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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 233 Documents
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UJI EFEKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Gultom, Evi Deviana
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2733

Abstract

Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol daun pepaya (EEDP) terhadap penurunan kadar glukosa darah pada tikus putih jantan (Rattus norvegicus) yang diinduksi aloksan, menentukan dosis yang paling efektif, dan membandingkannya dengan glibenklamid. Penelitian ini menggunakan metode eksperimen dengan rancangan post-test only control group design. Sampel daun pepaya dikumpulkan secara purposive dari Kabupaten Batu Bara, diolah menjadi obat sederhana, dan diekstraksi menggunakan metode maserasi dengan etanol 96%. Skrining fitokimia menunjukkan bahwa EEDP mengandung flavonoid, alkaloid, saponin, tanin, dan steroid/triterpenoid. Hewan uji dibagi menjadi lima kelompok: kontrol negatif (CMC Na 0,5%), kontrol positif (glibenklamid 0,45 mg/kgBB), dan tiga kelompok perlakuan dosis EEDP 100, 200, dan 400 mg/kgBB. Induksi diabetes dilakukan dengan menggunakan aloksan monohidrat. Kadar glukosa darah diukur menggunakan glukometer sebelum dan sesudah perlakuan. Hasil penelitian menunjukkan bahwa pemberian EEDP pada ketiga dosis mampu menurunkan kadar glukosa darah secara signifikan dibandingkan dengan kontrol negatif. Dosis 400 mg/kgBB memberikan penurunan paling besar dan mendekati efektivitas glibenklamid. Uji statistik tidak menunjukkan perbedaan yang signifikan antara kelompok EEDP pada dosis 400 mg/kgBB dan glibenklamid (p>0,05), yang mengindikasikan bahwa efek antidiabetik EEDP sebanding dengan obat konvensional. Mekanisme penurunan glukosa darah diduga terkait dengan kemampuan flavonoid untuk meningkatkan sensitivitas insulin, melindungi sel β pankreas, dan menghambat enzim α-glukosidase. Sebagai kesimpulan, EEDP berpotensi sebagai agen antidiabetik alami, dengan dosis optimal 400 mg/kgBB, yang efektivitasnya sebanding dengan glibenklamid. Temuan ini mendukung penggunaan daun pepaya sebagai obat tradisional yang aman, terjangkau, dan mudah didapat, serta membuka peluang untuk penelitian lebih lanjut dalam pengembangan fitofarmaka antidiabetik.
“UJI EFEKTIVITAS FORMULASI EKSTRAK ETANOL BUAH PARE (Momordica charantia L.) DENGAN DAUN PEPAYA (Carica Papaya L.) SEBAGAI LOTION AEDES AEGYPTI” SEMBIRING, TIO RANTI SARI; Simorangkir, Delisma Marsauli
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2734

Abstract

Flaviviridae, genus Flavivirus, and group of arthropod-borne viruses. Aedes mosquitoes, particularly Aedes aegypti or Aedes albopictus, are the primary vectors of dengue disease transmission. A product that is used in skin-protection cosmetics to protect the skin from mosquito bites is anti-mosquito lotion (repellent). Water, emulsifying agents, humectants, and fatty ingredients make up lotion preparations. The bitter gourd and papaya leaves employed in this study were the active ingredients used to make lotion preparations. The lotion formulation used in this investigation contained flavonoid chemicals at varied extract concentrations of 0%, 2%, 4%, and 6%. The bitter gourd's and leaves' active components Because papaya is known to contain a lot of antioxidants, it can be used as an insecticide and lotion to ward against mosquitoes. According to SNI-16-4399-1996, preparations for anti-mosquito lotion made from papaya leaves and bitter melon extract pass the physical quality test because they are all homogeneous, have an oil-in-water emulsion type, are stable during storage for two weeks, and do not irritate the skin. Anti-mosquito lotion made with bitter melon fruit extract and papaya leaves, which is distinguished by the presence of dead mosquitoes in each formulation, has an effect on the effectiveness as an insecticide or repellent against mosquitoes on the skin that is applied. The extract lotion preparations' concentration The most powerful insecticide or mosquito repellant is a 6% extract of bitter gourd fruit and papaya leaves.
FORMULASI SEDIAAN LILIN EKSTRAK MINYAK ATSIRI BUNGA SEDAP MALAM (Polianthes tuberosa ) SEBAGAI AROMATERAPI anggara, Elysa; Harahap, Nina Irmayanti
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2737

Abstract

Stress is a common phenomenon that significantly impacts physical and mental health. One natural method widely developed to promote relaxation is aromatherapy. This study aimed to formulate tuberose (Polianthes tuberosa) essential oil into aromatherapy candles and evaluate their physical characteristics. Essential oil extraction was carried out using steam distillation, then formulated into candles using paraffin and stearic acid as the base ingredients. Four formulas with varying essential oil concentrations were selected: F1 (0 mL), F2 (5 mL), F3 (10 mL), and F4 (15 mL). Evaluation included organoleptic tests (color, aroma, and shape), homogeneity, melting point, and physical stability. The results showed that the candle with the addition of 15 mL of essential oil (F4) had the best physical characteristics: even color, a smooth surface, no cracks, easy lighting, and a strong, distinctive, calming aroma. Based on the evaluation results, tuberose essential oil was successfully formulated into a stable aromatherapy candle with the potential to provide a relaxing effect.
Skrinning Resep Interaksi Obat Pasien Hipertensi dan Gagal Ginjal Periode Oktober S.d Desember di Rumah Sakit Rasyida Medan alfitriani, sri devi
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2406

Abstract

Hypertension is a significant health issue in Indonesia, frequently referred to as a silent killer due to its asymptomatic nature. Hypertension complications may result in damage to essential organs, including the heart, brain, and kidneys, potentially culminating in chronic kidney failure (CKD). The therapy of hypertension and renal failure requires appropriate pharmacological intervention to avert complications and enhance patient quality of life. This research seeks to identify medications often prescribed to patients with hypertension and renal failure, ascertain the preval__ence of concurrent illnesses, and assess potential drug interactions in prescriptions at Rasyida Hospital Medan from October to December 2023. The research used a descriptive methodology via an analysis of patient prescriptions. The study's findings indicated the use of diverse combinations of antihypertensive medications and renal failure treatment, along with the possibility of drug interactions in multiple patient prescriptions. The results underscore the need of prescription screening and monitoring for drug interactions within clinical pharmacy services to mitigate the risk of medication mistakes and enhance the safety and efficacy of treatment in patients with hypertension and renal failure. Keywords: Hypertension, Kidney Failure, Drug Interactions, Prescription Screening.
Uji Aktivitas Antibakteri Pseudomonas Aeruginosa Pada Param Karo Sebagai Antidiabetic foot ARDHANA, RANIA RARA
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2407

Abstract

Param Karo is a traditional medicinal herb that is added with rice flour (Oryza sativa) as a solidifier. Param Karo has many properties, especially as an alternative treatment for fever, flatulence, and various other conditions. Param Karo is used by repeatedly applying it on the body to help normalize body temperature. The purpose of this study was to determine the activity of param Karo against Pseudomonas aeruginosa bacteria as the cause of diabetic foot wounds, as well as to identify the optimal concentration of param Karo needed to achieve significant antibacterial activity. Extraction was carried out using 96% ethanol solvent, and antibacterial activity testing was carried out by disc diffusion method on Pseudomonas aeruginosa bacteria with 3 concentrations namely, 25%, 50%, 75%. The results showed that the ethanol extract of Param Karo had the most significant antibacterial activity at a concentration of 75% with the formation of a clear zone around the disc. Ciprofloxacin was used as positive control, while DMSO 10% as negative control.
POTENSI ANTIBAKTERI PAREM KARO UNTUK MENANGANI INFEKSI Staphylococcocus aureus PADA PENDERITA DIABETIC FOOT Br Tarigan, Jenny Alfa Dilla; Sembiring, Novitaria Br; Bangar S, Roy Idrianto
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2411

Abstract

One of the cronic and serious complications of diabetes mellitus is diabetic foot. Staphyloccocus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. Testing the antibacterial activity of Karo hot parem against staphylococcus aureus bacteria using disc diffusion method with 255, 50% and 75% concentration of Karo hot parem extract, positive control Ciprofloxacin Disks (5µg) and negative control DMSO 10%. This disc diffusion method was carried out to determine the diameter of the inhibition formed by Karo hot parem extract in inhibiting the growth of Staphyloccocus aureus bacteria. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
SKRINNING RESEP INTERAKSI OBAT PASIEN DIABETES MELITUS DAN HIPERURISEMIA PERIODE OKTOBER 2023 S.D MARET 2024 DI RUMAH SAKIT ADVENT Surbekti, Destiana Tata
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2412

Abstract

Diabetes Mellitus and Hyperuricemia are two chronic non-communicable diseases with increasing preval__ence and are often comorbid in patients. Managing these conditions requires long-term pharmacotherapy, which may result in drug interactions. eval__uating prescription completeness and potential drug interactions is essential to ensure effective and safe therapy. Diabetes mellitus is a condition in which blood glucose levels are chronically higher (hyperglycemia) than normal because the body lacks insulin or insulin function is ineffective. Hyperuricemia is a condition in which uric acid levels increase in the blood. This condition can cause gouty arthritis, which is inflammation of the joints due to uric acid buildup. To identify medications prescribed for patients with Diabetes Mellitus and Hyperuricemia, eval__uate potential drug interactions, and assess prescription completeness based on administrative standards in accordance with Indonesia’s Ministry of Health Regulation No. 72 of 2016. This study used a descriptive retrospective design with a cross-sectional approach. A total of 50 outpatient prescriptions at Advent Hospital Medan that met inclusion criteria from October 2023 to March 2024 were analyzed. Prescription screening covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using the Drugs.com database and classified based on severity (major, moderate, minor). Commonly prescribed drugs for Diabetes Mellitus included Metformin, Glimepiride, Acarbose, and Pioglitazone; while for Hyperuricemia, Allopurinol, Meloxicam, and Sodium Diclofenac were most frequent. Ten drug interactions were identified: 8 moderate, 1 major, and 1 minor. The administrative eval__uation showed that most prescription components were complete, though some lacked documentation of body weight, address, and physician’s phone number. The most frequent drug interactions occurred at a moderate severity level, particularly between antidiabetic and NSAID medications. Comprehensive prescription screening is necessary to reduce adverse effects and improve therapeutic safety.
PENETAPAN KADAR FENOLIK TOTAL TUMBUHAN ENDEMIK KALIMANTAN UTARA Salsabillah, Nasywa Amelsya; Ahmad, Aktsar Roskiana; Syarif, Rezki Amriati
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2427

Abstract

North Kalimantan is home to a unique biodiversity, including medicinal plants traditionally used by local communities such as the Dayak people. Several of these plants are endemic—found exclusively in this region. Two notable endemic species, Dayak onion (Eleutherine palmifolia (L.) Merr.) and rose myrtle (Rhodomyrtus tomentosa), are known to contain secondary metabolites, including phenolic compounds. This study aimed to determine the total phenolic content of these two endemic plants. Extraction was performed using Ultrasonic-Assisted Extraction (UAE), resulting in extract yields of 11.42% (11.42 g) for Dayak onion and 24.33% (24.33 g) for rose myrtle. Preliminary phytochemical screening using 1% FeCl₃ reagent indicated the presence of phenolic compounds, evidenced by a color change to bluish-green or dark green. The quantitative analysis was performed using UV–Vis spectrophotometry at a wavelength of 752 nm, applying the Folin–Ciocalteu method with gallic acid as the standard. The results showed that Dayak onion extract contained 1.410 mg GAE/g extract (0.141%), while rose myrtle extract contained 2.259 mg GAE/g extract (0.2259%) of total phenolic compounds. These findings highlight the phenolic potential of endemic medicinal plants from North Kalimantan and support their further exploration for pharmacological and nutraceutical applications
eval_UASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN DEMAM TIFOID DI INSTALASI RAWAT INAP RSUD HAJI MAKASSAR PERIODE JUNI-DESEMBER 2024 Kakambong, Jessieca
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2458

Abstract

Typhoid fever is a common infectious disease in Indonesia, especially among productive age groups. The improper use of antibiotics in its treatment may lead to antibiotic resistance. This study aims to eval_uate the rational use of antibiotics in hospitalized typhoid fever patients at RSUD Haji Makassar using the Gyssens method. A descriptive observational study with a cross-sectional retrospective approach was conducted, using purposive sampling of 125 patient medical records from June to December 2024. Data were analyzed descriptively and statistically using Chi-square tests. Results showed that ceftriaxone was the most commonly used antibiotic (66%), followed by ciprofloxacin (22.8%). Rational use (category 0) was found in 59 cases (47.2%), while irrational use occurred in 66 cases (52.8%), predominantly in category III B (inappropriate duration). A significant association was found between gender and antibiotic rationality (p = 0.030), but no significant correlation was observed with age or length of stay. However, a highly significant correlation was found between the duration of antibiotic administration and rationality (p < 0.001). This study emphasizes the need for regular clinical audits and adherence to updated national treatment guidelines to prevent irrational antibiotic use and resistance.
GAMBARAN PENGETAHUAN IBU RUMAH TANGGA TERHADAP DAGUSIBU OBAT DI DUSUN SALO, DUA DESA SALO DUA, KECAMATAN MAIW, KABUPATEN ENREKANG TAHUN 2025 Sabila, Nur Zal
Jurnal Penelitian Farmasi Dan Herbal Vol. 8 No. 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2459

Abstract

This study aims to determine the level of knowledge among housewives regarding DAGUSIBU (Obtaining, Using, Storing, and Disposing of Medicines) in Dusun Salo Dua, Enrekang Regency, and to identify which components of DAGUSIBU are well understood or need further improvement. This research used a descriptive quantitative method involving 67 respondents selected through purposive sampling based on specific inclusion criteria. Data were collected using a validated and reliable questionnaire and analyzed using univariate descriptive statistics. The results showed that 70.15% of respondents had good knowledge, while 29.85% had sufficient knowledge of DAGUSIBU. Component-wise, knowledge about “obtaining” medicines was relatively low (66.67%), while “using” (79.85%), “storing” (89.05%), and “disposing” (83.6%) were classified as good. Higher knowledge was associated with age over 35 and higher education levels. However, many respondents still acquired medicines from unofficial sources, indicating the need for more targeted health education. This finding emphasizes the importance of strengthening public knowledge and behavior regarding medicine use. Future interventions should include structured community outreach and collaboration with healthcare providers. Moreover, qualitative studies are recommended to explore underlying factors affecting household medicine management and to support the rational use of medicines at the community level.

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