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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease) Sutamti Sutamti; Purwanto AP; MI. Tjahjati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1279

Abstract

Coronary artery disease is caused by atherosclerosis of the coronary arteries. Ox-LDL plays a role in atherosclerosis causing coronaryartery stenosis. There are differences in the research results on the relationship of ox-LDL levels and stenosis level of coronary arteryin patients with CAD. The aim of this study was to know the correlation between ox-LDL and stenosis level of coronary artery inCoronary Artery Disease (CAD). An observational study with cross sectional analytic approach was conducted on 37 patients with CADwho underwent coronary angiography in the Dr. Kariadi General Hospital and Telogorejo Hospital of Semarang, taken consecutivelyduring Febuary up to April 2014. The Ox-LDL levels were determined by sandwich ELISA and the stenosis levels were determined bycoronary angiography. The data were analyzed by non-parametric Spearman correlation test. Median of ox-LDL level in CAD patientswas 1666.8(846.15; 3324) pg/mL. The median of stenosis level was 80 (30;90)%. There was a significant correlation of ox-LDL leveland stenosis level (r=0.358; p=0.03) in CAD patients. Based on this study there was a weak positive correlation between ox-LDL leveland stenosis level in CAD patients.
DIAGNOSIS SEPSIS MENGGUNAKAN PROCALCITONIN Buchori Buchori; Prihatini Prihatini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.873

Abstract

Sepsis can be difficult to distinguish from non-infections conditions in critically ill patients with clinical signs of inflammation.Diagnosis of sepsis by conventional methods (erythrocyte sedimentation rate, CRP) are difficult to be confirmed. Procalcitonin (PCT)was found in 1990s, which number was enhanced in bacterial and fungi infections. Procalcitonin (PCT) is calcitonin (PCT) prohormonwhich presence increasing in sepsis and severe diseases. Procalcitonin (PCT) can be measured in serum and plasma by immunolometricmethods (immunoassay). The process needs 30 minutes to 1.5 hours depends on the selected method. It can be hope in the future,that methods of Procalcitonin (PCT) measurement can used as a means for early sepsis detection and can distinguish between systemicinfection and acute inflammatory disease.
INFEKSI VIRUS RABIES DI ANAK-ANAK A.A.N. Subawa; DGD. Dharma Santhi; A.A Raka Sudewi; IWP. Sutirta Yasa
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (566.285 KB) | DOI: 10.24293/ijcpml.v17i3.1093

Abstract

Rabies has been known in ancient Egypt and China since the fifth century. The disease is caused by the Rhabdovirus of the genusLyssavirus spread from animals or bats to humans by saliva. A five-year-old kid was admitted to Sanglah General Hospital on February19. 2010 with fever complaints, before admitted to the hospital, since the morning he always stuck out his tongue, bit his lips, drinkinga little of water and hard to swallow. From the anamnesis, it is known that the patient has a history of bitten by a dog on February 4.2010 at the lower eyelid and had received wound treatment and VAR, after a while having the treatment the patient eventually died onFebruary 21. 2010. According to the post-mortem sample of the LCS it is showed a positive PCR result of rabies virus infection.
VIROLOGICAL AND IMMUNOLOGICAL RESPONSE TO ANTIRETROVIRAL TREATMENT IN HIV-INFECTED PATIENTS (Respons Virologis dan Imunologis terhadap Pengobatan Anti-Retroviral di Pasien Terinfeksi HIV) Umi S. Intansari; Yunika Puspa Dewi; Mohammad Juffrie; Marsetyawan HNE Soesatyo; Yanri W Subronto; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1187

Abstract

Infeksi HIV/AIDS masih menjadi tantangan global. Pengobatan antiretroviral (ART) berperan dalam menurunkan replikasi virus,menurunkan tingkat kematian infeksi oportunistik dan meningkatkan kualitas hidup orang yang hidup dengan HIV/AIDS. Meskipundemikian data terkait respons virologis dan imunologis termasuk aktivasi imun masih sangat terbatas. Penelitian ini bertujuan untukmengetahui respons virologis dan imunologis pasien HIV setelah 6 bulan memulai pengobatan ARV. Subjek dari penelitian observasionalprospektif ini adalah 44 pasien HIV yang belum pernah mendapat pengobatan ARV, yang berobat di RSUP Dr. Sardjito Yogyakarta danRSUP Dr. Kariadi, Semarang. Sampel darah EDTA sebanyak 6 mL diambil pra dan pasca 6 bulan pengobatan ARV untuk pemeriksaanjumlah sel T CD4+, kadar RNA HIV dan persentase sel T CD8+/38+. Kadar RNA HIV turun secara bermakna sejalan dengan persentasesel T CD8+/38+, sementara jumlah sel T CD4+ meningkat bermakna. Sebanyak 79,5% pasien mengalami pemulihan sel T CD4 optimal(>50 sel/μL) dan kadar RNA HIV turun lebih dari 1 log10 kopi/mL pada 93% pasien. Pasien dengan respons tidak sesuai antara virologisdan imunologis didapatkan sebanyak 13,6%. Kadar HIV bernasab positif dengan persentase sel T CD8+/38+ (r=0,58, p<0,0001) danbernasab negatif dengan jumlah sel T CD4+ (r=–0,470 (p<0,0001). Berdasarkan telitian ini, sebagian besar pasien mempunyai responsvirologis dan imunonologis yang sesuai 6 bulan setelah ART. Sebanyak 20,45% pasien tidak berespons atau mengalami ketidaksesuaianrespons virologis dan imunologis dan memerlukan penilaian dan pengobatan secara terus menerus.
THE ROLE OF PLATELETS SCD40L TO ATHEROGENESIS (Peran sCD40L Trombosit terhadap Aterogenesis) Kurniawan, Liong Boy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1247

Abstract

Peran CD40 dan CD40L terhadap maturasi dan diferensiasi sel limfosit telah diteliti sebelumnya. CD40L diekspresikan oleh berbagaisel lainnya seperti: makrofag, sel dendritik, neutrofil dan endotelial. Trombosit juga dapat mengekspresikan CD40L dan dapat dilepaskandalam bentuk terlarut yaitu sCD40L. Telaahan ini bertujuan untuk mengetahui peran sCD4-0L yang dihasilkan oleh trombosit padaaterogenesis lewat penjelasan. sCD40L dapat menyebabkan gangguan fungsi endotel, pelepasan ROS, peningkatan aktivitas ICAM,VCAM dan MMP, aktivasi trombosit dan destabilisasi plak melalui interaksi dengan berbagai molekul lain seperti OxLDL. Aterogenesisdapat dipicu melalui interaksi sCD40L. Berbagai penemuan di bidang Farmakologi dan segi lain perlu dikaji untuk menghambat sCD40Ldalam aterogenesis. Penelitian lebih lanjut dan mendalam masih diperlukan untuk membuktikan peran sCD40L sebagai petanda peramalkejadian aterogenesis.
PENDEKATAN STEWART DALAM pH DARAH YANG MENDASARI ASIDOSIS METABOLIK Efrida Efrida; Ida Parwati; Ike Sri Redjeki
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1061

Abstract

Metabolic acidosis is the most frequent acid-base disorder in patients of the Intensive Care Unit. By conventional approach based onpH value, [HCO3–], and base deficit (BD) from blood gas analyzer (BGA) measurement are often inappropriate with the clinical stateand inadequate in explaining the mechanism of the metabolic acidosis. The Stewart approach states that the blood pH is determinedby a strong ion difference (SID), the carbon dioxide tension (pCO2), the total concentration of non-volatile weak acid. The Stewartapproach may give a better understanding of the mechanisms that underlie the metabolic acidosis. The purpose of this study is to knowthe correlation of blood pH value measurement from BGA and calculation based on Stewart approach and identifying the mechanismsthat underlie a metabolic acidosis. In this study an analytic observational cross-sectional method was used. The examined subjectsconsisted of 71 patients who were admitted with a metabolic acidosis at the ICU from July up to August 2007. All patients were measuredfor their blood pH, pCO2, [HCO3–], BD, sodium, potassium, calcium, magnesium, chloride, lactate, albumin, and phosphate. The resultwas reported as the mean and standard deviation. The data were analyzed by Pearson’s correlation test and linier multiple regression.Statistical significance was determined at p < 0.05. The mean values of blood pH measurement from BGA and blood pH calculationbased on the Stewart approach were 7.33 (0.11) and 7.49 (0.11) (r = 0.681; p < 0.001). Most patients had two underlying mechanisms ofmetabolic acidosis. Hyperlactatemia was present in 61.8%, hyperchloremia was present in 58.2% of patients. Based on this study so far,by using the Stewart approach there is an excellent and significant correlation between the blood pH measurement from BGA and bloodpH calculation. Hyperlactatemia and hyperchloremia are the main causes of the metabolic acidosis in patients of the ICU ward.
SERUM GLIAL FIBRILLARY ACIDIC PROTEIN LEVELS PROFILE IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY Arief S. Hariyanto; Endang Retnowati; Agus Turchan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1151

Abstract

Glial Fibrillary Acidic Protein (GFAP) sangat khas untuk otak (highly brain specific protein), sebagai petunjuk kerusakan sel,merupakan protein yang berhubungan dengan peningkatan tekanan intrakranial dan sebagai petanda perjalanan penyakit di pasiencedera otak. Penelitian ini menganalisis profil kadar GFAP serum pasien cedera otak berat sebagai petanda perjalanan penyakit dankeluarannya. Desain penelitian deskriptif observasional. Kadar GFAP serum dari sampel darah vena, diperiksa dengan metode ELISApada hari pertama datang ke Instalasi Gawat Darurat dan hari ke-2,3,4 perawatan. Jumlah sampel 25 orang, laki-laki 20 orang (80%),perempuan 5 orang (20%). Umur terbanyak ≤ 25 tahun, 8 orang (32%), rerata umur 35,92 ± 13,80 tahun. Jejas berdasarkan hasilCT Scan kepala terbanyak Diffuse Axonal Injury (DAI) 7 (28%), tindakan operasi sebanyak 18 (72 %), non-operasi 7 (28%), penyebabcedera, kecelakaan lalu lintas 23 (92%), jatuh 2 (8%). Rerata kadar GFAP serum hari ke-1,2,3,4 berturut-turut 2,72±1,44 ng/mL,1,85±0,85 ng/mL, 1,67±1,26 ng/mL, 0,79±0,35 ng/mL. Keluaran pasien, hidup 19 (76%), meninggal 6 (24%). GFAP sangat khaspada otak berguna sebagai petanda di pasien cedera otak berat, yaitu peningkatan kadarnya dapat digunakan sebagai faktor perjalananpenyakit untuk kematian dan keluarannya. Peningkatan kadar GFAP serum dapat digunakan sebagai faktor perjalanan penyakit.Penelitian lanjutan diperlukan dengan sampel yang lebih besar
ANGKA BANDING LIPID DI INFARK MIOKARD Liong Boy Kurniawan; Uleng Bahrun; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.437

Abstract

Lipid profiles are used as the regular tests which performed to predict and evaluate the risk of coronary heart disease. The routine lipid tests include total cholesterol, LDL, HDL and triglyceride level. The total cholesterol/HDL and LDL/HDL ratio are often used as predictors of coronary heart disease. This study was performed to know the lipid level and ratio by comparing the condition in myocardial infarction patients and young adult controls and to observe the percentage of their lipid level and ratio exceeding the recommended optimal value. A retrospective study was performed using secondary data of 73 myocardial infarction patients, whom hospitalized in the Intensive Cardiac Care Unit Dr. Wahidin Sudirohusodo Hospital Makassar from June 2010 to July 2011 and 21 healthy young adult as controls. The mean level of the total cholesterol, LDL, HDL, triglyceride, ratio of total cholesterol/HDL and LDL/HDL of myocardial infarction patients are compared with the control subjects were 209.99±51.70 vs 151.42±27.90 mg/dL (p=0.000), 141.18±41.92 vs 76.76±20.45 mg/dL (p=0.000), 36.96±10.47 vs 47.05±8.24 mg/dL (p=0.000), 132.27±65.67 vs 142.14±54.93 mg/dL (p=0.155), 5.99±1.71 vs 3.26±0.59 (p=0.000) and 4.06±1.45 vs 1.66±0.44 (p=0.000), respectively. It was shown that the percentage of myocardial infarction patients with total cholesterol, LDL level, total cholesterol/HDL and LDL/HDL ratio exceeding recommended optimal value were 57.53%, 63.01%, 73.97% and 86.30%, respectively. The level of total cholesterol and LDL, ratio of total cholesterol/HDL and LDL/HDL in myocardial infarction patients were significantly higher, but the HDL level was lower compared to the control subjects. The percentage of myocardial infarction patients with LDL/HDL ratio exceeding recommended optimal value was higher than the other lipid levels and ratio. Therefore, it is concluded that the LDL/HDL ratio is better in predicting coronary heart disease than other routine lipid markers.
PEMERIKSAAN TINGKAT sdLDL SERUM SEBAGAI PETANDA DIAGNOSTIK STENOSIS KORONER (Serum sdLDL Level as A Diagnostic Marker of Coronary Stenosis) Indranila K Samsuria; Laily Adninta
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1215

Abstract

Small dense LDL (sdLDL) is the LDL which particles are small and dense, it is pro-atherogenic. Increased levels of serum sdLDL areassociated with an increased risk of coronary stenosis. The aim of this study was to examine the diagnostic value of sd LDL in coronarystenosis. An analytical observational study with cross sectional approach was conducted at the Department of Clinical Pathology, MedicalFaculty of Diponegoro University/Dr. Kariadi Hospital and the Unit of Cardiac diseases during the period of March-October 2013. Thesubjects were 39 patients suspected of suffering a coronary stenosis. The diagnosis of coronary stenosis, degree of stenosis and numberof vascular stenosis was established at the time of cardiac catheterization. SdLDL assessment used a test kit. The statistical analysis usedwere unpaired t-test, Spearman correlation test, ROC analysis and diagnostic test. LDL levels in stenosis subjects, 35.4±9.01 mg/dL weresignificantly higher compared to levels in subjects that had no stenosis, 20.7±7.10 mg/dL (p<0.001; unpaired t-test). Correlation testresults showed a correlation between levels of serum sdLDL with severe degree of stenosis (correlation coefficient -0.64, p <0.001) and amoderate positive correlation between the number of vascular stenosis (Coefficient correlation 0.46; p=0.003; Spearman Correlation’sTest). The area under the curve of ROC was 0.9 (p <0.001). The cut off levels sdLDL were used to detect stenosis. The results showeda sensitivity of 85.2%, specificity of 75%, positive predictive value of 88.5%, negative predictive value of 69.2% and accuracy of 82%.Levels of serum sdLDL were associated with severe to extensive stenosis degree, and showed a good diagnostic value, thus, it can beused for screening to determine the presence of coronary stenosis.
ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH COEFFICIENT OF VARIATION ON STROKE PATIENT Kartika Paramita; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1482

Abstract

 Stroke is a functional disorder attributed to acute focal or global brain injury by vascular cause and persists more than 24 hours. Stroke is divided into ischemic and hemorrhagic strokes. Red Blood Cell Distribution Width (RDW) is a measurement of erythrocyte volume variation in blood circulation. Increased RDW reflects the inflammation that plays a role in the development of atherosclerosis in stroke. This study aims to analyze differences in RDW-CV values in patients with stroke. The design was cross-sectional with a retrospective approach, secondary data from medical records of inpatients with stroke from January to December 2016 at the Dr. Wahidin Sudirohusodo Hospital. The study population consisted of 490 patients aged ≥ 18 years old. The Kruskal-Wallis, Mann-Whitney, and Anova one way tests were used to analyze differences in RDW-CV values in patients with ischemic and hemorrhagic stroke. Mann-Whitney test results showed no significant difference in RDW-CV values between groups of ischemic and hemorrhagic stroke (p 0.96). Kruskal-Wallis and Anova one way tests showed no significant difference in RDW-CV values between four groups of patient outcomes in ischemic and hemorrhagic stroke (p 0.13 and p 0.35 consecutively). There were no significant RDW-CV values between ischemic and hemorrhagic stroke. There was no significant difference between RDW-CV values of four groups of patient outcomes in ischemic and hemorrhagic stroke. RDW-CV values cannot be used to distinguish both ischemic and hemorrhagic stroke, including the prediction of stroke mortality

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