cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Aji Winanta
Contact Email
ajiwinanta@umy.ac.id
Phone
+6282221556698
Journal Mail Official
jfaps2021@gmail.com
Editorial Address
K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
Location
Kab. bantul,
Daerah istimewa yogyakarta
INDONESIA
Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 5, No 1 (2024): August" : 6 Documents clear
In Vivo Antihyperuricemia Activity of Kelubut Leaf Ethyl Acetate Extract (Passiflora foetida, L.) From Samarinda City Mochtar, Chaerul Fadly; Faradillah, Ayu; Bakhtiar, Muh Irham; Devi, Reni Selviana; Husna, Qur’anni Akhwatun; Hafidzah, Elva; Varizza, Fathiah Putri; Aisyiyah, Novia Misnawati
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19171

Abstract

The development of the times creates shifts in lifestyle and eating patterns that trigger hyperuricemia. Hyperuricemia is generally treated with synthetic drugs, but on the other hand, it causes side effects. So the use of natural ingredients such as kelubut leaves can be an alternative treatment. The purpose of this study was to determine the ethyl acetate extract of kelubut leaves has activity as an anti-hyperuricemia. The research uses experimental research methods with a design in the form of a pretest and posttest design. Mice were used and divided into 5 groups, namely the positive control group, the negative control and the group given the extract with three different doses including doses of 250 mg/Kg BW, 125 mg/Kg BW, and 62.5 mg/Kg BW. Mice will be conditioned by hyperuricemia and given different treatments in each group. Data on uric acid levels were analyzed by Kruskal-Wallis and Mann-Whitney. The results of the study showed that administration of the extract at a concentration of 250 mg/Kg BW reduced uric acid levels as much as the positive control group at 120 minutes, but was not statistically different (p0.05) from the positive control. This study concludes that the ethyl acetate extract of kelubut leaves has anti-hyperuricemic activity at a dose of 250 mg/Kg BW showing the best-reducing activity in reducing uric acid levels in mice.
Antidiabetic Activity of Diospyros mespiliformis on Alloxan-Induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19798

Abstract

The rate of morbidity and mortality attributed to diabetes has become a concern and challenge for individuals and governments. The availability, affordability, and efficacy of plant-based drugs make them an attractive choice for diabetic management in low-income countries and rural communities. Thus, their application in folkloric medicine for diabetic management. This study investigated the antidiabetic activity of the crude ethanol extract (CRE), ethyl acetate (EAF), and aqueous (AQF) fractions Diospyros mespiliformis (DM) in alloxan-induced diabetic rats to justify its acclaimed applications in folkloric medicine. The effect of the plant extract and its fractions on the aspartate aminotransferase, glutamyl aminotransferase, albumin, urea, creatinine, electrolytes, and lipid profile was determined by biochemical assay methods. The result showed a significant (p 0.05) decrease in fasting blood glucose for all the extracts, while the aspartate aminotransferase, gamma-glutamyl transferase, and albumin were significantly (p 0.05) decreased in the EAF only. The urea and creatinine levels of the CRE and AQF were decreased significantly (p 0.05), while K+, Cl-, and HCO3- levels decreased significantly (p 0.05) for the treatment groups. Furthermore, a significant (p 0.05) decrease in total cholesterol and triglyceride was observed for the EAF. Conclusively, DM exhibited significant hypoglycemic and hypolipidemic potential with improved lipid profile and hepato-renal function. Thus, the observed antidiabetic activity of the plant might justify its acclaimed utilization in the treatment/management of diabetes and its related ailment.    
Evaluation of Sarcocephalus latifoliusAfzel. ex R.Br. Rubiaceae on Reduction of Creatinine Level and Its Antioxidant In-Vitro Obika, Ogochukwu Immaculate; Oyawaluja, Aminat Asabi; Odukoya, Olukemi Abiodun; Obika-Ndiri, Ngozi Afulenu; Oiseoghaede, Joseph Oisemuzeimen
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.22237

Abstract

Medicinal herbs are divine gifts from Mother Nature and have been used for centuries as natural remedies. Sarcocephalus latifolius has been reported to contain active substances that have therapeutic effects on the kidney. The study aims to investigate the medicinal effects of Sarcocephalus latifolius extract on creatinine levels. Phytochemical and antioxidant activity were carried out using standard methods. Vacuum Liquid chromatography and Thin Layer Chromatography were employed to separate constituents of the plant extract, which were then evaluated for their creatinine reduction ability using Jaffe’s method. Based on the IC50, which is half the maximal inhibitory concentration value, Sarcocephalus latifolius demonstrates stronger antioxidant activity at 43.34µg/ml compared to the standard ascorbic acid at 40.59µg/ml. The Two-way ANOVA Statistical analysis revealed significant differences between the patients’ urine (rows) as the P-value = 6.17×10-16 is less than 0.05 significant level, and the dose treatments (columns) as the P-value = 1.71×10-12 is less than 0.05 significant level. Fractions of Sarcocephalus latifolius at various concentrations exhibit varied effects on creatinine levels, which could be attributed to the bioactive compounds in the fractions. Sarcocephalus latifolius showed potential for creatinine reduction, especially at low doses.
Potential of Binahong Leaf Ethanol Extract (Anredera cordifolia (Ten.) Steenis) against Elevated HDL Levels (Rattus corvegious) Streptozonic-Induced Wistar Strain Orbayinah, Salmah; Auliya, Rizqa
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.22496

Abstract

Diabetes mellitus is frequently associated with decreased levels of high-density lipoprotein (HDL), which are prevalent cardiovascular disease risk factors. The use of synthetic drugs substantially increases the risk of atherosclerosis since they often have severe side effects, require high costs, and have poor prescription adherence. Anredera cordifolia (Ten.) Steenis, often known as the binahong plant, is a potentially effective complementary therapy for increasing HDL levels. Flavonoid compounds present in the ethanol extract of Binahong leaf have the potential to increase HDL levels. This work aims to evaluate the action of an ethanol extract from binahong leaves in raising HDL levels in rats of the Streptozotocin-induced Wistar strain (Rattus norvegicus). In this research, the Pretest-Posttest Control Group Design was used. The study involved the grouping of five Wistar strain rats (n=5) into five distinct groups: one received binahong leaf ethanol extract at concentrations of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW, which served as the positive control group and received a negative control group supplemented with atorvastatin at 0.9 mg/kg BW. The CHOD-PAP method was applied to measure HDL levels. SPSS software was used to run the normality test, Wilcoxon test, one-way ANOVA test, and paired sample t-test. No statistically significant difference in HDL levels was found between treatment groups. The 50 mg/kg BW binahong leaf extract group had significantly higher HDL levels (p-value 0.05). As a result, the ethanol extract obtained from binahong leaves presumably raises HDL levels in streptozotocin-induced Wistar rats.
Alpha Glucosidase Inhibitory Activity of Tiger Milk Mushroom (Lignosus rhinocerus) Ethanolic Extract Ulfah, Mariam; Efirani, Like; Hadi, Ismanurrahman
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.20299

Abstract

Tiger's milk mushroom (TMM) is a plant that can only grow in certain regions in Asia. Indonesia is the country that has the most TMM plants in the world. This plant grows wild in the forests of Kalimantan and Papua. This plant is widely used by people to treat fever, breast cancer and asthma. TMM is known to have various pharmacological activities such as anticancer. The research about TMM originate from Indonesia is still rarely carried out. So, the aim of this research is to carry out an alpha glucosidase inhibition activity test of TMM ethananolic extract. The method used for extraction the TMM is maceration method using ethanol solvent. To identify the secondary metabolite compounds from TMM, phytochemical tests and thin layer chromatography (TLC) tests were carried out.  Inhibition test of alpha glucosidase enzyme activity of TMM ethanolic extract was carried using p-nitrophenyl-alpha-D-glucopyranoside reagent. The results of this phytochemical test are the ethanol extract of TMM contains flavonoid, alkaloid, terpenoid and phenolic compounds. This is confirmed by the TLC test where this test indicates the presence of flavonoid and alkaloid compounds. The results of the alpha glucosidase enzyme inhibition activity test showed that the ethanol extract of tiger milk mushrooms had an IC 50 value of  39.96 ppm which are categorized strong antidiabetic activity. From this research can be concluded that TMM ethanlolic extract very potential as an antidiabetic drug.
Analysis of Triclosan Content in Cisadane River Water Using Gc-Ms (Gas Chromatography Mass Spectrometry) Cahyowati, Merliani Nur; Rudiana, Nita; Pratiwi, Dina
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19096

Abstract

The Ministry of Environment and Forestry states that 75% of river water in Indonesia has been polluted by household and industrial waste. Triclosan (2,4,4-trichloro-2-hydroxydiphenyl-ether) is an antibacterial that is widely used in various health and household supply products, such as detergents, toothpaste, mouthwash, bath soap and so on. This study approach employs liquid-liquid extraction on sampels, which are subsequently subjected to SIM mode analysis untilizing the Gas Chromatography Mass Spectometry (GC-MS) method. River water samples were taken from 3 points, namely village areas, fishing and industry. The results of this study indicate that the levels of the three Cisadane river water samples are positive for Triclosan with levels less than 0.3%, namely at the fishing point 598x10-9%, industrial point 1076x10-9% and residential point 1584x10-9% with a retention time of 19, 37 minutes.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol. 6 No. 1 (2025): August Vol. 5 No. 2 (2025): February Vol 5, No 1 (2024): August Vol 4, No 2 (2024): February Vol 4, No 1 (2023): August Vol 3, No 2 (2023): February Vol 3, No 1 (2022): August Vol 2, No 2 (2022): February Vol 2, No 1 (2021): August Vol 1, No 2 (2021): February Vol 1, No 1 (2020): August More Issue