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Ilil Maidatuz Zulfa
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Journal Pharmasci (Journal of Pharmacy and Science)
Published by Akademi Farmasi Surabaya
ISSN : 25276328     EISSN : 25493558     DOI : https://doi.org/10.53342/pharmasci
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. Pharmacology and Toxicology 3. Community pharmacy 4. Dosage forms formulation 5. Pharmaceutics 6. Pharmacognosy 7. Natural product 8. Biology and Microbiology 9. Pharmaceutical Chemistry 10. Applied physics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 135 Documents
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Optimization of Skin Moisturizer Formula Based on Fixed Oil (VCO, Olive Oil, and Jojoba Oil): Optimasi Formula Pelembab Kulit Berbasis Minyak Nabati (VCO, Minyak Zaitun dan Minyak Jojoba) Rakhma, Dita Nurlita; Nailufa, Yuyun; Ainun Najih, Yuli; Wahjudi, Hery
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.221

Abstract

Currently, formulations of skin moisturizers are derived from natural compounds. Fixed oils are known to have compounds that potential to be developed as skin moisturizers based on emollient mechanism. Therefore, this study aims to determine the effect of oil type on the physical characteristics of skin moisturizer creams. In this study, a skin moisturizer cream was formulated using three types of fixed oils: VCO (F1), Olive Oil (F2), and Jojoba Oil (F3). All formulas were tested for physical characteristics of pH, cream type, viscosity, spreadability, and homogeneity. The test results show that all formulas appropriate to the skin pH range, have o/w type creams and homogeneous texture. In the results of the viscosity test, there was a significant difference (p<0.05) with the highest value of viscosity for F2 (16750 ± 250 cP) > F3 (14200 ± 346cP) > F1 (5833 ± 58 cP), while for spreadability test there were also significant differences (p<0.05) with the highest diameter for F1 (5.8 ± 0.1 cm) = F3 (5.7 ± 0.2 cm) > F2 (4.3 ± 0.2 cm). Based on the results, it can be concluded that the type of oil can affect the physical characteristics of the moisturizer formula. F1 and F3 have better physical characteristics than F2.
Comparison of Antihyperlipidemic Activity Temu Mangga’s Rhizomes and Ketepeng Cina’s Leaves Infusion: Perbandingan Aktivitas Antihiperlipidemia Infusa Rimpang Temu Mangga dan Daun Ketepeng Cina Nugraha, Dyan; Noor Wildiati Magfirah; Novia Henjani
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.223

Abstract

Statins are first line therapy of antihyperlipidemia. It reduced LDL levels more than 50%. However, a serious side effects such as rhabdomyolisis which can lead to kidney failure. On other side, people often consumed boiled water of Temu Mangga’s Rhizome and/or Ketepeng Cina’s Leeaves as antihyperlipidemic. Both of them has a potential as adjuvant therapy. Purpose: To compare antihyperlipidemic activity of Temu Mangga’s Rhizome and Ketepeng Cina’s Leaves as alternative treatment. Method : Test animals were induced with High Fat Diet Food (HFDF) for the first 15 days, and with Temu Mangga’s Rhizome and Ketepeng Cina’s Leaves for the next 15 days. Study group: Simvastatin (positive control), Na CMC 0.5% (negative control), 450 mg/Kg BW; 900 mg/Kg BW; 1.800 mg/Kg BW of Temu Mangga’s Rhizome and 225 mg/Kg BW; 450 mg/Kg BW; and 900 mg/Kg BW Ketepeng Cina’s Leaves. Results: Temu Mangga 360 mg/200 gram BW was not significantly different from positive control in reducing total cholesterol, triglycerides, LDL and increasing HDL. Ketepeng Cina’s Leaves 180 mg/200 gram BW had the best effect, but it was not comparable to the positive control. Conclusion: 1.800 mg/Kg BW Temu Mangga’s Rhizome showed better antiyperlipidemic activity than 900 mg/Kg BW Ketepeng Cina’s Leaves.
Study on Synthesis of Solid Acid Catalyst from Borassus flabellifer L. Waste with Sulfonation Method: Kajian Sintesis Katalis Asam Padat dari Limbah Sabut Siwalan (Borassus flabellifer L.) dengan Metode Sulfonasi Kurniati, Yuni; Prasetya, Fandi Angga; Hanafi, Fathur Iqbal; Taufik, Nugroho Muchamad; Arifiyana, Djamilah
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.224

Abstract

Fiber of Borassus flabellifer L. includes agricultural wastes which containing lignocellulose components (hemicellulose and lignin) and high carbohydrate content. Siwalan coir fiber is quite potential to be used as a substrate in producing catalysts. Acid catalyst is one type of catalyst that as an important role in chemical process. This study aims to study the effect of the optimum mass ratio of carbon-KOH in the process of graphite synthesis based on siwalan charcoal so as to produce graphite with the most optimal characteristics, and optimum calcination temperature as a physical activation process in the synthesis of graphite based on siwalan coir fiber charcoal, and determine the time sulfonation which is optimum in producing acid catalysts There are 2 variables used in this study, temperature and sulfonation time. The method of making carbon is done by calcining to decompose the carbon source so that the composition is made according to what has been varied. After forming carbon-KOH composite, then sulfonation is carried out using sulfuric acid. The last step is to carry out the esterification step The process in this study discusses carboxylic acid, WCO (Cooking Oil Waste) and methanol (alcohol group).
The Effect of Curcuma (Curcuma xanthorrhiza Roxb.) Extract Capsule Treatment on Mice Blood Glucose Level: Pengaruh Pemberian Kapsul Ekstrak Temulawak (Curcuma xanthorrhiza Roxb.) terhadap Kadar Glukosa Darah pada Mencit Diah Nurcahyani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.280

Abstract

Diabetes melitus is a metabolic disorder with escalating blood glucose level (hyperglycemic) symptom. One of endemic plant in Indonesia which have antidiabetic properties potency is curcuma. This background leads to this research that was conducted to determines the effect of various curcuma extract capsule dose treatment to lowering mice blood glucose. This research was used glucose induced mice that were grouped into three groups: Group I (Negative control) aqua destilata treated group, Group II (Dose 1) curcuma extract capsule dose 18 mg/kgBW treated group, and Group III (Dose 2) curcuma extract capsule dose 20 mg/kgBW treated group. After 7 days of treatment, blood glucose level negative control group is 185 mg/dl, curcuma extract capsule dose 1 is 123 mg/dl, and dose 2 is 101 mg/dl. Curcuma extract capsule treated groups showed significant different blood glucose level with negative control treated group. This could be concluded that curcuma extract capsule has effect as antihyperglycemic on glucose 5% induced mice.
Effect of Gamma Radiation and Curcuma xanthorrhiza Extract Capsules on Damage Mus musculus Liver Cells: Efek Radiasi Gamma dan Kapsul Ekstrak Temulawak (Curcuma xanthorrhiza) terhadap Kerusakan Sel Hepar Mencit (Mus musculus) Septiana Kurniasari; Fatimah K Hentihu
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.281

Abstract

Gamma radiation produces free radicals when interacting with cells. The free radical can be neutralized and caught by an antioxidant compound. This research aimed to analyze the effect of gamma radiation exposure and treated Curcuma xanthorrhiza extract capsules on the cells damage to the mice’s liver. This study used mice of the Balb/c strain with an average body weight of 18-20 grams, aged 6-8 weeks and male. This study required 80 animals for 3 groups, namely K- (without radiation and extract), R- (gamma radiation without extract of Curcuma xanthorrhiza) and R+ (given extract and then irradiated). Radiation exposure was given for 10 minutes, 20 minutes, 30 minutes, 40 minutes and 50 minutes, while Curcuma xanthorrhiza extract was given in 5 different doses, namely, 1.4 g/kg body weight; 2.0 g/kg body weight; 2.6 g/kg body weight; 3.2 g/kg body weight and 3.8 g/kg body weight. The damaging of liver cells is done by analyzing its microscopic picture. The result showed increased exposure time to gamma radiation causes increased cell damage. Cell damage is low in a row of increasing Curcuma xanthorrhiza extract dose. The adequate amount of Curcuma xanthorrhiza extract is 3.8 g/kg body weight.
Pattern of Drug Use in Influenza Self-Medication Efforts in Communities in Bettet Village, Pamekasan Regency: Pola Penggunaan Obat dalam Upaya Swamedikasi Influenza pada Masyarakat di Desa Bettet, Kabupaten Pamekasan Achmad Fairuz Zabadi; Septiana Kurniasari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.282

Abstract

Influenza is the most common disease in humans. The average person gets influenza twice a year. To treat influenza, people usually take self-medicationby consuming medicines that are freely purchased at pharmacies or drug stores.This research aims to determine the pattern of drug use in an effort to self-medicate influenza in the community in Bettet Village, Pamekasan Regency. This research is descriptive, using questionnaires distributed to 100 respondents who meet the inclusion criteria. The results of this research were 69% of respondents used modern medicine, most of whom consumed MFB (42.03%), while 31% of the population used traditional medicine, of which 41.93% consumed chopped turmeric, ginger and lemongrass.The public believes that modern medicines circulating in Indonesia have guaranteed availability by the government, are safe, quality and useful and are available in sufficient and affordable quantities and types.
Development and Challenges of Using Serratiopeptidase Enzymes as Anti-Inflammatory in the Present Era: Literature Review: Pengembangan dan Tantangan Penggunaan Enzim Serratiopeptidase Sebagai Antiinflamasi di Era Masa Kini: Literature Review Faisal Akhmal Muslikh; Sukardiman
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.283

Abstract

Enzymes are proteins that control and carry out metabolic activities in the body, either directly or indirectly. Enzymes have various advantages over traditional pharmaceuticals in terms of therapeutic efficacy and toxicity. They have great specificity and affinity for their target, minimizing toxicity. Use the terms "Serratiopeptidase enzyme" and "inflammation" to search publications in Google Scholar, Sciencedirect, SAGE journal, and Pubmed databases. According to ten articles, the serratiopeptidase enzyme has been shown to have an anti-inflammatory effect by reducing inflammatory cytokines and adhesion molecules, thereby regulating the movement of inflammatory cells to the site of inflammation, which in clinical trials can reduce swelling of edema and metabolism of scar tissue in the body.
Decrease in Calcium Oxalate Levels in Porang Bulbs With Variations in Contact Time, Temperature and Volume of Averrhoa bilimbi Juice Solution: Penurunan Kadar Kalsium Oksalat Pada Umbi Porang Dengan Variasi Waktu Kontak, Suhu Dan Volume Larutan Sari Buah Belimbing Wuluh Ratih Kusuma Wardani
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.285

Abstract

Porang tubers contain glucomannan which is widely used in industry. The high calcium oxalate contained in porang tubers is an obstacle in the use of porang tubers in the food industry. Organic acids such as citric acid can reduce calcium oxalate levels in porang tubers. Porang tubers cut with a thickness of 0.5 cm were immersed in a 7% solution of star fruit juice with variations in soaking time, temperature and volume of the soaking solution. Soaking porang tubers in 250 mL of star fruit juice solution at 60 °C for 15 minutes gave better results than soaking porang tubers at room temperature for 60 minutes. The lowest level of calcium oxalate was found in porang tubers that had been soaked in 7% starfruit solution for 15 minutes at 60 °C, which was 1.0873% (w/w).
Antioxidant Activity Test of Ubiquinone Microemulsion with DPPH (1,1-Diphenyl-2-picrylhydrazyl) Method : Uji Aktivitas Antioksidan Mikroemulsi Ubiquinone dengan Metode DPPH (1,1-Difenil-2-pikrilhidrazil) Silvi Ayu Wulansari; Umarudin; Floreta Fiska Yuliarni
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.286

Abstract

Ubiquinone is an antioxidant formulated in cosmetic preparations. It is necessary to test the atioxidant activity to ensure the quality of the preparation. The purpose of this study was to determine the antioxidant activity of the ubiquinone formulated in microemulsion preparations. The Ubiquinone were formulated into mikroemultion with cocentrations 0.25%, 0.5%, 0.75% and 1%, separately. The DPPH method was selected as the atioxidant activity test.. The data analysis in this study was descriptive to determine the IC50 value of ubiquinone microemulsion preparations F1, F2, F3 and F4 and ubiquinone as a comparison. The result shows that the antioxidant value of IC50 ubiquinone microemulsion of F1, F2, F3, and F4 are 56.48 ppm, 49.92 ppm, 32.76 ppm, and 20.71 ppm, respectively. The average value of ubiquinone microemulsion is 59.16 ppm. This research concludes that the microemulsion formula F1-F4 of ubiquinon has a very strong antioxidant activity compared to ubiquinone.
Organoleptic and Qualitative Test of Borax Content in Meatballs and Cilok in Lakasantri Surabaya: Uji Organoleptis dan Kualitatif Kandungan Boraks pada Bakso dan Cilok di Lakasantri Surabaya Dewi Yuliani Setianingsih; Cicik Herlina Yulianti
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.288

Abstract

Meatballs and cilok are favorite’s food in public. Based on market surveys, it turns out that there are still foods containing dangerous preservatives like borax. Borax is a toxic material and can poison cells if ingested in large quantities. The purpose of this study was to determine the organoleptic characteristics of meatballs and cilok stored for 3 days at room temperature. In addition, to determine the presence or absence of borax in meatballs and cilok, a qualitative test was carried out using a borax rapid test kit. This research method was carried out by organoleptic and qualitative testing of meatball and cilok samples obtained around SMPN 28 Lakasantri, Surabaya. Sampling was done by total sampling method. Based on the number of meatball and cilok traders around SMPN 28 Lakasantri Surabaya, there were 5 meatball traders and 5 cilok traders with a total of 10 samples. Then, organoleptic and qualitative tests were carried out using a borax rapid test kit. The results showed that the meatball and cilok samples obtained around SMPN 28 Lakasantri Surabaya after being stored for three days at room temperature, experienced a decrease in quality in the form of a softer texture, a duller color and some even started to grow mold and mildew, and a rotting smell. Meanwhile, based on a qualitative test on all samples of meatballs and cilok using a borax rapid test kit, the results were negative.

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