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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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Perbandingan Uji Diagnostik Mesothelin Serum dengan CA-125 pada Kanker Ovarium Tipe Epitel ERI PERDANA USHAN; BRAHMANA ASKANDAR T; BUDIONO BUDIONO
Indonesian Journal of Cancer Vol 9, No 2 (2015): April-Juni 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

This study was conducted to determine and compare the sensitivity, specificity, PPA and NPV of Mesothelin tumor marker, CA-125, combination of Mesothelin and CA-125 as a tumor marker in patients with epithelial ovarian carcinoma. This is a cross sectional diagnostic test on 30 subjects with malignant dan 30 sunjects with benign ovarian tumors that meet the inclusion and exclusion of research criteria in Department of Obstetrics and Gynecology, Medical Faculty Airlangga University/Dr. Soetomo, Surabaya. Blood sample were taken prior to surgery to examine tumor markers (Mesothelin and CA-125) and ultrasound to evaluate tumor mass, and then histopathology of surgery specimen. Statistical data calculated using SPSS. There is a significant increase of Mesothelin serum level and can be used as a tumor marker (alone or in combination with other methods as a triage tool, consider the use of new cut-off value of 1.75 nmol/L). Sensitivity, specificity, PPV, NPV of CA125 is 70%, 33.3%, 51.2% and 52.6%. Sensitivity, specificity, PPV, NPV of Mesothelin-1 is 50%, 80%, 71.4% and 61.5%. Sensitivity, specificity, PPV, NPV of Mesothelin-2 is 36.7%, 93.4%, 84.6% and 59.6%. Sensitivity, specificit , PPV, NPV combination of CA-125 + Mesothelin-1 is 33.3%, 86.7%, 71.4%, 56.5% and 60%. Sensitivity, specificity, PPV, NPV combination of CA-125 + Mesothelin-2 is 23.3%, 93.3%, 77.8%, and 54.9%. Sensitivity, specificity, PPV, NPV of RMI is 83.3%, 36.7%, 56.8%, and 68.8%. CA-125 (as a single tumor marker) has the highest sensitivity and proved as a simple and effective method for the early detection at general population. Mesothelin-2 (either as a single tumor marker or in combination) is more appropriate for the diagnosis tools (triage, determining the risk of malignant from benign ovarian masses) are better than the current and can be considered to replace CA-125.Keywords: tumor marker, CA-125, Mesothelin, combine tumor marker.ABSTRAKPenelitian ini bertujuan mengetahui dan membandingkan sensitivitas, spesifisitas, PPV, dan NPV antara penanda tumor Mesothelin, CA-125, dan kombinasi Mesothelin dan CA-125 sebagai penanda tumor pada penderita keganasan ovarium tipe epitel. Penelitian ini merupakan uji diagnostik cross sectional terhadap 30 pasien tumor jinak dan 30 pasien tumor ganas tumor ovarium yang memenuhi kriteria inklusi dan kriteria eksklusi di Bagian Obstetri dan Ginekologi FK-Unair/RSU Dr. Soetomo, Surabaya. Dilakukan pengambilan serum darah untuk memeriksa tumor marker (Mesothelin dan CA-125) dan pemeriksaan ultrasonografi sebelum dilakukan tindakan pembedahan. Kemudian dilakukan pemeriksaan patologi anatomi spesimen operasi. Penghitungan data statistik menggunakan SPSS. Hasil penelitian menunjukkan terdapat peningkatan kadar serum Mesothelin yang dapat digunakan sebagai pemeriksaan penanda tumor tunggal atau kombinasi sebagai alat triase dengan mempertimbangkan penggunaan nilai cut-off 1,75 nmol/L. Sensitivitas, spesifisitas, PPV, dan NPV CA125 adalah 70%; 33,3%; 51,2%; dan 52,6%. Sensitivitas, spesifisitas, PPV, dan NPV Mesothelin-1 adalah 50%; 80%; 71,4%; dan 61,5%. Sensitivitas, spesifisitas, PPV, dan NPV Mesothelin-2 adalah 36,7%; 93,4%; 84,6%; dan 59,6%. Sensitivitas, spesifisitas, PPV, dan NPV kombinasi CA-125 + Mesothelin-1 adalah 33,3%; 86,7%; 71,4%; 56,5%; dan 60%. Sensitivitas, spesifisitas, PPV, dan NPV kombinasi CA-125 + Mesothelin-2 adalah 23,3%; 93,3%; 77,8%; dan 54,9%. CA-125 (sebagai penanda tumor tunggal) memiliki sensitivitas tertinggi sehingga merupakan metode sederhana dan efektif untuk deteksi dini pada populasi. Mesothelin-2 (baik sebagai penanda tumor tunggal maupun dalam kombinasi) lebih tepat untuk proses penegakan diagnosis (triase, penentuan risiko massa ovarium ganas dari jinak) yang lebih baik dan dapat menggantikan CA-125.Kata Kunci: penanda tumor, CA-125, Mesothelin, kombinasi CA-125 dan Mesothelin

Pengaruh Indeks Massa Tubuh terhadap Disease-Free Survival Lima Tahun Pasien Kanker Payudara di Rumah Sakit Kanker Dharmais Jakarta SAFARUDIN ATHOILLAH; NURHAYATI PRIHARTONO; WALTA GAUTAMA
Indonesian Journal of Cancer Vol 10, No 1 (2016): Jan - Mar 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTThere are some evidences that the metabolic changes in breast cancer patients with high body mass index (BMI) associated with insulin resistance and, in particular, the related alteration in cytokine production by adipose tissue which are major contributors to the aggressive behavior of breast cancer that develop through their effects in angiogenesis and stimulation of invasive capasity of cancer cells. Retrospective cohort study conducted at the Dharmais National Cancer Hospital aimed to determine the effect of BMI on five-year disease-free survival (DFS) breast cancer patients. This study was conducted from August to November 2014. The samples in this study were collected consecutively as many as 127 patients. From this study, it is known that the five-year DFS of breast cancerpatients was 70.0%. Based on the category of BMI, breast cancer patients with high BMI (>22.9 kg/m2) had the biggest DFS, followed by low BMI (<18.5 kg/m2) and normal BMI (18.5 22.9 kg/m2) that the precentages successively were 75.5%, 68.6%, and 60.4%. Multivariate analysis showed that BMI was not associated with the events of recurrence or metastases (HR 1.055; 95% CI 0.413-2.678) after being controlled by other variables, such as education, sosioeconomic, staging, lymph node involvement, histopathology, occupation, and biological subtypes.ABSTRAKBeberapa bukti menunjukkan perubahan metabolik pada pasien kanker payudara dengan indeks massa tubuh (IMT) tinggi berhubungan resistansi insulin dan khususnya perubahan terkait produksi sitokin oleh jaringan adiposa yang merupakan kontributor utama terhadap sifat agresif dari kanker payudara yang berkembang melalui pengaruhnya terhadap angiogenesis dan stimulasi kemampuan invasif dari sel kanker. Studi kohort retrospektif yang dilakukan di Rumah Sakit Kanker Dharmais ini bertujuan untuk mengetahui pengaruh IMT terhadap disease-free survival (DFS) lima tahun pasien kanker payudara. Penelitian ini dilakukan dari Agustus sampai November 2014. Sampel yangdigunakan pada studi ini diambil secara konsekutif sebanyak 127 pasien. Dari studi ini, diketahui bahwa DFS lima tahun pasien kanker payudara adalah 70,0%. Berdasarkan kategori IMT, pasien kanker payudara dengan IMT tinggi (>22,9 kg/m2) memiliki DFS lima tahun yang paling besar, yaitu 75,5% ; diikuti pasien dengan IMT rendah (<18,5 kg/m2) sebesar 68,6%; dan 60,4% untuk pasien dengan IMT normal (18,522,9 kg/m2). Hasil analisis multivariat menunjukkan bahwa IMT tidak memiliki asosiasi dengan kejadian kekambuhan atau metastase (HR=1,052, 95% CI 0,413-2,678) setelah dikontrol oleh variabel pendidikan, sosioekonomi, stadium, keterlibatan kelenjar getah bening, histopatologi, pekerjaan, dan subtipe biologis.

Kombinasi Pemeriksaan Potong Beku dan Imprint Meningkatkan Akurasi Diagnosis Intraoperatif Karsinoma Payudara I Gusti Ayu Sri Mahendra Dewi
Indonesian Journal of Cancer Vol 3, No 4 (2009): Oct - Dec 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Pemeriksaan potong beku intraoperatif memegang peranan penting dalam penatalaksanaan penderita, tetapi mempunyai beberapa keterbatasan dalam hal pengambilan sampel, teknik, serta pengalaman dan pengetahuan ahli patologi yang baik karena keputusan diagnostik harus dibuat dalam waktu yang singkat. Penelitian ini menilai akurasi kombinasi pemeriksaan potong beku dan imprint intraoperatif untuk diagnosis karsinoma payudara, dengan blok parafin sebagai baku emas. Kasus diperoleh dari penderita tumor payudara yang bahan biopsinya dikirim untuk pemeriksaan potong beku ke Bagian/SMF Patologi Anatomi FK UNUD/RSUP Sanglah, Denpasar, dari 1 Januari 2006 sampai 31 Desember 2008. Selama periode tersebut didapatkan 35 kasus, terdiri dari 23 kasus karsinoma dan 12 kasus nonkarsinoma. Akurasi dihitung untuk masing-masing pemeriksaan potong beku, imprint, dan kombinasi keduanya. Sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif untuk potong beku berturut-turut adalah 91,3%; 91,7%; 95,5%; dan 84,6%. Sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif untuk imprint berturut-turut adalah 86,9%; 91,7%; 95,2%; dan 78,6%. Sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif untuk kombinasi keduanya berturut-turut adalah 95,7%; 100%; 100%; dan 92,3%. Pemeriksaan kombinasi potong beku dan imprint intraoperatif dapat meningkatkan akurasi diagnosis karsinoma payudara.Kata kunci: akurasi, potong beku, imprint, karsinoma payudara.

Sistem Skoring Nefrometri R.E.N.A.L: Sistem Berstandar yang Komprehensif Dalam Menilai Ukuran, Lokasi, dan Kedalaman Tumor Ginjal MOCHAMMAD REZA; ARIEF RAKHMAN; CHAIDIR A MOCHTAR
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v8i2.301

The treatment of localized renal cell carcinoma remains subjective.The R.E.N.A.L.- Nephrometry Score quantifies the characteristics of renal mass anatomy based on radiologic findings to provide a standardized objective descriptive system in an reproducible manner. We evaluate the utility of this system in predicting tumor resectability, operative approach and risk of complication, and their relevance to clinical practice.Electronic literature research was performed to access the main series of literature in the past 4 years since the scoring system developed. The articles were then analyzed and selected to address these issues. Fifteen peer-reviewed publications (2009 to 2012) were selected. Most of the studies were analyzed using the prospective acquired database. Increasing tumor complexity was asscociated with greater overall nephrometry score in patient underwent renal neprectomy and partial neprectomy. Compared with patients who underwent partial nephrectomy, the patients treated with radical nephrectomy had a significantly greater size (R), central proximity (N), and location (L) component scores. There were more complications among patients with higher R.E.N.A.L scores who underwent partial nechrectomy (PN) thanin patients with PN who did not developcomplications. The R.E.N.A.L nephrometry scoring system has good interobserver reliability showed by the similar sum of nephrometry score concordance to the R, E, N, A, and L components among surgeons in different centre. The R.E.N.A.L nephrometry standardize the reporting of solid renal masses and appears to effectively stratify the treatment choice for patients. Nephrometry aids in objectifying previously subjective measure and provide more meaningful comparison of treatment recommendation or results in published series.

The Accuracy of Plasma EBV-DNA Quantification Using LMP2 as Primer to Detect Distance Metastasis After Radiation of Nasopharyngeal Cancer in Dharmais National Cancer Center Dewi Soeis Marzaini; Demak L. Tobing; Siti Boedina Kresno
Indonesian Journal of Cancer Vol 3, No 2 (2009): Apr - Jun 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kanker nasofaring (NPC) biasa ditemukan di Indonesia dan berkaitan dengan penyakit tingkat lanjut (advanced disease). Keberadaan virus Epstein-Bar deoxyribonucleic acid (EBV-DNA) sudah lama ditawarkan untuk deteksi awal terhadap kegagalan jarak (distant failure) setelah pemberian radiasi (radiation theraphy). Selaput laten protein-2 (LMP-2) sangat potensial untuk diterapkan di Indonesia, karena efektif dalam menekan biaya. Namun, hal ini belum pernah di pelajari sebelumnya.Penelitian ini bertujuan untuk mengetes penghitungan akurasi plasma EBV-DNA menggunakan LMP2 sebagai cara awal untuk mendeteksi metastasis setelah pemberian radiasi pada pasien NPC.Contoh plasma diambil dari pasien penderita kanker nasofaring paling tidak enam bulan setelah pemberian radiasi. DNA diekstrak dan dianalisis dari reaksi rantai polymerase berdasarkan hitungan waktu (real-time polymerase chain reaction RT-PCR) (Light Cycler, Roche Diagnostics) menggunakan spesifikasi dasar LMP-2. Hasilnya kemudian dibandingkan dengan standar kuantitatif RT-PCR antara EBNA-1 dan segmen DNA dalam area BamHi-W dari genome EBV.Perbedaan rata-rata (mean) dari level EBV-DNA kemudian dibandingkan menggunakan tes analisis varian (ANOVA). Perhitungan sensitivitas dan spesifikasi dihitung berdasarkan kurva ROC (receiver-operating characteristics).Kajian ini menggunakan dua puluh tiga kasus NPC yang non-metastatik, di mana jumlah pasien laki-laki 17 orang (73,9%) dan wanita 6 orang (26,1%). Median dari umur pasien adalah 48 tahun (21-67 tahun). Kebanyakan kasus sudah mencapai stadium III (56,5%), diikuti stadium IVA-B (26,1%). Semua pasien menerima radiasi sebanyak 6000-7000 cGy. Sepuluh pasien (43,5%) telah mendapatkan metastasis (distant metastasis) paling tidak enam bulan setelah terapi radiasi. Tidak ada tanda-tanda kambuh pada lokasi awal (primary site). Tidak ada perbedaan mean pada tingkat EBV-DNA, yaitu antara penggunaan EBNA-1 secara dasar antara pasien dengan metastasis dan pasien tanpa metastasis (5135 copies/mL vs. 7827 copies/mL; p=0,245). Ada perbedaan mencolok pada mean EBV-DNA antara pasien dengan metastasis dan pasien tanpa metastasis saat menggunakan LMP2 sebagai dasar dan menggunakan BamHI-W sebagai dasar. BamHI-W primer memberikan tingkat sensitivitas 100% dan spesifisitas 100% pada tingkat EBV-DNA 1080 copies/mL dengan AUC 1,0. Perhitungan dengan LMP2 primer memberikan tingkat sensitivitas 89% dan spesifisitas 100% pada pemberian 17 copies/mL dengan AUC 0,944.Kesimpulannya, deteksi EBV-DNA menggunakan LMP2 primer berguna bagi deteksi awal metastatik setelah pemberian radiasi bagi pasien NPC yang tidak memiliki metastasis pada saat proses diagnosis. Primer ini memiliki tingkat sensitivitas dan spesifisitas hampir seakurat BamHi-W primer.Kata kunci: Metastasis, Radiasi, Nosofaring.

Trichilemmal Carcinoma on the Head (Surgical Challenge to Achieve Free Margin): A Case Report Daan Khambri
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Trichilemmal carcinoma is a rare tumor derived from the outer hair sheath. It usually appears on the face, ears, neck, scalp, and sun-exposed areas. It generally occurs in patients older than 50 years old, and there is no sex predilection to this disease.Case Presentation: A 60-year-old woman came with a complaint of a lump in the head that often bled. The size of the lump was approximately like a bean seed and broke when she combed her hair. The lump was getting bigger within a year and easier to bleed. She often felt pain. Based on the history of surgery 2 months ago, the examination implies that the patient had trichilemmal carcinoma.Conclusions: Trichilemmal carcinoma generally occurs in the elderly category. Although trichilemmal carcinoma has a benign clinical course and local recurrence cases are uncommon, sufficient free margin and immediate reconstruction are challenging if the predilection is in the head and neck. Surgical excision is the recommended treatment for this disease

Luaran Klinis Orkhidektomi Bilateral pada Kanker Prostat Metastasis: Pengalaman Indonesia Syarif Bakri; Rainy Umbas; Chaidir Arif Mochtar
Indonesian Journal of Cancer Vol 5, No 4 (2011): Oct - Dec 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kanker prostat merupakan kanker yang lebih banyak ditemukan di negara Barat dibandingkan Asia. Berbagai faktor prognostik telah diteliti untuk memprediksi angka kesintasan pasien yang diterapi hormonal. Pada penelitian ini dievaluasi peranan usia, PSA, jumlah lesi metastasis, skor Karnofsky, hemoglobin, dan kreatinin sebagai faktor prognostik untuk menilai angka kesintasan pada kanker prostat metastasis di Indonesia yang dilakukan kastrasi dengan orkhidektomi. Penelitian dilakukan secara retrospektif dengan mengumpulkan data rekam medik penderita kanker prostat dengan metastasis yang dilakukan orkhidektomi subkapsular dan belum mengalamihormone resistance prostate cancer(HRPC) di Klinik Khusus Urologi RSCM dan RS Kanker Dharmais Jakarta, periode Januari 1995- Desember 2008 denganfollow-up24 bulan. Selama periode penelitian, terdapat 194 pasien yang memenuhi kriteria dan 99 pasien di antaranya memiliki data lengkap untuk dianalisis. Dari analisis multivariat didapat kekuatan hubungan dari yang terbesar sampai yang terkecil, yaitu jumlah lesi (HR=8,56), kreatinin (HR=3,24), hemoglobin (HR=0,94), dan skor Karnofsky (HR=0,28). Disimpulkan bahwa jumlah lesi dan kreatinin secara statistik signifikan mempengaruhi kesintasan.Kata kunci: jumlah lesi, kanker prostat, kesintasan, kreatinin, metastasis

Strategi Global Pengendalian Tembakau Widyastuti Wibisana; Yodi Christiani; Albert Maramis; Jusni Solichin; Stephanus Indradjaya
Indonesian Journal of Cancer Vol 2, No 2 (2008): Apr - Jun 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Penggunaan tembakau telah menjadi masalah kesehatan global, baik di negara maju maupun negara berkembang. Tembakau telah membunuh 100 juta jiwa selama abad ke 20 dan diperkirakan akan membunuh 1 milvar jiwa pada abad 21 bila hal ini terus dibiarkan. World Health Organization (WHO) pada awal tahun 2008 telah mengajukan enam langkah strategis pengendalian tembakau yang merupakan pencerminan traktat internasional aksi globalKengendalian tembakau atau Framework Convention on Tobacco Control (FCTC). Keenam langkah tersebut meliputi lonitor penggunaan tembakau dan kebijakan pencegahannya; Perlindungan terhadap asap rokok; Optimalkan dukungan untuk berhenti merokok; Waspadakan masyarakat akan bahaya tembakau; Eliminasi iklan, promosi dan sponsor terkait tembakau; dan Rain kenaikan cukai tembakau (MPOWER). Keenam langkah ini, bila dilaksanakan secara komprehensif yang melibatkan berbagai pihak akan dapat mengendalikan dampak penggunaan tembakau.Kata kunci: penggunaan tembakau, strategi pengendalian tembakau, MPOWER

The Difference of Hypoxia Inducible Factor 2α mRNA Expression in High-Grade and Low-Grade Glioma Tissue Bagus Ramasha Amangku; Syaiful Ichwan; Septelia Inawati Wanandi; Novi Silvia Hardiany
Indonesian Journal of Cancer Vol 13, No 2 (2019): June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: HIF-2α is a transcription factor in hypoxic condition, and high expression levels of it correlate with the concepts of metastasis, therapy opposition and reduced quality of prognosis in various forms of cancerous growth. Due to the exceedingly infiltrative ability of brain glioma cells, gliomas cannot be completely deteriorated with surgery and the relapse rate is high. This study goal to identify the relative expression of HIF-2α gene in the direction of glioma malignancy and its classification. Methods: Specimens used in this research comprise of 20 glioma samples obtained from glioma patients in Cipto Mangunkusumo Hospital. Relative expression of HIF-2α was measured by utilizing quantitative Real Time-Polymerase Chain Reaction (RT-PCR). Cycle threshold (CT) values were achieved correlated with the amplified DNA, and then the relative expression was attained by using Livak method of calculation. Results: The results produced a greater average of relative expression of HIF-2α in the grade III and IV types (18.64; n=7) rather than in the lower grades (5.68; n=13). However, the data is statistically inconsequential. Conclusions: High-grade glioma tends to express HIF-2α mRNA higher compared to the lower grade. Therefore, it is possible to use HIF-2α as a prognostic marker for glioma- diagnosed patients, although additional experiments need to be performed to strengthen these facts.

Evaluating the Association between Clinical Characteristics with Progression-Free Survival and 3-Year Survival in Patients with Epithelial Ovarian Cancer Brahmana Askandar Tjokroprawiro; Sonny Fadli; Budiono Budiono
Indonesian Journal of Cancer Vol 15, No 4 (2021): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: This study was conducted to determine the association between clinical characteristics, progression-free survival (PFS), and 3-year survival in patients with epithelial ovarian cancer who underwent surgery in 2016-2017 at RSUD Dr. Soetomo. This study was carried out with the hope of contributing to services for patients with epithelial ovarian cancer to improve outcomes at RSUD Dr. Soetomo. Methods: This retrospective analytic study used medical record data. Survival analysis was done employing Kaplan-Meier and log-rank tests, while Cox regression was utilized to analyze characteristics, recurrence, and mortality. Results: In 2016-2017, 56 patients with epithelial ovarian cancer met the inclusion criteria. Clinical characteristics of residue, stage had significant associations with PFS (P-value of 0.007 and P-value of 0.005, respectively). Residue, stage, histopathology, and the number of chemotherapy cycles had significant associations with 3-year survival (P-value of 0.001, P-value of < 0.001, P-value of < 0.001, P-value of 0.031, respectively). Recurrence and stage had a significant association with the following hazard ratios: stage I HR: 1 (CI 95%, P-value 0.145), stage II HR: 6.5 (CI 95% 0.6–74.7, P-value 0.134), stage III HR: 12.2 (CI 95% 1.4–105.4, P-value 0.061), and stage IV HR: 10.4 (CI 95% 0.8–120.8, P-value 0.061). Mortality had significant associations with stage, histopathology, and the number of chemotherapy cycles, with hazard ratios as follows: stage IV HR: 43.6 (CI 95% 4.5–417.9, P-value 0.001), seromucinous histopathology HR: 20.1 (CI 95% 0.9–408.6, P-value 0.026), chemotherapy cycles < 3 HR: 3.6 (CI 95% 1.2–11.5, P-value 0.459), and > 3 HR: 1 (CI 95%, P-value 0.028).Conclusions: Residue and stage had statistically significant associations with PFS and can be predictors for disease recurrence. Residue, stage, histopathology, number of chemotherapy cycles had significant associations with 3-year survival, but only the latter three characteristics can be predictors for mortality

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admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA