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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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Jhan Saberlan Purba Purba, Jhan Saberlan
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2000

Abstract

Rhodamin B merupakan pewarna sintetik yang digunakan sebagai zat warna tekstil, rhodamin B tidak diperbolehkan digunakan pada produk makanan karena sangat berbahaya bagi kesehatan manusia. Rhodamin B mempunyai sifat kimia dan kandungan logam berat seperti senyawa alkilasi (CH3-CH3) dan juga mengandung senyawa (Cl) yang bersifat radikal yang dapat berikatan dengan DNA, protein dan lemak dalam tubuh, sehingga senyawa yang terikat tidak ada. lagi berfungsi dengan baik dan kinerja tubuh tidak lagi optimal, apabila rhodamin B terakumulasi dalam konsentrasi tinggi dalam tubuh dapat menyebabkan penyakit liver. Menurut Direktur Jenderal Badan POM No.00366/C/II/1990 menyatakan bahwa pewarna rhodamin B termasuk dalam 30 bahan pewarna yang tidak boleh ditambahkan pada makanan. Namun nyatanya rhodamin B masih terdapat pada berbagai produk pangan untuk memberikan warna yang lebih kuat, salah satunya pada saus. Tujuan: Penelitian ini bertujuan untuk menganalisis keberadaan dan kadar rhodamin B yang terdapat pada kuah bakso bakar yang beredar di Deli Tua. Metode : menggunakan metode uji warna kualitatif dan spektrofotometri tampak secara kuantitatif. Hasil: hasil analisis kualitatif dengan metode uji warna 3 dari 9 sampel yang digunakan teridentifikasi positif mengandung rhodamin B dengan kode sampel A, sampel B, dan sampel H ditandai dengan terbentuknya warna merah jambu. Analisis kuantitatif spektrofotometri tampak diperoleh panjang gelombang maksimum 545 nm dengan kadar rhodamin B pada sampel saus kode A 13,79744215 (± 2,76035 µg/mL), sampel saus B sebesar 11,31734153 (± 2,2615 µg/mL) , dan sampel saus H sebesar 12,12968009 (± 2,4214 µg/mL), konsentrasi tertinggi terdapat pada sampel saus A. Kesimpulan: dari penelitian ini terdapat beberapa saus bakso bakar yang digunakan oleh pedagang bakso panggang di Deli Tua masih mengandung pewarna rhodamin B
A The Formulation And Stability Formulation And Stability Testing Of Lotion From Ethanol Extract Pagoda Flower (Clerodendrum Paniculatum L.) And Rhizomes Key Find (Boesenbergia Rotunda (L.) Mansf.) As Antioxidant Barus, Bunga Barus
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2001

Abstract

Unhealthy lifestyles and air pollution can cause the number of free radicals in the body to increas. The formation of free radicals is a widely accepted important mechanism that causes skin aging. For this reason, the body needs antioxidants that can neutralize very dangerous free radicals. A plant whose efficacy as an antioxidant has been proven is the pagoda flower plant. Another plant used to ward off free radicals is the rhizome of Temu Kunci (Boesenbergia rotunda (L.) Mansf.) which is from the Zingiberaceae family which has compounds that have the potential to act as antioxidants. This research aims to formulate a lotion preparation of pagoda flower extract and ginger root rhizome extract as well as carrying out a stability test of the preparation and determining the IC 50 value using the DPPH method. The research used the maceration method with 96% ethanol. Then the extract is formulated into a lotion with varying concentrations of pagoda flower extract: ginger rhizome extract, namely: F1(1:1); F2(2:1); F3(1:2). The preparations of pagoda flower extract lotion and ginger root rhizome extract were eval_uated for organoleptic tests, pH tests, homogeneity tests, viscosity tests and hedonic tests and antioxidant tests were carried out with a wavelength of 516nm. The results of the research on pagoda flower extract lotion and ginger root rhizome extract have met the requirements for organoleptic tests, pH test, homogeneity test, and viscosity test. The IC50 value of the lotion preparation of ethanol extract of pagoda flowers and ethanol extract of ginger rhizome showed a strong category (50-100) with an IC50 value of F1 86.13 µg/ml, F2 73.91 µg/ml and F3 75.83 µg/ml.
PENETAPAN KADAR AKRILAMIDA DALAM MAKANAN KAKI LIMA KENTANG GORENG DI PASAR TRADISIONAL DELI TUA DENGAN METODE HPLC (High Performance LiquidChromatography)) sulasmi, sulasmi
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2002

Abstract

ABSTRACT Background: This study examines acrylamide levels in french fries sold in the traditional market of Deli Tua using the High Performance Liquid Chromatography (HPLC) method. Purpose: is to identify the concentration of acrylamide contained in the samples, as well as provide information regarding the potential health risks associated with the consumption of foods containing the compound. This research Method : is descriptive, carried out in the Quantitative Analysis Chemistry Laboratory, Faculty of Pharmacy, Deli Husada Institute of Health. French fries samples were taken from traders at the Deli Tua traditional market. Acrylamide levels were analyzed using the High Performance Liquid Chromatography (HPLC) method, with procedures including standard solution preparation and measurement using a UV-VIS detector. Results: showed that all the French fries samples analyzed contained acrylamide with varying concentrations. The average acrylamide content in the sample from trader A was 0.7%, while from trader B was 0.5%. These findings show that the acrylamide levels in the fries circulating in the Deli Tua traditional market are not in accordance with the standards set by the Regulation of the Minister of Health. Conclusion: of this study is that the fries sold in the Deli Tua traditional market contain acrylamide with levels that exceed the safe limit. It is recommended to the public to be more careful in choosing fast food, especially french fries. Further research is suggested to use other analysis methods, such as FTIR, with different solvents to obtain more comprehensive results.
FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL KOMBINASI DARI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus) DAN DAUN PEPAYA (Carica papaya L) TERHADAP PENYEMBUHAN LUKA BAKAR TIKUS PUTIH JANTAN (Rattus norvegicus) SEMBIRING, TIO RANTI SARI
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2003

Abstract

ABSTRACK Background: According to research conducted at Cipto Mangunkusumo Hospital (RSCM) in 2011-2012, it was reported that the average age was 28 years from a range of 2.5 months to 76 years, while the mortality rate was 36.6% in patients with extensive burns. more than 60.0% of them all experienced death. Research was carried out at the Pharmaceutical Biology Laboratory and the Pharmaceutical Qualitative Laboratory at the Deli Husada Deli Tua Health Institute, as well as at the Pharmaceutical Preparation Technology Laboratory for the manufacture of extracts and gel preparations. The research took place from March to May 2024. This research is a laboratory experimental research. The research population is jackfruit leaves and papaya leaves. The samples used were jackfruit leaf and papaya leaf extracts with concentrations of 3%, 6%, 9%, as well as bioplacenton gel. Research procedures include making simplicia, making extracts using the maceration method, characterization of simplicia, as well as formulation and quality eval_uation of gel preparations. Effectiveness testing was carried out by observing the healing time of burn wounds in mice treated with ethanol extract gel from jackfruit leaves and papaya leaves. The results of this study showed that the effectiveness of healing burn wounds from the combination of ethanol extracts from jackfruit leaves and papaya leaves every day in each formulation. In the positive control (bioplasma) at a concentration of 6% there was no significant difference of p0.05 on days 3, 6, 12 and 15. On day 9 there was a significant difference of p0.05 in each formulation. However, it can be concluded that the 6% concentration is the most effective in healing burns. The bioplacenton gel preparation has better effectiveness in healing wounds compared to the gel preparation combining the ethanol extract of jackfruit leaves and papaya leaves. Keywords: Artocarpus heterophyllu,Carica papaya L, effectiveness test
UJI AKTIVITAS PRODUK KECANTIKAN FACIAL WASH TERHADAP BAKTERI PENYEBAB JERAWAT (Propionibacterium acnes) Harnis, Zola Efa; Harahap, Nina Irmayanti Harahap; Simorangkir, Delisma Simorangkir; Sari, Rika Puspita; Hayati, Silmi Hayati
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2039

Abstract

Background: Acne occurs on the surface of the skin of the face, neck, chest, and back when the oil glands in the skin are overactive so that the pores of the skin will be clogged with excessive fat deposits. If the deposits are mixed with sweat, dust, and other dirt, it can cause fat deposits with black spots on them called blackheads. If the blackheads have a bacterial infection, then there is an inflammation known as acne, one of the bacteria is Propionibacterium acnes. Objective: This study aims to test the antibacterial activity of face wash containing gotu kola leaf, moringa leaf, and green tea leaf extracts. Results: Inhibition zone test results obtained facial wash containing gotu kola leaf extract (Facial wash B), moisture test results obtained that facial wash containing green tea leaf extract (Facial wash C) is more effective in moisturizing the skin, brightness test results obtained that facial wash containing moringa leaf extract (Facial wash A) is more effective in brightening the skin.
UJI EFEKTIVITAS HIPERKOLESTEROLEMIA EKSTRAK ETANOL DAUN KECIPIR (Psophocarpus tetragonolobus L) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI KUNING TELUR BEBEK sianipar, masria phetheresia; Syafitri, Anggun; Sembiring, Pintata
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 1 (2024): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i1.2074

Abstract

This study explored the effectiveness of winged leaf ethanol extract (Psophocarpus tetragonolobus L) in lowering cholesterol levels in male white rats (Rattus norvegicus) induced with duck egg yolk. An experimental method was used to eval__uate the impact of the extract on cholesterol levels, with the aim of providing an alternative treatment of hyperglycoleemia based on natural ingredients. The results show the significant potential of the extract. This research method uses an experimental approach with laboratory design. Male white rats (Rattus norvegicus) were divided into treatment and control groups. Winged leaf ethanol extract was administered to the treatment group, while the control group did not receive the treatment. Cholesterol level measurements were carried out after induction with duck egg yolk, to eval__uate the effectiveness of the extract in lowering cholesterol levels. The results showed that the administration of winged leaf ethanol extract significantly reduced total cholesterol, LDL, and triglyceride levels in induced male white rats. The group that received the highest dose of the extract showed the most favorable reduction in cholesterol levels, close to the effects of simvastatin. These findings indicate the potential of winged leaves as an alternative in the management of hypercholesterolemia. The conclusion of this study showed that winged leaf ethanol extract (Psophocarpus tetragonolobus L) was effective in lowering cholesterol levels in induced male white rats. A dose of 300 mg/kgBB has been shown to be the most effective. Recommendations for further research are to explore different dosage forms and extract concentrations, as well as conduct toxicity studies to ensure their safe use as a hypercholesterolemia therapy.
ANALISIS KADAR TANIN BERBAGAI JENIS TEH HITAM DAN TEH HIJAU KHAS KOTA PAGARALAM SEBAGAI ANTIOKSIDAN MENGGUNAKAN METODE SPEKTROFOTOMETER UV-VIS Krishna, lora Krisina
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2186

Abstract

The plant known as tea (Camellia sinensis L.) is widely grown in Indonesia. The shoots of young tea leaves are brewed into a health drink. This research was carried out with the aim of determining the tannin content of green tea and black tea as well as their antioxidant activity using the UV-Vis spectrophotometer method. Thick extracts from black tea and green tea from qualitative and quantitative test results showed the presence of tannin compounds with tannin levels in the samples obtained were T1 Black tea (CTC Tea) Slopes of Mount Dempo 0.070, T2 Green tea (PTPN 7) Pagaralam tea typical of South Sumatra 0.061, T3 Green tea (PTPN 7) Gunung Dempo 0.028, T4 Black Tea (CTC Tea) Pucuk Gunung Dempo 0.059, and antioxidant activity was tested using 2,2 diphenyl-1-picrylhydrazyl (DPPH). Black tea and green tea extracts have antioxidant activity with a value of IC50 (Inhibition Concentration 50). T1 has very strong antioxidant activity (13.89%), followed by code T2, the antioxidant activity is also very strong (3.67%), code T3 has very strong antioxidant activity. strong (2.02 %), and T4 code moderate antioxidant activity (6.02 %). Black tea and green tea extracts contain high levels of tannin and have very strong antioxidant activity.
Formulasi Dan Uji Stabilitas Sediaan Lip Tint Kombinasi Ekstrak Kulit Buah Naga (Hylocereus Polyhizu) Sebagai Pewarna Dan Kulit Jeruk Nipis (Citrus Aurantifolia) Sebagai Inhibitor Tirosinae pian, alfian
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2195

Abstract

Kulit buah naga merah (Hylocereus polyrhizus) dapat digunakan untuk menetralisir radikal bebas dan dimanfaatkan sebagai pewarna alami. memiliki daya antioksidan tang tinggi. Kulit jeruk nipis (Citrus aurantifolia) mempunyai manfaat sebagai antioksidan dan mengandung enzim tirosinase. Tujuan penelitian ini untuk mengetahui ekstrak kulit buah naga merah (Hylocereus polyrhizus) dengan kombinasi ekstrak kulit jeruk nipis (Citrus aurantifolia) dalam pembuatan sediaan lip tint dan stabilitasnya. Kulit buah naga merah (Hylocereus polyrhizus)dibuat sediaan Lip Cream menggunakan variasi konsentrasi ekstrak pada 10%, 15%, 20% sedangkan kulit jeruk nipis (Citrus aurantifolia) 40% untuk semua konsentrasi. Penelitian ini menggunakan metode eksperimen, uji secara fisika kimia, cycling test dan menguji antioksidan menggunakan metode DPPH. Hasil penelitian diperoleh bahwa ekstrak kulit buah naga merah (Hylocereus polyrhizus) dan ekstrak kulit jeruk nipis (Citrus aurantifolia) dapat dibuat sediaan lip tint karena memenuhi uji stabilitas fisik. Hasil penelitan menunjukkan pada Formula I memiliki nilai IC50 77,77 μg/mL, formula II memiliki nilai IC50 55,58 μg/mL, formula III memiliki nilai IC50 70,63 μg/mL, dan formula (-) tanpa ekstrak memiliki nilai IC50 38,91. Sediaan lip tint ekstrak kulit buah naga merah (Hylocereus polyrhizus) dan ekstrak kulit jeruk nipis (Citrus aurantifolia) memiliki aktivitas antioksidan.
ANALISIS ANTIOKSIDAN PADA KAPSUL HABBATUSSAUDA (Nigella sativa L.) DENGAN METODE DPPH SECARA SPEKTROFOTOMETRI UV-Vis Tahun 2022 sulasmi, sulasmi
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2201

Abstract

Background: One of the plants that is often used as a medicinal plant is Black Seed. Black Seed in Indonesia is called of black cumin. Main contains of black cumin (Nigella sativa L.) are Thymoquinone, Dithymoquinone, Thymohydroquinone, and Thymol as antioxidants.. Purpose: of this research to test the antioxidant activity contained in Black Seed capsules. Black Seed capsules were tested for weight uniformity, and phytochemical screening. This research Method : Then the Black Seed capsules were tested for antioxidant activity using the DPPH method using a Spectrophotometer UV-Vis at a wavelength of 516 nm, then the value of IC50 was determined in the sample and for comparison, Vitamin C as a comparison. Results: results of uniformity test of capsule weights A1 = 2.72%, A2 = 2.54%, B = 2.00%. The results of phytochemical screening of Black Seed capsule powder contain alkaloids, flavonoids, tannins, saponins, and steroids. The results of the antioxidant activity test using the DPPH method showed that Black Seed capsules with methanol solvent had antioxidant activity with an Inhibitory Concentration (IC50) of 97.635 µg/ml categorized in a class of strong antioxidant and vitamin C as a comparison has IC50 of 4.397 µg/mL with a very strong category.. Conclusion: so that vitamin C has a stronger antioxidant activity than black seed capsules. The results showed that Black Seed capsules contained antioxidants and had strong antioxidant activity. .
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitis gracilisWall) TERHADAP PENAMBAH STAMINA PADA MENCIT JANTAN Syafitri, Anggun; Sianipar, Masria Phetheresia; Agustina, Putri
Jurnal Penelitian Farmasi Dan Herbal Vol 7 No 2 (2025): Jurnal Penelitian Farmasi Dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v7i2.2202

Abstract

Stamina is the ability of human endurance to withstand fatigue within a certain time limit, where activities are carried out with high intensity and always use energy that can be treated with traditional medicine derived from plants. One example of plants that can increase stamina is tiger gagatan leaves which contain flavonoids that can increase the motor activity of mice by inhibiting the absorption of calcium ions entering the sarcoplasmic reticulum after that with the obstacle causing high calcium ion levels in sarcoplasm and containing tonic effects. The purpose of the study was to determine the effect of giving tiger gagatan leaf extract in increasing stamina compared to caffeine. This research was conducted by experimental method, samples were extracted maceration using 96% ethanol solvent and concentrated with a rotary evaporator. Using 25 mice and divided into 5 groups. The control group was negative CMC-Na 0.5%, the control group positive for caffeine 0.13mg/kgBB, EDGH with a dose of 50mg/kgBB, EDGH with a dose of 100mg/kgBB, EDGH with a dose of 200mg/kgBB. Then observed the endurance time of mouse stamina and calculated the average physical endurance time of mice by swimming method. From the results of the study that the EDGH dose of 200mg/kgBB had optimal effectiveness close to the positive control group with swimming endurance time of 52.18 minutes, while EDGH with a dose of 100mg / kggBB showed a physical endurance time of mice of 49.07 minutes, and EDGH 50mg / kg BB showed a physical endurance time of mice of 48.24 minutes. So it can be concluded that tiger gagatan leaf extract at a dose of 200mg/kgBB has an effectiveness equivalent to caffeine in increasing stamina against male white mice.

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