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Medicra (Journal of Medical Laboratory Science/Technology)
Published by Universitas Muhammadiyah Sidoarjo
ISSN : 25807730     EISSN : 25807730     DOI : https://doi.org/10.21070/medicra
Core Subject : Health,
Health Professions Public Health
Focus : to facilitate scholar, researchers, and lecturers for publishing the original articles of review articles. Scope : Medicra publishes research articles in the field of “medical laboratory (science/technology)” with the following scope: Clinic Chemical Hematology Microbiology Parasitology Immunology Food and beverage analysis Chemical Molecular Diagnostics Toxicology Cytology Histology Epidemiology Laboratory Management Laboratory Quality Control
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 7 Documents
 1 
Search results for , issue "Vol. 8 No. 1 (2025): July" : 7 Documents clear
Factors Contributing to the Failure of In Vitro Fertilization (IVF): A Review of Male, Female, and Laboratory-Related Causes Abdolhussein M, Mudhafar
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1771

Abstract

Infertility is big problem with some couples, infertility is an inability to get pregnancy and live birth after one year of marriage. There are many causes for this problem. In vitro fertilization (IVF) is one of the process to treat infertility. In vitro fertilization is includes induction of the ovaries to produce numerous oocytes, than fertilize the oocytes and development of the embryo, finally transfer the embryo. The most important reasons for repeated failure in vitro fertilization (IVF) cycle are related to the male characteristics, such as low semen concentration low sperm motility and morphology of sperm, there is a relationship between sperm quality and IVF outcome. Most of the maternal factors that contribution in decrease implantation and IVF cycle are uterine anomalies, adhesions, septa, and many more. Other factors such as body mass index (BMI), and smoking status for failure IVF. In this study review some of the causes of failure In vitro fertilization.
Influence of Hydrocortisone on Blood Profile, Total Protein, And Glucose in Female Rabbits Ali, Wasfi Dhahir Abid
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1783

Abstract

The purpose of this study is to examine how hydrocortisone affects a few blood parameters in female rabbits. Ten local rabbits were split into two equal and random groups. As a control, the first group was employed. The second group received daily intramuscular injections of hydrocortisone at a dose of 0.1 mg/kg B.W. Blood serum was collected every day from the first day and evaluated for total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), TG (triglycerides), and total protein after five weeks. The findings demonstrated that hydrocortisone reduced total protein and cholesterol.
Effectiveness of Mangrove Kateng Leaf Extract (Avicennia lanata Ridl.) as a Natural Preservative for Fresh Vannamei Shrimp Meat (Litopenaeus vannamei): Efektivitas Ekstrak Daun Kateng Mangrove (Avicennia lanata Ridl.) sebagai Pengawet Alami Daging Segar Udang Vannamei (Litopenaeus vannamei) Pramudya, Arkan Setia; Yachya, Arif; Suparman, Suparman
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1781

Abstract

Vannamei shrimp (Litopenaeus vannamei) is a mainstay export fishery product. Its meat is rich in protein and fat, but the quality is easy to reduce due to decay over storage time. Decay occurs due to bacterial activity and oxidation. The freezing preservation method requires relatively expensive costs, so it often uses hazardous materials for substitution, such as formalin as a preservative. Therefore, it is necessary to research the effectiveness of natural materials sourced from plant organs as relatively safe preservatives. One of the plants is Kateng (Avicennia lanata), whose leaves are rich in secondary metabolite compounds that inhibit growth and kill bacteria. This study aims to determine the effectiveness of A. lanata water extract as a natural preservative for fresh Vannamei shrimp meat. The research was an experimental laboratory study using a completely randomized design with three repetitions. The concentrations of the A. lanata water extract solution tested were 0, 25, 50, 75, and 100% (w/v). Variations in the storing time of shrimp meat after being soaked in the test extract solution were 2 and 4 hours. The storage was at room temperature. The parameters of shrimp meat quality observed at the end of the storage period included total bacterial population, hydrogen sulfide gas (H2S) production, acidity level (pH), and trimethylamine (TMA) content. The results showed that the quality of fresh Vannamei shrimp meat depends on various concentrations of A. lanata water extract solution (0-100% w/v) and storage periods (2 and 4 hours). Water extract of A. lanata leaves at a concentration of 75% (w/v) with 2 hours of storage is the optimal concentration and storage time to preserve fresh L. vannamei shrimp meat naturally.
Sex Determination Based on Finger Bones: A Systematic Review: Penentuan Jenis Kelamin Berdasarkan Tulang Jari: Tinjauan Sistematis ur Rahman, Ateeq; Kristianto, Sonny; Widodo, Wimbuh Tri; Rayditya Milanio, Roderikus; ur Rahman, Anees; Setiawardani, Alvina; ul Haq, Ihtisham
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1754

Abstract

Sex determination is a crucial step in forensic investigations, particularly when skeletal remains are incomplete. This study aims to evaluate the accuracy of using finger bones as indicators of sex through a systematic review approach. The literature selection followed PRISMA guidelines, with data retrieved from PubMed and Google Scholar using relevant keywords. Out of 95 identified articles, only 10 met the inclusion criteria and were further analyzed. Findings indicate that the length and proportion of finger bones—especially the ring and little fingers—differ significantly between males and females. Classification accuracy based on phalangeal and metacarpal measurements ranged from 80% to 94%. Additionally, hormonal influences such as testosterone contribute to these morphological differences. These results support the effectiveness of finger bones as an alternative method for sex estimation, particularly when pelvis or skull bones are unavailable in forensic contexts.
Assessment of Nitrate, Nitrite, and Ammonia Levels In Palu Bay and Its Impact on Health: Analisis Kandungan Nitrat, Nitrit dan Amonia di Perairan Teluk Palu dan Dampaknya Bagi Kesehatan Paundanan, Matius; Hikmah, Sitti Ainun
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1775

Abstract

Water pollution due to nitrate, nitrite, and ammonia content has become a significant issue in Indonesian waters, including Palu Bay, which has the potential to affect water quality and human health. This study aims to analyze the levels of nitrate, nitrite, and ammonia in Palu Bay waters and their impacts on human health. Water samples were collected from 10 observation stations in Palu Bay and then brought to the laboratory for analysis. The laboratory results were compared with the Water Quality Standards as set by the Minister of Environment Regulation of the Republic of Indonesia No. 51 of 2004 concerning Marine Water Quality Standards for Marine Biota. The results of the study show that nitrate concentrations varied between 0.326 mg/l and 1.199 mg/l, exceeding the established standard of 0.008 mg/l. Meanwhile, nitrite was found at very low levels (<0.003 mg/l) and was only slightly detected at a few stations, while ammonia concentrations ranged from <0.03 mg/l to 0.06 mg/l, still within the standard limit of 0.3 mg/l. High nitrate levels have the potential to cause water pollution and negatively impact aquatic ecosystems as well as human health, particularly through respiratory and digestive issues, and pose a risk to infants consuming nitrate-contaminated water. Although nitrite and ammonia levels were not significant, the presence of these compounds still requires monitoring. This study suggests the need for better water quality management to prevent long-term health impacts and damage to aquatic ecosystems. 
Relationship between Knowledge Level and Incidence of Skin Diseases: Hubungan Tingkat Pengetahuan Terhadap Kejadian Penyakit Kulit Prasetya, Didik; Abadi, Moh Fairuz
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1785

Abstract

Onychomycosis is a fungal infection of the nail frequently found in tropical regions and may negatively impact community health and quality of life. This study aimed to examine the association between public knowledge and the incidence of onychomycosis in Banjar Dinas Batang, Karangasem Regency. An analytical observational design with a cross-sectional approach was employed. A total of 30 adults were selected using purposive sampling based on inclusion criteria. Knowledge levels were assessed using a closed-ended questionnaire, and laboratory diagnosis was confirmed through culture on Sabouraud Dextrose Agar and microscopic observation with Lactophenol Cotton Blue staining. The results revealed that 60% of participants had nail fungal infections, most commonly in those with low knowledge levels (66.7%). Statistical analysis showed a significant association between knowledge and infection incidence (p = 0.045; PR = 4.25). Identified fungal species included Aspergillus spp., Zygomycetes, and yeasts. These findings suggest that limited knowledge increases the risk of onychomycosis. Community-based health education is essential to promote preventive behavior, especially in moist environments that favor fungal growth. 
Proliferation, Migration, and Expression of Tumor Necrosis Factor-α from Green Tea Leaf Extract (Camellia sinensis) on Keloid Fibroblast Cells: Proliferasi, Migrasi, dan Ekspresi Tumor Necrosis Factor-α Ekstrak Daun Teh Hijau (Camellia sinensis) pada Sel Fibroblas Keloid Dewi, Lia Sari Utami; Hadi, Restu Syamsul; Eliana, Fatimah; Hakim, Jasir
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 1 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i1.1769

Abstract

Keloid is a fibroproliferative dermal disorder caused by abnormal wound healing, characterized by excessive collagen deposition that extends beyond the wound boundaries. Keloids can cause pruritus and even pain. In addition to these two issues, keloids also diminish a person's quality of life due to aesthetic problems, especially if they appear on the face or other visible areas of the skin. Combination treatments for keloids are usually more successful than single treatments. Green tea leaf extract contains epigallocatechin-3-gallate polyphenols as anti-inflammatory agents. The aim of this study is to determine the potential of green tea leaf extract by observing the proliferation, migration, and expression of TNF-α in keloid fibroblast cells. Keloid fibroblast cells were divided into five treatment groups (TH100, TH200, TH400, TH800, and DEX100) and one negative control (DS). Cell proliferation was tested using a cell counting kit-8, migration was assessed using a scratch assay, and TNF-α expression was measured using an ELISA kit. All data were analyzed using SPSS, performing One-Way ANOVA, followed by Kruskal Wallis and Mann Whitney tests. The results showed that green tea leaf extract at a dose of 800 μg/mL significantly reduced the proliferation and migration rate of keloid fibroblast cells (p < 0.05). Meanwhile, in the TNF-α expression test, no significant difference was found in reducing TNF-α expression levels in keloid fibroblast cells (p > 0.05). Green tea leaf extract has the potential to be used as an alternative treatment for keloids as it reduces the proliferation and migration of keloid fibroblast cells. 

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