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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 133 Documents
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Antimicrobial and Antioxidant Activities of Various Freeze-Dried Yogurt Fermented with The Addition of Pineapple: An In Vitro Study Auli, Winni Nur; Fajriani, Rahmatul; Anisah, Nadya; Lianti, Lita; Rahmadi, Isnaini; Nasution, Syahrizal
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.274

Abstract

As a fermented milk, yogurt is functional food which contains a lot of bioactive compounds beneficial for human health. Yogurt can also be made with the addition of fruit such as pineapple, where pineapple contains phytochemical compounds as antimicrobial and antioxidant. This research aims to determine the antimicrobial and antioxidant activity of freeze-dried yogurt with raw material skim milk, full cream, and soy powder with addition of pineapple juice. Antimicrobial activity was conducted using disc diffusion and macro-dilution methods. While antioxidants activity conducted using the DPPH method at a maximum wavelength of 516 nm and FTIR method. The results showed that the antimicrobial activity of freeze-dried yogurt macro-dilution method against Escherichia coli showed that most yogurt at a concentration of 1 g/mL could be determined as minimum bactericidal concentration (MBC). Antioxidant activity showed pineapple soy yogurt has the lowest IC50 namely 43.67 ± 0.21 μg/mL. Functional group analysis of samples with the highest antioxidant activity in pineapple soy yogurt showed C–H, C–C, C=O, N–H, C=C, and amide II groups. The antimicrobial and antioxidant activities of freeze-dried yogurt are influenced by the raw materials used and the addition of pineapple fruit.
Traumatic Physiological Vital Sign Fusion: Insight from Composite Spatial Similarity Measure Modelling Mensah, David Kwamena; Ofori, Micheal Arthur; Orwa, George Otieno; Hewson, Paul
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.275

Abstract

This paper develops a non-linear composite similarity-based framework for generating univariate physiological vital signs data from an input multivariate counterpart. The framework is built on mixture random variate using information provided by the inter-relationships among variables. This allows the latent one-dimensional data to be generated as a weighted linear combination of the multivariate data, providing an easy way to model the weights in terms of desirable data features of interest. Using variable specific non-linear composite similarity statistic to handle short, medium- and long-term auto-relationships, the framework provides a unified context for easy quantification and assessment of both vital sign and observation level relative relevance. With the above formulation, better calibration and indication of key vital signs in traumatic events is presented. An illustrative example using real physiological vital sign datasets on trauma and non-traumatic patients provides evidence on its utility in handling both key informative incident and non-incident vital sign-specific features, events and patterns for development of pragmatic health monitoring indicators.
Assessment of the Dynamics and Condition of Post-Fire Forest Recovery in the Amankaragay Massif, Kostanay Region, Republic of Kazakhstan Ozgeldinova, Zhanar; Zhanguzhina, Altyn; Mukayev, Zhandos; Berdenov, Zharas; Ulykpanova, Meruert
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.276

Abstract

The study evaluates the dynamics and condition of post-fire forest recovery in the Amankaragay massif of the Kostanay region, Republic of Kazakhstan, which has been subjected to both natural and anthropogenic pyrogenic influences, resulting in structural transformations within the forest ecosystems and pyrogenic succession processes. The objective of this research is to assess natural forest regeneration after wildfires through an integrated approach, combining field studies and remote sensing data, and to analyze structural changes in forest landscapes due to fire disturbances. Three sample plots were selected for analysis: all affected by wildfires between 2004 and 2024, with assessments carried out using high- and medium-resolution satellite imagery. The methodology included the use of differenced normalized burn ratio (dNBR) analysis to assess fire severity, normalized difference vegetation index (NDVI) analysis to evaluate the intensity and dynamics of post-fire vegetation recovery, and geospatial analysis using ArcGIS 10.8. Additionally, supervised classification of satellite imagery and field surveys were conducted to validate remote sensing data. The results indicate significant structural changes in forest-forming species following fire disturbances, confirmed by both remote sensing and field data. As a result, the natural regeneration of forest ecosystems was evaluated, and significant findings were obtained. Fire intensity and type influence the rate of forest recovery. The dNBR and NDVI analyses confirm the effectiveness of remote sensing for monitoring post-fire forest recovery. Remote sensing data and field assessments enable not only the evaluation of the current forest condition but also predictions for its future development. This study underscores the effectiveness of remote sensing techniques in evaluating pyrogenic succession and contributes to a deeper understanding of natural forest regeneration processes in the region. The findings can inform the development of evidence-based strategies for forest ecosystem management and post-fire restoration efforts.
Synthesis, Characterization and Biological Activity of Some New Pyrimidine Derivatives Abdul-Bary, Mariam; Haddad, Batool; Al Ameri, Jenan
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 3 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.277

Abstract

In this study, four derivatives of pyrimidine-2(1H)-thione were synthesized via the reaction between the compounds of α,β-unsaturated ketone and thiourea. The first step included a reaction between 1 mol of four different derivatives of primary amines and 1 mol of benzil. In the second step, the resulting compound was interacted with acetone to prepare α,β-unsaturated ketone. In the third step, the resulting compound was then interacted with thiourea to form the following compounds: 5,6-dihydropyrimidin-2(1H)-thione. The IR, (1H and 13C) NMR and MS spectroscopies were used to confirm the structures of the prepared compounds and examine their antibacterial activities against (Staphylococcus aureus and Escherichia coli) by well diffusion method. It was found that the synthesized compounds have high activity against these two types of bacteria, especially compound P2 had the most inhibitory activity.
The Nature of Processes Affecting the Solubility, Viscosity, and Density Characteristics of Aqueous Electrolyte Systems Kambarova, Galiya; Nazarbek, Ulzhalgas; Nazarbekova, Saule; Abdurazova, Perizat; Raiymbekov, Yerkebulan
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.281

Abstract

This study investigates the key factors influencing the solubility, viscosity, and density of aqueous electrolyte systems. Model solutions of types 1-1, 1-2, 2-1, and 2-2 electrolytes were examined across a wide concentration range. The results show that solubility increases with temperature due to a higher proportion of free water molecules, while greater electrolyte concentrations lead to a rise in viscosity and density. It was found that ion radius and charge density strongly impact solution properties: larger ion radii and lower charge densities decrease viscosity and increase density, whereas smaller radii and higher charge densities have the opposite effect. The findings offer new insights into the relationship between ionic parameters and macroscopic solution behavior, supported by mathematical modeling and graphical analysis.
Biosynthesis of Silver Nanoparticles from Callistephus chinensis Flower Waste: Evaluation of Antibacterial, Anticancer, and Contaminated Water Remediation Applications Kakodkar, Shruti; Dhawal, Pranjali; Kadam, Janvi; Khan, Rumanna; Shewale, Pradnya; Chaukekar, Tejaswi
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.282

Abstract

The present study explored antibacterial and anticancer properties of silver nanoparticles (AgNPs) uniquely synthesized using aster (Callistephus chinensis) flower waste (AFW) via a microwave-assisted approach. The nanoparticles were also tested for their effectiveness in treating coliform-contaminated borewell water. The AFW extract was characterized using LC-HRMS and quantitatively analysis using TPC and TFC assays. Nanoparticle characterization was performed using UV-spectroscopy, FT-IR, SEM, EDX, TEM, SAED and XRD instruments. The AFW extract showed 1.6687 mg of gallic acid equivalent (GAE) and 9.71 mg quercetin equivalent TPC and TFC, respectively. The LC-HRMS profile also revealed the presence of various polyphenols followed by organic acids and alkaloids. The minimum inhibitory concentration required to inhibit 90% of bacterial growth (MIC90) was determined against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The cytotoxic activity of AgNPs was analyzed against cervical cancer cell line HeLa and normal human dermal fibroblast (HDF) cells. AgNPs exhibited a strong antibacterial activity, with MIC90 of 0.0625 mg/mL against E. coli and P. aeruginosa, and 0.125 mg/mL against S. aureus. Nanoparticle treatment did not alter the physicochemical parameters of borewell water beyond their permissible limits. According to MPN analysis, untreated borewell water contained 1600 coliforms/100 mL, which were eliminated following nanoparticle treatment (0 coliforms/100mL). AgNPs displayed anticancer activity against HeLa cell lines with an inhibitory concentration (IC50) of 0.21 mg/mL. The IC50 of AgNPs against normal HDF cells was 0.414 mg/mL — higher than that observed against HeLa cell lines and the bacterial MIC90, thus indicating selective cytotoxicity. To conclude, the study demonstrated the promising use of AFW in the green synthesis of AgNPs, which exhibited potent antibacterial and anticancer properties, along with low toxicity to HDF cell lines. These AgNPs also demonstrated promising applications in treating coliform-contaminated borewell water.
Design of Hydroxyxanthone Derivatives as Breast Cancer Inhibitors: A QSAR Modeling, Molecular Docking, Molecular Dynamics, MM-PBSA and ADMET Prediction Fatmasari, Nela; Hermawan, Faris; Jumina, Jumina; Kurniawan, Yehezkiel Steven; Pranowo, Harno Dwi; Puspitasari, Anita Dwi; Hastuti, Lathifah Puji; Marlina, Lala Adetia; Putra, Nicky Rahmana
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.283

Abstract

A comprehensive QSAR analysis, in conjunction with molecular docking, molecular dynamics simulations, MM-PBSA binding energy estimations, and ADMET profiling, was conducted to facilitate the development of novel anticancer agents based on hydroxyxanthone derivatives. Molecular and electronic descriptors were calculated using the DFT method with the 3-21G basis set. The best QSAR model identified several descriptors that significantly influence anticancer activity, including the atomic charges at positions C1, C3, C4a, and C7, as well as the highest occupied molecular orbital (HOMO), surface area (SA), molecular volume (VOL), and molecular weight (MW). This model was used to design novel hydroxyxanthone derivatives (X27 to X47). The docking result showed that compounds 7-bromo-3-hydroxy-1-(methylamino)-9H-xanthen-9-one (X43), 6-hydroxy-8-(methylamino)-9-oxo-9H-xanthene-2-carbonitrile (X44), and 3-hydroxy-7-mercapto-1-(methylamino)-9H-xanthen-9-one (X45) had stronger binding energy values than gefitinib as a native ligand. Gefitinib had a binding energy of -6.84 kcal/mol, while those compounds had values of -6.92, -7.12, and -6.92 kcal/mol, respectively. In a molecular dynamics simulation of 100 ns, compounds X43, X44, and X45 exhibited stability comparable to that of gefitinib against the EGFR protein. Additionally, the binding energy MM-PBSA of compound X43 was the lowest (-29.18 kcal/mol), followed by X44 (-27.11 kcal/mol), gefitinib (-26.06 kcal/mol), and X45 (-25.21 kcal/mol). Furthermore, these compounds met Lipinski's rule parameters and the minimal standard parameters in terms of ADMET characteristics, as predicted by physicochemical properties. In conclusion, compounds X43, X44, and X45 are potential anticancer agents for MDA-MB-231 breast cancer cells.
Phytochemical Profiling, Antibacterial Properties and Toxicity of Amla Fruit Tea (Phyllanthus emblica L.): An In Vitro and In Silico Study Cahyaningrum, Putu Lakustini; Sudaryati, Ni Luh Gede; Bogoriani, Ni Wayan; Asih, Ida Ayu Raka Astiti; Adnyana, I Made Dwi Mertha; Jenar, Putut Dewantha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.284

Abstract

Antimicrobial resistance represents a critical global health challenge, necessitating the exploration of alternative therapeutic agents. This study investigated the antimicrobial potential of amla fruit tea (Phyllanthus emblica L.) through comprehensive phytochemical characterization, antibacterial assessment, and computational modeling to identify potential mechanisms of action. LC-HRMS analysis was employed for phytochemical profiling, antibacterial activity was evaluated via disk diffusion method against Staphylococcus aureus and Escherichia coli, and molecular docking studies were conducted against tyrosyl-tRNA synthetase and FimH adhesin proteins. Analysis identified 89 bioactive compounds, with oxidized hydroxytetrahydrofuranyl acetate, L-α-palmitin, and ellagic acid predominating. Antibacterial activity against S. aureus and E. coli was evaluated via the disk diffusion method, revealing that moderate inhibition increased at higher concentrations (25%) and with extended exposure, with E. coli exhibiting greater susceptibility than S. aureus. Molecular docking studies against tyrosyl-tRNA synthetase (S. aureus) and FimH adhesin protein (E. coli) identified the W-18 benzenesulfonamide derivative as the most promising compound, which demonstrated strong binding affinities of -11.01 and -7.48 kcal/mol, respectively. While all five principal compounds met Lipinski's drug-likeness criteria, toxicological assessment revealed varying safety profiles, with two compounds classified as "possibly hazardous" and two as "toxic when swallowed." These findings suggest that amla fruit tea has antibacterial properties through two mechanisms: disruption of protein synthesis and bacterial adhesion. However, its efficacy remains considerably lower than that of conventional antibiotics, suggesting potential applications as complementary therapy rather than antibiotic replacement.
Addressing Awareness and Affordability of Generic Medicines in India: A Data Driven Strategic Framework Banerjee, Saurabh Kumar; Lahiri, Moon Moon; Agarwal, Devika; Agrawal, Happy
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.285

Abstract

Access to quality and affordable generic medicines is vital to address the challenging situation which the country is currently facing in the present context. Less than 50% of medications are prescribed in India under their generic (INPN) names, despite the country being one of the leading suppliers of generic medications globally. Up to 90% of the money that impoverished people spend on healthcare can be attributed to medications. Thus, affordability of medications is essential for achieving desired treatment outcome since high drug costs lead to a reduction in access to healthcare. There is a lack of scientific data concerning the understanding of generic medicines among various stakeholders, including physicians, pharmacists, the general public, and health policy advocates, hence a need was felt to do an in-depth introspection of the scientific data centered around awareness and affordability of generic medicines in India and propose a conceptual framework for developing a strategic roadmap for popularizing generic medicines in India. Extensive literature search of research papers with high citations published between 2011–2024 were retrieved and investigated using PRISMA 2020 Flow diagram. In context to physicians the study suggested that physicians should choose less expensive brands of antibiotics and there is a need to design interventions at the fresh graduate level at medical colleges centered around the efficacy of generic drugs over the branded drugs. In context to Govt health policymakers the study suggested that policies towards opening Fair Price Medicine Shop (FPMS) taking the Government of West Bengal model could be taken into consideration and Pradhan Mantri Bhartiya Jan Aushadhi Pariyojana (PMBJP) drug policies on medicine distribution and procurement must be revisited with reference to the NELM. In context to pharmacists, community chemists regulatory agencies and educational institutions should work together to raise the level of generic drugs expertise among community chemists and drug store employees. Finally in context to patients, patient centric educational and awareness programs should be developed at the primary care level related to awareness and misconceptions of generic drugs in the public.
Optimization of In Vitro Microcloning of Lagochilus inebrians Bunge Sultonova, Kumush; Alikulov, Begali; Xasanov, Normat; Abdullayeva, Yulduz; Sharopova, Shahnoza; Jabborov, Baxtiyor; Hotamova, Hulkar; Dilshoda, Mamadiyarova; Khusniddin, Boymurodov
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.286

Abstract

In the following years, introduction (in situ) of rare and promising medicinal plants, determination of morphological and ecological adaptability to selected soil and climate conditions, and obtaining pathogen-free seedlings through microclonal (in vitro) reproduction in areas affected by environmental stress factors creation of plantations are gaining importance. This research aimed at choosing the optimal conditions for obtaining pathogen-free seedlings of Lagochilus inebrians in vitro and acclimatization in arid conditions. The optimal amounts of added phytohormones were chosen to increase the efficiency of the nutrient media used in the microconal propagation of L. inebrians, based on the possibility of acclimatization in arid conditions. The obtained results serve to multiply L. inebrians in vitro and create plantations in arid regions based on the obtained seedlings.

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