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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Genotyping of Exon 2 BRCA1for Breast Cancer in Iraqi Women by Sanger Sequencing MahanaOied Hussein1 , Khitam Abdul-Wahhab Ali2 , Najwa S. Ahmed3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12074

Abstract

Background: Sporadic, familial and hereditary kinds account for approximately (70-75%), (10-15%) and(five-10%) of all breast cancers respectively. Although numerous chance factors predispose to hereditarybreast cancer, the maximum mighty is mutations within the breast cancer susceptibility genes, BRCA1.Animportant example for tumor suppressor genes are BRCA1 .Material and methods:We examined the frequency of the BRCA1 Exon 2 in 80Iraqi breast cancer (BC)patients, and 60 controls and then the previously genotyped variants in ages between 25 to 45 and also 45 to70,who attended the Oncology Hospital in the City of Medicine during the period from June 2018 to April2019, The products of PCR from amplification of BRCA gene analyzed by PCR-sequencing method.Result: Our study refer to the genotyping of BRCA1 that distributed to ( GG and TT genotyping while TGequal zero.). A significant change was observed in the comparison between the newly diagnosis group andthe control group. T allele was associated with 3.0 fold higher risk for cancer than the G allele (OR=2.38;p=0.041). In BRCA-1 Polymorphism, the odd ratio for the mutant GG genotype was 2.12 with p=0.0141indicating that Patients with an allele GG genotype a higher risk factor of newly diagnosis group comparedto patients who carry allele TT genotype and control group. Also BRCA have a positive correlation with ageand BMI in newly and treatment group also with some biomarkers.Conclusion:SNP variants and different genotypes of BRCA1 have important roles in the development ofcancer. Their application on such patients would discriminate those with high susceptibility to DNA damagefrom those with low susceptibility. This is specially applied for the GG and TT variants of BRAC1 Exon 2.
Importance of FoxO3 Level in Progression of Nodal Osteoarthritis Disease Mahmood Nazar Mustafa/ Abdullah A.Mohammed
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12076

Abstract

Objective :To explain a important of Forkhead box O3(FoxO3 ) protein level in progression of Nodalosteoarthritis (NOA) disease , the location of study at fallujah – Iraq at February 2020 .Method: Collection of samples take for patients with NOA and controls at Rheumatology & RehabilitationConsultation Unit in Al-fallujah Teaching Hospital / Iraq .The Diagnosis NOA patients depended onAmerican College of Rheumatology (ACR) criteria and used technique of ELISA to measure FoxO3 proteinlevel.Results: This study show NOA patient grade 1 have non significant decrease when compare with controlgroup in FoxO3 protein level ,but observed significant decrease when compare with NOA patient grade 4.Also show significant decrease when compare NOA patient grade 4 with control group .Conclusion: This study show that level of FoxO3 protein decrease in NOA cartilage, this lead to reduce ofautophayg and antioxidant proteins .This decrease can result progression of NOA disease .
The Role of Anti-interleukin-4 in BALB/c Mice Infected with Visceral Leishmaniasis Manahel H. Mjefy1 , Altamemy A. K. Aakool2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12077

Abstract

Leishmaniasis is endemic in Iraq with the visceral form of the disease, caused by the L. donovani complex,is principally endemic in the central part of the country. 45 mice (male) were divided into three groups,the first was injected with (3x106) promastigote as control positive, the second was injected with (3x106)promastigote and treated with anti-interleukin 4 and the third was injected with PBS as control negative.After 30, 45 and 60 days the serum was taken and examined by the ELISA test to find out the level ofinterferon gamma (IFN-?).The present study revealed that the level of (IFN-?) at day 30, was higher in group 2 (539.45±2.352), than ingroup 1 (173.26±1.21), and group 3 (109.69 ± 0.25). At day 45, the level recorded in group 2 (393.89±2.012),than group 1 (286.6±1.521), and group 3 (109.93±0.22). At day 60, the level was in group 2 (259.48±1.841),than group 1 (310.22±1.632), and group 3 (109.69±0.23). The aim of present study was to determine theefficient role of anti IL-4 on IFN-? activity in mice infected with L. donovani. We concluded our results thatthe level of interferon gamma (IFN-?) was higher in group 2 at all periods.
Predictors of Malaria Incidence in Rural Eastern Indonesia Mara Ipa1 , Agung Dwi Laksono2 , Endang Puji Astuti1 , Heni Prasetyowati1 , Lukman Hakim1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12078

Abstract

In Indonesia, the largest number of malaria cases was contributed to by Eastern Indonesia. The study aimedto analyze the predictors of malaria incidence in rural Eastern Indonesia. This study analyzes the 2018Indonesia Basic Health Survey data. In the final stage binary logistic regression was used to determinethe incidence of malaria incidence in 86,382 respondents. Variables analyzed included malaria incidence,regional/province, age, gender, educational level, work type, marital status, wealth status, and healthinsurance. The analysis found that people who lived in rural Maluku and rural North Maluku had a lowerrisk of experiencing malaria than those who lived in rural areas of East Nusa Tenggara. People in ruralWest Papua and rural Papua have a higher risk than those who live in rural East Nusa Tenggara. Men were1.107 times more likely than women to have malaria incidence.People with primary school education were1.237 times more likely to develop malaria than those without education. People with a college educationwere 1.440 times more likely to develop malaria than those without education. People who have a wealth ofpoorer status are 0.804 times more likely to have malaria than those who are poorest. People who have therichest wealth status are 0.851 times more likely to have malaria than those who are the poorest. There were4 variables that have proven to be significant as predictors of incidence in rural Eastern Indonesia, namelyregional/province, gender, education, and wealth.
Relationship between Benzene Concentrations with Erythrocyte, Hemoglobin, and Health Complaints of Workers in Surabaya Printing Industry Maria Ayu Dwi Bestari1 , Abdul Rohim Tualeka2 , Putri Ayuni Alayyannur3 , Shintia Yunita Arini4 , Sy
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12079

Abstract

Printing industry uses a lot of raw materials that contain benzene in the production process. Exposure tobenzene can cause haematological effects that affect the production of blood cells. The purpose of thisstudy was to determine the relationship between benzene concentrations with erythrocytes, hemoglobin, andhealth complaints among workers in Surabaya Printing Industry. This research was conducted in PrintingX Surabaya. This research is observational, quantitative approach, and cross-sectional. The respondents inthis study were 19 people. The variables studied were the concentration of benzene in the air, erythrocytes,hemoglobin, and health complaints among workers at Printing X Surabaya. Data analysis using Spearmanrank correlation test. Measurement of the concentration of benzene in the air exceeds the Threshold LimitValue. There were 5 respondents had erythrocyte level above the normal and 1 respondent had hemoglobinlevel below the normal. There was a quite significant and positive relationship between the concentrationof benzene in the air and erythrocytes (p=0.033). But there was no significant relationship between theconcentration of benzene in the air and hemoglobin (p=0.158). Health complaints experienced by workersin Printing X Surabaya included coughing, headaches, and shortness of breath. There is a fairly strongrelationship between benzene concentrations and erythrocytes but there is no relationship between benzeneconcentration and hemoglobin.
mRNA Expression of PITX3 gene in Congenital Cataract Caused by Rubella Virus Infection Marlyanti Nur Rahmah Akib1,2 , Budu3 , Habibah S Muhiddin4, Andi Muhammad Ichsan4, Ratih Natasha Mah
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12080

Abstract

Objective: To analyze mRNA expression of PITX3 gene in congenital cataract caused by rubella virusinfectionMethods: Patients under the age of 18 who were diagnosed with congenital cataracts, were tested for antirubella antibodies, toxoplasma and cytomegalovirus and then underwent cataract surgery, and lens capsuleand lens mass samples were taken. Samples taken will be examined for mutation and expression of thePITX3 mRNA gene.Results: 15 eye samples were included in the study. there was no relationship with rubella infection withPITX-3 gene mRNA expression in the capsule sample and lens mass (p> 0.05). However, in terms ofaverage PITX-3 mRNA gene expression was found to be higher in rubella infection compared to non-rubellainfection. Based on the examination site, there was no significant difference in expression of PITX-3 mRNAgene between the lens capsule sample and the lens mass (p> 0.05). Although there was no statisticallysignificant difference, in terms of the average, the PITX-3 Gen mRNA expression was found to be higher inthe lens capsule compared to the lens mass.Conclusions: Rubella virus infection was the most common cause in the sample, which indicated the needfor prevention of rubella infection in pregnant women to reduce the adverse effects of rubella virus infection.PITX3 gene mRNA expression was higher in the Rubella infection group, indicating the possible role of thePITX3 gene in the pathogenesis of congenital cataracts due to rubella virus infection. The average mRNAexpression of the PITX3 gene is higher in the lens capsule compared to the lens mass although it does notsignificantly indicate the important role of the gene in the process of regulating epithelial cells and lensequatorials.
Determination of Sex Using Humeral Dimensions and Radiographic Measurements of the Humerus in Egyptian Population, Fayoum Governorate Marwa Ali Mwaheb1 , Eman Ali Ali Abd El-Meguid2 , Mohammed Ahmed Moussa3 , Enas Mohammed Morsi 1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12081

Abstract

Background: Sex determination of unidentified skeletal stays from crime scenes or uncovering destinationsis a significant part in the improvement of the natural profile in criminology and human science.Aim of work: The purpose of this research was to determine if sexing of obscure grown-up human humerusbones can be done by applying estimations of morphometric parameters produced by present investigationon these bones of grown up humans of known sex. Also, it aimed to discover the best parameters for sexdetermination.Method: This study was conducted on 52 humeri of 28 males and 24 females and 98 radiographs of patients(48 males and 50 females) from the population of Fayoum governorate in Egypt. Humeri bones used in thisstudy were collected from the Anatomy Department, Faculty of Medicine, Fayoum University.Results: The study illustrated that no statistically significant differences with p-value >0.05 were foundbetween bone and X-ray findings as regards age and sex distribution. Also, no statistically significantdifferences with p-value >0.05 were reported between both findings regarding other measures includingTDMS, UEB, VDH, and ad ML measures. On the other hand, statistically significant differences withp-value <0.05 were reported between different genders regarding EP, TDMS, UEB, VDH, ML, and CT withhigher mean values noticed among males.Conclusion: It is presumed that the distal humerus is a viable bone for sex estimation, even if the bone is ina fragmentary state.
Study the Effect of Chronic Toxoplasmosis on Serum Testosterone Level in Men Masar J.J. Al-Kurdy1 , Noaman N. A’aiz2, Thanaa I. Jawad3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12091

Abstract

Toxoplasma gondii (T.gondii) is an obligate intracellular protozoon which infects both human and animals.T. gondii parasitize in different organs even in testes and it was isolated from semen. The level of testosteronein the serum was evaluated for men with chronic toxoplasmosis.One hundred twenty-one blood samples were collected from apparently healthy men with different agegroups they were attending the teaching hospital in Al-Diwaniyah province. Three milliliters of blood wasdrawn from each man, and then sera were separated by centrifugation. Anti-Toxoplasma IgG antibody wasdetected. Same numbers of positive and negative sera were included in cases and controls groups respectively,and then the quantitative determination of testosterone was analyzed in the serum of both groups.Thirty eight (31.4%) out of 121 examined serum samples were given positive results for T.gondii IgGantibodies. The concentration of testosterone, in case group was relatively more than in the control groupwith no statistical differences (p>0.05). According to age, the comparison of testosterone in two groupsappeared that testosterone level in 15-29 age in case group was with significant differences (P<0.05).From the current study we concluded that the infection with T.gondii can affect the serum testosterone levelin men.
Curcumin vs Chloroquine in Coronavirus Global Pandemic: Trend analysis Study in Google Maslichah Mafruchati
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12092

Abstract

COVID-19 is an infectious disease caused by the newly discovered corona virus. Curcumin and Chloroquineare one of the medications to combat against the pandemic. This paper has objective to analyze the trendsinside the use of Chloroquine and Curcumin as medical treatment against corona in global big data. Thisstudy uses quantitative method of data mining design in collecting the data. This study uses simple randomsampling to determine the number of the population needed for this study. This study uses Google trendsto gather the statistical result based on the keyword. The result shows that curcumin is more popular tobe searched as information in bigdata. USA is the country with the biggest demand of information aboutcurcumin, as seen on the number of queries variation as well as the relevance score. It can be concluded thatinformation about curcumin has demanded more because of low side effect than chloroquine.
Influence of the Work Units’ Psychological Ownership and Intention in Establishing the Patient Safety Program in Hospitals in Probolinggo, East Java Mirrah Samiyah1 , Thinni Nurul Rochmah1 , Widodo J. Pudjihardjo1 , Usman Hadi2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12093

Abstract

Introduction: There is high rate of patient safety incidents in the hospitals, which reaches 1217 incidents(21,31%) from 2016 until July 2017. There are some factors which cause the high rate of the patientsafety incidents which come from the hospitals. The aim of this research is to analyze the effects of thepsychological ownership and intention towards the work units’ output performance in carrying out thepatient safety program in the hospitals.Materials and Method: This research uses the survey research method with the cross-sectional approach. Itwas carried out from October 2018 until January 2019. The research samples are the service unit, supportingunit, management and general sector in the work units 4 hospital ini Probolinggo City, Indonesia. Thesamples are obtained using the simple random sampling method. The instruments used are questionnairesand observation sheets. The analysis is carried out using linear regression tests.Result: The work unit’s psychological ownership in carrying out the patients’ safety program is regarded asgood, with the rate of 46,7%. The work unit’s intention in carrying out the patients’ safety program is alsoregarded as good, with the rate of 41,1%. The work unit’s output in carrying out the patients’ safety programin Probolinggo Regency is regarded as bad, with the rate of 64,5%. There is a significant influence of thepsychological ownership variable (p-value=0,02) and intention (p-value=0,00) towards the output’s workperformance in carrying out the patients’ safety program in the hospitals of Probolinggo Regency.Conclusion: The work unit’s psychological ownership and intention have a significant effect towards thework unit’s work performance in in carrying out the patients’ safety program in the hospitals of ProbolinggoRegency on 2019. The hospitals should carry out work unit approaches instead of individual approaches toincrease the report of the patient safety incidents.

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