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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 5 Documents
 1 
Search results for , issue "Vol. 11, No. 2" : 5 Documents clear
Challenges and Future Perspective of Gastroretentive Mucoadhesive Dosage Forms Akbar, Rayhan; Setiawan, Heri; Maggadani, Baitha Palanggatan; Iswandana, Raditya; Setio Putri, Kurnia Sari
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. This literature review is performed by searching Google Scholar, PubMed, and ScienceDirect and Google Patents using the terms “gastroretentive”, “mucoadhesive”, “challenge”, “strategy”, and “patent.” Additionally, searches were conducted in the US FDA and INA FDA Drug Approval Databases. Based on our study, we identified numerous challenges in developing GMDF, including patient physiological challenges, drug formulas, production processes, product analysis, and clinical trials. To address these challenges, multiple strategies should be developed to optimize the formulation, production process, and product analysis of GMDF, ultimately leading to successful clinical trials and regulatory approval of this product.
Harnessing the Potential of Several Local Indonesian Tuber-derived Starches as Pharmaceutical Excipients Horison, Ronald; Surini, Silvia
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations with distinct functional properties influenced by the natural starch granules’ properties and amylose-amylopectin ratio. Previous research utilizing natural and modified starches from these tubers has demonstrated their potential in pharmaceutical formulation. These starch tubers have been studied and provided promising results in tablet formulation and film development. Additionally, they could be involved in developing more advanced dosage forms, such as starch nanoparticles and nanocrystals. The rich versatility of these tuber starches solidified a promising future for their development, offering significant advantages for both pharmaceutical technology and economic value perspectives. Optimization of the starch yield, mainly through extraction, is crucial to fully realizing the economic prospect of tuber-derived starches.
Recent Updates on Dried Blood Spot and Volumetric Absorptive Microsampling as Microsampling Technique for Antiepileptic Drug Determination: A Systematic Review Pridilla, Asmiladita; Harahap, Yahdiana; Purwanto, Denni Joko; Maggadani, Baitha Palanggatan
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose of this review article. A total of 342 articles were identified from databases. From 8 primary studies included, analytical methods for 21 drug compounds as antiepileptic agents and 4 of their metabolites in DBS and VAMS were found. A summary of sample preparation, analytical method, and validation were presented in the narrative form of this review. Concentrations measured using DBS and VAMS demonstrate a strong correlation with conventional matrices; however, conversion factors based on the blood-to-plasma ratio are necessary for accurate comparison. Additionally, the comparison results between DBS and VAMS technique for TDM is still unsatisfactory to prove their interchangeability. Therefore, this comparison needs further evaluation with more samples and more analytes. Analysis of antiepileptic drugs using VAMS is also still limited and further optimization can be carried out to produce more stable, sensitive, fast, and suitable for TDM practice.
Application of PVP VA 64 and Poloxamer 188/407 in Solid Dispersion Technology for Improving Solubility of Valsartan Cahyani, Sulastari; Saifullah Sulaiman, Teuku Nanda; Laksitorini, Marlyn Dian
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve the solubility of valsartan using a solid dispersion system. Polyvinylpyrrolidone/vinyl acetate 64 (PVP VA 64), a hydrophilic polymer, was incorporated to inhibit the recrystallization of valsartan, while poloxamer 188 and poloxamer 407, used as surfactants, aimed to enhance valsartan’s solubility and intrinsic dissolution rate. Valsartan solid dispersions were prepared using the spray drying method, and the optimal formulation was determined using the Simplex Lattice Design (SLD). The composition of PVP VA 64, poloxamer 188, and poloxamer 407 were optimized factors, while saturated solubility, melting point, and intrinsic dissolution rate at pH 1.2 and 4.5 as optimized responses. The valsartan solid dispersions were characterized using Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) spectroscopy, Powder X-Ray Diffractometry (PXRD), and Scanning Electron Microscopy (SEM). The optimal composition of the valsartan solid dispersion was 40 mg of valsartan, 100 mg of PVP VA 64, 10 mg of poloxamer 188, and 30 mg of poloxamer 407. The results indicated that the solubility of valsartan solid dispersion was 27 times higher than that of the pure drug. Furthermore, the intrinsic dissolution rate of the valsartan solid dispersion at pH 1.2 and 4.5 exceeded that of pure valsartan.
Biosynthesis of AgNPs Mediated by Equisetum debile Roxb. Herb Water Extract and Its Potency as an Antioxidant Retnaningtyas, Yuni; Karmilasari, Alviani Dwi; Puspitasari, Endah
Pharmaceutical Sciences and Research Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Silver nanoparticles (AgNPs) are metal nanoparticles currently under development. AgNPs are recognized for their remarkable stability, low reactivity, and advantageous biological properties, including antioxidant activity. Phenolic compounds derived from the Equisetum debile Roxb. (Ed-R) herb have the potential to be explored as bio-reduction and capping agents in the synthesis of silver nanoparticles. The primary objective of this study is to synthesize AgNPs using a water extract from Ed-R herb and to assess their antioxidant activity. The optimal composition for the biosynthesis of AgNPs comprises 10% Ed-R water extract, 8.0 mM AgNO3, and deionized water in a ratio of 0.5:20:12 (v/v/v), with the mixture incubated for 60 minutes at 50°C. AgNPs were characterized by conducted using UV-Vis Spectrophotometry, FT-IR, Scanning SEM, and PSA. The total phenolic content (TPC) of the Ed-R herb water extract at the optimal concentration (10%) was determined to be 61.503 ± 0.089 mg GAE 100 mL-1. The characterization results indicated that the AgNPs exhibited a spherical morphology, with a particle size of 67 nm, a polydispersity index (PDI) of 0.424, a maximum wavelength of 423 nm, and an absorbance value of 1.397. The antioxidant activity of AgNPs was evaluated using the DPPH method, resulting in an IC50 value of 76.604 ± 0.846 μg mL-1, which signifies strong antioxidant activity. These findings suggest that the water extract from the Ed-R herb can effectively act as both bioreduction and capping agent in the synthesis of AgNPs, which demonstrates significant antioxidant properties.

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