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Jurnal Prima Medika Sains
Published by Universitas Prima Indonesia
ISSN : 26863502     EISSN : 27146707     DOI : https://doi.org/10.34012/jpms
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Prima Medika Sains adalah jurnal ilmiah di bidang kesehatan dan kedokteran yang terbit dua kali dalam setahun yaitu pada bulan Juni dan Desember. Diterbitkan oleh Universitas Prima Indonesia yang secara teknis dikelola Program Studi Magister Kesehatan Masyarakat Fakultas Kedokteran Universitas Prima Indonesia. Berisi tulisan hasil penelitian lapangan atau laboratorium maupun studi pustaka di bidang kesehatan dan kedokteran.
Arjuna Subject : Kedokteran - Kesehatan Masyarakat, Kesehatan Lingkungan dan Pekerjaan
Articles 154 Documents
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Medicinal potential of gambier extract for recurrent aphthous stomatitis treatment Amaliah, Nurfitri; Saud, Muhammad Yamin
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6581

Abstract

Recurrent aphthous stomatitis (RAS) remains as one of the most common disorders in the oral cavity. Various treatment options for RAS conditions include topical, systemic, and the use of traditional ingredients that have pharmacological content. One of the plants known to have good pharmacological content for RAS treatment is gambier (Uncaria Gambier). Gambir plant extract is known to have various benefits for health, including in the management of RAS due to the active ingredient compounds in the form of anti-inflammatory, antioxidant and antibacterial properties. One of the active compounds possessed by gambier plant extract in the form of catechine is proven to have the ability to reduce inflammation and help to accelerate the healing process in RAS cases.
Effectiveness of platelet rich plasma injection for achilles tendon injury in wistar rats: An experimental study Nasution, Nino; Reza, Muhammad
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6612

Abstract

Tendon injuries, particularly Achilles tendon ruptures, significantly impact athletes and labourers, affecting daily activities and quality of life. The platelet plasma rich (PRP) injections have emerged as a treatment option due to their abilities in stimulating growth factors, essential for the healing processes. This study investigates the effectiveness of PRP injections in healing Achilles tendon injuries in Wistar rats. Thirty male Wistar rats were divided into three groups: Group 1 received a 100 µL PRP injection, Group 2 received a 50 µL PRP injection, and Group 3 received a 100 µL NaCl injection as a control. The Achilles tendons were surgically transacted and sutured using modified Kessler method, followed by PRP or NaCl injections. Rats were euthanized on days 15 and 30 for histological and biomechanical evaluations. This study found that PRP administration had a significant effect on histological tendon healing on the 15th and 30th, with the best improvement at a PRP dose of 100 µL, especially in the early phase of healing. PRP also had a significant effect on tendon healing in terms of biomechanical function on the 15th and 30th days, with the best improvement at a PRP dose of 100 µL, especially in the final phase of healing. This study provides detailed biomechanical and histological insights into the tendon healing process, which may be challenging to obtain in human studies due to ethical and logistical constraints. The PRP injection improves healing in the Achilles tendon rupture in Wistar rats.
Lived experience and impact of oral phosphodiesterase-5 inhibitors among patients with type 2 diabetes mellitus complicated by erectile dysfunction: A qualitative study Ramali, Khairul Nazli; Draman, Nani; Zainuddin, Aida Maziha; Muhamad, Rosediani; Ismail, Shaiful Bahari
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6616

Abstract

This study explored the experiences of men with Type 2 Diabetes Mellitus (T2DM) who also experienced erectile dysfunction (ED) and delayed seeking medical treatment. Using a phenomenological approach, in-depth interviews were conducted with 15 male patients, aged 18 and above, who had been using phosphodiesterase-5 (PDE5) inhibitors for at least three months. Thematic analysis of the interviews, framed by sexual script theory, identified three key themes. Patients reported feelings of sexual distress, a perceived loss of manhood, and inadequacy as husbands, which negatively affected their wives and relationships. Many initially believed that alternative therapies could cure ED, delaying their pursuit of conventional medical treatment. However, after complementary treatments failed, they recognized the benefits of PDE5 inhibitors. These medications significantly helped patients regain sexual strength, self-esteem, and satisfaction in their relationships. This study underscores the profound impact ED has on the sexual well-being of men with T2DM and highlights the importance of PDE5 inhibitors in improving sexual function and restoring intimacy within couples. It also emphasizes the need for early intervention and education on the effectiveness of medical treatments for ED.
Cytotoxicity evaluation of combined Piper betle-bioactive glass on dental pulp stem cells Allosias, Jacqueline Ann; Noor, Siti Noor Fazliah Mohd; Luddin, Norhayati; Ghani, Huwaina Abd
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6626

Abstract

Recent advances in dentistry emphasize the use of synthetic and natural bioactive materials for regenerating the dentine-pulp complex. This study assesses the cytotoxic effects of Piper betle-conditioned media, alone and combined with bioactive glass 45S5 Bioglass. Three test groups were used: Piper betle-only, Bioactive glass-only, and the combined Piper betle-Bioactive glass. Cytotoxicity was measured using the MTT assay on dental pulp stem cells on day one, two, four, seven, and fourteen. Cells exposed to 4.00 mg/ml Bioactive glass-only showed the highest cell viability, while Piper betle-only demonstrated the highest viability at a concentration of 31.25 µg/ml. The combined Piper betle-Bioactive glass showed the best results at 4 mg/ml and 30 µg/ml. Overall, the combination group had the highest cell viability, followed by the Bioactive glass-only and Piper betle-only groups. No significant differences were found between the combination and Bioactive glass-only groups, but significant differences existed between the combination and Piper betle-only groups. In conclusion, the combination of Piper betle and Bioactive glass enhances dental pulp stem cell proliferation, warranting further investigation into its regenerative potential.
The combined effect of neonatal hypothyroidism and low family income on intellectual disability: A review of mechanisms and interventions Sutanti, Sutanti; Suryawan, I Wayan Bikin
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6651

Abstract

This review investigates the combined effect of neonatal hypothyroidism and low family income on the prevalence of intellectual disability, drawing insights from existing literature, including specific findings from studies involving neonatal cases such as 15 cases at Wangaya Regional Hospital Denpasar. Neonatal hypothyroidism significantly impacts cognitive development due to the critical role of thyroid hormones in brain maturation. Concurrently, low family income acts as a risk factor for intellectual disability by limiting access to essential healthcare, education, and developmental resources. The review explores the epidemiology of neonatal hypothyroidism, highlighting global and regional variations influenced by genetic, environmental, and socioeconomic factors. It delves into the mechanisms by which neonatal hypothyroidism affects brain and cognitive function, leading to deficits in intelligence, memory, attention, and executive function. Furthermore, the review examines the relationship between socioeconomic status and intellectual disability, emphasizing the role of resource scarcity and environmental factors associated with poverty. Findings from the reviewed literature suggest a compounding effect of neonatal hypothyroidism and low family income on a child's cognitive development and intellectual disability risk. Addressing this complex interplay necessitates a multifaceted approach, including early detection, prompt treatment, and integrated interventions spanning healthcare, education, and social support services. The review underscores the importance of equitable access to newborn screening, comprehensive early intervention programs, and family-centered support for children from low-income households.
Association between cardiothoracic ratio and aortic arch calcification with estimated glomerular filtration rate in hypertensive patients Pratomo, Fransiskus Aryo; Icksan, Aziza Ghanie; Nasution, Ikhwanul Hakim
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6677

Abstract

Hypertension remains a leading cause of global cardiovascular mortality, including in Indonesia. Target organ damage, particularly renal impairment, underscores the need for easily obtainable biomarkers for early detection. Although not explicitly recommended in current guidelines, the cardiothoracic ratio (CTR) and aortic arch calcification (AAC), both assessable via chest radiography, represent readily available and cost-effective screening tools. This study aimed to evaluate the association between these radiographic markers and decreased estimated glomerular filtration rate (eGFR) in hypertensive patients at Royal Prima Hospital, thereby addressing a crucial knowledge gap in resource-limited settings with restricted access to advanced imaging modalities. A cross-sectional analysis was conducted involving 175 hypertensive participants, stratified according to their chronic kidney disease (CKD) stage. Baseline demographics, hypertension status, CTR, AAC, and eGFR were assessed. Bivariate correlation and multivariate regression analyses were performed to determine the relationships between CTR, AAC, and eGFR. The study population exhibited a high prevalence of cardiovascular comorbidities, with 82.3% demonstrating cardiomegaly (mild-to-severe CTR) and 61.7% presenting with AAC. Bivariate analysis revealed a strong inverse correlation between eGFR and both CTR (r = −0.418, p < 0.001) and AAC score (r = −0.457, p < 0.001). Multivariate regression confirmed that both CTR (B = -1.738, p < 0.001) and AAC (B = -16.127, p < 0.001) were significant predictors of eGFR decline. Progressive CKD stages were associated with increased CTR (52.3% in Stage 1 vs. 58.7% in Stage 5) and greater AAC severity (0% advanced calcification in Stage 1 vs. 34% in Stage 5). Age, sex, and blood pressure did not show significant correlations with eGFR (p > 0.05). CTR and AAC are strongly associated with renal dysfunction, reinforcing the evidence of an interaction between cardiovascular pathology and CKD progression. These markers have the potential to serve as accessible biomarkers for identifying high-risk patients, thereby facilitating early intervention in resource-limited settings.
Association of perirenal fat thickness, abdominal subcutaneous fat thickness and renal sinus fat diameter with hepatic steatosis Ernes, Audrina; Ginting, Chrismis Novalinda; Pulungan, Ica Yulianti
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6758

Abstract

Hepatic steatosis (HS), characterized by the abnormal accumulation of triglycerides within hepatocytes, is a prevalent pathological condition. However, its detection rate often underestimates its true prevalence, particularly when assessed using abdominal computed tomography (CT) scans. This quantitative cross-sectional study, conducted from September 2024 to February 2025 at Royal Prima Hospital, aimed to investigate the associations of perirenal fat thickness (PrFT), abdominal subcutaneous fat thickness (ASFT), and renal sinus fat diameter (RSFD) with HS. A non-probability sampling method was utilized, and a total of 272 non-contrast abdominal CT scans were analyzed. Statistical analyses were performed using SPSS software. HS was defined as an average hepatic parenchymal Hounsfield Unit (HU) value at least 10 HU lower than that of the spleen, with an absolute hepatic HU attenuation of less than 40. The grading of HS was determined according to the CT liver-spleen (L-S) ratio: mild (0.7 < CT L-S < 1.0), moderate (0.5 < CT L-S < 0.7), and severe (CT L-S < 0.5). The results demonstrated a significant association between the mean right-left PrFT and the presence of HS (p = 0.007), suggesting that perirenal fat may contribute to the development of HS. In contrast, neither the mean right-left RSFD nor the ASFT showed a significant association with HS presence (p = 0.056 and p = 0.904, respectively). Furthermore, none of the fat measurements (PrFT, ASFT, and RSFD) were significantly associated with the grading of hepatic steatosis (p = 0.800, 0.288, and 0.996, respectively). These findings underscore the potential utility of PrFT as a non-invasive indicator for HS diagnosis. The study also highlights the importance of quantitative measurements, such as hepatic and splenic HU values and CT L-S ratios, for the accurate diagnosis of HS, as visual assessment alone may be insufficient.
Oral mucosal lesions associated with fixed orthodontic appliances: A review Kawono, Kawono; Chuan, How Kim; Halim, Susanna
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6764

Abstract

Orthodontic procedures enhance dental well-being, yet they can lead to painful sores due to irritation from devices. These sores, often found on the inner cheeks and lips, arise from friction caused by brackets, wires, and screws, resulting in discomfort and slow recovery. To prevent these issues, one can use orthodontic wax, materials that are friendly to the body, and make adjustments to the appliances. Innovative treatments like low-level laser therapy and personalized 3D-printed devices are proving to be promising options for relief. Regular check-ups and working together as a team are essential for providing effective care. Addressing issues early can lessen complications, boost comfort, and improve results of orthodontic care, emphasizing the importance of both preventive and treatment methods in practice.
The two way relationship between diabetes mellitus and periodontal disease Ongko, Darius Pranajaya; Chuan, How Kim; Halim, Susanna
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6765

Abstract

Periodontitis and diabetes mellitus are common chronic diseases with an established bidirectional relationships. Epidemiological studies have clearly identified that diabetes is a major factor for periodontitis, increasing the risk approximately three-fold compared to non-diabetic individuals, particularly if glycemic control is poor. This article discusses the possibility impact of diabetes on the periodontal patient and the ways in which untreated periodontitis may influence the course of diabetes. Diabetes mellitus is considered a risk factor and associated with an increased prevalence and severity of gingivitis and periodontitis. Inflammation plays an obvious role in periodontal diseases, evidence in literature also supports the role of inflammation as a major component in the pathogenesis of diabetes and diabetes complications. There is also evidence that periodontal disease can worsen a patient’s control of diabetes mellitus and proper management of periodontal disease can improve control of diabetes mellitus. The association between diabetes mellitus and periodontal diseases is clear that glycemic control improves periodontal conditions, while the management of periodontal infection improves glycemic control of diabetic patients (HbA1c reduction approximately 0,4%). Periodontal assessment is as important in people with diabetes as it is in people who do not have diabetes and people with diabetes should be made aware of their increased risk for periodontal disease.
Factors associated with nephrolithiasis at Royal Prima General Hospital Suryamin, Ricky; Pulungan, Ica Yulianti
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6770

Abstract

The high incidence of kidney stones, or nephrolithiasis, at Royal Prima General Hospital in Medan, affecting 234 patients, constitutes a significant problem requiring resolution. The varied nature of nephrolithiasis presentations observed is attributable to numerous influencing factors. Potential causes of kidney stones include inadequate fluid intake, excessive or insufficient physical activity, obesity, high salt consumption, and other unhealthy behaviours. Furthermore, underlying medical conditions such as diabetes, obesity, and hypertension can elevate the risk of kidney stone formation. This research aimed to analyse the factors associated with nephrolithiasis at Royal Prima General Hospital in Medan. This study employed an observational analytical design with a retrospective approach. The study population comprised the medical records of 234 patients diagnosed with nephrolithiasis who sought treatment at Royal Prima General Hospital in Medan between August 2023 and August 2024. Total sampling was utilised, resulting in a sample size of 234. Data analysis involved univariate, bivariate, and multivariate methods. The results revealed that the majority of patients were aged 46-60 years (n=99, 42.3%) and were male (n=147, 62.8%). Significant associations were found between blood pressure, body mass index (BMI), age, and nephrolithiasis at Royal Prima General Hospital in Medan. However, no significant association was observed between gender and nephrolithiasis. Age (X4) was identified as the variable most strongly associated with nephrolithiasis at Royal Prima General Hospital in Medan.

Page 15 of 16 | Total Record : 154

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