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Ilil Maidatuz Zulfa
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Akademi Farmasi Surabaya Jl. Ketintang Madya No. 81 Surabaya, Jawa Timur, Indonesia.
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INDONESIA
Journal Pharmasci (Journal of Pharmacy and Science)
Published by Akademi Farmasi Surabaya
ISSN : 25276328     EISSN : 25493558     DOI : https://doi.org/10.53342/pharmasci
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. Pharmacology and Toxicology 3. Community pharmacy 4. Dosage forms formulation 5. Pharmaceutics 6. Pharmacognosy 7. Natural product 8. Biology and Microbiology 9. Pharmaceutical Chemistry 10. Applied physics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 135 Documents
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Kajian Residu Tetrasiklin HCl dalam Daging dan Hati Ayam Broiler pada Beberapa Peternakan di Kabupaten Lamongan Menggunakan Metode Spektrofotometri Ultraviolet Fernanda, M.A. Hanny Ferry; Chrisnandari , Rosita Dwi
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.206

Abstract

Tetracycline HCl is one of the most commonly used antibiotics in animal feed additives to control disease caused by bacteria. The dosage of antibiotics added to animal feed is sometimes not in accordance with existing regulations, causing residues in the body to be left behind. The purpose of this study was to determine the presence and levels of tetracycline HCl antibiotic residues in the meat and liver of broiler chickens on farms in Lamongan City by using the spectrophotometric method by selecting the maximum wavelength which was carried out by making the absorbance relationship curve and the wavelength of the standard solution at a certain concentration. The results of tetracycline antibiotic residues in boiler chicken meat and liver on the first farm showed that the residual levels of tetracycline HCl were 3,969.10 ± 392.32 ppm and 14,247.74 ± 2,632.63 ppm, on the second farm showed residual levels of tetracycline HCl. 5,470.03 ± 512.76 ppm and 20,464.60 ± 5,985.63 ppm, respectively, and the third farm showed that the remaining levels of tetracycline HCl were 7,032.37 ± 971.99 ppm and 19,232.71 ± 6,404.63 ppm. The results showed that the residual content of tetracycline HCl in broiler meat and liver exceeds the maximum residual content of tetracycline class of antibiotics in meat and milk based on SNI 01-6366-2000 which limits the residue to not more than 0.1 ppm.
Formulasi dan Evaluasi Hidrogel Ekstrak Etanol Daun Gaharu (Aquilaria malacensis Lamk.) dengan Kombinasi Basis Karbopol 940 dan HPMC K4M Yenny Harliantika; Noval
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.208

Abstract

Hidrogel merupakan sediaan topikal dengan cara dioleskan pada kulit. Ekstrak daun gaharu terbukti mengandung senyawa flavonoid yang berperan dalam membantu proses penyembuhan luka. Kombinasi karbopol dan HPMC bertujuan untuk menutupi kekurangan karbopol saat digunakan pada konsentrasi tinggi dan memberikan pH asam. Mengetahui pengaruh kombinasi basis karbopol 940 dan HPMC K4M dan hasil stabilitas evaluasi terhadap formulasi hidrogel ekstrak etanol daun gaharu yang optimal. Metode yang digunakan ekperimental dengan rancangan true-eksperimental. Sampel yang digunakan daun gaharu di Kabupaten Tanah Bumbu. Determinasi, preparasi, ekstraksi, pembuatan hidrogel dan evaluasi. Data dianalisis dengan statistik ANOVA dan Kruskal-Wallis. Formulasi hidrogel dengan kombinasi basis karbopol 940 dan HPMC K4M memberikan pengaruh terhadap formulasi hidrogel ekstrak daun gaharu dengan uji stabilitas evaluasi organoleptik, homogenitas, pH, viskositas, daya sebar dan daya lekat. Hasil formulasi yang dapat mempertahankan stabilitas evaluasi selama penyimpanan 28 hari pada suhu ruangan adalah F2. Hasil uji statistik pH, viskositas, daya sebar dan daya lekat <0,05, p-value <0,05 menunjukkan adanya perbedaan yang signifikan pada tiap formula. Adanya pengaruh kombinasi basis karbopol 940 dan HPMC K4M terhadap formulasi hidrogel ekstrak daun gaharu dan formulasi yang baik terdapat pada F2.
Potensi Antimikroba Ekstrak Ethanol Ganoderma lucidum Menggunakan Metode Bioautografi terhadap Bakteri Escherichia coli dan Bacillus subtillis Sudarwati, Tri Puji Lestari; Fernanda, M.A. Hanny Ferry
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.212

Abstract

Potensi antibakteri ekstrak ethanol jamur lingzhi (Ganoderma lucidum) menggunakan metode analisis KLT bioautografi terhadap Escherichia coli dan Bacillus subtillis sebagai penelitian pendahuluan untuk mengetahui kandungan metabolit sekunder pada jamur lingzi. Soxhletasi merupakan metode untuk mengekstraksi serbuk jamur lingzhi menggunakan pelarut etanol. Bioautografi merupakan metode yang digunakan untuk mengetahui kandungan metabolit sekunder pada jamur lingzi dan potensi antibakteri. Konsentrasi yang digunakan yaitu: 2%, 4%, 6%, 8%dan 10%, dengan pengulangan sebanyak 5 kali. KLT bioautografi menggunakan n-butanol : Asam asetat glasial : Air (4:1:5) sebagai eluent. Analisis yang telah dilakukan menghasilkan 3 noda dengan Rf 0,5 dengan warna kuning, Rf 0,87 warna biru, Rf 0,93 warna coklat, dengan daerah hambatan pada noda coklat dengan Rf 0,93 merupakan senyawa triterpen. Hasil dari pengukuran nilai rata-rata zona hambat yang diperoleh terhadap bakteri E.coli adalah sebagai berikut, pada konsentrasi 2% 5,45 mm dengan kategori lemah, konsentrasi 4% 5,14 mm, konsentrasi 6% 5,48 mm, konsentrasi 8% 5,94 mm dan konsentrasi terbesar terdapat pada konsentrasi 10% 6,98 mm dengan kategori sedang. Pada bakteri Bakteri Bacillus subtillis konsentrasi 2% Sebesar 5,9 mm, Konsentrasi 4% Sebesar 6,34 mm, Konsentrasi 6% Sebesar 6,68 mm, Konsentrasi 8% Sebesar 7,88 mm, Dan Konsentrasi 10% Sebesar 8,6 mm dengan Kategori Sedang Maka dapat disimpulkan bahwa ekstrak jamur lingzhi memiliki aktivitas antibakteri terhadap bakteri Escherichia coli. Sehingga semakin besar konsentrasi yang digunakan, semakin besar pula aktivitasnya dalam menghambat pertumbuhan bakteri.
Relations of Antiretroviral Combinations to CD4 Levels of HIV TB Patiens in RSUD H.Abdul Manap Jambi: Hubungan Kombinasi Antiretroviral Terhadap Kadar CD4 Pasien HIV TB Rawat Jalan RSUD H. Abdul Manap Jambi Permatasari, Jelly; Meirista, Indri; Bafadhal, Hamira
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.198

Abstract

The cases of Human Immunodeficiency Virus (HIV) infection are increasing every year. This case is a disease that is very rapidly transmitted throughout the world. HIV increases the risk of developing tuberculosis (TB) and conversely TB infection increases HIV progression. In 2017, it is estimated that 10 million people have HIV TB. Combination of antiretrovirals is the basis for the management of antiretroviral therapy for HIV / AIDS patients, because it can reduce resistance, suppress HIV replication effectively so that transmission, opportunistic infections and other complications. The purpose of this study was to determine the relationship between antiretroviral combinations and CD4 levels in outpatient HIV TB patients at RSUD H. Abdul Manap Jambi. This study is a retrospective cohort study using medical records of outpatient HIV TB patients at RSUD H. Abdul Manap Jambi based on inclusion and exclusion criteria. Based on research conducted on outpatient HIV TB patients at Abdul Manap Hospital, Jambi, it was found that there was no relationship between antiretroviral combinations and CD4 levels in HIV TB patients, marked by Asimp.Sig 0.778> 0.05.
Effectiveness Test of Juwet Leaf Extract and Juwet Cortex Against Desreasing Blood Glucose Levels of Hiperglemic Mice: Uji Efektivitas Ekstrak Daun Juwet dan Ekstrak Kulit Batang Juwet (Syzygium cumini L.) Terhadap Penurunan Kadar Glukosa Darah Mencit (Mus musculus) yang Hiperglikemia Ajiningrum, Purity Sabila; Amilah, Susie; Kurela, Wela Anies
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.213

Abstract

Diabetes melitus drugs are currently quite expensive, so they require a cheaper and more effective substitute for drugs to control glucose levels in people with diabetes melitus. Exploring local potentials using medicinal plants can be an alternative to chemical drugs. One of the medicinal plants that is thought to be used for people with diabetes mellitus is juwet. Juwet leaves are suspected to have hypoglycemic activity, because they contain flavonoid and saponin compounds. Juwet bark also contains chemical compounds, namely flavonoids, saponins, and tannins. This study aims to determine the decrease in blood glucose levels in dextrose-induced mice by giving juwet leaf extract and juwet bark extract (Syzygium cumini L.). The test animals used were 36 male mice (Mus musculus) aged 2-3 months with a weight of 20-30 grams. This type of research was carried out experimentally and the design of this study used was Completely Randomized Design (CRD), which was divided into 12 treatments and 3 replications. The 12 treatments are juwet leaf extract and juwet bark with the same dose, namely the dose of 0 mg/kg BB, 150 mg/kg BB, 200 mg/kg BB, 250 mg/kg. Data from the research were analyzed statistically using One Way ANOVA and continued with the LSD test. The results showed that administration of juwet leaf extract and juwet bark extract at various doses had a significant effect on decreasing blood glucose levels of mice. The most effective dose to reduce blood glucose levels is juwet bark extract with a dose of 250 mg/kg BB.
Conjact Glucomannan Flour Extraction From Porang Tube (Amorphophallus muelleri Blume) with Differents Simplicia- Solvent Ratio (Subject were obtained from the Klagon Village of Saradan District): Ekstraksi Tepung Konyak Glukomanan dari Umbi Porang (Amorphophallus muelleri Blume) pada Berbagai Perbandingan Simplisia-Pelarut (sampel didapatkan dari desa Klangon Kabupaten Saradan) Kusumo, Galuh Gondo
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.215

Abstract

This study aimed to determine the best simplicia-solvent comparison to extract Konyak Glucomannan (KGM) flour from porang tubers (Amorphophallus muelleri Blume) that obtained from Klangon Village, Saradan District. Extraction was carried out by water solvent with solvent-simplicia comparison of 1: 100; 1: 200; 1: 300; 1,5: 100; 1,5: 200; and 1,5: 300. The extraction was carried out at a temperature of 45oC and 55oC for 60 minutes. The results showed that the extraction of Konjac Glucomannan (CGM) flour, was optimally extracted with a 1: 300 simplicia-solvent ratio at 55oC for 60 minutes.
Analysis Of The Effect Of Age On Medication Adherence With Oral Antidiabetes And Oral Antihypertension Drugs Using Pill Count Method: Analisis Pengaruh Usia terhadap Kepatuhan Minum Obat Oral Antidiabetes dan Oral Antihipertensi Menggunakan Metode Pill Count Mas Ulfa, Ninik; Darmawan, Rizky
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.216

Abstract

Compliance with taking medication is a problematic patients who get polypharmacy prescribing, this is because of the many drugs that must be consumed. As a result of the consumption of many drugs that cause sufferers of degenerative diseases are not compliant to take medication and health awareness decreases. This is not only experienced in elderly and geriatric patients but in adulthood also experience non-compliance with taking medication due to the many activities, lazy to take medication and also forget. This study was conducted to analyze the effect of age on adherence to taking oral antidiabetic drugs and oral antihypertensive drugs using the pill count method at the Regional Hospital of South Surabaya. The Pill Count method was chosen in this study with the aim of analyzing patient compliance in taking medication by calculating the remaining drug based on the rules of use and dosage when the patient returns to control. In addition, this study also aims to determine the effect of age on patient compliance in taking oral antidiabetic drugs and oral antihypertensive drugs. This research is descriptive observational with prospective data collection. Data analysis used descriptive and continued with statistical analysis using Chi-Square. The results of this study that adherence to take medication for elderly patients who received oral antidiabetic drug therapy obtained as much as 96.7% and 90% in adult patients. Compliance to oral antihypertension drugs in adult patients are 90% and 83.3% in elderly patients. Age does not effect compliance patients with Chi-Square analysis with p value = 0,301 and 0,448 > 0.05.
Comparison of Probiotic Isolate Growth in Natural Culture with Various Carbon Sources: Perbandingan Pertumbuhan Isolat Probiotik pada Media Alami dengan Berbagai Jenis Sumber Karbon Ilmiah, Sitti Nur; Dwyana, Zaraswati; Abdullah, Asadi
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.218

Abstract

Probiotik merupakan mikroba hidup yang memberikan pengaruh menguntungkan pada inang karena dapat menyeimbangkan mikroba yang ada dalam saluran pencernaan menjadi meningkat. Pemanfaatan tersebut dapat memberikan pengaruh positif dan kesehatan bagi inang sehingga sangat baik untuk diaplikasikan. Pemanfaatan bahan alami dapat menekan biaya media tumbuh sehingga perlu penggantian media sintetik dengan media alami karena memiliki harga yang relatif lebih murah tetapi mengandung nutrien penting bagi pertumbuhan mikroba. Tujuan penelitian ini adalah untuk mengetahui pertumbuhan isolat probiotik berdasarkan lama waktu kutur dalam media alami yang mengandung sumber karbon berbeda. Pertumbuhan isolat probiotik dalam berbagai sumber karbon dilakukan melalui metode Standard Plate Count (SPC). Melalui metode SPC didapatkan jumlah koloni isolat G dari masing-masing media berupa kanji, sagu, dan dedak yaitu 2,3 x 108 Cfu/mL, 6,4 x 106 Cfu/mL, dan 4,3 x 106 Cfu/mL selama 48 jam; 2,6 x 108 Cfu/mL, 1,6 x 108 Cfu/mL, dan 1,0 x 108 Cfu/mL selama 96 jam; 4,6 x 108 Cfu/mL, 1,8 x 108 Cfu/mL, dan 1,2 x 108 Cfu/mL selama 144 jam. Hasil yang didapatkan menunjukkan bahwa isolat G mampu ditumbuhkan dalam media alami berupa kanji, sagu dan dedak.
Physical Evaluation of Anti Acne Mask With Ethanol Extract of Purple Sweet Potato Leaf (Ipomoea batatas (L.) Antin-3 Varieties: Evaluasi Fisik Masker Anti Jerawat Dengan Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas (L.) Varietas Antin-3 Dipahayu, Damaranie; Lestari, Kinanti Ayu Puji
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.219

Abstract

Ethanol extract of purple sweet potato (Ipomoea batatas (L.)) leaves of Antin-3 variety contains flavonoids and polyphenols which can be used as a source of acne anti-bacterial because it can inhibit the growth of Staphylococcus aureus. This study aims to obtain data on physical characteristics, acceptability and stability of anti-acne mask formulation of 70% ethanol extract of Antin-3 leaves. The research method used were characteristic, acceptability and stability test. There were 4 types of samples tested, namely base, Antin-3 extract 5%: 10% and 20% (B: F1: F2: F3). The organoleptic results showed that the higher concentration of extract, the darker color of mask and the stronger of extract smell and the softer of consistency. The pH values ​​(B: F1:F2: F3) were respectively 6.46; 5.78; 5.75; 5.46. The value of adhesion (B: F1: F2: F3) were respectively 1.1; 1.46; 2.17 and 4.53 seconds. The value of spreading capacity (B: F1: F2: F3) were respectively 3.89; 4.15; 4.36 and 3.45 cm. The results of the acceptability test showed that F2 was the easiest formula to spread, clean and softest sensation on the skin. The results of the mechanical and cycling test showed that the four samples had not undergo phase separation. Anti-acne mask with 70% ethanol extract of Antin-3 leaves by 10% met the physical characteristics, acceptability and stability.
Detection of Heavy Metal Pb in Cosmetics at Traditional Market of Banjarmasin: Deteksi Logam Berat Timbal (Pb) dalam Kosmetik yang Beredar di Pasar Tradisional Banjarmasin Rahmadani; Alawiyah, Tuti; Herowati, Rina
Journal of Pharmacy and Science Vol. 6 No. 2 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i2.220

Abstract

Background: Impurities produced from the basic ingredients of making cosmetics, one of which is lead (Pb). Lead is a substance that is harmful and toxic to the human body. Lead can affect the hematopoetic system, nervous system, reproductive system, endocrine system and is carcinogenic. Objective: To determine the presence of lead (Pb) heavy metal contamination in mascara products circulating in the Banjarmasin traditional market. Methods: This study used a descriptive observational method. Testing qualitatively using KI, NaOH, and HCl reagents. Results: The test results obtained from the sample after being reacted with the three reagents showed a positive presence of lead (Pb) heavy metal. With KI solution shows a yellow-black precipitate, with NaOH solution shows a white precipitate and with HCl solution shows a white precipitate. Conclusion: Qualitative tests on mascara cosmetic products taken at different points of sale in the Banjarmasin traditional market using color reagents in KI solution, NaOH solution, and HCl solution, it can be concluded that the qualitative test results show a positive presence of heavy metal lead (Pb). on mascara products.

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