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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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THE CORRELATION OF NAIVE CD4+T LYMPHOCYTE CELL PERCENTAGE, INTERLEUKIN-4 LEVELS AND TOTAL IMMUNOGLOBULIN E IN PATIENTS WITH ALLERGIC ASTHMA (Kenasaban antara Persentase Sel Limfosit T-CD4+ Naive dengan Kadar Interleukin-4 dan Jumlah Imunoglobulin E Total di Pasien Asma Alergi) Si Ngr. Oka Putrawan; Endang Retnowati; Daniel Maranatha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1190

Abstract

Asma alergi merupakan fenotip asma paling sering didapatkan di anak dan dewasa. Alergen masuk ke saluran napas yang akanmemicu respons imun sehingga menimbulkan gejala asma.Tujuan penelitian ini adalah membuktikan adanya kenasaban antarapersentase sel limfosit T-CD4+ naive dengan kadar IL-4 dan jumlah IgE total di pasien asma alergi. Penelitian bersifat analitikobservasional dengan rancangan potong lintang. Sampel terdiri dari 25 pasien asma alergi yang diperiksa di Ruang Poliklinik Asmadan Poliklinik Paru RSUD Dr. Soetomo. Pemeriksaan persentase sel limfosit T-CD4+ naive dengan flowcytometri, kadar IL-4 denganEnzyme Linked Immunosorbent Assay (ELISA), dan jumlah IgE Total dengan chemiluminescence. Persentase sel limfosit T-CD4+ naivecenderung meningkat yang berkisar antara 25,74–47,68% dengan rerata 36,72% dan Simpang Baku (SB) 6,0%. Kadar IL4 meningkatberkisar antara 43,4–97,2 pg/mL dengan rerata 70,8 pg/mL dan SD 14,95 pg/mL. Jumlah IgE total juga meningkat berkisar antara231,8–684,8 IU/mL dengan rerata 410,9 IU/mL dan SD 114,65 IU/mL. Terdapat kenasaban antara persentase sel limfosit T-CD4+ naivedengan kadar IL-4 dan jumlah IgE total di pasien asma alergi.
LEUKOCYTE ESTERASE IN ASCITES FLUID FOR DETECTING SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS Mawar Afrida; Ricke Loesnihari; Juwita Sembiring
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1330

Abstract

Spontaneous Bacterial Peritonitis (SBP) is a frequent complication in liver cirrhosis with ascites patients. Spontaneous bacterial peritonitis is often without symptoms, so diagnosis is often delayed. Ascites fluid analysis is expensive, while the ascites fluid culture, as the gold standard, takes a long time and is expensive too. Besides, not all hospitals have the facilities to do both tests. Dye strip test that detect leukocyte esterase, that was originally developed to detect the presence of polymorphonuclear cells in the urine was also sensitive and accurate for detecting the presence of polymorphonuclear cells in the ascites fluid. This examination is easy and quick to do and very cheap so that can be used for early detection of SBP. To determine the sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of dye strip leukocyte esterase test for early detection of SBP in liver cirrhosis with ascites patients were studied. This study used a dye strip leukocyte esterase (Combur10 Test®M) in 28 samples of ascites fluid and compared with the results of ascites fluid culture. The ability of the leukocyte esterase test as a diagnostic test was very good at a cut-off +2 with 94.1% specificity, 63.6% sensitivity, 35% PPV and 80% NPV. Examination leukocyte esterase in the ascites fluid could be used for early detection of SBP in liver cirrhosis with ascites patients and could help to exclude SBP..
DIAZO TEST AS A SCREENING TEST OF TYPHOID FEVER A PRACTICAL APPROACH J. Nugraha; Meiti Muljanti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1016

Abstract

Typhoid fever represents an endemic acute infection with a high mortality, in this case a laboratory test is needed to establish theearly diagnosis. For this study the researchers prefer urine diazo test which is a relatively easy, simple and inexpensive test. The aimof this study is to know whether the urine diazo test can be used for screening typhoid fever and whether there is a concordance withthe Widal and TUBEX® TF serological tests. Forty patients aged 2–18 years, attending to the Jeremy Medical Service Clinic, Surabaya,suffering of fever more than 3 days were studied from June up to August 2010. Urine samples were tested by diazo test, while bloodsamples as comparison were tested by Widal and TUBEX® TF tests, and blood culture was carried out as the gold standard. The sensitivityand specificity of those tests were then recorded. From the 40 samples, 12 patients showed positive Salmonella typhi blood cultures,26 diazo positive, 22 Widal positive and 14 TUBEX® TF positive. Of the 12 positive blood cultures, 10 (83%) diazo positive, 7 (58%)Widal positive and 9 (75%) TUBEX® TF positive were found. The sensitivity and specificity of diazo test was 83% and 43%, Widal test58% and 46%, TUBEX® TF test 75% and 82%. It is shown that the Diazo test had a higher sensitivity value, while the TUBEX® TF testshowed a higher level of specificity. In conclusion, so far it can be concluded that the Diazo test is quite reliable in aiding the diagnosisof typhoid fever and can be considered as a screening test for typhoid fever.
HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2 Rikarni .; lillah .; yoesri .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 1 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i1.918

Abstract

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macroand microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there isendothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration andmicroalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectionalmethod and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinineratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with totalsample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, andfibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantlystatistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma andalbuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patientswith normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio
KADAR KOLESTEROL HDL TERUKUR MENGGUNAKAN REAGEN CHOLESTEST N HDL DAN HDL-C PLUS GENERASI KETIGA Ichwan Meinardi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 2 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i2.971

Abstract

The using of the open reagent system tools gives the possibility to choose the best quality of reagents including the reagent for HDLcholesterol concentration test. Hitachi 902 (Roche) as an open reagent system tool may used Cholestest N HDL (Daichi) as the firstHDL reagent and HDL-C plus 3rd generation reagent (Roche). The aim of this study was to know the correlation of HDL cholesterolconcentrations using Cholestest N HDL and HDL-C plus 3rd generation reagents measured by Hitachi 902. A cross sectional study wasdone from April to June 2008 at Ratulangi Medical Centre Laboratory, Makassar. The HDL cholesterol concentration was measured byHitachi 902 using Cholestest N HDL and HDL-C plus 3rd generation reagents. Sample was analyzed with SPSS 14 for Windows Programusing T test and Pearson Correlation. Among 80 samples we found the mean HDL concentration using Daichi reagent was 46.19 mg/dlranging from 34.99 mg/dl to 57.39 mg/dl and the mean using Roche 3rd reagent was 48.35 mg/dl ranging from 35.18 mg/dl to 61.52mg/dl, with p = 0.098 and Pearson Correlation was r = 0.967 with p = 0.000.There was no difference between HDL concentrationdetected by Cholestest N HDL and HDL-C plus 3rd generation reagents.
PROFIL TES DARAH RUTIN DAN JUMLAH LIMFOSIT TOTAL PADA PENDERITA HIV/AIDS Amraini Afiah; M. Arif; Hardjoeno Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 2 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i2.883

Abstract

CD4 test and Viral Load have been done for initiating, controlling, and deciding the treatment and prognosis of HIV/AIDS.If bothtests cannot be done, clinical symptoms and total lymphocyte count (TLC) can be used. TLC and Hb can be used for monitoring theHIV progressiveness. To evaluate routine blood test results, TLC, and CD4 of HIV/AIDS patients. Cross sectional and descriptive studyfrom October 2005 to April 2006, of 30 patients, i.e. 21 men (70%) and 9 women (30%). Leucopenia was found in 16.67% men and13.33% women. Anemia Hb in 70% men and 30% women with mean value 2.52 g/dl; lymphocytopenia in 46.67% men and 10%women; and netropenia in 16.67% men and 10% women. CD4 was discovered decline in 66.67% men and 30% women with mean value63.4 cell/mm3. TLC in 43.33% men and 16.67% women with mean value 1081.21 cell/mm3. In the study we found i.e. leucopenia,anemia, limfocytopenia, and neutropenia. CD4 and TLC are mostly decline. Further researches in the bigger populations are conductedto consider the parameter of routine blood tests, TLC, and CD4 on HIV/AIDS patients for initiating therapy.
ANALYTICAL PERFORMANCE OF PROCALCITONIN LEVEL BETWEEN CHEMILUMINESCENCE AND QUANTITATIVE IMMUNOCHROMATOGRAPHY METHODS IN SEPSIS PATIENTS Mario Mario; Betty Agustina Tambunan; Hardiono Hardiono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1454

Abstract

Sepsis is a public health problem in many countries. The latest diagnosis criteria are quick Sequential Organ Failure Assessment  (qSOFA). Procalcitonin (PCT) could be used to aid the diagnosis of sepsis. The aim of this study was to determine the diagnostic value of PCT between CLIA and quantitative immunochromatography tests in sepsis patients. Samples were obtained from the resuscitation room, intensive observation room, and Intensive Care Unit (ICU) Dr. Soetomo General Hospital between December 2017-February 2018. One hundred and one subjects were examined and classified into sepsis group (n=71) and healthy group (n=30), based on qSOFA and SIRS criteria. Procalcitonin test with CLIA and quantitative immunochromatography method were performed in all subjects, followed by culture examination in sepsis group using PhoenixTM 100. The diagnostic value of the two methods was analyzed by 2x2 table with a Confidence Interval (CI) of 95%. There were significant differences of procalcitonin level between CLIA and quantitative immunochromatography method in the sepsis group (p=0.009) and in the healthy group (p=0.002). The diagnostic value of procalcitonin level by CLIA method with a cut-off value ≥ 0.27 ng/mL (AUC=0.839, sensitivity (Sn)=74.6%, specificity (Sp)=86.7%, Positive Predictive Value (PPV)=93%, Negative Predictive Value (NPV)=59.1%) had the same sensitivity but higher specificity, PPV, and NPV rather than by quantitative immunochromatography method (AUC=0.786, Sn=74.6%, Sp=66.7%, PPV=84.1%, NPV=52.6%). Procalcitonin examination with CLIA had a better diagnostic value than quantitative immuno-chromatography method.
ANALYSIS OF MEAN PLATELET VOLUME, PLATELET DISTRIBUTION WIDTH, AND PLATELET COUNT IN HEMORRHAGIC AND NON-HEMORRHAGIC STROKE Gita Medita Sunusi; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1392

Abstract

Stroke merupakan gangguan fungsional otak fokal maupun global secara mendadak dan akut yang berlangsung lebih dari 24 jam akibat gangguan aliran darah otak (World Health  Organization).  Cedera yang dapat terjadi pada otak dan menyebabkan stroke adalah penyempitan pembuluh darah, sumbatan pembuluh darah, sumbatan atau penyempitan atau pecahnya pembuluh darah sehingga pasokan darah berkurang. Stroke menduduki posisi ke tiga setelah jantung koroner dan kanker di Indonesia.Stroke diklasifikasi menjadi stroke hemoragik dan stroke non hemoragik. Stroke non hemoragik  merupakan 80% penyebab stroke dan 20% disebabkan stroke hemoragik. Stroke non hemoragik menyebabkan gangguan pasokan oksigen dan nutrisi ke sel-sel otak akibat bentukan trombus atau emboli. Stroke hemoragik intraserebral dan subarachnoid disebabkan pecahnya pembuluh darah kranial.
SEL PLASMA LEUKEMIA HUBUNGAN DENGAN MIELOFIBROSIS Sri Sulistiandari; Budiman .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.937

Abstract

Plasma cell leukemia (PCL) is a variant form of myeloma which contain more than >20% plasma cells and an absolute plasmacell content ≥ 2.000/mm3 in peripheral blood. PCL is a rare disorder, whole PCL with myelofibrosis is even more rare disorder. Thecorrelation between plasma cell leukemia and myelofibrosis is unclear. A 59-years-old woman referred to our hospital with generalweakness and severe anemia. Physical examination: looks pale, anaemic of conjunctiva, hepatosplenomegaly. The laboratory findingsare Hb 4.1 gr/dL, MCV 81 fL, MCH 26.7 pg, leucocytes 22.500/mm3, thrombocytes 26.000/mm3, reticulocytes 1.8%. The peripheralblood showed leucoerythroblastic morphology with teardrop cells and 32% plasma cells. Bone marrow aspiration revealed massiveplasma cell infiltrations (90%). Protein electrophoresis showed hypogammaglobulinemia. There is no evidence of osteolitic bone lesionon radiological examination. Clinical and laboratory finding above support the diagnosis of Primary Plasma Cell Leukaemia that maylead to myelofibrosis as a complication. Bone marrow biopsy is required to confirm diagnosis of myelofibrosis.
PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F Adang Muhammad; Osman Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 1 (2005)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i1.833

Abstract

Background: The highest prevalence of nutrition problem due to nutrition deficiency is iron deficiency. Chronic disease anemia often occurs coincide with iron deficiency and both show of low iron serum appearance. Difficulty occurs when iron deficiency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. Objective: To know the more practical parameter that can determine iron deficiency in chronic disease anemia Discussion: Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inflammation process are varies. Recent evidence shows different changes of transferin receptor between iron deficiency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deficiency anemia. Studies on groups of iron deficiency anemia, iron deficiency with acute inflammation, chronic disease anemia and healthy control population showed significance differences of receptor transferin among them. sTrF-R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the ferritin level. The usage of sTfR-F index indicates more significance difference as compared to transferin receptor. Its sensitivity and specificity increase when it is applied to diagnose iron deficiency in elderly group. Conclusions: sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia

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