Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
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<![CDATA[A 24-Year-Old Male with Gigantism, Growth Hormone Deficiency, Suspected Clivus Chordoma, Primary Hypothyroidism, Hypogonadism and Pancytopenia ]]>
<![CDATA[W.A. Arsana]]>;
<![CDATA[M.I. Diah Pramudianti]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v26i2.1478
<![CDATA[Pituitary gigantism is a condition caused by excessive secretion of Growth Hormone (GH). The GH is the most commonpituitary hormone-deficient in pituitary disease. Chordoma is a bone primary tumor that grows slowly and is rarely found.Hypothyroidism is a pathological condition due to thyroid hormone deficiency. Symptoms of hypogonadism arenon-specific including libido disorders, erectile dysfunction, and decreased muscle mass and no hair growth in the head orbody. A 24-year-old male came with pain in the knee. Physical examination showed increased growth of natural and bodyparts as well as the loss of body hair. Laboratory investigations revealed pancytopenia, increased prolactin; decreased GH,Insulin-Like Growth Factor-1 (IGF-1) and testosterone; increased Thyroid-Stimulating Hormone (TSH), decreased FreeTriiodothyronine (FT3) and Free Thyroxine (FT4). Ahead MRI demonstrated the presence of a mass in the clivus. In this case,the patient presented with clinical gigantism. However, laboratory examination showed decreased GH and IGF-1 whichmight be due to the suppressive effect of mass on the clivus bone to the pituitary. Further examinations were needed to clearthe suspicion of hypothyroid. Hypogonadism can result from suppression in the pituitary. Pancytopenia can be caused by adeficiency of GH or from hypothyroidism. Gigantism may occur with GH and IGF-1 deficiency due to suppressed pituitarycaused by chordoma.]]>
<![CDATA[RELATIONSHIP BETWEEN NEUTROPHIL - LYMPHOCYTE RATIO AND DECREASED GLOMERULAR FILTRATION RATE IN DIABETIC NEPHROPATHY ]]>
<![CDATA[Asriyani Azikin]]>;
<![CDATA[Fitriani Mangarengi]]>;
<![CDATA[Uleng Bahrun]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v24i2.1311
<![CDATA[Diabetic nephropathy is one of the fairly severe Diabetes Mellitus (DM) complications and the main cause of renal failure that can result in mortality. Hyperglycemia in DM induces kidney injury that may result in hemodynamic and metabolic alterations, endothelial dysfunction and inflammatory cells activation. A persistent and continuous inflammation is observed in diabetic nephropathy. One of the inflammation process progression indicators is Neutrophil-Lymphocyte Ratio (NLR). To find out the relationship between NLR and decreased Glomerular Filtration Rate (GFR) in diabetic nephropathy. This study was an observational study with a retrospective approach. This study was conducted in Clinical Pathology Laboratory Installation and Medical Record Installation of Dr. Wahidin Sudirohusodo Makassar Hospital by collecting the patient’s data during February 2015 to February 2016. Patients that were diagnosed as type 2 DM without diabetic nephropathy complication were taken as control and those diagnosed as type 2 DM with diabetic nephropathy were treated as study subjects. One hundred and thirteen (113) samples met the inclusion criteria, consisting of 73 diabetic nephropathy patients with Chronic Kidney Disease (CKD) 13 diabetic nephropathy patients without CKD and 27 type 2 DM patients without diabetic nephropathy complication. Patients consisted of 57 males (50.4%) and 56 females (49,6%). Neutrophil-lymphocyte ratio and GFR values in the group of diabetic nephropathy without CKD were 2.03±0.68 and 85.38±24.63, respectively. Whereas, the NLR and GFR values in control group were 1.74±0.54 and 90.03±28.60, respectively. In the group of diabetic nephropathy with CKD, NLR value increased by 3.19±1.83 and GFR decrease by 30.54±16.45. Spearman test indicated a significant relationship between NLR increase and decreased GFR (r = -0.635, p=0.00). There is a significant relationship between NLR increase and decreased GFR in patients with diabetic nephropathy. ]]>
<![CDATA[CARCInoeMBRYonIC AnTIGen (CEA) DI KANKER KOLOREKTAL ]]>
<![CDATA[Nur Rahmi Raehaan]]>;
<![CDATA[Asvin Nurulita]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v20i3.465
<![CDATA[Colorectal cancer is a common gastrointestinal malignancy of the colon and rectum. According to the American Society of Clinical Oncology (ASCO) in 2006, preoperative CEA level is useful in dtermining the tumour stage, plan of action and monitoring therapeutic response during the active treatment. Several factors which influence CEA level in patients with colorectal cancer is the staging and the degree of tumour, liver function, and as well as its location. This retrospective study is aimed to know the preoperative CEA levels in 51 patients with colorectal cancer and to compare the levels of CEA based on tumour stage, degree of tumour based on histopathology and tumour location.. This study was carried out at the Dr.Wahidin Sudirohusodo Hospital (RSWS), Makassar during January 2009−December of 2011. The researchers found a significant difference between the levels of CEA with the tumour stage (p=0.000) and its relation with the degree of the tumour (p=0.002), however, based on the tumour location (p=0.585) there was no significant difference between the levels of CEA. In conclusion, it was found that the higher the tumour stage, the higher the levels of the produced CEA. A well differentiated tumour of colorectal cancer produced a higher level of CEA compared to the moderate or poor-differentiated tumours.]]>
<![CDATA[Increased Insulin Like Growth Factor-1 and Antropometri in Premature Infants with Breast Milk ]]>
<![CDATA[I Dewa Ayu Agung Sridharaswari]]>;
<![CDATA[Mira Irmawati]]>;
<![CDATA[Ahmad Suryawan]]>;
<![CDATA[Irwanto idris]]>;
<![CDATA[Endang Retnowati]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v26i1.1399
<![CDATA[Massage stimulation has consistently led to greater anthropometric in preterm infant by increasing IGF-1 in which plays an important role in promoting growth by stimulating cell growth, multiplication and inhibiting apoptosis. This research to analyze the effect of massage stimulation on IGF-1 and anthropometric in breastfeeding preterm infant. A randomized control trial was conducted on preterm infant with gestational age less than 37 weeks between February – May 2018 in nursery Dr. Soetomo Hospital. Fifty infants in nursery was randomly assigned to massage stimulation or control group. Massage stimulation consisted for three, 15 minutes periods per day for 10 days. Insulin Growth Factor -1 serum was examined on day 1 and 10. Data were analyzed by statistical software using t-test and spearman correlation. The average increase of IGF -1 in massage group was 4.8 (SD 4.41) and 3.1 (SD 3.57) in control group. The average increase of body weight was 252.2 (SD 208.55) in massage group, and 137.9 (SD 69.78) in control group. The average increase of body length was 2 (0.68) in massage group, and 1.1 (0.33) in control group. The average increase of head circumference was 1.5 (SD 0.82) in massage group, and 0.9 (0.28) in control group. The positive correlation between the mean increase of IGF-1 and body length was 0.347. The conclusion was IGF-1 and anthropometric increase in both groups, but the massage group has a significantly higher mean. An increase in IGF-1 correlates with increase in body length.]]>
<![CDATA[PERBANDINGAN PEMERIKSAAN TRIGLISERIDA METODE GLYCEROL BLANKING DAN NON GLYCEROL BLANKING PADA SIROSIS HEPATIS ]]>
<![CDATA[Sri Widyaningsih]]>;
<![CDATA[Leonita Anniwati]]>;
<![CDATA[Juli Soemarsono]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v19i1.393
<![CDATA[Liver cirrhosis is a chronic liver disease with fibrosis and impairment of function. In liver disease increasing endogenous free glycerol has been found which constitutes a source of interference in the measurement of (TG). The aim of this study is to compare the glycerol blanking (TG-GB) which does not interfere with endogenous free glycerol to non glycerol blanking (TG-NGB) method in measuring TG in liver cirrhosis patients. In this study, sera were obtained from 22 liver cirrhosis and 30 healthy persons. All sera were measured for TG using TMS 1024i (Tokyo Boeki Medical System) with glycerol blanking (TG-GB) to non glycerol blanking (TG-NGB) method. In addition to this study, measurement of free glycerol was also compared to difference calculated TG-NGB and TG-GB in liver cirrhosis patients. The mean of TG-GB and TG-NGB measurements from healthy persons was 115.30±70.35 mg/dL and 121.27±67.14 mg/dL (p=0.108), respectively. The mean of TG-GB and TG-NGB measurements from liver cirrhosis patients was 101.09± 78,55 mg/dL and 120.91±79.44 mg/dL (p<0.0001). There was a significant difference between TG-GB and TG-NGB, and there was no significant difference between measurement of free glycerol to difference calculated TG-NGB and TG-GB in liver cirrhosis (p=0.784). However, there was a significant correlation between TG-GB and TG-NGB in healthy persons and liver cirrhosis patients. (p<0.0001). The measurement of TG-GB is more accurate than TG-NGB method in liver cirrhosis patients.]]>
<![CDATA[Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major ]]>
<![CDATA[Ade Hariza Harahap]]>;
<![CDATA[Bidasari Lubis]]>;
<![CDATA[Herman Hariman]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v26i1.1384
<![CDATA[There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia major. Recently, there is evidence to suggest that in β-thalassemia major there is hypocalcemia and hypovitaminosis D. So, this study is to clarify if hypovitaminosis D is trully the cause of bone problem in thalassemia. Forty five subjects were recruited in this study, 35 were β-thalassemia major patients and 10 normal subjects as controls. Ten mL of venous blood were taken from median vein for investigations of total vitamin D [25(OH) vitamin D], total calcium and phosphor using the Enzyme-Linked Fluorescent Assay (ELFA), metallochromic dye (Arsenazo III) and chemical reaction of inorganic phosphate with amonium mollybdate respectily. Mean ± SD of vitamin D in β-thalassemia major is 21.28 ± 6.36 ng/ml and in control 34.85 ± 3.50 ng/ml (p<0.05); total calcium in β-thalassemia major is 8.58 ± 0.68 mg/dl and in control 9.22 ± 0.35 mg/dl (p<0.05); and phosphor in β-thalassemia major 3.98 ± 0.53 mg/dl and control 3.89 ± 0.49 mg/dl (p>0.1). There was no significant correlation (r = 0.17, p>0.05), when vitamin D was analysed against calcium for the correlation study,. This study demostrates that there was state of hypovitaminosis D and hypocalcemia in β-thalassemia major but hypovitaminosis D is not the only causative factor of the calcium levels. There should be another factor responsible for the calcium levels in β-thalassemia major and marrow expansion may remain the factors responsible for bone abnomarlities.]]>
<![CDATA[ANALYSIS OF IMMATURE PLATELET FRACTION AND MEAN PLATELET VOLUME IN ACUTE CORONARY SYNDROME PATIENT ]]>
<![CDATA[Pratia Paramita]]>;
<![CDATA[Asvin Nurulita]]>;
<![CDATA[Ruland DN Pakasi]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v25i3.1390
<![CDATA[Platelets have a central role in the pathogenesis of ACS. Immature Platelet Fraction (IPF) considered as a potential marker of the platelet activation process and platelet turnover process. Immature platelets have greater prothrombotic potential and aggregate more rapidly with collagen that affects platelet hemostasis potential that may contribute to the formation of thrombus. Therefore IPF is associated with the progression of coronary heart disease. MPV values reflect platelet activation. A cross sectional study was held in the clinical pathology laboratory of Dr. WahidinSudirohusodo Hospital Makassar during September-November 2016. 67 samples underwent and declared ACS by the physician. 67 patients with ACS were involved with a distribution of 30 patients STEMI (44.8%), 30 patients NSTEMI (44.8%), and 7 patients UAP (10.4%). Subjects are mostly male (73.1%) and young adult age (82.1%). There was significant difference of IPF value especially in STEMI group with mean 3,1 (p = 0,004) and no significant difference of MPV value in ACS group.Pearson correlation test showed there was positive correlation with weak strength of IPF and MPV values in ACS patients (p = 0.02, r = 0.388). There was a significant difference between IPF scores according to GRACE score (p = 0.005). Increased IPF value in STEMI group. The IPF score can be considered as a risk stratification of ACS patients replacing GRACE score. There was a positive correlation with weak strength of IPF and MPV value in ACS patients.]]>
<![CDATA[ANALISIS FERITIN DAN AST TO PLATELET RATIO INDEX SEBAGAI PETANDA DERAJAT FIBROSIS PENYAKIT HATI KRONIS (Analysis Ferritin and AST to Platelet Ratio Index as a Marker Degree of Fibrosis Chronic Liver Disease) ]]>
<![CDATA[Yulianti Yasin]]>;
<![CDATA[Uleng Bahrun]]>;
<![CDATA[Ibrahim Abdul Samad]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v22i1.1226
<![CDATA[Chronic liver disease is an endemic disease in Indonesia which is still a global health problem and detected when it’s developinginto fibrosis. The determination of fibrosis is important for the treatment and prognosis of chronic liver disease. AST to Platelet RatioIndex (APRI) score is the most common used to assess the degree of liver fibrosis. Ferritin is an iron deposit that found in the liver andthe levels depend on the degree of the cell damage. The aim of this study was to analyze ferritin levels as a marker of the fibrosis degreein the chronic liver disease. This cross-sectional study of 47 patients with chronic liver disease performed at Dr. Wahidin SudirohusodoGeneral Hospital between May–June 2012. The subjects are grouped into cirrhotic and noncirrhotic, based on the theory that in cirrhoticliver fibrosis was considered as an irreversible condition. AST to platelet ratio index score based on the Wai CT formulation, includingthe examination of AST by optimizing UV-test according to International Federation of Clinical Chemistry (IFCC) modified method onthe ABX Pentra 400, examination of platelet by impedance method on Sysmex XT 2000i and ferritin levels were measured by ECLIAmethod using Elecsys 2010 Analyzer. The Spearman correlation tests showed no association between ferritin levels and APRI in cirrhoticand non cirrhotic patients (p=0.704 and r=–0.057). In conclusion, ferritin can not be used as the marker in determining the degreeof fibrosis patients suffering chronic liver disease. Further studies are expected using a more valid method for determining the degree offibrosis such as liver biopsy or fibro scan.]]>
<![CDATA[Correlation between Plasma Osteopontin and Alkaline Phosphatase in Type 2 Diabetes Mellitus Patients ]]>
<![CDATA[Sinambela, Josua TH]]>;
<![CDATA[Pramudianti, M.I Diah]]>;
<![CDATA[Ariningrum, Dian]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v26i2.1468
<![CDATA[Diabetes Mellitus (DM) is a chronic disease caused by pancreas the inability to produce insulin or ineffectively insulin use.Fracture risk in type 2 DM patients increases even though the bone density is normal. This study aimed to examine thecorrelation of osteopontin (OPN) and alkaline phosphatase (ALP) in type 2 DM patients. An observational analytical studywas conducted in 73 type 2 DM patients in Dr. Moewardi Hospital, Surakarta from October to November 2018. The subjectswere examined for blood pressure, fasting blood glucose, two hours postprandial blood glucose, HbA1c, OPN, and ALPlevels. P-value <0.05 was statistically significant with a 95% confidence interval. Poorly controlled type 2 DM had higher OPNlevels than well-controlled (20.5±2.8 vs. 14.8±3.1 ng/mL, p <0.001). The ALP concentration was also higher in poorlycontrolled type 2 DM patients (79.9±31.7 vs. 61.1±25 U/L, p=0.003). The levels of OPN and ALP were significantly correlatedin type 2 diabetes (r=0.273; p=0.020) and in well-controlled patients (r=0.353; p=0.047) but no correlation was found inpoorly controlled type 2 DM patients (r= -0.073; p= 0.652). In this study, a significant correlation was found between OPNand ALP in patients with type 2 DM and well-controlled. Further study involving healthy controls and bone ALPmeasurement is needed.]]>
<![CDATA[Seropositivity of Anti-Rubella Antibodies as A Marker for Rubella Infection in Infants at High Risk of Congenital Deafness ]]>
<![CDATA[Nyilo Purnami]]>;
<![CDATA[Risa Etika]]>;
<![CDATA[Martono Martono]]>;
<![CDATA[Puspa Wardhani]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 2 (2020) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v26i2.1479
<![CDATA[Hearing loss in newborns or congenital deafness can be caused by the development of several parts of the auditorysystem. Congenital deafness is often associated with infections, such as Toxoplasmosis, Rubella, Cytomegalovirus (CMV),and Herpes (TORCH). Deafness is very difficult to be early detected. Therefore, simple but fast methods are needed. Earlydetection is based on the Newborn Hearing Screening (NHS) program. Otoacoustic Emission (OAE) and AutomatedAuditory Brainstem Response (AABR) checks are raw materials for early detection. Congenital deafness often occurs withpregnancy infections with viruses such as Rubella. Rubella infection during pregnancy, especially during the first trimester,often causes Congenital Rubella Syndrome (CRS). Rubella infection often occurs with other causes, such as Toxoplasma,CMV, and Herpes. A Serological test can be used as one of the diagnostics of this infection. This study used single RubellaIgG and IgM antibodies and double antibodies test as a marker for the infection. The authors wanted to correlate theserological examination of this infection with the auditory function. Rubella infection was detected with single serologicalanti-Rubella IgG and IgM and double multiple Rubella and TORCH serological tests. Also, the auditory function wasassessed using the OAE and AABR test in this research. The result showed 35 (77.7%) patients with positive Rubellaserological tests among 45 NICU patients at Dr. Soetomo Hospital. There were number of patients was 12 (34.2%) patientswith a single positive serological test and 23 (65.7%) patients with positive multiple TORCH serological tests. The number ofpatients with Rubella negative infection was 10 (22.2%). There were 11 (31.4%) patients of positive Rubella infections withpositive hearing loss and 24 (68.6%) patients with negative hearing loss. From the results of the study, 35 patients were athigh risk of disturbance and the statistical analysis showed that there were no significant serological differences in Rubellapositive with hearing loss (p=0.087). Hearing loss in NICU infants has a high risk of factors causing Rubella infection andother related causes. In most Rubella positive serological tests IgG was found, which can be due to maternal factors.Serology tests need to be repeated for confirmation under the surveillance program. How to follow-up the patients anddefine the next laboratory test after six months remain a great challenge. The efforts need to be strengthened in surveillanceprograms.]]>
