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<![CDATA[PENGARUH EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUZ) DALAM MENGHAMBAT DEGRANULASI SEL MAST DAN MENCIT PUTIH JANTAN YANG TERSENSITISASI AKTIF ]]>
<![CDATA[Relin Yesika]]>;
<![CDATA[Meiridha Mutiara A.]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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<![CDATA[Type I hypersensitivity reactions, also known as allergic reactions or anaphylactic reactions. The mechanism of anaphylaxis involves the release of mediators from mediator cells. The degranulation of mast cells and basophils causes an exaggerated immune response and causes the signs and symptoms of anaphylaxis. Red dragon fruit peel contains secondary metabolites such as triterpenoid flavonoids and steroids. This study was an in vitro study of the ethanol extract of red dragon fruit peel (Hylocereus polyrhizuz) on the mast cells of male white mice induced by antigen. Five variations of the concentration used are 25; 50; 100; 200; 400 µg/mL. The percentage of mast cell degranulation by red dragon fruit peel extract at concentrations of 25; 50; 100; 200 dan 400 µg/mL is 75.27; 69.05; 64.04, 56.61; 45.17; dan 27.88%. There Red dragon fruit peel extract had a significant effect in inhibiting mast cell degranulation (p<0.05).]]>
<![CDATA[FORMULASI & EVALUASI FISIK GRANUL EFFERVESCENT KOMBINASI EKSTRAK ETANOL 70% BUNGA ROSELLA (Hibiscus sabdariffa L.) & BUNGA TELANG (Clitoria ternatea L.) SEBAGAI ANTIOKSIDAN ]]>
<![CDATA[Wahyudin Bin Jamaludin]]>;
<![CDATA[Nadia Masytoh]]>;
<![CDATA[Eka Fitri Susiani]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1065
<![CDATA[Rosella (Hibiscus sabdariffa L.) and telang flower (Clitoria ternatea L.) contain anthocyanins which have antioxidant, so the researchers combined to use as effervescent granules. This study aims to determine the characteristics, and the antioxidant activity of effervescent granule combination of rosella and telang flower extract. Antioxidant activity testing using DPPH. The antioxidant activity of the combined thick extract was obtained ???????? 50 7.5 ppm, after that it was made into an effervescent granule preparation in 4 formulas. The resut show that all formulas had a characteristic taste of almost uniform color, dark turquoise. In all test formulas for water content, the results obtained are 1.68%-2.82%, compressibility index 11.641%-16%, angle of repose 31.2º-34.43º, flow time 6.25-6.83 seconds, dissolving time 208 -257 seconds and pH 6.2-6.6. The results of the antioxidant activity of effervescent granules revealed ???????? 50 of 62,628 ppm (strong).]]>
<![CDATA[OPTIMASI FORMULA HAIR TONIC MIKROEMULSI BIOTIN (VITAMIN B7) DENGAN METODE FACTORIAL DESIGN ]]>
<![CDATA[Fauziyyah Al Hasanah]]>;
<![CDATA[Gunawan Pamudji Widodo]]>;
<![CDATA[Endang Dyah Ikasari]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1071
<![CDATA[Loss becomes a problem in the hair that causes baldness. Biotin is a vitamin that nourishes hair and prevents hair loss. Biotin which is formulated in microemulsion tends to be transparent, has low viscosity and high solubility. Formula optimization was carried out to determine the concentration of span 80, tween 80, and PEG 400 in biotin microemulsion hair tonic. The research was conducted on an experimental basis using a factorial design method with 3 factors, namely span 80, tween 80, and PEG 400. The optimum microemulsion formula was determined using Design Expert 13 software using the Factorial Design method. Testing the physical quality of the preparation is carried out at the optimum formula. Optimization of biotin microemulsion hair tonic showed results of span 80 (20%), tween 80 (9.466%) and PEG 400 (5%) with a predicted viscosity of 46.75 cPs and globule size of 2.98 µm. Prediction testing and test results compared to the One Sample T-test showed results that were not significantly different with a significance value of >0.05. The optimum formula has a viscosity value of 47.67 cPs and a globule size of 2.4 µm. The results obtained concluded that the optimal composition composition of the biotin microemulsion formula from the combination of span 80, tween 80 and PEG 400 which produces hair tonic with good effects and physical quality is span 80 20%, tween 80 9.47% and PEG 400 5%.]]>
<![CDATA[KARATERISTIK ENKAPSULASI LIPOSOM EKSTRAK SUPEROKSIDA DISMUTASE (SOD) Bacillus altitudinis ]]>
<![CDATA[Nurfitriyawatie Nurfitriyawatie]]>;
<![CDATA[Ana Indrayati]]>;
<![CDATA[Rizal Maarif R.]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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<![CDATA[Photoaging causes the dermis and collagen fibers to decrease which results in skin aging. Genus Bacillus has SOD activity as an anti-photoaging agent that can neutralize ROS (Reactive Oxygen Species) due to exposure to UV-A rays. This study aimed to examine the activity of crude extract and the encapsulation characteristics of liposomes from B. altitudinis. The study began with the isolation of the SOD enzyme, determination of the total protein content of the crude extract of the SOD enzyme and liposome encapsulation, then characterization liposome tes including particle size analysis, sorption efficiency and zeta potential. The results of the crude extract activity test were 85.09% ± 1.24%. The characteristic test was produced with a size of 112.96 ± 17.3 ; the adsorption efficiency was 81.1% and the zeta potential was 7.0 ±5.1 mV. The results showed that the SOD B. altitudinis liposomes were in the nanoparticle range.]]>
<![CDATA[STUDI IN SILICO PEMBENTUKAN KOKRISTAL MELOXICAM DENGAN BERBAGAI KOFORMER PERBANDINGAN (1 : 1) ]]>
<![CDATA[Yuli Ainun Najih]]>;
<![CDATA[Farizah Izazi]]>;
<![CDATA[Siswandono Siswandono]]>;
<![CDATA[Bella Anggraini Putri]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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<![CDATA[Cocrystal is one form of modification in increasing the solubility of meloxicam which is included in Biopharmaceutics Classifications System (BCS) II. Cocrystal is a multicomponent system with a stoichiometric ratio between the active ingredient and the coformer which are bound in the crystals lattice to form hydrogen bonds. Design of new drugs can be done through an in silico program to optimize the parent compound before the synthesis of derivative compounds. This study aims to predict which coformers are most stable in the formation of crystals. Cocrystal formation is done by drawing a two-dimensional structure from meloxicam and coformer using ChemBioDraw Professional 16.0 software from CambridgeSoft®. The prediction will result in the amount of bond energy formed between meloxicam with coformer. The smaller the bond energy, the more stable the meaning of the bond. The smaller the bond energy formed, the more stable the bond is. Stable bonds have a high probability of forming cocrystals meloxicam. Hydrogen bonds occur between hydrogen atoms and other atoms that have high electronegativities such as O and N atoms which have lone pairs of electrons. This electronegativity difference makes H atoms tightly bound to O and N atoms so that the hydrogen bonds in the meloxicam cocrystal are tightly bound and stable. From the results of the study showed that the most stable coformer can form cocrystals with a small bond energy that can produce bonds with meloxicam, namely urea.]]>
<![CDATA[AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK BUAH MAHKOTA DEWA (Phaleria macrocarpa) DENGAN EKSTRAK HERBA MENIRAN HIJAU (Phyllantus niruri Linn.) TERHADAP PERTUMBUHAN Staphylococcus aureus ]]>
<![CDATA[Aulia Rahmah Triastanti]]>;
<![CDATA[Putri Vidiasari Darsono]]>;
<![CDATA[Siti Malahayati]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1101
<![CDATA[S.aureus infection was found to be around 5%-35% and cases of S.aureus resistance increased by 22.8% due to people being less compliant in treatment. One of the preventions of resistance is to return to the use of natural materials, especially plants that have been scientifically and empirically proven, one of which is Mahkota Dewa Fruit (Phaleria macrocarpa) and Green Meniran Herb (Phyllanthus niruri L.). The study was conducted using the True Experimental method using S.aureus bacteria. 3 treatment groups were used, namely positive control (Amoxicillin), negative control (DMSO), as well as Mahkota Dewa extract (Phaleria macrocarpa) and Green Meniran Extract (Phyllanthus niruri L.). Using the disc diffusion method and the dilution method to determine the magnitude of the inhibition zone, the value of MIC, and MBC. The extract of the Crown of God Fruit, The Green Meniran Herb, as well as the combination of the two extracts have successive bacterial inhibitory power with an average of 18.02 mm; 15.95 mm; and 15.09 mm against S.aureus. Testing by the dilution method obtained a KHM value of 60% (0.06g/mL) in each extract. KBM is not obtained in each extract.]]>
<![CDATA[AKTIVITAS ANTIHIPERTENSI EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R.Forst. & G.Forst.) PADA MODEL HEWAN HIPERTENSI YANG DIINDUKSI PREDNISON DAN NaCl ]]>
<![CDATA[Kharina Septi Lestari]]>;
<![CDATA[Elis Susilawati]]>;
<![CDATA[Aulia Nurfazri Istiqomah]]>;
<![CDATA[Silvi Nur Amalia]]>;
<![CDATA[Widhya Aligita]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1103
<![CDATA[Hypertension is a disease without symptoms that is very dangerous (silent killer) because it is often not realized. Conditions that are not controlled and occur continuously will cause a disease factor related to cardiovascular disease. Empirically, matoa leaves are commonly used as antihypertensive drugs. This study aims to determine the activity of the ethanolic extract of matoa leaves as a diuretic and antihypertensive. Diuretic testing was carried out for 6 hours with urine volume measurement every hour. Each test animal was given warm water as a loading dose, using a comparison (Furosemide 3.6 mg/KgBW) and the matoa leaf ethanol extract test group with doses of 150, 300, and 500 mg/KgBW. Antihypertensive testing was carried out in a preventive manner using Prednisone 1.5 mg/KgBW and NaCl 2%, comparison (Hydrochlorothiazide 2.25 mg/KgBW) and the test group ethanol extract of matoa leaves with doses of 150, 300, and 500 mg/KgBW. given orally for 14 days. The test parameters were urine volume, systolic blood pressure and diastolic pressure. The data obtained were analyzed using One Way ANOVA and Kruskall Wallis. The results showed that the ethanol extract of matoa leaves could increase urine output, and decrease systolic and diastolic blood pressure because it had a comparable activity with the comparison group (p<0.05). A dose of 150 mg/kgBW has the most effective activity as an antihypertensive.]]>
<![CDATA[LETHAL CONCENTRATION OF Saussurea costus WITH BRINE SHRIMP LETHALITY TEST METHOD ]]>
<![CDATA[Dhigna Luthfiyani Citra Pradana]]>;
<![CDATA[Hany Yusmaini]]>;
<![CDATA[Erna Harfiani]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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<![CDATA[The safety of using herbal plant extracts is essential for COVID-19 patients who consume herbal plants daily to increase immunity and overcome the symptoms of the disease. One of the herbal plants used by the community in COVID-19 therapy is Qusthul Hindi (Saussurea costus). The public needs to know the safety of these herbal remedies when consuming them. Therefore it is essential to conduct a toxicity test of Hindi Qusthul extract. Secondary metabolite compounds present in plant extracts can be tested for toxicity in vitro using the Brine shrimp lethality test (BSLT) method using Artemia salina Leach larvae to determine LC50 values. The BSLT method is used to determine biological activities in extract plants, such as cytotoxic activity, phototoxic, enzyme inhibition, and ion regulation, using Artemia salina Leach shrimp larvae as bioindicators. The BSLT method is carried out by observing the mortality rate in Artemia salina Leach shrimp larvae which are given extracts from plants and then incubated for 1x24 hours. The results obtained from this study as an LC50 (Lethal concentration) value of 532.78 ppm. LC50 (Lethal Concentration) value of 532.78 ppm indicates that the concentration of the compound can cause death in Artemia salina Leach by as much as 50%.]]>
<![CDATA[OPTIMASI SODIUM LAURIL SULFAT DAN NATRIUM CHLORIDA PADA SABUN CAIR EKSTRAK LIDAH BUAYA: SIMPLEX LATTICE DESIGN ]]>
<![CDATA[I Gusti Ngurah Agung Windra Wartana Putra]]>;
<![CDATA[Ni Made Maharianingsih Maharianingsih]]>;
<![CDATA[I Gusti Rai Widowati]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1169
<![CDATA[This study aims to determine the concentration of SLS and NaCl which can produce the best formula of aloe vera extract liquid soap (Aloe vera L.). The method used in this study is the Simplex Lattice Design method. Eight formulas were made with different concentrations of SLS and NaCl, then the parameters of viscosity, specific gravity, foam resistance, and pH were determined. The data obtained was tested with one sample t-test to see the difference between the software's design expert predicted results from the optimization method and the results of laboratory tests. From the results of testing the 8th parameter of the formula, the formula that has the closest desire ability value to 1 was chosen as the optimum formula, namely at a concentration of 180 g of SLS and 65 g of NaCl. From this formula, a one sample t test was carried out between the software's predicted value and laboratory parameter values. The significant values obtained for the parameters of viscosity, specific gravity, foam resistance and pH were 0.570; 0.245; 0.882; 0.069. which means there is no difference in parameter values between the software and the laboratory. It can be concluded that the formula with a variation of SLS of 180 g and NaCl of 65 g is the best formula in the formulation of aloe vera extract liquid soap which produces values that meet quality requirements such as viscosity of 3270 Cp, Specific Weight of 1.079 g/ml, foam resistance of 67%, and pH value 6.73.]]>
<![CDATA[PROFIL PENGETAHUAN DAN PERSPEKTIF HIPNOTERAPI DI KALANGAN MASYARAKAT WILAYAH SURABAYA ]]>
<![CDATA[Fauziyyah Syandria Afrisa]]>;
<![CDATA[Amara Damayanti]]>;
<![CDATA[Mutmainnah Mutmainnah]]>;
<![CDATA[Shabrina Insan Nabil]]>;
<![CDATA[Luthfia Andini Nathaneila]]>;
<![CDATA[Febri Zalfa’ Pratama]]>;
<![CDATA[Avif Muhammad Zaki Hidayat]]>;
<![CDATA[Reza Fahlevy Firmansyah Putra]]>;
<![CDATA[Alwiyah Alwiyah]]>;
<![CDATA[Abdul Rahem]]>
<![CDATA[ Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 1 (2023): JIIS ]]>
Publisher : <![CDATA[Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin ]]>
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DOI: 10.36387/jiis.v8i1.1259
<![CDATA[Hypnotherapy is an alternative and complementary therapy or non-pharmacological therapy that uses hypnosis as a suggestion of the human unconscious. Many people are negative about hypnotherapy and do not know that it has many benefits. The purpose of this study is expected to increase knowledge and change people's perspectives on hypnotherapy treatment. This study is a cross sectional study with non-random sampling (accidental sampling) techniques with research instruments in the form of online questionnaires and spread leaflets. The study was 108 respondents, with 108 respondents meeting the inclusion criteria. The results of the knowledge study showed 38.0% with good knowledge, 46.3% of respondents with sufficient knowledge and 15.7% of respondents with low knowledge and results at perspective showed 18% of respondents were positive, and 82% were negative. Based on the results of the respondents' knowledge and perspective, there is a need for an introduction to hypnotherapy treatment to prevent misperception among the people of Surabaya.]]>
