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Ilil Maidatuz Zulfa
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Akademi Farmasi Surabaya Jl. Ketintang Madya No. 81 Surabaya, Jawa Timur, Indonesia.
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Kota surabaya,
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INDONESIA
Journal Pharmasci (Journal of Pharmacy and Science)
Published by Akademi Farmasi Surabaya
ISSN : 25276328     EISSN : 25493558     DOI : https://doi.org/10.53342/pharmasci
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Journal of Pharmacy and Science (Pharmasci) publishes full-length original articles and reviews. The scope of the journal is pharmaceutical and basic science, including its research and application. The editors, therefore, welcome contributions on the following topics: 1. Clinical pharmacy 2. Pharmacology and Toxicology 3. Community pharmacy 4. Dosage forms formulation 5. Pharmaceutics 6. Pharmacognosy 7. Natural product 8. Biology and Microbiology 9. Pharmaceutical Chemistry 10. Applied physics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 135 Documents
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Identification of Secondary Metabolites of Onion Peels Extract (Allium cepa L.) of Various Solvent: Identifikasi Senyawa metabolit Sekunder Ekstrak Kulit Bawang Merah (Allium cepa L.) dari Berbagai Macam Pelarut Mercyska Suryandari; Galuh Gondo Kusumo
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.289

Abstract

Onion peels (Allium cepa L.) is often disposed of without being used and ends up as waste in markets that can pollute the environment. Onion peels can potentially be developed for treatment as an anti-cancer because of its phytochemical compounds. Previous studies have shown that secondary metabolites found in onion peels using different solvents produce different secondary metabolites. So the purpose of this study was to find out the secondary metabolite compounds from onion peels extract (Allium cepa L.) qualitatively when extracted using 5 different solvents. This research was conducted using a phytochemical screening method on the onion peels extract (Allium cepa L.). n-Hexane, Ethyl Acetate, Acetone, Ethanol 96%, and Chloroform were used in the maceration extraction method separately. The results showed that the yield value was 0.96%; 2.66%; 3.90%; 4.80%; 1.62%. The results showed that acetone, ethanol, and chloroform extracts of onion peels extract (Allium cepa L.) contained alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins. Meanwhile, the ethyl acetate extract of onion peels contains alkaloids, flavonoids, steroids, terpenoids, and tannins. Lastly, the n-hexane extract of the onion peels only contains steroids and terpenoids. So it can be concluded that secondary metabolites in onion peels extract contain alkaloids, flavonoids, saponins, steroids, terpenoids, and tannins.
Prescribing Profile among Pregnancy in the Outpatient Pharmacy Installation of Bokor Hospital, Malang : Prescribing Profile of Pregnant Women at the Outpatient Pharmacy Installation of Bokor Hospital Malang Regency Endang Susilowati; Dini Mei Arisa
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.291

Abstract

Drug therapy in pregnant women is important because it can cross the placental blood barrier so that it has a negative effect on fetal development. This study aims to determine the profile of drug prescription in pregnant women including drug therapy class, drug name, drug category based on fetal safety. This study aims to determine the profile of drug prescribing in pregnant women including drug therapy class, type of drug and drug category based on safety for the fetus. The study used retrospective data in the form of 100 prescription sheets at the Outpatient Pharmacy Installation of Bokor Hospital, Malang Regency, the period July-September 2021. The results showed that there were 14 different classes of drug therapy prescribed to pregnant women. The number of vitamin and mineral prescription cases was 116 prescriptions (54%) with 100 prescriptions (46%) consisting of 13 drug therapy classes. Five percentages of prescriptions were vitamin-mineral 54%, analgesic 18.5%, tocolytic 5.1%. 4.6% and antiemetics 4.2%. Four types of drugs were prescribed from each therapeutic class, namely mefenamic acid (analgesic), Isoxsuprine HCl (tocolytic), Ondansetron (antiemetic) and amoxicillin (antibiotic). Based on drugs to the fetus, drugs prescribed to pregnant women are included in categories A, B, C and D. In conclusion, the most prescriptions for pregnant women are vitamin and mineral supplements, analgesics, and tocolytic drugs.
Phytochemical Screening of Chloroform Extract from Javanese Long Pepper which Dried Through 2 Different Methods: Skrining Fitokimia Ekstrak Kloroform dari Buah Cabe Jawa yang Dikeringkan dengan 2 Metode Berbeda Diah Wulan Safitri; Meyke Herina Syafitri
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.292

Abstract

Fruit is easily damaged and has a short shelf life due to the high water content. Drying is one of the post-harvest handling processes that can reduce the water content of the product to increase stability during product distribution and storage. Javanese long pepper (Piper retrofractum Vahl.) is included in the 10 largest raw materials absorbed by the traditional medicine industry. Purpose of this study is to carry out phytochemical screening of chloroform extract from javanese long pepper which dried through 2 different methods. Group 1 was air-dried, while group II was pre-treated with blanching, which was boiled for a few minutes before drying in direct sunlight. The dried implicia produced from both groups were macerated with chloroform for 3 days each. The maceration filtrate then tested to determine the secondary metabolite compounds contained in it through phytochemical screening. The test is carried out by observing the presence or absence of a precipitate formed or the color change that occurs after the addition of reagents. The results showed that both groups were positive for alkaloids, flavonoids and steroids, but negative for terpenoids, tannins, and saponins. There was no difference in content between the two treatment groups.
The effect of Material used in the Lime Infused water Packaging on Vitamin C Level: Pengaruh Bahan Kemasan Penyimpanan Minuman Infused Water Jeruk Nipis terhadap kadar Vitamin C Vika Ayu Devianti; Djamilah Arifiyana
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.293

Abstract

The storage process can affect the level of vitamin C in lime Infused water. The purposes of this research was to know the effect of storage container on vitamin C level in lime Infused water. The material used in the Infused water packaging are plastic and glass. Analysis of vitamin C levels in sample using Iodimetric method. The results of this research indicated that vitamin C levels in plastic and glass container was 2,499 mg/100 mL and 3,034 mg/100 mL, respectively. The siginificants results (Sig 2-tailed) of this study was 0,235 (p<0,05). From this study can be concluded that the use of plastic and glass packaging affect the vitamin C level in lime Infused water.
Antibacterial Assay Of Cyperus rotundus Rhizomes Against Gram Positive And Gram Negative Bacteria: Uji Potensial Antibakteri Umbi Rumput Teki (Cyperus rotundus) terhadap bakteri Gram positif dan bakteri Gram negatif Diana Yuni Anjarsari; Kinanti Ayu Puji Lestari
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.294

Abstract

Studies on antibacterial tests derived from natural ingredients were more intensively carried out. This was to reduce the side effects of using antibiotics related to the incidence of pathogenic bacteria. Nut grass tubers were one of the natural ingredients that are widely known for their benefits for human health. Nut grass tubers were also known to contain antibacterial compounds such as flavonoids, tannins, saponins and so on. This study aims to determine the potential of nut grass tuber extract as antibacterial of Gram positive and Gram negative. This study used a completely randomized design with the treatment of teki grass tuber extract with concentrations of 25%, 50% and 100%. Based on the research, it was known that the nut grass tubers were able to inhibit the growth of Gram positive and Gram negative bacteria in the category of weak to moderate ability. This study used the treatment of teki grass tuber extract with concentrations of 25%, 50% and 100%. Based on the research, it was found that the tuber of teki grass was able to inhibit the growth of Gram positive bacteria with the highest inhibition at 100% concentration of 5.53 mm and Gram negative with the highest inhibition at 100% concentration of 6.57 mm.
Profile Of Antihypertensive Drug Use At Clinic M Surabaya : Profil Penggunaan Obat Antihipertensi di Klinik M Surabaya Diana Rahmawati; Ninik Mas Ulfa
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 7 No. 2 (2022): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v7i2.296

Abstract

Hypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg on two measurements with an interval of five minutes in a state of sufficient rest/quiet. The purpose of this study was to determine the profile of the use of antihypertensive drugs at Clinic M Surabaya for the period July-December 2021. This study was conducted by collecting data retrospectively from July-December 2021 by screening and classifying antihypertensive drug prescriptions based on age and gender, drug class , generic name of the drug, dosage of the drug, rules for taking the drug. The number of samples that met the inclusion criteria were 552 recipes. From the study results, it was known that the patients with the most age were in the 56-65 year age group by 29.9%. Female patients were 51.1% more than male patients, namely 48.9%. The group of drugs that are often prescribed is the Calcium Channel Blocker group of 73.2%. The generic name of the drug that is often prescribed is Amlodipine as much as 72.9%, with a dose of 5 mg (59.1%) and the rule of use is 1 time a day after meals (27.2%).
Antifungal Activity of Auricularia nigricans Methanol Extract against Candida parapsilosis using The Well Method : Aktivitas Antifungi Ekstrak Metanol Auricularia nigricans Terhadap Candida parapsilosis dengan Metode Sumuran Septiani Resika Dewi; Floreta Fiska Yuliarni
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.300

Abstract

This study aims to determine the ability of the methanol extract of the fungus Auricularia nigricans to inhibit the growth of Candida parapsilosis. The extraction method used was maceration with the antifungal test method, namely the well method, the concentrations used were 0.2g/mL, 0.3g/mL, 0.4g/mL and 10% DMSO as a negative control. The results of the study showed that all concentrations used did not form inhibition zones. This result is included in the inactive category. So that Auricularia nigricans does not have antifungal activity against Candida parapsilosis.
Effect of Plant Growth Regulators on Callus Induction in Piper betle L. var. Nigra: Pengaruh Berbagai Jenis ZPT terhadap Induksi Kalus Piper betle L. var. Nigra Junairiah Junairiah; Ni'matuzahroh Ni'matuzahroh; Nabilah Istighfari Zuraidassanaaz; Lilis Sulistyorini
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.302

Abstract

Callus culture is one of the plant tissue culture techniques that used to study aspects of plant nutrition, somatic embryogenesis, cell suspension culture, secondary metabolite production, and genetic transformation. Callus induction was carried by adding growth regulators. Black betel (Piper betle L. var. nigra) is a medicinal plant that has the potential to produce secondary metabolites. The aim of this study was to obtain the best formula for callus induction of P. betle L. var. nigra. The single growth regulator used is 2,4-Dichlorophenoxyacetic acid (2,4-D), Benzyl Amino Purine (BAP), Indole Butyric Acid (IBA), Indole Acetic Acid (IAA), and Naphthalene Acetic Acid (NAA) with variations the concentration used is 0; 0.5; 1; 1.5; 2; 2.5 mg/L. Each treatment consisted of 6 replicates grown using Murashige and Skoog (MS) medium in vitro for eight weeks. The results showed that the 1.5 mg/L 2,4-D treatment produced the highest fresh weight (1389.5 mg) and dry weight (55.7 mg). Callus P. betle L. var. Nigra in various treatments showed various textures such as compact and friable with callus colors such as white, greenish-white, brownish-white, yellowish-green, greenish-yellow, brownish-yellow, greenish-brown, brown, and gray.
Forced Degradation Study Of Paracetamol Levels Using Uv-Vis Spechtrophotometry: Studi Degradasi Paksa Terhadap Kadar Paracetamol Menggunakan Spektrofotometri UV-Vis M.A. Hanny Ferry Fernanda; Maulidia Ningsih
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.312

Abstract

Paracetamol or acetaminophen is a class of over-the-counter drugs widely used by the general public to treat fever and mild pain. The study aimed to determine the effect of forced degradation by hydrolysis on paracetamol levels using Uv-Vis Spectrophotometry. This type of research is experimental with the method used is Uv-Vis Spectrophotometry which is carried out at a wavelength of 200-400 nm. The results obtained from the study in the form of a linear regression equation y=0,0652x + 0,0269 with a value of R2 = 0,9938. Furthermore, paracetamol without degradation was 90,40%, while paracetamol with degradation was 87,98%. It was concluded that there was a decrease in the levels of paracetamol treated with degradation, so it was stated that there was an indication of the effect of forced degradation by hydrolysis of paracetamol. The advice given by the researcher is to develop further research related to validation methods and degradation studies in determining the levels of paracetamol tablets.
Corticosteroid Use for Upper Respiratory Tract for Adult Patients at TM Clinic in Surabaya: Penggunaan Kortikosteroid untuk Infeksi Saluran Pernafasan Atas Pada Pasien Dewasa di Klinik TM di Surabaya Endang Martiniani; Teddy Punky
Journal Pharmasci (Journal of Pharmacy and Science) Vol. 8 No. 1 (2023): Journal Pharmasci (Journal of Pharmacy and Science)
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v8i1.314

Abstract

Corticosteroid doesnt give additional benefit for upper respiratory tract infection (URTI), instead it increases risk of adverse effects especially if there is a concomitant comorbid or chronic disease although for short term use. This study is aimed to investigate if corticostroid drugs are still prescribed for URTI at TM Clinic in Surabaya. This is a retrospective study with the medications prescribed are taken from the medication records or presriptions during the period of Januari until March 2020. Diagnose is based on ICD 10 at the visit book wich then refers to the medication record and the prescription given. There are totally 92 cases of URTI and 22 (24%) of them are still given corticosteroid drugs which are dexamethasone 0,5 mg and methylprednisolone 4 mg with the frequency of use are 14 (15%) and 8 (9%) resepectively. In conclusion, dexamethasone and methylprednisolone orally are still prescribed.

Page 11 of 14 | Total Record : 135

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