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eJournal Kedokteran Indonesia

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Published by Universitas Indonesia

ISSN : 23381426 EISSN : 23386037 DOI : http://doi.org/10.23886/ejki

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

eJournal Kedokteran Indonesia (eJKI) is a general medical journal, published quadrimester (April, August, December) by Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. eJKI aims to published the manuscript of students (Bachelor of Medicine (S.Ked), study Program of Medical Profession, magister/specialist, doctoral, and fellow). The journal is a general medical journal that covering all areas of biomedical science, basic medical science, clinical science, medical technology, and medical education. The journal accepts editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. This work was supported by Faculty of Medicine, Universitas Indonesia.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 162 Documents

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Observational Study of Paclitaxel-Carboplatin versus Pemetrexed-Carboplatin for Advanced Pulmonary Adenocarcinoma at Single-Centre in Indonesia Rianyta Rianyta; Melva Louisa; Elisna Syahruddin; Vivian Soetikno
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Platinum-based chemotherapy regimens with two types of drugs, such as paclitaxel-carboplatin and pemetrexedcarboplatin, are first-line therapy for pulmonary adenocarcinoma patients with negative epidermal growth factor receptor (EGFR) mutation. This study aimed to determine the efficacy, toxicity, and cost profile of paclitaxel-carboplatin compared to pemetrexed-carboplatin. This is a cross-sectional study. Pulmonary adenocarcinoma negative EGFR mutation naïve patients treated with paclitaxel-carboplatin or pemetrexed-carboplatin were included. Effectiveness was assessed based on the overall response rate (ORR) according to the response evaluation criteria in solid tumours (RECIST). A pharmacoeconomic analysis is performed based on clinical outcomes consisting of effectiveness and direct medical costs. Medical records from 21 patients with paclitaxel-carboplatin and 21 patients with pemetrexedcarboplatin were successfully evaluated. The effectiveness of the two chemotherapy regimens was not significantly different (OR, 1.25; 95% confidence interval, 0.34 to 4.64; p = 0.739). Frequent haematological toxicities experienced in the two groups were grade 1-2 anaemia, neutropenia, leukopenia. Grade 3 anaemia, leukopenia, and neutropenia were more common in the paclitaxel-carboplatin group. The two groups’ nonhematological toxicities were nausea vomitus and hair loss, with peripheral neuropathy more experienced by the paclitaxel-carboplatin group. Costminimization analysis reveals that the average cost per patient with pulmonary adenocarcinoma negative EGFR mutation with paclitaxel-carboplatin regimen was cheaper IDR 10,986,257.55 or 50.25%, compared to pemetrexedcarboplatin. In conclusion, there was no significant difference in the effectiveness of the two regimens. The most common adverse effects in both regimens were haematological toxicities. The average cost per patient with a paclitaxel-carboplatin regimen was cheaper compared to pemetrexed-carboplatin.

Red Blood Cell Transfusion for Pediatric Autoimmune Hemolytic Anemia in an Emergency Situation Murti Andriastuti; Ni Ken Ritchie; Kartika Anastasia Kosasih; Fakhri Muhammad; Anisa Dwi Fathinasari; Djajadiman Gatot
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Autoimmune hemolytic anemia (AIHA) is often presented with severe anemia. Currently, several centers in Indonesia use washed red blood cells (RBCs) to transfuse AIHA patients. However, washed RBCs are not widely available, causing a delay in therapy. We herein report two cases of pediatric AIHA who presented with severe anemia with hemoglobin level of 4.1 g/dL and 5.3 g/dL. Both patients were delayed for two and five days to be given blood transfusion because of the unavailability of washed RBC in Sorong General Hospital and Fatmawati Hospital and must wait to be referred to RSCM to receive washed RBCs. We conducted literature searches to review several articles that focus on AIHA transfusion management. AIHA is characterized by the production of autoantibodies directed against antigens on the surface of RBCs. RBC washing is not currently required in AIHA patients. It is also not widely available, takes a long time to process, and can cause a delay in emergency cases. Although RBC transfusion is not contraindicated in AIHA, its use should be limited to life-threatening cases of anemia with signs of cardiac and neurological compromises. In emergency cases, ABOmatched and Rhesus-matched RBCs can be safely administered if alloantibodies are reasonably excluded based on the previous transfusion and pregnancy history. ABO-matched and Rh-matched RBC transfusion is safe as AIHA’s transfusion management for patients with severe anemia with clinical symptoms.

Hubungan Diabetes Melitus dengan Kejadian Mortalitas pada Pasien Terkonfirmasi Covid-19 Tahun 2020: Systematic Review Ahda Faza Hunafa; Salman Paris Harahap; Retno Yulianti; Yudhi Nugraha
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

COVID-19 merupakan penyakit saluran napas disebabkan oleh strain coronavirus yang baru ditemukan, yaitu severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Diabetes melitus (DM) diduga meningkatkan keparahan dan angka kematian pasien COVID-19. Pemahaman mengenai COVID-19 disertai DM hingga kini belum lengkap karena penyakit ini terus menyebar dengan cepat. Telaah ini bertujuan untuk mengetahui hubungan DM dengan kejadian mortalitas pada pasien terkonfirmasi COVID-19 tahun 2020 melalui systematic review. Pencarian jurnal dilakukan pada bulan Mei hingga 8 Juli 2020 di pusat literatur publikasi dengan kata kunci “COVID-19” AND “Glycemic Control” OR “Diabetes Control” AND “Mortality” sesuai Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). Telaah kritis dilakukan berdasarkan pedoman instrumen telaah National Heart Lung and Blood Institute and the Research Triangle Institute International. Data diperoleh dari 8 jurnal yang memenuhi kriteria penelitian; dibagi menjadi kategori DM terkontrol dan atau tidak terkontrol. Hasil telaah menunjukkan tingginya persentase kejadian mortalitas pada pasien terkonfirmasi COVID-19 yang disertai dengan DM, terutama lebih tinggi pada kelompok pasien dengan DM tidak terkontrol yaitu 11% dengan nilai risk ratio 2,56. Kata kunci: COVID-19, diabetes melitus, kontrol glikemik, kontrol diabetes, mortalitas. The Correlation between Diabetes Mellitus and Mortality of Patient with Confirmed COVID-19: Systematic Review Abstract COVID-19 is a respiratory disease caused by the new coronavirus strain, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Diabetes Mellitus (DM) is suspected as one of the causes that intensify the number of death of the COVID-19 patients. The literatures for DM in COVID-19 have been updated as the disease swiftly spreading. This study aims to know the relation between DM and the mortality of confirmed patients of COVID-19 in 2020 using systematic review method. Journal searches are conducted from April to July 8th 2020 in publication literature center with keywords “COVID-19” and “Glycemic Control” or “Diabetes Control” and “Mortality” reported in Preferred Reporting Items for Systematic Reviews and MetaAnalyses Protocols (PRISMA-P). Critical appraisal is made based on National Heart Lung and Blood Institute and the Research Triangle Institute International. The data are collected from 8 journals that involved the research criteria (controlled DM and not controlled DM ). This study proved high number of mortality cases of COVID-19 confirmed patients with DM. Uncontrolled DM group has the higher percentage of mortality cases of 11% with a Risk Ratio (RR) of 2.56. Keywords: COVID-19, diabetes mellitus, glycemic control, diabetes control, mortality.

Association Between Active or Passive Smoking and Allergic Rhinitis: an Evidence-Based Case Report: Smoking and Allergic Rhinitis Lupita Reksodiputro; Thalia Mufida; Niken Poerbonegoro; Mirta Hediyati Reksodiputro
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

This evidence-based case report (EBCR) aims to investigate the association between active or passive smoking with allergic rhinitis by summarizing existing studies on the topic. A literature search was done on major databases with keywords related to this study’s research question. The literature was appraised using CEBM University of Oxford for etiology study and systematic review sheets. The search obtained two articles for critical appraisal, includes a meta-analysis and a cohort study. The studies were appraised as valid, important, and applicable to the writer’s setting. Saulyte et al’ s2 article described RR active smoking with allergic rhinitis of 1.02 (95%CI 0.92-1.15), with no significant association. They resolved the heterogeneity by making subgroups. The cross-sectional subgroup with RR 1.09 (95%CI 1.06-1.12) is statistically significant. There was a significant association in passive smoking and obtained RR 1.10 (95%CI 1.06-1.15). In the study by Mlinaric et al4 the RR of active and passive smoking compared to non-smoker are 1.82 and 2.00; both show statistical significance. Both active and passive smoking is associated with a high risk of allergic rhinitis in adults and children. Keywords active smoking, passive smoking, allergic rhinitis. Hubungan Perokok Aktif dan Pasif dengan Rhinitis Alergi: Laporan Kasus Berbasis Bukti Abstrak Pada laporan kasus berbasis bukti ini bertujuan untuk menginvestigasi hubungan antara perokok aktif dan perokok pasif pada pasien dengan rinitis alergi. Dilakukan pencarian literatur menggunakan kata kunci yang berhubungan dengan kasus pada beberapa search engine, kemudian dilakukan penilaian kelayakan dengan lembar appraisal dari CEBM University of Oxford for etiology study and systematic review sheet. Dari pencarian didapatkan dua artikel yang mepresentasikan kasus tersebut, yaitu studi meta analisis dan studi cohort. Studi meta analisis oleh Saulyte et al2 menyatakan RR pada perokok aktif dengan rinitis alergi adalah 1,02 (95%CI 0,92-1,15). Pada subgrup potong lintang didapatkan perbedaan bermakna dengan RR 1,09 (95%CI 1,06-1,12). Pada studi cohort oleh Minaric et al didapatkan RR pada perokok aktif 1,82 dan pada perokok pasif 2,00, keduanya menunjukan angka yang signifikan. Pada perokok aktif dan pasif berhubungan dengan risiko tinggi pada rinitis alergi di pasien dewasa dan anak-anak. Kata kunci: perokok aktif, perokok pasif, rhinitis alergi.

Profil Dehabilitasi Pasien Kusta di Rumah Sakit Kusta Alverno Singkawang: Studi Pendahuluan Sri Linuwih Susetyo Wardhani Menaldi; Valensia Vivian The; Inosensia Diajeng Kusumo; Melani Marissa
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Abstrak Kusta dapat menyebabkan disabilitas permanen yang memengaruhi fisik dan psikis pasien. Stigmadiri dan stigma sosial menyebabkan pasien mengalami dehabilitasi yang dapat menurunkan kualitashidup penyandangnya. Penelitian ini merupakan studi pendahuluan yang bertujuan untuk mendapatkanprofil dehabilitasi pasien kusta termasuk orang yang pernah mengalami kusta (OYPMK). Penelitian inimenggunakan metode potong lintang untuk menilai profil dehabilitasi pasien kusta dan OYPMK menggunakanskala dehabilitasi Anandaraj di RS Kusta Alverno Singkawang, bulan Juli 2019. Delapan puluh delapan subjekdiikutkan dalam penelitian ini. Analisis data dilakukan menggunakan uji Mann Whitney untuk menilai hubungantipe kusta dan derajat dehabilitasi, serta uji Kruskal Wallis untuk melihat hubungan antara reaksi kusta danderajat disabilitas terhadap skala dehabilitasi. Analisis dilakukan menggunakan perangkat lunak SPSS formac. Subjek terbanyak adalah laki-laki, usia produktif, bekerja sebagai petani, berpenghasilan kurang dari 1,5juta per bulan, tidak bersekolah, sudah menikah, etnis Tionghoa, tinggal di dalam rumah yang padat, memilikikeluarga serumah yang menderita kusta, terdiagnosis kusta tipe multibasiler, pernah mengalami reaksi dantelah menyelesaikan pengobatan. Dari penelitian ini didapatkan bahwa tipe kusta dan disabilitas derajat noldan dua berhubungan dengan skala dehabilitasi Anandaraj (p<0.05). Stigma terhadap kusta hingga kinimerupakan masalah yang belum dapat diatasi. Stigma dan disabilitas akibat kusta berperan penting terhadapkejadian dehabilitasi yang menyebabkan penurunan kualitas hidup pasien kusta dan OYPMK. Kata kunci: Anandaraj, dehabilitasi, kusta, Singkawang. Dehabilitation Profile of Leprosy Patients in Alverno Singkawang Hospital: a Preliminary Study Abstract Leprosy causes permanent disability that affects both physical and psychological aspect of the patient.Self-stigma and social stigma cause dehabilitation; therefore, reducing the quality of life of the patients. Thisresearch is a preliminary study to assess the dehabilitation profile of leprosy patients, including people whohave had leprosy (OYPMK). A cross-sectional method was used to assess the dehabilitation scale of leprosypatients in Alverno Leprosy Hospital, Singkawang, using the Anandaraj dehabilitation scale. Eighty-eightsubjects were included in the analysis. Mann-Whitney test was done to analyze the association betweentype of leprosy and dehabilitation scale, and Kruskal Wallis test was done to analyze the association betweenleprosy reaction and grade of disability with dehabilitation scale. Most subjects are male, productive age,farmers, less than 1.5 million wages per month, uneducated, married, Chinese ethnicity, living in a crowdedhouse, had a family with leprosy, diagnosed with multibacillary leprosy, had an episode of leprosy reaction danreleased from treatment. Type of leprosy and WHO disability grade 0 and 2 are related to the dehabilitationscale. Leprosy stigmatization is still a worrisome problem. Together with the disability, stigmatization affectsthe dehabilitation scale of leprosy patients leading to reduced quality of life. Keywords: Anandaraj, dehabilitation, leprosy, Singkawang.

Perilaku Merokok pada Mahasiswa Fakultas Kedokteran dan Fakultas Pertambangan Universitas Papua, Sorong Astrid B Rase; Jamal Zaini; Samuel S Kamalle; Siti Syahral Ain
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Indonesia merupakan salah satu negara dengan prevalensi perokok tertinggi di dunia. Saat ini merokok masih menjadi gaya hidup di lingkungan mahasiswa, tetapi perilaku merokok pada populasi di wilayah TImur Indonesia terutama Papua masih jarang diteliti. Penelitian ini bertujuan untuk mengetahui perilaku merokok pada mahasiswa Fakultas Kedokteran (FK) dan fakultas non-kesehatan (Fakultas Teknik Pertambangan dan Perminyakan/FTPP). Studi ini menggunakan desain studi potong lintang. Pengambilan data dilakukan pada Maret 2019 dengan teknik total sampling dan instrument yang digunakan yaitu kuesioner tervalidasi dari Global Adult Tobacco Survey (GATS) dan Global Youth Tobacco Survey (GYTS). Didapatkan 113 responden mahasiswa FK dan 72 responden mahasiswa FTPP. Perilaku merokok 1 batang setiap hari dalam 30 hari terakhir didapatkan terbanyak pada mahasiswa FTPP (29,8%) dibandingkan FK (7,1%). Ditemukan juga kekerapan kebiasaan yang berpengaruh terhadap kesehatan seperti mengunyah sirih, mengunyah pinang, VAPE bahkan konsumsi alkohol pada populasi baik mahasiswa FK maupun mahasiswa FTPP. Prevalensi merokok, menyirih dan konsumsi alkohol pada mahasiswa fakultas teknik lebih tinggi daripada mahasiswa fakultas kedokteran dan perlu dilakukan penelitian terkait terjadinya gangguan kesehatan dimasa depan. Kata kunci: merokok, menyirih, mahasiswa kedokteran, mahasiswa teknik. Smoking Behavior among Medical and Engineering Students in Universitas Papua, Sorong Abstract Indonesia is among the highest prevalence of cigarette smoking in the world and it is a common lifestyle among undergraduate students. This study aims to measure smoking behaviour among undergraduate medical student and non medical students in West Papua. A cross sectional study with total sampling was done among undergraduate students in Faculty of Medicine and Faculty of Mining Engineering Universitas Papua, Sorong. Global Adults Tobacco Survey (GATS) and Global Youth Tobacco Survey (GYTS) questionnairre were administered with additional question regarding other habits that might be related to addiction such as betel nut chewing, consuming alcohol and vaping. There are 113 medical student and 72 non medical students were recruited. The prevalence of smoking among undergraduate medical students was 7.1% and 29.8% among undergraduate non medical students. Interestingly the prevalence of betel nut chewing is high among non medical students. The prevalence of smoking among undergraduate non medical students is higher compared with medical students in West Papua. The prevalence of betel-nut chewing and alcohol consumption were also high among non medical student and need further study regarding its health risk. Keywords: cigarette smoking, betel nut chewing, medical students, non medical students

Pengaruh Pemberian Ekstrak Plumeria Rubra terhadap Fungsi Ginjal Tikus Model Hiperurisemia Nahdah Aidah; Muttia Amalia; Tuty Rizkianti
eJournal Kedokteran Indonesia Vol 9, No. 2 - Agustus 2021
Publisher : Faculty of Medicine Universitas Indonesia

Kadar asam urat tinggi dapat meningkatkan stres oksidatif di ginjal yang menyebabkan kerusakan glomerulus dan iskemia tubular. Ekstrak bunga kamboja (Plumeria rubra) mengandung kadar flavonoid tinggi yang dapat mencegah stres oksidatif dan menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak P. rubra terhadap fungsi ginjal pada tikus model hiperurisemia. Penelitian dilakukan pada bulan Februari – Maret 2020 di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjajaran Bandung. Desain penelitian adalah eksperimental menggunakan tikus Rattus novergicus sebanyak 30 ekor yang dibagi dalam 5 kelompok dengan 6 tikus pada masing-masing kelompok. Kelompok kontrol terdiri atas kelompok 1 (kontrol negatif) dan kelompok 2 (kontrol positif dengan alopurinol ), kelompok 3, 4 dan 5 yang masing-masing mendapatkan dosis ekstrak P. rubra 200, 400 dan 600 mg/KgBB/hari. Penelitian dilakukan selama 14 hari dengan intervensi pada minggu pertama berupa induksi dan seminggu selanjutnya perlakuan. Sampel darah diambil melalui ekor tikus untuk menilai kadar asam urat dan kreatinin. Data dianalisis dengan uji Kruskall-Wallis. Hasil yang berbeda bermakna terdapat pada dosis 200, 400 dan 600 mg terhadap kadar asam urat (nilai p=0,004, 0,008 dan 0,004) sedangkan pada kreatinin perbedaan bermakna terdapat pada dosis 200 dan 400 mg (nilai p=0,004 dan 0,042). Terdapat penurunan signifikan pada kadar kreatinin setelah pemberian ekstrak P. rubra 400 mg/KgBB/hari yang berarti dapat memperbaiki fungsi ginjal tikus hiperurisemia. Kata kunci: fungsi ginjal, P. rubra, hiperurisemia, potasium oksonat dan antioksidan. The Effect of Plumeria rubra Extract on Kidney Function in Hyperuricemic Rat Model Abstract Hyperuricemia can increase oxidative stress in kidney which will cause glomerular damage and tubular ischemia. Frangipani flower extract (Plumeria rubra) contains high amounts of phenols and flavonoids which can prevent the formation of oxidative stress and can reduce uric acid levels. This study aims to determine the effect of frangipani flower extract on kidney function in white rats induced by potassium oxonate. This research was conducted in February – March 2020 at the laboratory of pharmacology and therapy, faculty of medicine, Universitas Padjajaran, Bandung. The design of this study was experimental using 30 Rattus novergicus rats divided into 5 groups with 6 mice in each group. The control group consisted of group 1 (negative control) and group 2 (positive control with alopurinol ). The treatment group consisted of groups 3, 4, and 5, which were variations in doses of P. rubra extract 200, 400, and 600 mg/KgBB /day. The study was conducted for 14 days with the first week of induction and a week later of treatment. Blood samples are taken through the tail to assess uric acid and creatinine levels. The study was analyzed using Kruskall-Wallis. The results of significant differences were found at doses of 200, 400 and 600 mg of uric acid levels (p-value 0.004, 0.008 and 0.004) while the mean creatinine differences were found at doses of 200 and 400 mg (p-values 0.004 and 0.042). In this study, a significant decrease in creatinine levels after treatment showed that there was an effect of P. rubra extract on kidney function with an effective dose of 400 mg/kg/day. Keywords: kidney function, P. rubra, hyperuricemia, potassium oxonate and antioxidants.

Hubungan Usia, Derajat Ketulian, dan Onset Tuli Mendadak dengan Perbaikan Pendengaran setelah Hyperbaric Oxygen Therapy Savira Chrisna; Pritha Maya Savitri; Yanti Harjono
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Tuli mendadak adalah penurunan pendengaran sensorineural 30 dB pada tiga frekuensi berturut-turut dalam waktu 72 jam. Penatalaksanaannya dengan terapi steroid dan adjuvan hyperbaric oxygen therapy. HBOT yaitu seseorang bernapas dengan oksigen 100% di dalam ruang udara bertekanan lebih dari 1 ATA. Tujuan terapi adalah meningkatkan tekanan parsial oksigen dan memaksimalkan oksigenasi di dalam koklea sehingga tercapai perbaikan pendengaran yang ditentukan oleh faktor prognostik. Penelitian ini bertujuan untuk mengetahui hubungan usia, derajat, ketulian, dan onset tuli mendadak dengan perbaikan pendengaran setelah HBOT di Rumah Sakit Angkatan Laut Dr. Mintohardjo tahun 2016-2019. Desain studi potong lintang 36 pasien tuli mendadak. Faktor usia tidak dapat dinilai karena datanya konstan. Hasil uji Fisher menunjukkan tidak ada hubungan derajat ketulian dengan perbaikan pendengaran (p = 0,307). Onset tuli mendadak sebagai faktor prognostik tidak hubungan dengan perbaikan pendengaran (p = 0,559). Derajat ketulian dan onset tuli mendadak disebut faktor prognostik baik terhadap perbaikan pendengaran pasien tuli mendadak yang diterapi HBOT, tidak menunjukkan hubungan. Kata kunci: Usia, derajat ketulian, onset, tuli mendadak, HBOT. Relationship between Age, Degree of Hearing Loss, and Onset of Sudden Deafness with Hearing Improvement after Hyperbaric Oxygen Therapy Abstract Sudden deafness is sensorineural hearing deterioration of at least 30 dB in 3 sequential frequencies occuring within 72 hours. Management of sudden deafness is steroid and hyperbaric oxygen therapy HBOT as adjuvan therapy. HBOT is a therapy in which a person breathes with 100% oxygen in a compressed air space of more than 1 ATA. The therapy is intended to increase the parsial oxygen pressure and improve oxygenation in the cochlea so the hearing improvement is achieved, which determined by prognostic factors. This aim of this study is to determine the relationship between age, degree of hearing loss, and onset of sudden deafness with hearing improvement using HBOT at Dr. Mintohardjo Naval Hospital in 2016-2019. The cross-sectional study design was used in this research of 36 sudden deafness patients. Age cannot be assessed because the data is constant. Fisher's test results showed no relationship with the degree of hearing loss on hearing improvement with p = 0.307. Onset of sudden deafness as a prognostic factor showed no relationship with hearing improvement with p = 0.559. The degree of hearing loss and onset of sudden deafness which is referred to as a good prognostic factor for hearing improvement in sudden deafness treated with HBOT did not show any relationship. Keywords: age, degree of hearing loss, onset, sudden deafness, HBOT.

The Role of Cognitive Reserve as Measured by Cognitive Reserve Index Questionnaire Indonesia Version in Geriatric Delirium Cases Profitasari Kusumaningrum; Dewanto Andoko; Charles Evert Damping; Martina Wiwie Setiawan Nasrun
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Delirium is often associated with factors that worsen the condition and prognosis of a person's health. The Cognitive Reserve Index questionnaire Indonesia version (KICK) is a questionnaire that quantifies the cognitive reserve (CR) into a single index. This study aims to obtain an instrument to assess CR, namely KICK, and test its validity and reliability and finding the role of CR in geriatric delirium cases. The study was conducted in the integrated geriatric outpatient and acute geriatric inpatient of Cipto Mangunkusumo Hospital on June 2019 to September 2019, by validity testing and case control study in geriatric delirium cases to 33 subjects with delirium and 33 controls. Content validity test was carried out through a panel test with the conclusion that KICK is relevant for use as an instrument to examine CR. The construct validity of the three variables showed significant correlation with total score with p-value <0,001). Reliability test showed Cronbach’s Alpha of 0,688. Significant differences in CR score of delirium versus control (p<0,01) with OR 9 (95% CI 2.86 to 28.22).KICK is valid and reliable to measure CR of Indonesian elderly and patients with low CR score have a higher chance of developing delirium.

Cancer Epidemiology Based on Hospital-Based Cancer Registry at National Referral Hospital of Indonesia, 2013 Soehartati Gondhowiardjo
eJournal Kedokteran Indonesia Vol 9, No. 1 - April 2021
Publisher : Faculty of Medicine Universitas Indonesia

Cancer is the primary cause of death in developed or developing country. To develop hospital policy and research, comprehensive epidemiological data are needed. This research aims to provide epidemiological and demographical profiles of cancer from a hospital-based cancer registry (HBCR) at Cipto Mangunkusumo Hospital in 2013. This is a descriptive study involving cancer patients based on the HBCR from January-December 2013. Cancer frequency at the hospital in 2013 was 4,915 cases, with the majority of the patients were 45-54 years old, regardless of their sexes. Sex ratio was 3:2 for women and men, respectively. The most frequent age of female patients was 45-54 years old, while for male patients was 55-64 years old. In 2013, the hospital served more cancer patients from outside Jakarta than from Jakarta itself. Breast cancer, cervical cancer, and hematopoietic and reticuloendothelial systems cancer were the most prevalent types of cancer in women. Additionally, hematopoietic and reticuloendothelial systems cancer, nasopharyngeal cancer, and lymphoma were the most prevalent types of cancer in men. Most breast and cervical cancers came in either locally advanced or advanced stage. Histopathological examination revealed that most prevalent types of cancer were Infiltrating duct carcinoma of breast, nonkeratinized squamous cell carcinoma of cervix, and acute lymphoblastic leukemia. Keywords: hospital-based cancer registry, epidemiology, histopathology, staging, demography. Epidemiologi Kanker Berdasarkan Registrasi Kanker Berbasis Rumah Sakit di Pusat Rujukan Nasional Indonesia, 2013 Abstrak Kanker merupakan penyebab kematian utama pada negara maju maupun berkembang. Untuk menentukan arah kebijakan rumah sakit dan penelitian, diperlukan data komprehensif mengenai epidemiologi kanker. Penelitian ini bertujuan untuk memberikan gambaran profil epidemiologi dan demografi kanker di Rumah Sakit Cipto Mangunkusumo berdasarkan Registrasi Kanker Berbasis Rumah Sakit (HBCR) tahun 2013. Studi ini menggunakan desain deskriptif yang melibatkan semua pasien kanker berdasarkan data HBCR. pada Januari-Desember 2013. Frekuensi kanker di RSCM pada tahun 2013 adalah 4,915 kasus, dengan mayoritas pasien berusia 45-54 tahun, baik jenis kelamin wanita ataupun pria. Rasio jenis kelamin perempuan dibandingkan laki-laki adalah 3:2. Rentang usia paling sering pada pasien wanita adalah 45-54 tahun, sedangkan pada laki-laki adalah 55-64 tahun. Pada tahun 2013, RSCM lebih banyak melayani pasien kanker dari luar Jakarta dibandingkan dari Jakarta. Kanker payudara,serviks dan kanker darah dan sistem retikuloendotel merupakan jenis kanker tersering pada perempuan. Sebagai tambahan, kanker darah dan sistem retikuloendotel, nasofaring dan kegasanan kelenjar getah bening (limfoma) merupakan kanker tersering pada laki-laki. Sebagian besar kanker payudara dan serviks datang dengan stadium lokal lanjut atau lanjut. Pemeriksaan histopatologi menunjukkan bahwa tipe patologi kanker tersering adalah karsinoma duktal invasif pada kanker payudara, karsinoma sel skuamosa tidak berkeratin pada kanker serviks, dan leukemia limfoblastik akut. Kata kunci: Registrasi kanker berbasis rumah sakit, epidemiologi, histopatologi, stadium, demografi.

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Home Page

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Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Saleha Sungkar

Contact Email
ejki.fkui@ui.ac.id

Phone
+6282123550275

Journal Mail Official
ejki.fkui@ui.ac.id

Editorial Address
Departemen Parasitologi FKUI Jl. Salemba Raya No. 6 Jakarta Pusat

Location
Kota depok,

Jawa barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Saleha Sungkar

Contact Email ejki.fkui@ui.ac.id

Phone +6282123550275

Journal Mail Official ejki.fkui@ui.ac.id

Editorial Address Departemen Parasitologi FKUI Jl. Salemba Raya No. 6 Jakarta Pusat

Location Kota depok, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Saleha Sungkar

Contact Email
ejki.fkui@ui.ac.id

Phone
+6282123550275

Journal Mail Official
ejki.fkui@ui.ac.id

Editorial Address
Departemen Parasitologi FKUI Jl. Salemba Raya No. 6 Jakarta Pusat

Location
Kota depok,

Jawa barat

INDONESIA