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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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INDONESIA
Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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UJI EFEKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Gultom, Evi Deviana
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2733

Abstract

Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol daun pepaya (EEDP) terhadap penurunan kadar glukosa darah pada tikus putih jantan (Rattus norvegicus) yang diinduksi aloksan, menentukan dosis yang paling efektif, dan membandingkannya dengan glibenklamid. Penelitian ini menggunakan metode eksperimen dengan rancangan post-test only control group design. Sampel daun pepaya dikumpulkan secara purposive dari Kabupaten Batu Bara, diolah menjadi obat sederhana, dan diekstraksi menggunakan metode maserasi dengan etanol 96%. Skrining fitokimia menunjukkan bahwa EEDP mengandung flavonoid, alkaloid, saponin, tanin, dan steroid/triterpenoid. Hewan uji dibagi menjadi lima kelompok: kontrol negatif (CMC Na 0,5%), kontrol positif (glibenklamid 0,45 mg/kgBB), dan tiga kelompok perlakuan dosis EEDP 100, 200, dan 400 mg/kgBB. Induksi diabetes dilakukan dengan menggunakan aloksan monohidrat. Kadar glukosa darah diukur menggunakan glukometer sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan bahwa pemberian EEDP pada ketiga dosis mampu menurunkan kadar glukosa darah secara signifikan dibandingkan dengan kontrol negatif. Dosis 400 mg/kgBB memberikan penurunan paling besar dan mendekati efektivitas glibenklamid. Uji statistik tidak menunjukkan perbedaan yang signifikan antara kelompok EEDP pada dosis 400 mg/kgBB dan glibenklamid (p>0,05), yang mengindikasikan bahwa efek antidiabetik EEDP sebanding dengan obat konvensional. Mekanisme penurunan glukosa darah diduga terkait dengan kemampuan flavonoid untuk meningkatkan sensitivitas insulin, melindungi sel β pankreas, dan menghambat enzim α-glukosidase. Sebagai kesimpulan, EEDP berpotensi sebagai agen antidiabetik alami, dengan dosis optimal 400 mg/kgBB, yang efektivitasnya sebanding dengan glibenklamid. Temuan ini mendukung penggunaan daun pepaya sebagai obat tradisional yang aman, terjangkau, dan mudah didapat, serta membuka peluang untuk penelitian lebih lanjut dalam pengembangan fitofarmaka antidiabetik.
“UJI EFEKTIVITAS FORMULASI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN DAUN PEPAYA (Carica Papaya L.) SEBAGAI LOTION AEDES AEGYPTI” SEMBIRING, TIO RANTI SARI; Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2734

Abstract

Flaviviridae, genus Flavivirus, and group of arthropod-borne viruses. Aedes mosquitoes, particularly Aedes aegypti or Aedes albopictus, are the primary vectors of dengue disease transmission. A product that is used in skin-protection cosmetics to protect the skin from mosquito bites is anti-mosquito lotion (repellent). Water, emulsifying agents, humectants, and fatty ingredients make up lotion preparations. The bitter gourd and papaya leaves employed in this study were the active ingredients used to make lotion preparations. The lotion formulation used in this investigation contained flavonoid chemicals at varied extract concentrations of 0%, 2%, 4%, and 6%. The bitter gourd's and leaves' active components Because papaya is known to contain a lot of antioxidants, it can be used as an insecticide and lotion to ward against mosquitoes. According to SNI-16-4399-1996, preparations for anti-mosquito lotion made from papaya leaves and bitter melon extract pass the physical quality test because they are all homogeneous, have an oil-in-water emulsion type, are stable during storage for two weeks, and do not irritate the skin. Anti-mosquito lotion made with bitter melon fruit extract and papaya leaves, which is distinguished by the presence of dead mosquitoes in each formulation, has an effect on the effectiveness as an insecticide or repellent against mosquitoes on the skin that is applied. The extract lotion preparations' concentration The most powerful insecticide or mosquito repellant is a 6% extract of bitter gourd fruit and papaya leaves.
FORMULASI SEDIAAN LILIN EKSTRAK MINYAK ATSIRI BUNGA SEDAP MALAM (Polianthes tuberosa ) SEBAGAI AROMATERAPI anggara, Elysa; Harahap, Nina Irmayanti
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2737

Abstract

Stress is a common phenomenon that significantly impacts physical and mental health. One natural method widely developed to promote relaxation is aromatherapy. This study aimed to formulate tuberose (Polianthes tuberosa) essential oil into aromatherapy candles and evaluate their physical characteristics. Essential oil extraction was carried out using steam distillation, then formulated into candles using paraffin and stearic acid as the base ingredients. Four formulas with varying essential oil concentrations were selected: F1 (0 mL), F2 (5 mL), F3 (10 mL), and F4 (15 mL). Evaluation included organoleptic tests (color, aroma, and shape), homogeneity, melting point, and physical stability. The results showed that the candle with the addition of 15 mL of essential oil (F4) had the best physical characteristics: even color, a smooth surface, no cracks, easy lighting, and a strong, distinctive, calming aroma. Based on the evaluation results, tuberose essential oil was successfully formulated into a stable aromatherapy candle with the potential to provide a relaxing effect.

Page 20 of 20 | Total Record : 193

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