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Ilil Maidatuz Zulfa
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Akademi Farmasi Surabaya Jl. Ketintang Madya No. 81 Surabaya, Jawa Timur, Indonesia.
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INDONESIA
Journal Pharmasci (Journal of Pharmacy and Science)
Published by Akademi Farmasi Surabaya
ISSN : 25276328     EISSN : 25493558     DOI : https://doi.org/10.53342/pharmasci
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. Pharmacology and Toxicology 3. Community pharmacy 4. Dosage forms formulation 5. Pharmaceutics 6. Pharmacognosy 7. Natural product 8. Biology and Microbiology 9. Pharmaceutical Chemistry 10. Applied physics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 135 Documents
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Analysis of Proximate Level of Porang Tubers (Amorphophallus muerelli Blume) After Drying with Oven and Sun: Analisis Kadar Proksimat Umbi Porang (Amorphophallus muerelli Blume) Setelah Pengeringan dengan Oven dan Sinar Matahari Ratih Kusuma Wardani; M.A. Hanny Ferry Fernanda
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.315

Abstract

Porang tubers are one of the tubers that have special features compared to other tubers. Porang tubers contain glucomannan which has many health benefits. Glucomannan is a polysaccharide compound and contains high fiber. People have not been able to consume porang tubers directly because they contain high concentration of calcium oxalate. Soaking porang tubers in lime solution can help lower calcium oxalate levels. In addition to the content of glucomannan and calcium oxalate, proximate levels in porang tubers also need to be analyzed to determine the quality of processed porang tubers. In this study, an analysis of proximate levels in porang tubers was carried out before and after soaking in lime solution. The proximate levels of porang tubers before and after soaking with lime solution did not differ much. Porang tubers that have been dried for 6 days have a lower water content and higher carbohydrate content than tubers that have been dried for 4 days. Likewise, porang tubers that have been dried at 70 °C have a lower moisture content and higher carbohydrate content than tubers dried at 60 °C.
Profile of Prescribing Chemotherapy Regimens for High-Risk Acute Leukemia in Children : Profil Peresepan Regimen Kemoterapi Leukemia Akut Risiko Tinggi Pada Anak Ninik Mas Ulfa; Eka Sari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.317

Abstract

Cancer is one of the non-communicable diseases but is a health problem in the world, including in Indonesia. The results of the 2018 Basic Health Research showed that the prevalence of cancer rose from 1.4% in 2013 to 1.8% in 2018. Acute Lymphoblastic Leukemia (ALL) is a malignant disease characterized by progressive infiltration of immature lymphoid cells in the bone marrow and lymphatic organs. , with leukocyte cells proliferating irregularly and uncontrollably. This study aims to analyze the descriptive profile of prescribing high-risk ALL chemotherapy regimens in children at a hospital in East Surabaya. This study was conducted on inpatients, chemotherapy regimens using the 2018 ALL National Protocol. The protocol consists of 4 phases of chemotherapy, namely the induction, consolidation, intensification and maintenance phases. The results of the study from the drug administration record data, there were 143 pediatric patients with a diagnosis of ALL. high risk from the period July to August 2022. The most widely used drug classification is the glucocorticoid group with use in the induction phase 38,17%, intensification 43,2%, and maintenance 50%. Dexamethasone was the most used generic name 38,17% was used in the induction phase and 43,2% for the intensification phase. The use of ALL chemotherapy doses is Dexamethasone with doses based on the age of the child, the most being 1 mg (97,62%) and 12 mg (88,10%).
The Effect Of Microwave Pre-treatment On The Antioxidant Activity Of Candlenut Oil Using The DPPH Method: Pengaruh Pra-perlakuan Microwave terhadap Aktivitas Antioksidan Minyak Kemiri dengan Menggunakan Metode DPPH Lahifah Ramadhaningtyas; Aldi Budi Riyanta; Akhmad Aniq Barlian
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Candlenut is one of the industrial plant commodities that can be extracted so that the candlenut seeds produce oil with levels of 55-65% of the weight of the seeds. The main components of candlenut oil are saturated and unsaturated fatty acids such as oleic acid which are antioxindants. This study aims to determine the effect of the time factor of using the microwave on the yield of candlenut oil and its antioxidant activity. This research method uses a microwave power intensity of 100 watts with a variation of the microwave time for 60, 90 and 120 seconds. Determination of the antioxidant activity of candlenut oil using reagents 2,2diphenyl-1-picrihydrazil or DPPH. The results of this study indicate that there is an antioxidant activity in candlenut oil given microwave pre-treatment. The results of the antioxidant activity of the candlenut seed extract which were pre-treated with microwave 60, 90, and 120 seconds with IC50 values ​​were 979489.985 g/ml, respectively; 1241,652 g/ml; and 70.307 g/ml. While the yield is 49,75%; 55,7%; and 48,47% which indicates there is a decrease in the yield of thirtd sample. The yield is influenced by the lenght of micorwave irradiation, seed condition, power intensity and oil press. Based on these results, it can be concluded that there is an effect of microwaves on the antioxidant activity of candlenut oil.
The Borax Test Using Purple Sweet Potatoes (Ipomoea batatas Var. Ayumurasaki) Extract on Meatball Samples in Banyuwangi District 2022: Uji Boraks Menggunakan Ekstrak Ubi Jalar Ungu (Ipomoea batatas Var. Ayumurasaki) pada Sampel Bakso di Kecamatan Banyuwangi 2022 Citra Aisyah; Azmi Prasasti; Stephanie Devi Artesimia
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.320

Abstract

Borax or sodium biborate is a white crystalline compound that is stable at room temperature. Ii is usually used to make detergents and antiseptics. However, nowadays there is still a lot of borax added to food ingredients to make food chewier, such as tofu, wet noodles, meatballs, ​​chicken, fresh and salted fish. Purple potatoe (Ipomoea batatas Var. Ayumurasaki) has fairly high anthocyanin content, 5.92-402 mg/25 mg of fresh purple potato. Anthocyanins are compounds that are able to detect the presence of borax in food samples because they can break down borax bonds into borax acid by binding it to a blue color. This study aimed to determine the presence of borax in meatball samples in Banyuwangi district using purple potato extract with the maceration and pressing method, then a comparative test was carried out using the test kit method for valid results. The positive control used was borax with a level of 0.02 mg/2 ml, and the negative control used aquadest. The maceration method produced a significant color change when compared to other method, namely bluish green when interacting with borax. The meatball samples in Banyuwangi sub-district showed that all samples were free from borax, this was indicated by the absence of a color change when interacting with the purple sweet potato or the test kit.
The Comparison of Refined Sugar Concentration in Hard Candy Nutgrass Extract Formulation (Cyperus rotundus L.): Perbandingan Konsentrasi Gula Halus pada Formulasi Sediaan Permen Keras Ekstrak Rumput Teki (Cyperus rotundus L.) Roxana Faradibah; Stephanie Artemisia; Fitri Maulida N; Khoizun Husna Humda K; Rosselya Shakina; Fira Rizkia Sundari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.325

Abstract

Pain is an unpleasant sensory and emotional experience due to actual or potential tissue damage. Pain is also a warning form of the danger of tissue damage. One of the people who often experience pain is women, especially during menstruation. Based on the American Family Physician, the incidence of dysmenorrhea throughout the world is still very large, the percentage of the dysmenorrhea incidence in the world is on average more than 50% or ranging from 15.8-89.5% of women in each country. Some women who experience dysmenorrhea take analgesic drugs regularly. Nutgrass (Cyperus rotundus) contains a wide variety of secondary metabolites, one of which is flavonoids, has an analgesics effect. This research was aimed to compare the level of refined sugar in the hard candy formulation of the nutgrass. Extraction of flavonoids from Nutgrass can be done by infusion method. The infusion of Nutgrass was processed into candy preparations. This research was conducted by adding a variety of refined sugar. In the first formulation using refined sugar as much as 47 grams and in the second formulation using refined sugar as much as 62 grams. The research results found that the first formula where the sugar content was lower (47 grams) could not crystallize perfectly, while second formula where the sugar content was higher (62 grams) could crystallize well. Hence, it can be said that the higher refined sugar content can make the candy crystallize well.
Analysis of Borax and Formalin in Wet Noodles From Sidoarjo Traditional Market: Analisis Boraks dan Formalin dalam Mi Basah dari Pasar Tradisional Sidoarjo Cicik Herlina Yulianti; Surahmaida
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.329

Abstract

Wet noodles are a type of noodle with a fairly high water content (35-52%), so it is easy to spoil if stored for more than 12 hours at room temperature. Misuse of the addition of borax and formalin by irresponsible food manufacturers, aims to make wet noodles last longer. This study aims to determine whether the wet noodles sold in several traditional markets in Sidoarjo contain harmful ingredients borax and formaldehyde. The research design in this study began with organoleptic observations on several wet noodles found in several traditional markets in Sidoarjo Regency, followed by a borax test using a borax rapid test kit and a formalin test with UV Vis spectrophotometry and Nash reagent. Based on the test results, it can be concluded that organoleptic observations showed that there were 3 samples of wet noodles with a floury smell and 5 samples with a sour smell, in terms of texture all samples showed a soft and easily broken texture while in terms of color there were 5 samples that were pale yellow and 3 samples were bone white. Based on the results of the qualitative test of borax, all samples of wet noodles were negative for borax and based on the results of the quantitative test of formalin with UV Vis spectrophotometry, showed a negative result of formalin.
Comparison and Evaluation of Fermentation Results of Probiotic Products by Acenobacter xylinum: Komparasi dan Evaluasi Hasil Fermentasi Produk Probiotik dengan Kultur Acenobacter xylinum Kinanti Lestari; Floreta Fiska Yuliarni; Lailatus Sa’diyah; Silvi Ayu Wulansari; Selvyronica Eka Agustine; Fatma Ariska Trisnawati; Silfiana Nisa Permatasari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.334

Abstract

products with Acetobacter xylinum starter included Nata and Kombucha. The large number of studies on probiotic product innovation should be followed by a survey on public acceptance of the products. This research aim to compare of the yield of probiotic products after fermentation process which was evaluated from a physical perspective, pH and public acceptance. This research is an experimental study to compared the fermented results of two types of probiotic products, nata and kombucha which are differentiated based on their raw ingredients. The nata products sample which had the largest thickness and weight of cellulose biofilm was NDC, while the kombucha products sample which had the largest thickness and weight of cellulose biofilm was KGF. pH of all samples, both nata and kombucha, decreased during the fermentation process. The samples of nata products that were most accepted by the panelists were NDC and NDM in terms of color, smell and taste. The samples of kombucha products that were most accepted by the panelists were KAF and KMF in terms of color, smell and taste.
Comparison of the Effect of Morning Versus Night Amlodipine Administration on Blood Pressure Reduction in Primary Hypertensive Patients: Perbandingan Pengaruh Waktu Pemberian Amlodipin Pagi Versus Malam Terhadap Penurunan Tekanan Darah Pasien Hipertensi Primer Eziah Ika Lubada; Selly Septi Fandinata; Rizky Darmawan
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.304

Abstract

Human blood pressure goes according to a circadian rhythm, blood pressure drops during sleep and increases in the morning this happens in most individuals. One of the hypertension drug therapies is Amlodipine Calcium Channel Blocker class which has a long half-life, so it can be used once a day, and amlodipine works as a long-acting antihypertensive. On reducing blood pressure in primary hypertensive patients. The design of this study was a cohort by measuring blood pressure before and after administration of amlodipine therapy in the morning or amlodipine at night in outpatients with a diagnosis of primary hypertension who received amlodipine therapy at the “X” Clinic in Surabaya with retrospective data collection. The results of this study were obtained from 20 patients who stated that there was no significant difference in difference in systolic and diastolic blood pressure between January and December 2019 in patients receiving amlodipine therapy 5 mg in the morning, 10 mg in the morning, 5 mg in the evening and 10 mg in the evening. There is an effect of giving amlodipine therapy in the morning and evening.
The Hydroquinone Content in Whitening Cream Samples Sold Through Online Marketplace: Kandungan Hidroquinon Dalam Sampel Krim Pemutih Yang Dijual Melalui Online Shop Nuriyah Umi Lathifatun Nuriyah; Herni Setyawati; Eviomita Rizki Amanda
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.327

Abstract

Whitening cream is a product that has an active ingredient composition that can slow down the formation of melanin so that it can whiten the skin. Hydroquinone is an active compound that is usually added to whitening cream preparations to prevent pigmentation which causes skin darkening. So that the process of use must be monitored. But the rise of cosmetic products on the market, especially online marketplaces, is an opportunity for weak supervision by drunken parties. For this reason, qualitative and quantitative analysis of hydroquinone compounds in whitening cream preparations sold on online marketplaces needs to be carried out. Qualitative analysis was carried out by testing the color reaction using FeCl3, benedict, and fluoroglucine reagents. From the qualitative analysis, 2 hydroquinone positive samples were obtained from 10 tested whitening cream samples. Quantitative analysis was carried out using the UV-Vis spectrophotometry method using fluoroglucin. The results of the analysis showed that the cream sample proved to contain hydroquinone, namely sample B with 0.073 ppm and sample F 0.044 ppm.
Patterns of Antihistamin and Corticosteroids Usage In Dermatitis Patients At Primary Public Health Center in Jombang: Pola Penggunaan Antihistamin dan Kortikosteroid Pada Pasien Dermatitis di Puskesmas Kabupaten Jombang Shofiatul Fajriyah; Dea Justisia Ayu Nandya; Erni Anikasari; Fenita Shoviantari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 2 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i2.328

Abstract

Dermatitis or eczema is a form of the condition in which the layers of the skin (epidermis and dermis) have general inflammation which is usually influenced by endogenous and exogenous factors causing clinical abnormalities in the form of polymorphic efflorescence (erythema, edema, papules, vesicles, scales, lichenification) and itching complaint. This study simed to determine the treatment pattern given to patients with atopic dermatitis and contact dermatitis at the Jelakombo Health Center Jombang. This was an observational study with retrospective data collection. The data sourced used was existing medical records from January to December 2020. Data analysis was carried out descriptively with purposive sampling. The results showed that the most common dermatitis patients were atopic dermatitis (34%) which mostly treated with CTM+Dexamethasone. Patients with allergic contact dermatitis were 38 patients (38%), the most common drug regimen to manage it was Cetirizine+Hydrocortisone ointment. There were 28 patients (28%) with irritant contact dermatitis, which mostly treated with Cetirizine+Hydrocortisone Ointment followed by CTM + Dexamethasone. This study concluded that the drug regimen for the three types of dermatitis was almost the same, namely a combination of oral and topical antihistamines and corticosteroids. The antihistamines used were first-generation antihistamines (CTM) and second-generation (Cetirizine and Loratadine). Further assessment related to whether the sedation effect was wanted or it was disturbing side effect is needed. The widely used oral corticosteroid was dexamethasone, which is a high-potency corticosteroid, so its use must be judicious. Topical corticosteroids were hydrocortisone ointments that include low potency topical corticosteroids which are the first line of atopic dermatitis and allergic contact dermatitis.

Page 12 of 14 | Total Record : 135

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