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livana ph
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INDONESIA
Indonesian Journal of Global Health research
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr.v2i2
Core Subject : Health, Education,
Indonesian Journal of Global Health Research (IJGHR) menyediakan forum untuk berbagi publikasi penelitian ilmiah, perawatan kesehatan yang tepat waktu dan terkini serta mempromosikan pengembangan keperawatan, kesehatan masyarakat, masyarakat, lingkungan, dan kesehatan kerja. Jurnal ini menerbitkan makalah penelitian asli ilmu kesehatan. Prioritas tinggi akan diberikan pada artikel tentang kesehatan masyarakat, keperawatan, remaja, masyarakat, kesehatan lingkungan dan pekerjaan, dan sebagainya. Kategori berikut diterimapenelitian asli. Topik-topik yang berkaitan dengan jurnal ini termasuk tetapi tidak terbatas pada: kesehatan masyarakat, promosi kesehatan, kesehatan lingkungan, kesehatan kerja, aspek klinis yang berkaitan dengan kesehatan, layanan kesehatan, kebijakan dan manajemen kesehatan, kesehatan sekolah, kesehatan makanan, kesehatan jarak jauh, kesehatan pedesaan , kesehatan masyarakat, kesehatan mental, kesehatan remaja, kesehatan industri, kesehatan sirkumpolar, pemerataan dalam kesehatan, perawatan kesehatan reproduksi, kesehatan perkotaan, geografi kesehatan, kesehatan wanita, pediatri dan kesehatan anak.
Articles 136 Documents
Search results for , issue "Vol 7 No 5 (2025): Indonesian Journal of Global Health Research" : 136 Documents clear
Advances in Gene-Based Therapies for Leber Congenital Amaurosis: A Review of Clinical Trials Wiryadana, Michael; Sigalingging, Talenta
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7086

Abstract

Leber congenital amaurosis (LCA) is characterized by early-onset significant vision loss in infancy. Conventional therapeutic strategies offered limited benefits, thus escalating the focus on research into gene-based therapies. This review aimed to explore the clinical trials focusing on gene-based therapies for LCA. This literature review identified clinical trials on gene-based therapies for LCA registered on ClinicalTrials.gov using the keyword “Leber congenital amaurosis OR LCA,” with no restriction on year of registration. Trials not involving gene therapy were excluded. For each eligible trial, the corresponding National Clinical Trial (NCT) number was used to search the PubMed database for peer-reviewed publications, and grey literature was sourced when no publications were available. Extracted data included patient inclusion criteria, sample size, intervention dosage, safety profiles, adverse events, and efficacy outcomes. Numerous gene-based therapies for LCA have been reported, especially those targeting mutations in RPE65, CEP290, GUCY2D, AIPL1, and LCA5. Adeno-associated virus (AAV)-mediated gene replacement therapies, CRISPR/Cas9 gene editing, and antisense oligonucleotides (AONs) have been reported to deliver promising outcomes for LCA. Luxturna (voretigene neparvovec) has been FDA-approved for RPE65-LCA, while trials on emerging therapies like EDIT-101 and sepofarsen hold therapeutic promise for CEP290-LCA. The review underscores emerging strategies in gene therapy that lay the foundation for tailored, mutation-specific treatments. Several challenges remain in optimizing delivery vectors, preserving long-term efficacy, and minimizing adverse events.
The Effect of Antenatal Diaphragmatic Breathing Exercise in Preventing Decreased Uterine Contractions in Caesarean Section Patients Haryani, Euis Tuti; Widiasih, Restuning; Murtiningsih, Murtiningsih; Suryati, Yayat; Nurbayanti, Siti
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7112

Abstract

The number of sectio caesarea (sc) deliveries has increased, the main side effect of sc is bleeding caused by inadequate contractions. Understanding the risk of atony management is very important starting from antenatal care, various education is given to mothers including doing aerobic exercises including diphragmatic breathing as a prevention of uterine atony. The aim of this study was to see the effect of antenatal diaphgramatic breathing (dbe) exercise on preventing a decrease in uterine contractions in CS patients. This research method used a quasi-experimental posttest nonequivalent design with control group design, the sample in this study were 3rd trimester pregnant women who were at risk of being elective, totaling 56 people by using incidental sampling techniques, using the uterine contraction observation sheet instrument, data analysis used the chi square test. The results of the study showed that there was a significant effect of antenatal dbe implementation on preventing a decrease in intraoperative uterine contractions after the placenta came out. However, there was no effect of antenatal dbe on preventing uterine contractions 1-2 postoperative sc.
Varicella Presentation in Adult: A Case Report Dhillon, Jesryn; Dalimunthe, Dina Arwina
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7114

Abstract

Varicella is a disease caused by the varicella-zoster virus (VZV), a herpesvirus specific to humans. It is highly contagious but preventable through vaccination. It is usually diagnosed clinically and is often self-limiting. However, complications can include pneumonia, neurological, hematologic, ocular, renal, hepatic conditions, as well as sepsis, and secondary infections that can be fatal. Effective antiviral therapy has reduced associated morbidity and mortality. To report a case of varicella with bronchopneumonia in an adult patient. A 58-year-old male presented with persistent vesicular eruptions on the face, chest, back, and extremities. He was admitted to the emergency room and referred to dermatology. He had no history of prior varicella or vaccination. He was diagnosed with varicella with pneumonia and treated with acyclovir, cetirizine, paracetamol, and fusidic acid cream. Data were obtained through anamnesis, physical examination, and relevant supporting investigations, then qualitatively analyzed by correlating clinical findings and investigation results to confirm the diagnosis, evaluate treatment response, and construct the case narrative. Adult varicella is up to 25 times more severe than in children. The virus is transmitted via the respiratory tract with an incubation period of 10–21 days. Physical stress and disruption of circadian rhythms may impair immune response. Lesions typically start on the face and scalp and spread to the body. A This case highlights a presentation of adult varicella with systemic involvement. Early antiviral treatment can improve prognosis.
Mothers’ Lived Experiences in Preventing Toddler Diarrhea Using Local Wisdom Poda Na Lima: A Phenomenological Study Sari, Elpiana; Amvina, Amvina; Alwi, Fahrizal; Siregar, Hotma Royani; Hasibuan, Zainal Efendi
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7121

Abstract

Diarrhea remains one of the leading causes of morbidity and mortality among children under five in Indonesia. Prevention efforts based on local wisdom, such as Poda Na Lima, a traditional life philosophy of the Batak Angkola community, hold significant potential as a promotive and preventive approach to child health. This study aims to explore the experiences of mothers of children under five in implementing Poda Na Lima as a preventive measure against diarrhea in their children. A qualitative approach with a phenomenological method was employed. Participants were selected using purposive sampling, with the number determined by the principle of data saturation, resulting in a total of ten participants. Data were collected through in-depth interviews guided by a semi-structured interview protocol developed based on the five principles of Poda Na Lima. Thematic analysis was used to analyze the data. The findings of the study revealed five themes: maintaining cleanliness of the heart, maintaining personal hygiene, maintaining cleanliness of clothing, maintaining cleanliness of the home, and maintaining cleanliness of the yard. Mothers of young children perceive Poda Na Lima not merely as a traditional custom, but also as a guide for daily healthy living. Personal, family, and environmental hygiene practices are considered key to diarrhea prevention.
Healthcare Financing for Bone Marrow Transplants: A Scoping Review Santosa, Damai; Suryawati, Chriswardani; Sriatmi, Ayun
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7125

Abstract

Bone marrow transplantation (BMT) is a life-saving procedure for haematological malignancies and other severe blood disorders. It is need resource-intensive treatment with significant financial implications. The cost of BMT varies across different countries and healthcare systems, influenced by factors such as treatment protocols, hospital infrastructure, medication expenses, and post-transplant care. Understanding the financial aspects of BMT is crucial for improving accessibility and ensuring sustainable healthcare service. Objective to analyse the cost of BMT across different regions, identify sources of financing, and explore financial challenges and potential solutions for patients undergoing BMT. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases from 2001 - 2025. MeSH Terms using ((haematology malignancy OR leukaemia OR acute leukaemia OR acute myeloid leukaemia OR acute lymphoblastic leukaemia OR myeloma OR lymphoma OR thalassemia) AND (bone marrow transplantation OR stem cell transplantation OR haematopoetic stem cell transplantation OR hematopoietic stem cell transplantation OR allogeneic transplantation ) AND (OR costing OR payer)). Data were extracted on total BMT costs, cost components, sources of financing, and financial challenges associated with the procedure. The analysis followed the Cochrane Handbook for Systematic Reviews of Interventions. Out of 528 initially screened studies, 19 articles met the inclusion criteria. The cost of BMT varied significantly by country, with developed nations reporting higher costs than developing countries. The primary cost components included hospital and treatment expenses, medications, and follow-up care. Financing sources varied across regions, including private health insurance, government-funded healthcare programs, non-profit organisations, fundraising efforts, and out-of-pocket payments. Many patients in low- and middle-income countries face financial barriers due to limited insurance coverage and high out-of-pocket expenses. BMT remains a costly procedure with significant financial challenges, particularly in regions with limited healthcare funding.
Antioxidant Activity Ethanolic Extract of Kalakai Leaf (Stenochlaena Palustris (BURM.F) Bedd) From Central Kalimantan by DPPH Method Adawiyah, Rabiatul; Suryadini, Halida; Abrar, Atika; Fauzia, Husna; Faradila, Faradila
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.4935

Abstract

The diseases triggered by free radicals in Indonesia are increasing. Free radicals can be neutralized by antioxidants. The main sources of antioxidants are plants or fruits. Kalakai (Stenochlaena palustris (Burm.f.) Bedd.) is one of the typical plants of Kalimantan known for its medicinal properties. The leaves of Kalakai contain compounds such as flavonoids, phenols, tannins, alkaloids, and saponins, which have antioxidant abilities. This research aims to determine the antioxidant activity of Kalakai leaf extract from Central Kalimantan against DPPH free radicals based on the IC50 value. Antioxidant activity was measured using the DPPH method and analyzed using UV-Vis spectrophotometry at a wavelength of 516.6 nm. The results showed that Kalakai leaf extract had moderate antioxidant activity with an IC50 value of 241.547 ppm, while vitamin C as a positive control had strong activity with an IC50 of 10.031 ppm. These findings indicate that Kalakai leaves, although less potent than vitamin C, may serve as a promising natural antioxidant source. The conclusions is kalakai leaf extract exhibits moderate antioxidant activity and holds potential for further development in natural antioxidant applications.

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