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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Curcumin Improves the Regulation of Ovarian Folliculogenesis in Culture Media with Peritoneal Fluid from Infertile Women with Endometriosis Hendy Hendarto1, M Yohannes Ardianta Widyanugraha1, Widjiati2, Soehartono Darmosoekarto1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3154

Abstract

Background : Peritoneal fluid (PF) from infertile women with endometriosis contains a variety of inflammatory mediators that may interfere with folliculogenesis. The aim of the study was to evaluate effects of curcumin on the regulation of ovarian folliculogenesis by evaluating Growth Differentiation Factor (GDF)-9, Kit Ligand (KitL) and Tumor Necrosis Factor (TNF)? expressions in bovine cumulus oocyte complexes (COC)s cultured with PF from infertile women with endometriosis. Method: COCs were aspirated from antral follicles of bovine ovaries. PF was collected from infertile women with endometriosis undergoing laparoscopy for infertility evaluation. Curcumin, a strong antiinflammatory turmeric, was added in Tissue Culture Media (TCM)199 and PF from infertile women with endometriosis for culture media. Bovine COCs were cultured into 3 groups of media: 1) TCM199, 2) TCM199+PF from infertile women with endometriosis, and 3) TCM199+PF from infertile women with endometriosis+curcumin. GDF-9, KitL and TNF? expressions were examined using immunohistochemistry technique. Results: GDF-9 expression of bovine COCs cultured in PF from infertile women with endometriosis with curcumin addition (2.67±0.98) was found to increase compared to those cultured without curcumin (0.50±0.67) but reduced compared to the control. This result was similar to KitL expression of bovine COCs cultured with curcumin (2.67±1.23), in which it increased compared to those without curcumin (0.33±0.49) (p<0.05). A significant difference in TNF? expression was noted between groups with or without curcumin (p<0.05). Conclusion: In the culture of PF from infertile women with endometriosis, curcumin addition may improve the regulation of ovarian folliculogenesis through the decrease of inflammation factor.
Correlation of Fugl-Meyer Assesment Score with Barthel Index and Functional Independence Measure in Patients with Stroke Husnul Mubarak1, Noor Idha1, Bayu Santoso1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3155

Abstract

Background: The prevention of stroke morbidities that is oriented to the approach of functional performance improve is expected improve the productivity of post-stroke patients. One of the tools to measure the physical performance is Fugl-Meyer Assessment (FMA) scale, while the recommended tests to measure interpedency level are Barthel Index (BI) and Functional Independence Measure (FIM). Method: This study was conducted on 20 outpatient stroke patients in Medical Rehabilitation Installation of Dr. Soetomo General Hospital Surabaya, Indonesia. FMA, BI and FIM examination were performed in all subjects. Results: The authors obtained the correlation coefficient value with r=0.816 and therefore a high positive correlation was found between the total score of FMA and BI, while the correlation coefficient value between the total score of FMA and FIM showed r of 0.728. Thus, the author concluded that there was a positive correlation between the total score of FMA and FIM. The sub-domains FMA-UE, FMA-LE and FMA Balance were highly correlated with BI and FIM. This implied that physical performance measured using FMA could describe the interdependency level of stroke patients in doing ADL. Conclusion: Physical performance (based on Fugl-Meyer Assessment) was positively correlated with the interdependency level of BI and FIM of inpatient stroke patients in Medical Rehabilitation Dr. Soetomo General Hospital Surabaya.
Determination of Priority Elements of Vigilance in the Use of Pesticides based on Difficulty and Usefulness (A Supporting Study for Law and Policy in Health) Ilyas Ibrahim1, I Ketut Sudiana2, H J Mukono3, Suhartono4, Heru Santoso Wahito Nugroho5
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3156

Abstract

The use of pesticides is still a problem for public health, therefore we need a regulation by the authorities, which can lead to the behavior of using pesticides correctly. This is part of the area of law and health policy. Pesticide poisoning can cause breathing difficulties, headaches, neurological or psychological effects, and skin irritation and mucous membranes. The purpose of this study is to provide an overview of some elements of vigilance in the use of chemical pesticides for farmers. The variables studied were difficulty and usefulness with eight elements, namely the use of personal protective equipment (PPE), pesticide storage, pesticide use procedures, use of pesticide doses, duration and frequency of pesticide spraying, maintaining equipment cleanliness, pesticide spraying according to wind direction and time of pesticide spraying. The sample size of this study was 100 respondents from the community who knew about the use of pesticides throughout Indonesia. The research instrument used was a Google form questionnaire sent to respondents via Whatsapp social media. The data that has been collected is analyzed descriptively to get an idea of which elements are the priorities for improvement. Referring data analysis result, the elements with high difficulty and usefulness together were use of pesticide doses and procedures for using pesticides. Thus, the two elements selected as priority elements will be fixed first. It is suggested that the pesticide control policy makers can develop regulations by prioritizing the two main elements, without ignoring the other six elements. In addition, it is also recommended that other control efforts be made that can be recommended to related parties in the area of law and health policy, related to the prevention of health problems caused by the use of pesticides.
The Association Between Myoglobin, Troponin I, Hfabp and Nt-Probnp Levels with Acute Myocardial Infarction in Patients with Acute Coronary Syndrome Ime Fransiska Adidharma1, Jusak Nugraha1, Muhammad Aminuddin1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3157

Abstract

Introduction: Myocardial infarction is one of the five major manifestations of coronary heart disease. Myoglobin heart markers, Isoenzyme Creatine Kinase-MB (CK-MB), cardiac Troponin I (cTnI) or Troponin T (cTnT), Heart type fatty acid-binding protein (HFABP) and NT-proBNPare currently used in assisting the diagnosis of acute myocardial infarction. The study aimed to analyze the association of cardiac marker examination results of myoglobin, cTnI, HFABP and NT-proBNP with AMIoccurrence on examination I and examination II. Method: This study enrolled33 patients in Installation of Emergency Carewith suspected acute coronary syndrome, from March to August 2013. Serum samples were taken including cTnT, myoglobin, cTnI, HFABP and NT-proBNP. Then, it was further analyzed. Results: There was an association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events. Myoglobin and HFABP wereearly markers for the diagnosis of AMI, the mean levels of both markers was higher at the first examination (<1 hour admitted patients) when compared with 6 hours later after being tested. Essentially, the diagnostic value of both did not differ, only HFABP was more specific than myoglobin. Troponin I showed to be the best choice in the diagnosis of AMI because of the high sensitivity and specificity. Conclusion: An association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events was found. Myoglobin, cTnI, HFABP can be used in diagnosing AMI patients, whereas NT-proBNP is not recommended for the diagnosis of AMI due to its low specificity.
Evaluation of Some Inflammatory Cytokines and Glycated Hemoglobin in Uncontrolled Type 2 Diabetes Mellitus with Nephropathy Inaam Ahmed Ameen1, EmanSaadi Saleh1, Sarah Hashim Mhaibes1, KaledNather Taha2, Dhikra Abdul Hameed
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3158

Abstract

Background: Chronic hyperglycemia causes diabetic nephropathy(DN), which is a typical microvascular complication of type 2 diabetes mellitus. The pathogenesis of DN is not fully understanding. The inflammation may possess a significant role in the progression of DN in diabetic patients. Method: The study accomplished at teaching laboratories of medical city, Baghdad, Iraq.It was included 50uncontrolled diabetic type 2 patients with nephropathy, age range (40 –78) years and 42 controlled diabetics type 2 without nephropathy, age range (35 – 52) years as a control group.The participants divided in to two groups according to HbA1c measurement which is described as follows: < 7.5% of HbA1c describes controlled diabetes, and > 9% of HbA1c describes uncontrolled diabetes. The calculation of the Glomerular filtration rate (GFR) was used to determine the renal function for each participant. A venous blood sample was obtained to estimate HbA1c,fasting serum glucose (FSG), urea, creatinine, interleukin6(IL-6),interleukin-1 beta( IL-1?)and tumor necrosis factor – alpha(TNF- ?. ). Results : Significantly higher serum urea and creatinine levels in uncontrolled diabetic patients with nephropathy than controlled diabetic without nephropathy. The mean of HbA1c of DN group was higher as compare to diabetic control (DC) group, Results of IL-1?, IL-6 and TNF-? exhibits a significant raised level for diabetics with nephropathy, (p< 0.05) for IL-1?, (p< 0.05) for IL-6 and (p< 0.01) for TNF-? . Conclusion :Raised serum levels of TNF- ?, IL-1?and IL-6 in uncontrolled diabetic patients with nephropathy concurrently with raising the average HbA1c in them indicate that the inflammation may have a role in the advancement of DN in diabetic patients with poor glycemic control.
Journal of Forensic Medicine & Toxicology, April-June 2020, Vol. 14, No. 2 1633 The Impact of High Cortisol Level in Increasing Incidence of Infection Cases among Acute Stroke Patients Indah Ari Handaayani1, Joseph Eko Wahono Rahardjo1, Muhammad Hamdan1, Paulus Sugianto1, Achmad Firda
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3159

Abstract

Background: Infection in the stroke was a treatment major problem, because it determines the prognosis. In the acute phase of stroke, high level cortisol may lead to a decreased immune system and patients tend to be more susceptible to infection. The correlation of serum cortisol level among acute stroke patients with incidence of infection was not fully investigated. Objective: The aim of this study was to determine the relationship between initial serum cortisol levels and the incidence of infection in acute stroke patients. Method: A prospective cohort study was conducted on 32 of acute stroke patients who admitted in RSUD Dr. Soetomo Surabaya during the period December 2015 to February 2016. Total of 2 cc to the venous blood within 48 hours in onset of stroke being examined of serum cortisol. During the 7 days of hospitalization, the patient was observed for signs of infection, both clinically and the investigation in accordance with the operational definition. Results: In the infected group there were 8 people (50%) with high cortisol levels (p = 0.015; RR 15,000; 95% IK 1.583-143,171); 6 people were (50%) using urine catheter (p = 0.049; RR 6,667; 95% IK 1.067-30.085); And 6 people were (54.5%) using NGT (p = 0,035; RR 7,200; 95% IK 1.311 - 39,557). In multivariate analysis obtained that Odds Ratio (OR) 15,468 based on high cortisol and OR 7,469 based on NGT usage. Conclusion: High cortisol levels and the use of NGT had the effect on the incidence of infection in acute stroke
Time Recommendation and Alternative Parameters for Severe Maxillofacial Trauma Reconstruction Indri Lakhsmi Putri1, Magda Rosalina Hutagalung1, Ida Bagus Narmada2, David Sontani Perdanakusuma1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3160

Abstract

Background: Severe maxillofacial trauma often associated with other injuries, therefore the delay of reconstruction often occur until the patients are stable. Early reconstruction results a better facial function and appearances. Aim: The aim of this study to give the recommendation and alternative parameters for severe maxillofacial trauma reconstruction. Methods: The method of this study is adult patients with bimaxillary and bilateral maxillofacial trauma were eligible for this study, while pregnant women were excluded. Nine patients with maxillofacial trauma were involved in this study and we measured 15 facial anthropometric and 41 lateral cephalometricon 7, 14, 21 days compared to 3 months post-reconstruction. Results: The result of this study showed reconstruction can be planned 14 days after trauma for lower jaw fracture and 21 days after bimaxillary fracture. Lateral cephalometry was a reliable method to measure facial edema following surgery which combined facial anthropometry with lateral cephalometry using parameters that are not affected by edema. This can be applied as an additional guiding tool in surgical planning for maxillofacial trauma patients especially those with bimaxillary and bilateral fractures. Conclusion: Combination of anthropometric and cephalometric parameters which are not affected by edema can be applied as an additional guiding tool in surgical planning for maxillofacial trauma patients.
Development of Geogebra Learning Media Based on Statistical Reasoning on Statistics Materials of Junior High School Students and its Influence for the Inteligent of Student Intan Sari Rufiana1, Cholis Sa’dijah2, Subanji3, Hery Susanto4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3161

Abstract

This research aimed to develop geogebra learning media based on statistical reasoning. For the purpose of this research and development, ADDIE model by Dick & Carry was used. This research and development produced geogebra learning media based on statistical reasoning for junior high school students. Class environment that applies technology based on statistical reasoning is another variable besides genetic which is adaptive. The integration of new technologies for education is no longer an alternative; it has become an obligation and even guidance to develop these knowledge-sided. Through geogebra, students are directed to build their knowledge not just to memorize rules. The class that applies technology based on this statistical reasoning will develop students’ intelligence
The Association between Blood Glucose Control Measured with Serum Hna1c Level with Peroneal Motor Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus with Polyneuropathy Muhammad Hamdan1, Raini Wisnujono1 , Mudjiani Basuki1, Fidiana, Fadil1, Intan Sudarmadi1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3162

Abstract

Background and Objective. The poor control of blood glucose levels in patients with diabetes mellitus is a major risk factor from various complications of diabetes mellitus, such as polyneuropathy. One of the nerves that are often affected in the case of diabetic neuropathy is the peroneal nerve. This study aimed to determine the association between blood glucose level control measured with serum hemoglobin A1c (HBA1c) levels with peroneal motor nerve conduction velocity in type 2 diabetes mellitus patients with polyneuropathy. Methods. The study was conducted on diabetic neuropathy patients who fulfilled inclusion and exclusion criteria in neurology unit and diabetes unit Dr. Soetomo General Hospital Surabaya on a consecutive basis from February to July 2013. The serum HbA1c level and nerve conduction velocity in peroneal motor nerve were examined; then, the results were grouped into two groups which were serum HbA1c <7% and ?7% and NCV in normal and low peroneal motor nerve Results. There were 26 subjects, consisting of 6 subjects with serum HbA1c <7% and 20 subjects with serum HbA1c ? 7%. There was an association between blood glucose level control measured by serum HbA1c levels and NCV in peroneal motor nerve with statistical significance of p = 0.0018 (Odd ratio 15; 95% IK 1.397 - 161.045). Conclusion. There was an association between blood glucose level control measured by serum HbA1c levels with NCV in peroneal motor nerve in type 2 diabetes mellitus patients with polyneuropathy
Decrease of Sensorineural Hearing Frequency and Cochlear Hair Cell Function in Malignant Head and Neck Tumor Post Cisplatin Chemotherapy Series II Irawati1. Bakti Surarso1.Haris M. Ekorini1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3164

Abstract

Background: Malignancy in head and neck is mostly squamous cell carcinoma which are relatively radiosensitive. Giving chemotherapy combination of cisplatin-5 fluorouracil most frequently used in Lotus inpatients unit of Dr. Soetomo General Hospital Surabaya. Purpose : This study aimed to prove the decrease of sensorineural hearing frequency and cochlear hair cells function in malignant head and neck tumors patients post- cisplatin chemotherapy series II. Method: The samples were malignant head and neck tumor patients that would receive cisplatin chemotherapy. The inclusion criteria wereaged 18 to 65 years, malignant head and neck tumors planning to get cisplatin chemotherapy, intact tympanic membrane, ANM checks within normal limits. Tympanogram type A, DPOAE examination with pass results. Results: Pre-and post-cisplatinchemotherapy series I did not obtain any changes, those were pass on all frequencies. Mc Neymar test on DPOAE post-cisplatin chemotherapy I obtained p = 0.250 in 6 kHz frequency (p>0.05). DPOAE post-cisplatin II in 6 kHz frequency showed no significant difference (p>0.05) Conclusion: There was no decrease of outer cochlear hair cells function in malignant head and neck tumors patients who received cisplatin chemotherapy series II.

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