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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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INDONESIA
Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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Uji Aktivitas Antibakteri Pseudomonas Aeruginosa Pada Param Karo Sebagai Antidiabetic foot ARDHANA, RANIA RARA
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2407

Abstract

Param Karo is a traditional medicinal herb that is added with rice flour (Oryza sativa) as a solidifier. Param Karo has many properties, especially as an alternative treatment for fever, flatulence, and various other conditions. Param Karo is used by repeatedly applying it on the body to help normalize body temperature. The purpose of this study was to determine the activity of param Karo against Pseudomonas aeruginosa bacteria as the cause of diabetic foot wounds, as well as to identify the optimal concentration of param Karo needed to achieve significant antibacterial activity. Extraction was carried out using 96% ethanol solvent, and antibacterial activity testing was carried out by disc diffusion method on Pseudomonas aeruginosa bacteria with 3 concentrations namely, 25%, 50%, 75%. The results showed that the ethanol extract of Param Karo had the most significant antibacterial activity at a concentration of 75% with the formation of a clear zone around the disc. Ciprofloxacin was used as positive control, while DMSO 10% as negative control.
POTENSI ANTIBAKTERI PAREM KARO UNTUK MENANGANI INFEKSI Staphylococcocus aureus PADA PENDERITA DIABETIC FOOT Br Tarigan, Jenny Alfa Dilla; Sembiring, Novitaria Br; Bangar S, Roy Idrianto
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2411

Abstract

One of the cronic and serious complications of diabetes mellitus is diabetic foot. Staphyloccocus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. Testing the antibacterial activity of Karo hot parem against staphylococcus aureus bacteria using disc diffusion method with 255, 50% and 75% concentration of Karo hot parem extract, positive control Ciprofloxacin Disks (5µg) and negative control DMSO 10%. This disc diffusion method was carried out to determine the diameter of the inhibition formed by Karo hot parem extract in inhibiting the growth of Staphyloccocus aureus bacteria. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
SKRINNING RESEP INTERAKSI OBAT PASIEN DIABETES MELITUS DAN HIPERURISEMIA PERIODE OKTOBER 2023 S.D MARET 2024 DI RUMAH SAKIT ADVENT Surbekti, Destiana Tata
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2412

Abstract

Diabetes Mellitus and Hyperuricemia are two chronic non-communicable diseases with increasing preval__ence and are often comorbid in patients. Managing these conditions requires long-term pharmacotherapy, which may result in drug interactions. eval__uating prescription completeness and potential drug interactions is essential to ensure effective and safe therapy. Diabetes mellitus is a condition in which blood glucose levels are chronically higher (hyperglycemia) than normal because the body lacks insulin or insulin function is ineffective. Hyperuricemia is a condition in which uric acid levels increase in the blood. This condition can cause gouty arthritis, which is inflammation of the joints due to uric acid buildup. To identify medications prescribed for patients with Diabetes Mellitus and Hyperuricemia, eval__uate potential drug interactions, and assess prescription completeness based on administrative standards in accordance with Indonesia’s Ministry of Health Regulation No. 72 of 2016. This study used a descriptive retrospective design with a cross-sectional approach. A total of 50 outpatient prescriptions at Advent Hospital Medan that met inclusion criteria from October 2023 to March 2024 were analyzed. Prescription screening covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using the Drugs.com database and classified based on severity (major, moderate, minor). Commonly prescribed drugs for Diabetes Mellitus included Metformin, Glimepiride, Acarbose, and Pioglitazone; while for Hyperuricemia, Allopurinol, Meloxicam, and Sodium Diclofenac were most frequent. Ten drug interactions were identified: 8 moderate, 1 major, and 1 minor. The administrative eval__uation showed that most prescription components were complete, though some lacked documentation of body weight, address, and physician’s phone number. The most frequent drug interactions occurred at a moderate severity level, particularly between antidiabetic and NSAID medications. Comprehensive prescription screening is necessary to reduce adverse effects and improve therapeutic safety.
PENETAPAN KADAR FENOLIK TOTAL TUMBUHAN ENDEMIK KALIMANTAN UTARA Salsabillah, Nasywa Amelsya; Ahmad, Aktsar Roskiana; Syarif, Rezki Amriati
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2427

Abstract

North Kalimantan is home to a unique biodiversity, including medicinal plants traditionally used by local communities such as the Dayak people. Several of these plants are endemic—found exclusively in this region. Two notable endemic species, Dayak onion (Eleutherine palmifolia (L.) Merr.) and rose myrtle (Rhodomyrtus tomentosa), are known to contain secondary metabolites, including phenolic compounds. This study aimed to determine the total phenolic content of these two endemic plants. Extraction was performed using Ultrasonic-Assisted Extraction (UAE), resulting in extract yields of 11.42% (11.42 g) for Dayak onion and 24.33% (24.33 g) for rose myrtle. Preliminary phytochemical screening using 1% FeCl₃ reagent indicated the presence of phenolic compounds, evidenced by a color change to bluish-green or dark green. The quantitative analysis was performed using UV–Vis spectrophotometry at a wavelength of 752 nm, applying the Folin–Ciocalteu method with gallic acid as the standard. The results showed that Dayak onion extract contained 1.410 mg GAE/g extract (0.141%), while rose myrtle extract contained 2.259 mg GAE/g extract (0.2259%) of total phenolic compounds. These findings highlight the phenolic potential of endemic medicinal plants from North Kalimantan and support their further exploration for pharmacological and nutraceutical applications
eval_UASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN DEMAM TIFOID DI INSTALASI RAWAT INAP RSUD HAJI MAKASSAR PERIODE JUNI-DESEMBER 2024 Kakambong, Jessieca
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2458

Abstract

Typhoid fever is a common infectious disease in Indonesia, especially among productive age groups. The improper use of antibiotics in its treatment may lead to antibiotic resistance. This study aims to eval_uate the rational use of antibiotics in hospitalized typhoid fever patients at RSUD Haji Makassar using the Gyssens method. A descriptive observational study with a cross-sectional retrospective approach was conducted, using purposive sampling of 125 patient medical records from June to December 2024. Data were analyzed descriptively and statistically using Chi-square tests. Results showed that ceftriaxone was the most commonly used antibiotic (66%), followed by ciprofloxacin (22.8%). Rational use (category 0) was found in 59 cases (47.2%), while irrational use occurred in 66 cases (52.8%), predominantly in category III B (inappropriate duration). A significant association was found between gender and antibiotic rationality (p = 0.030), but no significant correlation was observed with age or length of stay. However, a highly significant correlation was found between the duration of antibiotic administration and rationality (p < 0.001). This study emphasizes the need for regular clinical audits and adherence to updated national treatment guidelines to prevent irrational antibiotic use and resistance.
GAMBARAN PENGETAHUAN IBU RUMAH TANGGA TERHADAP DAGUSIBU OBAT DI DUSUN SALO, DUA DESA SALO DUA, KECAMATAN MAIW, KABUPATEN ENREKANG TAHUN 2025 Sabila, Nur Zal
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2459

Abstract

This study aims to determine the level of knowledge among housewives regarding DAGUSIBU (Obtaining, Using, Storing, and Disposing of Medicines) in Dusun Salo Dua, Enrekang Regency, and to identify which components of DAGUSIBU are well understood or need further improvement. This research used a descriptive quantitative method involving 67 respondents selected through purposive sampling based on specific inclusion criteria. Data were collected using a validated and reliable questionnaire and analyzed using univariate descriptive statistics. The results showed that 70.15% of respondents had good knowledge, while 29.85% had sufficient knowledge of DAGUSIBU. Component-wise, knowledge about “obtaining” medicines was relatively low (66.67%), while “using” (79.85%), “storing” (89.05%), and “disposing” (83.6%) were classified as good. Higher knowledge was associated with age over 35 and higher education levels. However, many respondents still acquired medicines from unofficial sources, indicating the need for more targeted health education. This finding emphasizes the importance of strengthening public knowledge and behavior regarding medicine use. Future interventions should include structured community outreach and collaboration with healthcare providers. Moreover, qualitative studies are recommended to explore underlying factors affecting household medicine management and to support the rational use of medicines at the community level.
Formulasi Dan eval_uasi Sediaan Handbody Lotion Ekstrak Pegagan (Centella Asiatica L.) Kombinasi Niacinimade M. Ali, Nur Faizah
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2464

Abstract

Pegagan extract comes from the pegagan plant (Centela Asiatica L.) containing saponins, asiticosides, asiatic acid, and madecasate which can stimulate the production of collagen I, a protein that stimulates the wound healing process. This plant can be used as a raw material for skin care. Pegagan in the form of hand body lotion is used for skin care and other body parts. This study aims to determine the effect of differences in the concentration of Stearic Acid and cetyl alcohol in the Handbody Lotion formulation on the results of the preparation eval_uation test. Physical eval_uation tests of the preparation include organoleptic tests, homogeneity tests, pH tests, viscosity tests, and stability tests. The test results obtained the optimum formula, namely formula 1 with a ratio of cetyl alcohol and stearic acid with a desirability value of 1. The results of the stability test showed that the handbody lotion preparation was stable from the organoleptic parameters, homogeneity, pH, viscosity
THE eval_UATION OF PRESCRIPTION SCREENING PHASE PRESCRIBING ERROR IN PEDIATRIC PRESCRIPTIONS AT MITRAKITA CLINIC SEMARANG PERIOD JANUARY 2024 Damayanti, Widiya Widiya
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2471

Abstract

The issue of Medication Error in prescriptions can cause harm to patients that may result in a mistake in the use of drugs. Incomplete prescriptions, whether administratively, pharmaceutically, or clinically, can lead to medication errors. This study was conducted to eval_uate the completeness of prescriptions in the administrative, pharmaceutical, and clinical aspects of pediatric prescriptions at the Mitrakita Clinic and to ascertain compliance with Minister of Health Regulation No. 34 of 2021. This research is an observational study that is descriptive in nature, using a retrospective data collection method on pediatric prescriptions at the Mitrakita Clinic for the month of January 2024. Data collection in this research employed random sampling with a sample size of 160 prescriptions. Prescriptions were eval_uated for their compliance administratively, pharmaceutically, and clinically based on Minister of Health Regulation No. 34 of 2021. The data obtained was processed using SPSS with univariate analysis methods (descriptive analysis) and presented in the form of tables and percentages. This study aims to reduce the risk of medication errors in prescriptions at Mitrakita Clinic Semarang. Data from 160 prescriptions, after being tested and analyzed using SPSS, showed that the data were normally distributed and homogeneous. The results of the prescription screening eval_uation for prescribing errors in pediatric prescriptions at Mitrakita Clinic Semarang showed that the percentage of errors in the administrative review was 29.922%, in the pharmaceutical review was 5.104%, and in the clinical review was 14.018%. Thus, the average medication error occurring in pediatric prescriptions at Mitrakita Clinic during January 2024 was 16.348%, leading to the conclusion that prescriptions made at Mitrakita Clinic Semarang are in accordance with Minister of Health Regulation No. 34 of 2021.
eval_UASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI BALAI BESAR KESEHATAN PARU MASYARAKAT (BBKPM) MAKASSAR Arifin, Erlin Putri Hendrawati
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2486

Abstract

Pneumonia is one of the leading causes of death in children under five, particularly in developing countries such as Indonesia. Antibiotics are the mainstay of therapy for bacterial pneumonia; however, inappropriate use can lead to resistance and treatment failure. This study aims to eval_uate the rationality of antibiotic use in pediatric pneumonia patients at the Public Lung Health Center (BBKPM) Makassar using the Gyssens method. This was a descriptive study conducted from April to June 2025 using retrospective medical record data from 33 pediatric inpatients aged 1–5 years diagnosed with pneumonia and receiving antibiotic therapy from January to December 2024. Antibiotic rationality was assessed using the Gyssens algorithm, which classifies antibiotic use into category 0 (rational) and categories I–VI (irrational). The results showed that out of 64 antibiotic prescriptions, 20 (31%) were categorized as rational (category 0), while 44 (69%) were irrational. The highest proportion of irrational use was category III B (34%) for too-short duration, followed by category IV A (31%) for suboptimal effectiveness, and IV B (3%) for safety concerns. No cases were found in categories I, II, III A, IV C, IV D, V, or VI. These findings indicate that while some antibiotic use was appropriate, a significant portion was not, highlighting the need for regular eval_uation and better adherence to clinical guidelines to optimize antibiotic therapy and reduce resistance risks in pediatric pneumonia treatment.
Interaksi Obat dan Makanan Pada Pasien Diabetes Melitus Asiyah, Siti Nur
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2495

Abstract

Diabetes mellitus merupakan penyakit metabolik yang disebabkan oleh gangguan metabolisme pada organ pankreas ditandai dengan terjadinya peningkatan gula darah atau hiperglikemia. Pengelolaan diabetes umumnya melibatkan terapi farmakologis dengan berbagai jenis obat antidiabetik dalam mengontrol kadar gula darah serta mencegah terjadinya komplikasi jangka panjang. Tujuan penelitian ini adalah menganalisis interaksi obat Glibenklamid dan Metformin yang dikonsumsi pasien diabetes mellitus dengan minuman herbal. Metode penelitian yang digunakan adalah penelitian deskriptif kualitatif dengan memperoleh data primer dan data sekunder. Hasil penelitian menunjukkan bahwa mengonsumsi obat-obatan, Glibenklamid dan Metformin bersamaan dengan minuman herbal akan menimbulkan efek sinergis. Dengan penggunaan tanaman herbal, seperti daun keres, bunga telang, dan daun kelor bersamaan dengan obat - obatan yang dapat menurunkan kadar gula darah. Kesimpulan dari penelitian adalah didapatkan jika interaksi obat-makanan, yakni minuman herbal dan interaksi obat-obat dapat berpengaruh terhadap penurunan kadar gula darah meski tidak secara efektif.

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