in the examination of HbA1c levels using K2EDTA anticoagulantvhas yet to be widely carried out in Indonesia. 2. The analysis conducted utilizing K2EDTA tubes revealed that the varying proportions of blood samples had no effectvon HbA1c levels. 3. This article highlights the necessity of evaluating the pre-analytical phase (sample preparation) of a laboratory process to improve the accuracy of the results and minimize false high or low results in the HbA1c test. Abstract Hemoglobin A1c (HbA1c) examination is the gold standard for diagnosing and monitoring diabetes mellitus patients. In the examination, the pre-analytical phase has the most considerable error rate at 61%. One of the contributing factors is the use of anticoagulants that do not adhere to established guidelines. Additionally, the incompatibility of the sample volume proportions and the anticoagulants in K2EDTA tubes has been observed in numerous cases. The significance of HbA1c testing, particularly in the prevention of diabetes complications, underscores the need for appropriate procedures to be followed throughout the sampling and pre-analytical phases. This study aimed to determine the effect of differences in the proportion of blood sample volume and anticoagulants in K2EDTA tubes on HbA1c levels. This research was conducted in August–September 2022. The research samples were collected from the staff and students at the Department of Medical Laboratory Technology, Politeknik Kesehatan Kemenkes Surabaya, Surabaya, Indonesia. The blood samples were divided into K2EDTA tubes with varying volumes of 1 mL, 2 mL, 3 mL, and 4 mL. The HbA1c levels were then examined at the Clinical Chemistry Laboratory of Politeknik Kesehatan Kemenkes Surabaya. The data were analyzed using a one-way ANOVA test. The statistical test results (p>0.05) indicated that the proportion of samples containing anticoagulants in the K2EDTA tubes did not have any significant effect on HbA1c levels. In conclusion, it is acceptable to utilize K2EDTA tubes with varying blood sample volumes for the measurement of HbA1c levels.
Analysis of the Leukocyte Profile for Peripheral Blood Smear Stained with Diff-Count Based on Fixation Time Variation Museyaroh Museyaroh; Musholli Himmatun Nabilah; Lully Hanni Endarini
Health Dynamics Vol 2, No 2 (2025): February 2025
Publisher : Knowledge Dynamics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hd20202

Abstract

Background: Peripheral blood smear examination (HDT) is a test to observe the morphology of blood cells microscopically. A peripheral blood smear is a simple method, and its examination is widely available in laboratories. The advantage of peripheral blood smear examination is its ability to assess various components of peripheral blood cells, such as cell morphology (erythrocytes, leukocytes, and platelets). One of the commonly used methods for peripheral blood smear examination is Giemsa staining. The process of Giemsa staining fixation aims to preserve the cell structure and its components before the staining is performed. The precise fixation time is key to obtaining optimal staining results, which allows for accurate observation of cell morphology. The aim of this study is to analyze the morphology of leukocyte profiles in peripheral blood smears stained with Giemsa based on variations in fixation time to determine the optimal time. Methods: This research was conducted in August-September 2024. The sample in this study was whole blood taken from the academic community of the Department of Medical Laboratory Technology and examined with a peripheral blood smear using Giemsa staining, and analyzed using descriptive statistical tests with the SPSS for Windows 22 software. Results: The research results showed that at a fixation time of 3 minutes, 60% were good and 40% were less good; at 5 minutes, 100% were good; at 10 minutes, 100% were good; at 15 minutes, 40% were good and 60% were less good; and at 20 minutes, 20% were good and 80% were less good. Conclusion: The best time variation in Giemsa staining using phosphate buffer is fixation for 5 minutes and 10 minutes, where all preparations (5 preparations) are 100% in the good category.
Viability of Gram-Positive and Gram-Negative Bacteria in Liquid Storage Media Tacik Idayanti Idayanti; Musholli Himmatun Nabilah Nabilah; Retno Werdiningsih
JURNAL PROTEKSI KESEHATAN Vol 15 No 1 (2026): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bacteria can be cultivated and stored in media. In educational laboratories, liquid media are used to maintain stock cultures due to simplicity and cost-effectiveness. Maintaining bacterial viability is essential to ensure bacterial stability. Several factors influence bacterial survival, including temperature storage, duration, nutrient composition, osmotic pressure, pH, and sterility. Previous studies have applied glycerol supplementation in Tryptic Soy Broth as a preservative to improve bacterial viability. This study to observe bacterial survival in two types of liquid Bouillon and Tryptic Soy Broth (TSB)—with storage durations of one week, two weeks, and one month. The spread plate method used "L" glass rod on Nutrient Agar, with four treatment groups and replications. The results showed a significant increase numbers of bacteria in TSB after two weeks of storage, followed by a sharp decrease after one month. Showed that TSB was better at maintaining the viability of Gram-positive and Gram-negative bacteria.
AKURASI KADAR LDL METODE INDIRECT TERHADAP METODE DIRECT Marina Putri Rahajeng; Anik Handayati; Musholli Himmatun Nabilah; Edy Haryanto
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14483

Abstract

Lipid profile examination is used to help assess the risk of cardiovascular disease. LDL level examination can be performed using the indirect method (Friedewald Formula) and the direct method (homogeneous test). The indirect method is more economical and is still frequently used in laboratories, but its accuracy is starting to be questioned at high triglyceride levels. This study aims to determine the accuracy of LDL levels using the indirect method (Friedewald Formula) compared to the direct method (homogeneous test) at triglyceride levels of 200-300 mg/dL. This study used a comparative analytical quantitative design with a paired cross-sectional approach. The study sample used primary data, namely the serum of patients with triglyceride levels of 200-300 mg/dL examined using the indirect and direct methods on the same sample. Data analysis was performed using the Wilcoxon test, mean %Bias, Bland-Altman, and linear regression. The results showed that there was no significant difference between the indirect and direct methods with a significance value (p > 0.05). The average %Bias value of -0.3962% still meets the acceptance limits of the National Cholesterol Education Program (NCEP). Bland-Altman analysis showed that most of the data were within the limits of agreement. Based on the results of the study, the indirect method (Friedewald Formula) has good accuracy and relatively comparable results with the direct method (homogeneous testing) at triglyceride levels of 200-300 mg/dL. ABSTRAK Pemeriksaan profil lipid digunakan untuk membantu menilai risiko penyakit kardiovaskular. Pemeriksaan kadar LDL dapat dilakukan menggunakan metode indirect (Friedewald Formula) dan metode direct (homogeneous assay). Metode indirect lebih ekonomis dan masih sering digunakan di laboratorium, tetapi akurasinya mulai diragukan pada kadar trigliserida tinggi. Penelitian ini bertujuan untuk mengetahui akurasi kadar LDL metode indirect (Friedewald Formula) terhadap metode direct (homogeneous assay) pada kadar trigliserida 200–300 mg/dL. Penelitian ini menggunakan desain kuantitatif analitik komparatif dengan pendekatan cross-sectional berpasangan. Sampel penelitian menggunakan data primer, yaitu serum pasien dengan kadar trigliserida 200–300 mg/dL yang diperiksa menggunakan metode indirect dan metode direct pada sampel yang sama. Analisis data dilakukan menggunakan uji Wilcoxon, mean %Bias, dan Bland-Altman. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna antara metode indirect dan metode direct dengan nilai signifikansi (p > 0,05). Nilai mean %Bias sebesar -0,3962% masih memenuhi batas keberterimaan National Cholesterol Education Program (NCEP). Analisis Bland-Altman menunjukkan sebagian besar data berada dalam batas kesepakatan. Berdasarkan hasil penelitian, metode indirect (Friedewald Formula) memiliki akurasi yang baik dan hasil yang relatif sebanding dengan metode direct (homogeneous assay) pada kadar trigliserida 200-300 mg/dL.
KORELASI MEAN PLATELET VOLUME (MPV), HBA1C, DAN TEKANAN DARAH PADA PASIEN DIABETES MELITUS DENGAN HIPERTENSI Noer Widy Astutik; Dwi Krihariyani; Musholli Himmatun Nabilah
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.15196

Abstract

Diabetes mellitus with hypertension may increase the risk of cardiovascular complications through endothelial dysfunction and increased platelet activity. Mean Platelet Volume (MPV) is a hematological parameter that describes platelet size and activity. This study aimed to analyze the correlation of MPV with HbA1c levels and blood pressure in patients with diabetes mellitus and hypertension at Syarifah Ambami Rato Ebu Regional General Hospital, Bangkalan. An observational analytic study with a cross-sectional design was conducted involving 21 patients selected using purposive sampling from October 2025 to May 2026. MPV was measured using a Sysmex XN-550 Hematology Analyzer, while HbA1c data were obtained from medical records and blood pressure was measured using a digital device. Spearman correlation analysis was used to examine the relationships among variables. The results showed that 15 respondents (71%) had MPV >10.5 fL, with a mean value of 10.7 fL. The mean HbA1c level was 9.7%, while the mean blood pressure was 166/107 mmHg. No significant correlation was found between MPV and HbA1c (p=0.370), systolic blood pressure (p=0.108), or diastolic blood pressure (p=0.336). In conclusion, elevated MPV was not significantly correlated with HbA1c or blood pressure in the studied patients. ABSTRAK Diabetes melitus dengan hipertensi dapat meningkatkan risiko komplikasi kardiovaskular melalui gangguan fungsi endotel dan peningkatan aktivitas trombosit. Mean Platelet Volume (MPV) merupakan parameter hematologi yang menggambarkan ukuran dan aktivitas trombosit. Penelitian ini bertujuan menganalisis korelasi MPV dengan kadar HbA1c serta tekanan darah pada pasien diabetes melitus dengan hipertensi di RSUD Syarifah Ambami Rato Ebu Bangkalan. Penelitian menggunakan desain observasional analitik dengan pendekatan cross-sectional. Sebanyak 21 pasien yang memenuhi kriteria inklusi dan eksklusi dipilih menggunakan purposive sampling selama Oktober 2025–Mei 2026. Pemeriksaan MPV dilakukan menggunakan Hematology Analyzer Sysmex XN-550, sedangkan kadar HbA1c diperoleh dari rekam medis dan tekanan darah diukur menggunakan alat digital. Analisis korelasi dilakukan dengan uji Spearman. Hasil penelitian menunjukkan 15 responden (71%) memiliki MPV >10,5 fL dengan rata-rata 10,7 fL. Rata-rata HbA1c sebesar 9,7% dan tekanan darah sebesar 166/107 mmHg. Tidak terdapat korelasi signifikan antara MPV dengan HbA1c (p=0,370), tekanan darah sistolik (p=0,108), maupun diastolik (p=0,336). Disimpulkan bahwa peningkatan MPV tidak berkorelasi signifikan dengan HbA1c maupun tekanan darah pada kelompok pasien yang diteliti.
Co-Authors Agil Saputra Alfino Validita Sidiq Arifa Mustika Baiq Nasha Islaeli Desty Indah Sari Dwi Hidayah Septiana Edy Haryanto Endarini, Lully Hanni Evy Diah Woelansari Fita Triastuti Handayati, Anik Istanto, Wisnu Kartika Rahayuningsih Krihariyani, Dwi Marina Putri Rahajeng Mochammad Reza Desianto Museyaroh, Museyaroh Nastasya Nunki Noer Widy Astutik Novi Ersanto Puspa Wardhani Retno Werdiningsih Retno Werdiningsih Riyanto, Digdo Siti Khaerunnisa Syamsul Arifin Tacik Idayanti Teguh Satrio Triasworo Nawangwulan Uli Mas'uliyah Indarwati Widaninggar Rahma Putri Yetti Hernaningsih