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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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PENGEMBANGAN FACEMIST KOMBINASI EKSTRAK DAUN BIDARA (Ziziphus spina cristi (L.) Desf) DAN DAUN BENALU DUKU (Dendrophthoe pentandra (L.) Miq ) SEBAGAI ANTIOKSIDAN PADA KULIT WAJAH anggara, Elysa; syafitri, anggun; sari, tio ranti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2257

Abstract

The skin needs antioxidant compounds that can ward off free radicals caused by several factors, one of which is air pollution. Bidara leaves (Zizipus spina Cristi (L) Desf) and benalu duku leaves (Dendrophthoe pentandra (L.) Miq) contain flavonoid compounds that function as antioxidants that can ward off free radicals. This study aims to formulate bidara leaf extract and benalu duku leaf into the form of Facemist preparation and determine the best Facemist product formula with the addition of bidara leaf extract, benalu leaf, and a combination of two extracts through antioxidant activity parameters. The antioxidant activity test was carried out using the DPPH (1,1-dipenyl-2-picrylhydrazyl) method. The Facemist sample was formulated into a Facemist with concentration variations: F1 : EEDB 5%, F2 : EEDBD : 5%, F3 : EEDB : 2.5% EEDBD 2.5%, F4 : EEDB : 5% EEDBD : 5%, F5 : EEDB : 10% EEDBD : 10%. Facemist preparations are eval_uated for their physical characteristics, namely organoleptic test, homogeneity test, pH test, viscosity test, dry time test, irritation test. The results showed that Facemist was a combination of bidara leaf extract and benalu duku leaf homogeneous, pH <7, had a viscosity value of <500 cps, a good drying time of <5 minutes and did not cause irritation to the skin. The formulation of Facemist preparation that has the best antioxidant activity value is F5 with antioxidant activity (IC50) of 58.33 ppm in the strong category.
UJI AKTIVITAS ANTIBAKTERI FORMULASI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN PALA (Myristica fragrans Houtt) TERHADAP BAKTERI Staphylococcus epidermidis DAN Streptococcus sp Sanjaya, Angga Nugraha; Sari, Tio Ranti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2258

Abstract

The pala leaves contain alkaloids, flavonoids, saponins, tannins, and steroids which high antiseptic and antibacterial effects. The goal of the research make a formulation of hand sanitizer gel with etanol extreact by pala leaves (Myristica fragrans Houtt) as the antibacterial againt the Staphylococcus epidermidis and Streptococcus sp bacteria with CMC-Na base. Pala leaves hand sanitizer gel with etanol extract was formulation I 5%, formulation II 10%, and formulation III 15%. The method used in this study was antibacterial testing method used is the disc diffusion technique. Hand sanitizer gel is tested for the physical properties including organoleptic test, pH test, homogeneity test, and spreadability test. Hand sanitizer gel which has antibacterial activity against the Staphylococcus epidermidis and Streptococcus sp, bacteria is second (III) formulation in with concentration 15% that has an inhibition zone of 17 mm on bacteria Staphylococcus epidermidis and 16,86 mm on bacteria Streptococcus sp, mean while in formulation II with concentration 10% that has an inhibition zone of 13,16 mm on bacteria Staphylococcus epidermidis ang 13,16 on bacteria Streptococcus sp, mean while in formulation I with concentration 5% that has an inhibition zone of 12,02 mm on bacteria Staphylococcus epidermidis and 12,16 mm on bacteria Streptococcus sp, and the last positive control (nuvo gel hand sanitizer) that has an inhibition 17,73 mm on bacteria Stahylococcus epidermidis and 17,69 mm on bacteria Streptococcus sp. The final results of the research indicate, there is an ability of hand sanitizer gel pala leaves (Myristica fragrans Houtt) extract to prevent the growth of Staphylococcus epidermidis and Streptococcus sp bacteria with concentration of 15% hand sanitizer gel preparation.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN RARU (Cotylelobium Melanoxylon) SEBAGAI ANTIINFLAMASI TERHADAP EDEMA KAKI TIKUS YANG DI INDUKSI KARAGENAN TAHUN 2023 Marbun, Novarianti
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2259

Abstract

Flavonoids contained in raru leaves (Cotylelobium Melanoxylon) have anti- inflammatory activity. This study aims to determine the anti-inflammatory effect of raru leaf extract (Cotylelobium Melanoxylon) on white rats. Tests were carried out by producing edema on rat feet induced by 1% carrageenan. The anti- inflammatory effect test was divided into 5 treatment groups, each treatment group consisted of 3 rats, group 1 (negative control) was given CMC 0.5% Na suspension, group 2 (positive control) was given 2.25 mg/day diclofenac Na suspension. kgBB, group 3 raru leaf extract suspension dose of 50 mg/kgBB, group 4 raru leaf extract dose 100 mg/kgBB, and raru leaf extract dose of 150 mg/kgBB. The extract used the percolation method, with 70% ethanol solvent, measurement of inflammation volume was measured using a pletistometer, carried out for 180 minutes with an interval of 30 minutes after being induced with 1% carrageenan. From the results of this study, high doses of raru leaf extract have an anti-inflammatory effect. Data were analyzed using one way ANOVA. the data of this study that a dose of 150 mg/kgBB, is the dose with the most effect which is almost equivalent to the positive control group as an anti- inflammatory.
FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana L) SEBAGAI PENYEMBUHAN LUKA BAKAR TERHADAP TIKUS PUTIH JANTAN Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2266

Abstract

Burn wound treatment is still carried out simply and is generalized with a certain pattern for various wound conditions and problems. One of the natural ingredients (herbs) that has an effect as a medicine for burns is the Bidara plant (Zizipus mauritiana L.), which has antibacterial, anti-viral, antiseptic properties and its function in regenerating and repairing skin cells. This research is a type of experimental research. Sampling was carried out purposively. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The research procedure consisted of several stages, namely making reagents, phytochemical screening tests, and examining the characteristics of the ethanol extract. The results of microscopic examination of sapodilla leaf simplicia powder showed the presence of stomata, tissue cells, parenchymal tissue and normal hair. In the One Way Anova results table for total burn wound healing after treatment, it shows a sig value <0.05 with the burn wound healing value from day 1 showing a significant value: 0.000. This shows that there is a significant difference in the value of burn wound healing from day 1. 1st to 14th day. The identification results of Bidara leaf extract (Zizipus mauritiana L.) showed that it positively contained secondary metabolite compounds, namely alkaloid compounds, flavonoid compounds, tannin compounds, saponin compounds and terpenoid compounds. The ethanol extract gel preparation of bidara leaves is less effective than bioplacenton for healing burns.
Penelitian Uji Aktivitas Antibakteri Pseudomonas Aeruginosa Pada Param Karo Sebagai Antidiabetic Foot ARDHANA, RANIA RARA
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2334

Abstract

Param Karo is a traditional medicinal herb that is added with rice flour (Oryza sativa) as a solidifier. Param Karo has many properties, especially as an alternative treatment for fever, flatulence, and various other conditions. Param Karo is used by repeatedly applying it on the body to help normalize body temperature. The purpose of this study was to determine the activity of param Karo against Pseudomonas aeruginosa bacteria as the cause of diabetic foot wounds, as well as to identify the optimal concentration of param Karo needed to achieve significant antibacterial activity. Extraction was carried out using 96% ethanol solvent, and antibacterial activity testing was carried out by disc diffusion method on Pseudomonas aeruginosa bacteria with 3 concentrations namely, 25%, 50%, 75%. The results showed that the ethanol extract of Param Karo had the most significant antibacterial activity at a concentration of 75% with the formation of a clear zone around the disc. Ciprofloxacin was used as positive control, while DMSO 10% as negative control.
Skrinning Resep Interaksi Obat Pasien Diabetes Melitus Dan Hiperkolestrol Periode Oktober S.D Desember 2023 Di Rumah Sakit Advent Medan Khairunnisa Lubis, Nazla
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2338

Abstract

Prescription screening is done to prevent the presence or absence of errors in drugs. Prescription screening is a stage in pharmaceutical services carried out by pharmacists who provide pharmaceutical services and pharmaceutical personnel can receive prescriptions from patients. This study aims to conduct prescription screening for drug interactions in patients with diabetes and hypercholesterolemia in the period October to December 2023. Patients with diabetes mellitus and hypercholesterolemia often receive combination therapy, which increases the risk of drug interactions. Lack of understanding of the potential for drug interactions can result in patient safety risks. Therefore, this study focuses on prescription screening to identify and analyze possible drug interactions
FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL EKSTRAK ETANOL DAUN SAMBUNG RAMBAT (Mikhania mikrantha) SEBAGAI ANTIINFLAMASI PADA TIKUS PUTIH JANTAN Harahap, Nurul Dahlia
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2351

Abstract

Background: Inflammation is a normal response due to the immune to eliminate pathogens, prevent the spread of tissue damage and repair damaged tissue due to pathological symptoms of a disease, Objective: To determine the concentration that provides effectiveness as an anti-inflammatory against male white rats induced with 1% carrageenan. . Methods: The vines were extracted using 96% ethanol as a solvent. 15 wistar rats were adapted for seven days. The rats were randomly divided into 5 groups. Group I (negative control) based on gel, group II (positive control) voltaren gel, group III ethanolic extract of vines with a concentration of 5%, group IV of ethanolic extract of vines of leaves 10%, group V of ethanolic extract of vines of leaves 15%. All treatment groups were sublanted with 1% carrageenan. Edema in rat feet was measured at 30 minutes to 180 minutes. Data analysis used the one way ANOVA method. Results: from the result of the study show that each treatment group experienced a reduction in inflamasi,in the 5 treatment groups, the best reduction in inflmation was the consentration 15% wich was the best compared to voltaren gel in reducing inflamation,Conclusion: the ethanolic extract of vines has an almost equeval__ent effect the drug voltaren but the drug voltaren is more effegtive reducing inflamation.
PENETAPAN KADAR VITAMIN C PADA DAGING BUAH CABAI MERAH KERITING (Capsicum annum L.) YANG BEREDAR DI PASAR BUAH BERASTAGI KABUPATEN KARO MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS purba, jhan saberlan; elia, Sofia; Barus, Lidia Klorida
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2356

Abstract

Background: Vitamins are complex compounds that are needed by the body that function to help regulate or regulate the body's metabolic processes. One of the vitamins needed by the body is vitamin C. Vitamin C is a nutrient that acts as an antioxidant and is effective in overcoming free radicals that can damage cells or tissues, including protecting the lens from oxidative damage caused by radiation. Vitamin C or ascorbic acid is one of the vitamins that is soluble in water, easily oxidized, and sensitive to light stimulation. One of the plants that contain vitamin C is curly red chili. Red chilies have different levels of spiciness. Determination of vitamin C levels in red chili was carried out by UV-Vis spectrophotometry. This study aims: to determine the levels of vitamin C contained in the flesh of curly red chili (Capsicum annum L.) circulating in the Berastagi fruit market, Karo Regency. Methods: The sample used was curly red chili meat obtained from Berastagi fruit market, Karo Regency. The test was carried out by UV-Vis spectrophotometry with a wavelength of 296 nm. Results: The results of research conducted by UV-Vis spectrophotometry obtained an average level of vitamin C in the flesh of red curly chilies of 5.4689 mg/g. Conclusion: The results of the study showed that the flesh of curly red chilies had vitamin C.
SKRINNING RESEP INTERAKSI OBAT PASIEN DIABETES MELITUS DAN GAGAL GINJAL PERIODE OKTOBER S.D DESEMBER 2023 DI RUMAH SAKIT RASYIDA MEDAN Rambe, Octia Rambe Octia; Br Sembiring, Novitaria
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2357

Abstract

Prescription screening is a critical phase in pharmaceutical services conducted bypharmacists and pharmaceutical technical personnel upon receiving aprescription from a patient. This study specifically aims to eval_uate the outcomesof prescription screening based on administrative and pharmaceutical conformityanalysis at Rasyida Hospital, Medan. The research method employed is adescriptive cross-sectional approach with a retrospective design, collecting datafrom the period of October to December 2023. The study reveals thatadministrative eval_uations in prescription screening include several essentialelements such as the patient's name, age/date of birth, address, body weight,the prescribing doctor's name and registration number (SIP), hospital address,doctor’s initials, practice phone number, and the prescription date. On the otherhand, pharmaceutical review focuses on elements such as the name of themedication. With the rising morbidity rate and increased medication use inhospitals, addressing drug-related problems—particularly those stemming frominappropriate medication use—has become more urgent. Prescriptionassessment plays a key role in preventing such issues. This study aims toidentify the elements with the highest level of incompleteness or prescribingerrors. Incomplete prescriptions are a major trigger for medication errors,making prescription screening by pharmacists across healthcare facilities—suchas hospitals, community health centers, and pharmacies—a critical practice.Screening encompasses both administrative and pharmaceutical aspects,highlighting the essential role of pharmacists in mitigating potential health risksfor patients.
Skrinning Resep Interaksi Obat Pasien Hipertensi dan Gagal Ginjal Periode Oktober S.d Desember di Rumah Sakit Rasyida Medan alfitriani, sri devi
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2406

Abstract

Hypertension is a significant health issue in Indonesia, frequently referred to as a silent killer due to its asymptomatic nature. Hypertension complications may result in damage to essential organs, including the heart, brain, and kidneys, potentially culminating in chronic kidney failure (CKD). The therapy of hypertension and renal failure requires appropriate pharmacological intervention to avert complications and enhance patient quality of life. This research seeks to identify medications often prescribed to patients with hypertension and renal failure, ascertain the preval__ence of concurrent illnesses, and assess potential drug interactions in prescriptions at Rasyida Hospital Medan from October to December 2023. The research used a descriptive methodology via an analysis of patient prescriptions. The study's findings indicated the use of diverse combinations of antihypertensive medications and renal failure treatment, along with the possibility of drug interactions in multiple patient prescriptions. The results underscore the need of prescription screening and monitoring for drug interactions within clinical pharmacy services to mitigate the risk of medication mistakes and enhance the safety and efficacy of treatment in patients with hypertension and renal failure. Keywords: Hypertension, Kidney Failure, Drug Interactions, Prescription Screening.

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