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Nursalam Hamzah
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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
 1 
Search results for , issue "Vol. 6 No. 2 (2023)" : 6 Documents clear
Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review Doloking, Haeria; Lallo, Subehan; Manggau, Marianti A; Rifai, Yusnita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.39968

Abstract

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Burns Wound-Healing Activity in Male White Rats of Matoa Stem Bark (Pometia pinnata) Ethanolic Extract Lilianturi, Fresi; Fajriyah, Shofiatul Fajriyah; Shoviantari, Fenita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42469

Abstract

Introduction: Burns are a global public health problem. The activity of herbal products in stimulating burn wound healing is supported by many animal studies and few clinical trials. The people of Papua New Guinea use the chewed bark of the matoa tree to heal burns. Matoa's stem bark contains flavonoids, terpenoids and tannins that promote wound healing. These compounds have antimicrobial, antioxidant and wound healing properties. They increase blood clotting, fight infection and accelerate wound healing. Aims: The aim of this research was to determine whether ethanol extract of Matoa stem bark has anti-burn activity against male white rats of the Sprague Dawley strain. Method: In this study, a method was used to measure the area of burn wound in 5 treatment groups for 14 days. Group I were treated with the MEBO ointment (the positive control group); Group II with vaseline flavum (the negative control); Group III was given Matoa bark extract ointment at a concentration of 10%; group IV at a concentration of 20%, while group V at a concentration of 30%. Result: Qualitative analysis of chemical compounds shows that the ethanolic extract of Matoa stem bark contains flavonoids, triterpenoid tannins, and saponins. Ethanol extract of matoa bark 20% and 30% had burn wound healing activity in male Sprague-Dawley white rats. Activity was significantly different from negative control and not significantly different from positive control. Conclusion: A 20% and 30% ethanolic extract of the stem bark Matoa is considered a topical agent for use in treating burns wound.
Mechanism of Apoptosis Induction in Oral Cancer Cells by Uncaria-derived Flavonoids Ridho, Fiki Muhammad; Iqbal, Mohammad; Agustina, Arista Widya; Syachputra, Andika Julyanto
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42944

Abstract

Introduction: Oral cancer is cancer that occurs in the oral cavity and oropharynx, ranking 16th as the most common cancer found with a number of new cases of 377,713 and a number of deaths of 177,757 cases in 2020. Several types of flavonoids contained in the genus Uncaria were found to have anticancer bioactivity, one of which is inducing apoptosis in oral cancer cells. Aim: This study aims to review the potential and mechanisms involved of flavonoids in inducing apoptosis in oral cancer cells. The literature review method was used in this study by conducting a systematic literature search on PubMed, ScienceDirect, and Google Scholar until October 2023. Results: A total of 13 studies were included in this study and our findings conclude that flavonoids, especially quercetin, kaempferol, rutin, umbelliferon, and epigallocatechin gallate (EGCG), have the potential to be used as anticancer agents, one of which has the ability to induce apoptosis, both through extrinsic and intrinsic pathway, in several oral cancer cell lines, including SCC-4, SCC-9, SCC-25, SAS, KB/VCR, Tca-8113, YD10B, YD38, MC-3, KB, and HSC-3, through the mechanism of inhibiting anti-apoptotic expression, activating pro-apoptotic protein expression, generating ROS, and regulating PI3K/AKT, MAPK, and JAK/STAT signaling pathways. Conclusion: We conclude that Uncaria-derived flavonoids hav the potential to induce apoptosis, both extrinsic and intrinsic, in oral cancer cells.
Effects of Enhancment Span-60 of Vernonia amygdalina Leaves Extract-loaded Niosomes Pratiwi, Afrianty; Syahrana, Nur Azizah; Ismail, Isriany; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.45956

Abstract

Introdiction: Niosomes are a promising drug carrier because of their bilayer structure and the fact that they are produced by the self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are non-toxic, biodegradable, and compatible with human cells. Aims: This research aimed to create niosomes from V. amygdalina leaves and investigate how span 60 addition affects niosome properties. Methods: Extraction V. amygdalina using maceration, niosomes synthesized using a thin-film hydration process, and characterization performed by SEM, particle size, polydispersity index, zeta potential, and FTIR. Conclusion: V. amygdalina succesfully to loaded into niosomes. Span-60 with various concentration affected of characterization of niosomes. Increased span-60 increasing particle size, polydispersity index, and %EE.
Breaking Boundaries: A Comparative Analysis of Weak vs. Strong Bases in Eugenol Isolation from Syzygium aromaticum (L.) Merr. & LM Perry Handayani, Dwi; Sitindaon, Rina SE; Hidayati, Nurul; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.47483

Abstract

Eugenol, a phenolic compound classified within the phenylpropanoid group, stands out as a key constituent of clove oil, boasting a myriad of biological activities. Its isolation typically involves the utilization of an alkaline solution, yet the choice of alkaline agent significantly impacts the yield of eugenol. This study delves into the impact of various alkaline solutions on the isolated eugenol content from Syzygium aromaticum essential oil, leveraging its acidic properties to form a soluble eugenol salt in an aqueous medium. Employing alkaline solutions with a concentration of 1 N, including both strong bases (such as KOH, NaOH, and Ba(OH)₂) and weak bases (like Ni(OH)₂, Al(OH)₃, and Zn(OH)₂), we scrutinized the diverse outcomes on eugenol content. Results revealed that KOH yielded the highest eugenol content at 96.91%, while Zn(OH)₂ displayed the lowest at 20.99%. Nevertheless, the potential of weak alkaline solutions in the eugenol isolation process from Syzygium aromaticum essential oil remains noteworthy. Future endeavors should focus on optimizing the ideal concentration of weak alkaline solutions for this purpose.
The Evaluation of Loose Powder Formulation of Manihot Starch and Maydis Starch with Natural Orange Sweet Potato Monika, Kris MonikaYanti; Dewi, Putu Indra Cyntia; Pasha, Ni Luh Sanjiwani Putri
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.47656

Abstract

Introduction: Starch is an inert additive and can be mixed with almost all drugs without causing a reaction. The use of natural dyes has a better level of safety compared to synthetic dyes. Objective: Comparing the physical evaluation of loose powder preparations made from maydis starch with manihot starch and the use of a natural dyes in the form of orange sweet potato. Method: Making orange sweet potato tuber extract using meseration and the solvent ethanol (95%): acetone (98%) (5:5). Then the powder preparation is made and a physical evaluation is carried out in the form of organoleptics, particle size distribution, homogeneity, humidity and flow rate. Results: The results show that the organoleptic test for each formula is good, the distribution of F2 particles is the best, the homogeneity test for each formula is good, the humidity test is that F1 is higher than F2 by 1.05 ± 0.01%, the flow speed test for F2 is better than F1 namely 23.53 ± 0.35 g/sec. Conclusion: Powder preparations made from Manihot starch are better than powder preparations made from Maydis starch.

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