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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan As-syifaa Jurnal Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Medfarm: Jurnal Farmasi dan Kesehatan Journal Pharmasci (Journal of Pharmacy and Science) Indonesian Journal of Pharmaceutical Education Jurnal EduHealth Journal of Health Research Science Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Jurnal Farmasi Indonesia Jurnal Farmasi SYIFA Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pharma Bhakta
Shofiatul Fajriyah
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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UJI AKTIVITAS GEL LENDIR BEKICOT (ACHATINA FULICA) SEBAGAI PENYEMBUHAN LUKA SAYAT Shoviantari, Fenita; Fajriyah, Shofiatul; Agustin, Ela; Khairani, Shafia
Jurnal Ilmiah As-Syifaa Vol 13, No 1 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v13i1.648

Abstract

Snail mucus (Achatina fulica) has a high protein content, which includes beta agglutinin, achasin protein, acharan sulfate, and glycoconjugate. The objectives of this study was to determine differences in physical evaluation of the quality of the gel preparation against snail mucus concentration and to determine the efficacy of snail mucus gel as a wound healing. This study used an experimental research method with a sample of 4 male rats (Rattus novergicus) which were divided into 6 groups in each. The results showed that there was no effect of the physical quality of snail slime gel (Achatina fulica) on the concentration of snail slime formulated. It has been proven in the Kruskall wallis statistical test with the Sig. > 0.05. The results of the wound healing activity test showed an average value of K (+) 49.61%, K (-) 17.48%, P1 48.23%, P2 43.63%, P3 43.43%, and P4 23, 97. Values that indicate differences in K (-) and P4 are evidenced in the Post Hoc LSD test with Sig. <0.05. It can be concluded that the concentration of snail mucus does not affect the physical quality of snail mucus gel preparations and snail mucus gel with snail mucus concentration of 10% is effective in the process of wound healing.
UJI IRITASI GEL LENDIR BEKICOT (Achatina fulica) SECARA HISTOPATOLOGI Shofiatul Fajriyah; Fenita Shoviantari; Binti Nurkayati; Shafia Khairani; Lia Agustina
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 7, No 2 (2020)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

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Abstract

Latar Belakang: Lendir bekicot (Acahtina fulica) mengandung glikokonjugat kompleks yaitu glikosaminoglikan dan proteoglikan yang memiliki banyak fungsi diantaranya dapat menyembuhkan luka. Salah satu syarat sediaan topikal yang baik adalah tidak mengiritasi kulit. Sediaan topikal yang mengiritasi kulit justru akan memperparah kondisi pada kulit. Tujuan: Penelitian ini bertujuan untuk mengetahui uji mutu fisik dan efek iritasi dalam sediaan gel dari perbedaan konsentrasi lendir bekicot. Metode: Lendir bekicot diformulasikan dalam bentuk sediaan gel menggunakan gelling agent karbopol 940 dengan perbedaan konsentrasi dari lendir bekicot 10%, 15%, dan 20%. Hasil: Hasil penelitian menunjukkan bahwa tidak adanya pengaruh mutu fisik sediaan gel dengan perbendaan konsentrasi lendir bekicot. Hasil uji iritasi secara mikroskopis dari skor indeks pada preparat histologi kulit tikus jantan yang diwarnai dengan Hematoxillyn eosin menghasilkan bahwa sediaan gel pada formula 1 dan 2 sedikit mengiritasi serta pada formulasi 3 menghasilkan sediaan gel dengan iritasi sedang. Simpulan: dari hasil penelitian dapat disimpulkan bahwa perbedaan konsentrasi lendir bekicotengan rentang 10 – 20% tidak mempengaruhi hasil uji mutu fisik dan penggunaan lendir bekicot sampai dengan kadar 15% aman digunakan.
The Use of Prophylactic Antibiotics for Cesarean Section Delivery and The Incident of Surgical Site Infection Shofiatul Fajriyah; Umul Farida; Sri Agustina; Lelly Winduhani Astuti; Esti Ambar Widyaningrum
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19864

Abstract

According to the 2018 Riskesdas data, the ratio of deliveries by cesarean section in 2018 was recorded at 17.6% of a total of 78,736 deliveries. One of the serious problems in postoperative treatment that has an impact on increasing morbidity, mortality, and increasing medical costs is surgical site infection (SSI). To reduce the risk of infection, efforts are made by giving prophylactic antibiotics followed by surgical procedures. The aim of this study was to determine the use of prophylactic antibiotics in cesarean section surgery and to determine the incidence of surgical site infection (SSI) in patients after Sectio Caesarea surgery in one of a private hospital in Kediri City. This study was an observational descriptive study with retrospective data collection through tracing of medical record data of patients who underwent Caesarean section surgery in 2021. The samples that entered the inclusion criteria were patients who received surgical prophylaxis with antibiotics and returned to the hospital for control after 1 week postoperatively. Samples that met the inclusion criteria were 89 patients. The sampling technique used purposive sampling. This study collected data on prophylactic antibiotics used and the incidence of SSI on days 1, 3 and (7-10) postoperatively.  The results showed that the types of prophylactic antibiotics in patients undergoing sectio caesarea were ceftriaxone 2 g (99%) and cefotaxime 2 g (1%). Whereas there were 3 patients (3%) who had SSI on days 7-10 postoperatively.
Patterns of Antihistamin and Corticosteroids Usage In Dermatitis Patients At Primary Public Health Center in Jombang: Pola Penggunaan Antihistamin dan Kortikosteroid Pada Pasien Dermatitis di Puskesmas Kabupaten Jombang Shofiatul Fajriyah; Dea Justisia Ayu Nandya; Erni Anikasari; Fenita Shoviantari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.328

Abstract

Dermatitis or eczema is a form of the condition in which the layers of the skin (epidermis and dermis) have general inflammation which is usually influenced by endogenous and exogenous factors causing clinical abnormalities in the form of polymorphic efflorescence (erythema, edema, papules, vesicles, scales, lichenification) and itching complaint. This study simed to determine the treatment pattern given to patients with atopic dermatitis and contact dermatitis at the Jelakombo Health Center Jombang. This was an observational study with retrospective data collection. The data sourced used was existing medical records from January to December 2020. Data analysis was carried out descriptively with purposive sampling. The results showed that the most common dermatitis patients were atopic dermatitis (34%) which mostly treated with CTM+Dexamethasone. Patients with allergic contact dermatitis were 38 patients (38%), the most common drug regimen to manage it was Cetirizine+Hydrocortisone ointment. There were 28 patients (28%) with irritant contact dermatitis, which mostly treated with Cetirizine+Hydrocortisone Ointment followed by CTM + Dexamethasone. This study concluded that the drug regimen for the three types of dermatitis was almost the same, namely a combination of oral and topical antihistamines and corticosteroids. The antihistamines used were first-generation antihistamines (CTM) and second-generation (Cetirizine and Loratadine). Further assessment related to whether the sedation effect was wanted or it was disturbing side effect is needed. The widely used oral corticosteroid was dexamethasone, which is a high-potency corticosteroid, so its use must be judicious. Topical corticosteroids were hydrocortisone ointments that include low potency topical corticosteroids which are the first line of atopic dermatitis and allergic contact dermatitis.
EVALUASI PENGGUNAAN CLOPIDOGREL TERHADAP LAMA RAWAT PASIEN STROKE RAWAT INAP DI RSUD KOTA KEDIRI Erni Anikasari; Shofiatul Fajriyah; Mufthirza Ramdini; Sri Endang I
JURNAL PHARMA BHAKTA Vol 1 No 1 (2021): Mei 2021
Publisher : FAKULTAS FARMASI, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Latar Belakang : Di Indonesia diperkirakan setiap tahun terjadi 500.000 penduduk terkena serangan stroke, 25% orang meninggal sedangkan sisanya mengalami cacat ringan bahkan bisa menjadi cacat berat. Terapi antiplatelet digunakan untuk mengurangi kejadian stroke pada pasien yang beresiko tinggi terjadinya atherosklerosis dan penyakit serebovaskuler yang penyebabnya simtomatik. Antiplatelet yang digunakan adalah aspirin, clopidogrel baik monoterapi atau kombinasi. Adanya pemilihan penggunaan Clopidogrel tunggal sebagai antiplatelet menjadi alasan penulis untuk melakukan penelitian bagaimana efek dari pemberian Clopidogrel terhadap lama rawat inap pada pasien stroke. Metode Penelitian: Peneliti mengunakan metode penelitian diskriftif dengan menggunakan data retrospektif yang berasal dari data Rekam medis pasien. Sampel pada penelitian ini adalah pasien stroke rawat inap yang menggunakan Clopidogrel di RSUD Gambiran periode Januari-Juni 2018. Hasil Penelitian: Sampel penelitian didapatkan 43 pasien stroke rawat inap yang menggunakan Clopidogrel. Dimana lama waktu pemberian dan lama rawat inap pasien menjadi bahan evaluasi. Kesimpulan: Berdasarkan penelitian ini dapat disimpulkan bahwa rata-rata pemberian Clopidogrel lebih pendek dibandingkan lama rawat inap pasien stroke iskemik, meskipun dapat dikatakan bahwa lama rawat inap pasien stroke termasuk singkat.
Burns Wound-Healing Activity in Male White Rats of Matoa Stem Bark (Pometia pinnata) Ethanolic Extract Lilianturi, Fresi; Fajriyah, Shofiatul Fajriyah; Shoviantari, Fenita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42469

Abstract

Introduction: Burns are a global public health problem. The activity of herbal products in stimulating burn wound healing is supported by many animal studies and few clinical trials. The people of Papua New Guinea use the chewed bark of the matoa tree to heal burns. Matoa's stem bark contains flavonoids, terpenoids and tannins that promote wound healing. These compounds have antimicrobial, antioxidant and wound healing properties. They increase blood clotting, fight infection and accelerate wound healing. Aims: The aim of this research was to determine whether ethanol extract of Matoa stem bark has anti-burn activity against male white rats of the Sprague Dawley strain. Method: In this study, a method was used to measure the area of burn wound in 5 treatment groups for 14 days. Group I were treated with the MEBO ointment (the positive control group); Group II with vaseline flavum (the negative control); Group III was given Matoa bark extract ointment at a concentration of 10%; group IV at a concentration of 20%, while group V at a concentration of 30%. Result: Qualitative analysis of chemical compounds shows that the ethanolic extract of Matoa stem bark contains flavonoids, triterpenoid tannins, and saponins. Ethanol extract of matoa bark 20% and 30% had burn wound healing activity in male Sprague-Dawley white rats. Activity was significantly different from negative control and not significantly different from positive control. Conclusion: A 20% and 30% ethanolic extract of the stem bark Matoa is considered a topical agent for use in treating burns wound.
Hubungan Tingkat Stres Pengobatan Terhadap Kadar Gula Darah Penderita Diabetes Melitus Tipe 2 Di Puskesmas Kota Kediri Farida, Umul; Fajriyah, Shofiatul; Kusuma, Ayu; Prameswari, Adisty Berlia
Jurnal Farmasi SYIFA Vol 1 No 1 (2023): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v1i1.173

Abstract

Diabetes mellitus merupakan penyakit autoimun dimana terdapat gangguan metabolisme tubuh kronis ditandai dengan fungsi insulin yang tidak mencukupi, berakibat pada meningkatnya kadar gula darah serta gangguan metabolisme dari karbohidrat, lipid, dan protein. Komplikasi dan kompleksnya penanganan yang dialami pasien dapat mempengaruhi status psikologis pasien. Salah satu hal yang bisa muncul adalah stres. Pada tahun 2021, 537 juta orang di seluruh dunia hidup dengan diabetes. Prevalensi diabetes di Indonesia adalah 2%. Pada 2019, jumlah penderita diabetes di Kota Kediri mencapai 9.435. Tujuan dari penelitian ini yakni untuk mengetahui gambaran dan hubungan antara tingkat stres pengobatan dan kadar gula darah pada pasien diabetes di Puskesmas Kota Kediri dengan menggunakan metode observasi analitik dan cross sectional. Data dikumpulkan secara prospektif menggunakan alat bantu pengambilan data berupa kuesioner. Penelitian ini menggunakan teknik sampling jenis quota sampling. Dengan menggunakan SPSS25 untuk menganalisis data, ditemukan bahwa 7 orang (8%) memiliki tingkat stres berat, 41 orang (47,2%) memiliki tingkat stres sedang, 39 orang (44,8%) tidak memiliki tingkat stres, dan 25 orang memiliki darah buruk. kadar gula darah (28,7%), 26 orang (29,9%) dengan kadar gula darah sedang dan 36 orang (41,4%) dengan kadar gula darah baik. Uji korelasi Spearman rho rank memberikan nilai signifikansi P-value 0,000 < 0,05 dan nilai koefisien korelasi 0,76 dari hasil tersebut disimpulkan bahwa antara 2 variabel yang diteliti memiliki hubungan yang signifikan dengan tingkat korelasi hubungan yang kuat.
Factors Affecting Potentially Inappropriate Medications (PIMs) Based on STOPP/START Criteria in Geriatric Patients at RSUD Dr. Soedomo Trenggalek: Faktor-Faktor yang Mempengaruhi Potentially Inappropriate Medications (PIMs) Berdasarkan Kriteria STOPP/START pada Pasien Geriatri di RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Fitriani, Marina; Irawati, Reny Nur Satya; Fajriyah, Shofiatul; Kurniawati, Evi; Lestari, Tri Puji
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16641

Abstract

Background: Geriatric patients often have multiple comorbidities and decreased physiological function, leading to polypharmacy and potential exposure to inappropriate medications (PIMs). Objectives: This study investigates geriatric inpatients' characteristic profiles, evaluates PIMs using STOPP/START criteria, and explores factors influencing PIM incidence. Method: This study employed a retrospective observational analytical approach. The sampling technique was purposive sampling. The sample involved in this study was 312 patients. Results: The geriatric patients involved in this study had the following characteristics: 62% male and 38% female; 69% youngest-old (65-74 years), 30% middle-old (75-90 years), and 1% oldest-old (>90 years); 87% with BPJS service type and 13% with general service type; main diagnosis groups of the patients were gastrointestinal of 9%, cardiovascular of 31%, respiratory of 3%, neurological of 1%, infection of 11%, endocrine of 13%, genitourinary of 15%, immune an malignant of 1%, blood of 11%, musculoskeletal of 2%, eyes of 2% and skin of 1%; 13% patients had one disease, 43% had two diseases, 25% had three diseases, and 19% had ≥ four diseases;29% had 15 drugs, 50% had 6-10 drugs, 17% had 11-15 drugs, 3% had 20 drugs, and 1% had ≥ 20 drugs. There were 72 PIMs based on STOPP/START criteria. The results of the analysis using the C contingency coefficient test showed the following factors, such as gender (p-value of 0.894), age (p-value of 0.470), type of service (p-value of 0.166), main diagnosis (p-value of 0.042), number of illness (p-value of 0.106), and number of drugs (p-value of 0.182). Conclusion: There is a correlation between the main diagnosis factor and PIMs with a p-value of 0.042 (p-value < 0.05).
Analysis Of Patient Perceptions, Awareness, Experience And Expectations Of The Role Of Pharmacist In Counseling Service At Pharmacies Dyah Ayu Kusumaratni; Eko Yudha Prasetyo; Indah Srihartini; Shofiatul Fajriyah; Widhi Astutik; Aprillia Putri G.R
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

Counseling services are a form of communication between pharmacists and patients in pharmaceutical services with the aim of increasing patient understanding of drug use and preventing medication errors. The presence of pharmacists is very necessary to be able to meet the diverse demands of society to be able to provide information regarding the correct use of medicines so that they can increase public knowledge. The interactions that occur between pharmacists and patients in counseling services will have an influence on public assessment. This research was conducted with the aim of knowing patients' perceptions, awareness, experiences and expectations of the role of pharmacists in counseling services in pharmacies. Method: The research is descriptive with a cross sectional design with a purposive sampling technique, the number of subjects involved was 143 respondents. Descriptive data analysis and normality test. Results: showed that 67.13% of patients had good awareness. As many as 53.14% of patients had a good perception. Then as many as 100% of patients had good hopes, and as many as 72.02% of patients had good experiences. Conclusion: the overall category shows the percentage of patients who have good perceptions, awareness, expectations and experiences regarding the role of pharmacists in counseling services in pharmacies.
Analisis Faktor-Faktor yang Mempengaruhi Kejadian Potentially Inappropriate Medications (PIMs) pada Pasien Geriatri Rawat Inap RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Rizky, Fara Nikhmatul; Irawati, Renny Nur Satya; Fajriyah, Shofiatul; Rilawati, Fentyana Dwi; Kurniawati, Evi; Lestari, Tri Puji
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.271

Abstract

Background: Geriatric patients are elderly patients with multiple diseases. Geriatric patients have more comorbidities and often receive polypharmacy prescriptions. PIMs have been identified in many elderly patients. One of the explicit criteria that can be used to identify the incidence of PIMs in geriatric patients is the Beers Criteria. Objective: To determine the frequency of PIMs and the factors that can influence the occurrence of PIMs based on the Beers Criteria in hospitalized geriatric patients at RSUD Dr. Soedomo Trenggalek. Method: This research uses a type of research with a retrospective observational analytical approach. The sampling technique used was purposive sampling with a total sample of 312 medical records.  Inclusion criteria: age ≥ 65 years and exclusion: incomplete medical record data. Results: The most common characteristic profiles were male gender (62%), elderly (65-74 years) 69%, type of BPJS service (87%), main disease with the cardiovascular system (31%), number of diseases 2 (43%) and the number of drugs 6-10 drugs (50%). There was an incidence of PIMs of 78.53%. The factors gender, age, type of service, main diagnosis have a p value ≥ 0.05, while the number of diseases and medications have a p value ≤ 0.05. Conclusion: There is an incidence of PIMs in hospitalized geriatric patients of 78.53% with the number of diseases and number of medications influencing the incidence of PIMs in hospitalized geriatric patients.
Co-Authors Ade Giriayu Anjani Agustin, Ela Anikasari, Erni Aprillia Putri G.R Astuti, Lelly Winduhani Binti Nurkayati Dea Justisia Ayu Nandya Dyah Aryantini Eko Yudha Prasetyo Erni Anikasari Esti Ambar Widyaningrum Evi Kurniawati, Evi Faizatul Fitria Farida, Umul Fenita Shoviantari, Fenita Fitriani, Marina Indah Sri Hartini Irawati, Renny Nur Satya Irawati, Reny Nur Satya Irma Tristanti Khairani, Shafia Kusuma, Ayu Kusumaratni, Dyah Ayu Lelly Winduhani Astuti Lestari, Tri Puji Lia Agustina Lilianturi, Fresi Mufthirza Ramdini Nur Rohmah, Dilla Salwa Nurul Istiqomah PALUPI SUSILOWATI Prameswari, Adisty Berlia Reza Arrayan Rilawati, Fentyana Dwi Rizky, Fara Nikhmatul Sari, Dwi Evi Diyan Seran, Krisogonus Ephriono Shafia Khairani Sri Agustina Sri Endang I umul farida Umul Farida Wahyuni, Kumala Sari Poespita Dewi Wahyuningwulan, Fitria Widhi Astutik Winduhani, Lelly Wulan, Fitria Wahyuning Yudha Prasetyo, Eko