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INDONESIA
Indonesian Journal of Chemistry and Environment
Published by Universitas Negeri Yogyakarta
ISSN : -     EISSN : 25993186     DOI : 10.21831
Core Subject : Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Materials Science & Nanotechnology
Articles are welcome that deal with theoretical analysis, meta-anaysis reviews, and result of research or empirical studies from all aspect of Chemistry and Environment. Reports on new methodologies and comprehensive assessments of existing ones, as well as applications to new types of problems are especially welcome. Experimental papers are expected to be brought into relation with theory, and theoretical papers should be connected to present or future experiments. Manuscripts that apply routine use or minor extensions or modifications of established and/or published experimental and theoretical methodologies are appropriate if they report novel results for an important problem of high interest and/or if they provide significant new insights.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol 6, No 2 (2023): DECEMBER 2023" : 6 Documents clear
VEGETATION STRUCTURE, BIOMASS, AND CARBON STOCK OF MANGROVE FOREST IN EASTERN POHUWATO DISTRICT, MARISA SUB-DISTRICT Liberty Lodjo; Dewi Wahyuni K. Baderan; Marini Susanti Hamidun; Sukirman Rahim; Iswan Dunggio
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.68288

Abstract

Background: Mangrove forests are forests that have the potential to mitigate climate change from the effects of global warming, because mangroves can absorb CO2 in the atmosphere. Mangrove areas in the coastal area of East Pohuwato Regency, Marisa District are quite numerous and have the potential to absorb carbon, so that with a large enough carbon absorption can be able to reduce the levels of CO2 contained in the air. Objective: This study aims to identify vegetation structure, biomass, and carbon stocks in the coastal area of East Pohuwato Regency, Marisa District. Results: the study showed that there were 8 types of mangroves, including Soneratia alba, Rhizophora mucronata, Ceriops decandra, Ceriops tagal, Avicennia marina, Rhizophora stylosa, Sonneratia caseolaris, Rhizophora apiculata. The highest IVi value was found in the Ceriops decandra species with an IVi value of 119.21 in the tree category, then for the sapling category which had the highest IVi value found in the Rhizophora apiculata species of 98.6, for the seedling level the IVi value was found in the Rhizophora apiculata species of 80.23%. The total biomass value is 37,027.2 Kg/ha and the carbon contained in the mangrove forest of East Pohuwato Regency, Marisa District is 18,535.7 Kg C/ha with carbon dioxide absorption of 68027.5 Kg CO2/ha. Conclusion: There are 8 types of mangrove species found in the mangrove forests of the Coastal Area of East Pohuwato Regency, Marisa District at.
Analysis of the Quality and Quantity of Ngade Lake as a Source of Clean Water in Ternate City Nani Nagu; Badrun Ahmad; Sary Shandy
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.66494

Abstract

The Ngade Lake is one of the lakes on the island of Ternate. People use the lake as a tourist destination and fishing activity. This affects the lagoon's water quality, so measuring the water pollution parameters is necessary. This is because the lake can be used as a source of clean water. After all, the city of Ternate is currently experiencing limited water resources. The research was conducted to determine the availability of Ngade Lake as a source of clean water in terms of quality and quantity. The research method used in this study is experimental descriptive by conducting experiments and tests on the quality of Ngade Lake water and determining the amount of lake water through calculation from the measurement data. The water quality tests are carried out directly in Ngade Lake and the Laboratory physically and chemically. Physically includes taste, odor, temperatures, and temperatures. Chemical tests are conducted through COD, DO, pH, TDS, Density (CaCO3), metals (copper, iron, manganese), and other minerals. The results show that the quality testing of lake water meets the quality standards according to Permenkes No. 32 of the Year 2017, where the water in the middle of the lake has better water quality than the water on the lake's edge. The amount of water in Ngade Lake is measured at 3.394.744.000 litres. PDAM currently uses a pump with a discharge of 5 litres/second while the discharges of the water that is the reserve of water resources for Ngade Lake of 45 litres/second, so the water of the Lake of Ngade deserves to be used as a clean water source in terms of quality and quantity.   Keywords: Quantity, Quality, Water, Lake, Analysis  
Virtual Screening, Pharmacokinetic Prediction, Molecular Docking and Dynamics Approaches in the Search for Selective and Potent Natural Molecular Inhibitors of MAO-B for the Treatment of Neurodegenerative Diseases Suwardi Suwardi; Agus Salim; Joanda Ario Yudha Mahendra; Daniel Bima Aji Wijayanto; Nurul Azqiya Rochiman; Sigit Khoirul Anam; Nur Hikmah
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.68338

Abstract

This research aims to find natural product compounds that have the potential to act as MAO-B inhibitors that are useful in the treatment of neurodegenerative diseases, through the stages: a) Virtual Screening, b) Molecule Docking, c) Pharmacokinetic and toxicity prediction, and d) Simulation approach Molecular dynamics.The research steps include the following steps: a) searching for molecules in the ZINC15 data base that are similar to the natural ligand molecule (safinamide) obtained from the protein data bank (PDB code: 2v5z) and the control ligand L-DOPA. A total of 481 molecules were downloaded from the data base and then molecular docking was carried out using the autodock program on the MAO-B target in the 2v5z receptor. After carrying out the docking analysis, 48 ligand molecules were selected which had a binding affinity (DG/kcal/mol) that was smaller than the DG of the natural ligand and the control ligand and nine (9) ligand molecules were taken to be tested: (i) ligand-ligand interactions MAO-B with discovery studio, (ii) Absorption, Distribution, Metabolism and Excretion properties with SwissADME and (iii) toxicity using PROTOX-II. Molecular dynamics simulations were carried out to determine the stability of ligands in proteins. Ligand complex [CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1]-2v5z was chosen to simulate for 100 ps. The results of the molecular docking study showed that there were 9 molecules that had binding affinity values that were smaller than the binding affinity of the natural ligand and the control ligand. Ligand and residue interactions are dominated by hydrogen bonds, donor-donor and pi-pi stacked interactions. Based on SwissADME, the Blood Brain Barrier (BBB) permeant on ligand number 1, 2, 3, 5, 6, and 9 shows that it is orally active and cannot pass through the BBB and will not cause any side effects, whereas ligand number 4, 7, 8, 10, and 11 can cross the BBB and may cause side effects. Based on the results of toxicity prediction (PROTOX-II), it is known that there are four (4) ligands in class V, five (5) ligands in class IV and the rest in class II. Hepatotoxicity, carcinogenicity, and Phosphoprotein (Tumor Suppressor) p53 in eleven ligands are predicted to be inactive and have a small probability. The stimulated [CC(C)c1ccc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)cc1]-2v5z complex apparently still shows ligand-protein fluctuations so that its conformation is still unstable.
Synthesis of Natural Zeolite/ZnO and its photodegradation activity on congo red M. Pranjoto Utomo; A. K. Prodjosantoso; Kun Sri Budiasih; Isti Yunita; Tisia Miftakhul Triani; Vera Dwi Nur Rahmawati
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.68334

Abstract

Dyes are the most common compound used in the textile industry. Dyes consisted of azo compound that is difficult to be degraded. Undegradated azo compound, such as congo red, danger for the environment. An alternative effort to handle congo red waste must be conducted. Natural zeolite/ZnO is a material that can be used to degrade congo red to be simpler compound. Based on the analysis, the characters of natural zeolite/ZnO are hexagonal wurtzite structure, particle size 24.264 nm, band gap energy 2.96 eV. The highest degradation percentage in photodegradation activity of natural zeolite/ZnO on congo red is 99.41%.
Chemistry and Biology of Cyanides: A Literature Review I Wayan Muderawan; I Wayan Karyasa; I Nyoman Tika; Gede Agus Beni Widana
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.67030

Abstract

The term cyanide is used to describe compounds that contain the cyano, -C≡N, group. The cyanides exist in nature as inorganic as well as organic compounds in the forms of gas or liquid such as HCN, CNCl and acetonitrile, or solids such as NaCN, KCN, and Ca(CN)2. Cyanide compounds are also found in addible plants as cyanogenic glycosides. Compounds that can release cyanide are known as cyanogenic compounds. HCN has a low boiling point (25.63 oC) and is as weakly acidic with a pKa 9.2. It partially ionizes in water to give the cyanide anion, -CN. Cyanide ion from salt reacts with acid to give HCN, but at high pH (8-10), it remains as cyanide ion even if the temperature of the water is 80.0-100.0 °C. Cyanide is one of the deadliest poisons, LC50 is 1.1 and 5.0 mg/kg for HCN and NaCN, which can cause death to those who come into contact within a few minutes or hours of exposure, depending on the level and route of exposure. It is a rapidly acting, potentially deadly chemical that interferes with the body’s ability to use oxygen. Due to its toxicity, cyanide has many roles in industry such as pesticides and medicines as nitrile-containing pharmaceuticals. Organic compounds that have a −C≡N functional group are called nitriles. Over 30 nitrile-containing pharmaceuticals are currently marketed for a diverse variety of medicinal indications with more than 20 additional nitrile-containing leads in clinical development. In addition, over 120 naturally occurring nitriles have been isolated from terrestrial and marine sources.  In plants, cyanides are usually bound to sugar molecules in the form of cyanogenic glycosides. Hydrogen cyanide can be released from hydrolysis of cyanogenic glycosides which are commonly present in edible plants. Because it is a relatively common toxin in the environment, the body can detoxify a small amount of cyanide. The major route of metabolism for cyanides is detoxification in the liver by the mitochondrial enzyme rhodanese, which catalyzes the transfer of the sulfane sulfur of thiosulfate to the cyanide ion to form thiocyanate. Ingested cyanide may be countered by administering antidotes, such as natural vitamin B12 and sodium thiosulfate, that detoxify cyanide or bind to it.
In Vitro Antioxidant Activity, Flavonoid and Phenolic Contents of 70% Methanol Extract from Purple and Yellow Passion Fruit Peel Khoirul Ngibad; Siti Nur Husnul Yusmiati; Setyo Dwi Santoso; Firda Inayah; Rizky Dwi Nur Faizi
Indonesian Journal of Chemistry and Environment Vol 6, No 2 (2023): DECEMBER 2023
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v6i2.57725

Abstract

Peel of purple and yellow passion fruit has the potential to be an antioxidant. The flavonoid and total phenol compound groups are two examples of natural antioxidant compounds that can potentially be antioxidants. Many studies have used 70% methanol solvent to extract flavonoids and total phenolics from plants. The aim of this study is to analyze the potential of 70% methanol extract from the peel of purple and yellow passion fruit as an in vitro antioxidant using the DPPH method, total flavonoid, and phenolic levels. The passion fruit peel powder was macerated with 70% methanol for four days. The total flavonoid contents were determined using quercetin, and total phenols were determined using gallic acid. The 2.2-diphenyl-1-picrylhydrazyl (DPPH) was used for in vitro antioxidant activity by determining the percent inhibition of DPPH radicals. The flavonoid content in the 70% methanol extract of purple and yellow passion fruit peel is 1.2824 and 1.9775 mg QE/g extract, respectively. In contrast, the total phenolic content in 70% methanol extract of purple and yellow passion fruit peel is 15.8 and 3.6 mg GAE/g extract, respectively. The 70% methanol extract of purple passion fruit peel at a concentration of 80 mg/L resulted in a more significant percent inhibition of DPPH free radicals (72.80 %) than yellow passion fruit (64.91 %). In conclusion, the results suggest that 70 % methanol extract from purple and yellow passion fruit peel can decrease free radicals and be a natural antioxidant.Keyword: Antioxidant activity, Flavonoid, Methanol extract, Passion fruit peel, Total phenol

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