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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 11 Documents
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Search results for , issue "Vol. 2, No. 3" : 11 Documents clear
Peranan Bioteknologi Dan Mikroba Endofit Dalam Pengembangan Obat Herbal Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Plants have been the chief source of compounds of medicine for thousand of years. Plants are also the source of many medicines for the majority of the worldÂ’s population. The role of biotechnology is very important for multiplying, conserving the spesies, and enhancing the production of secondary metabolites. Endophytes are microbes that inhabit plants are currently considered to be a wellspring of novel secondary metabolites offering the potensial for medical and industrial exploitation. Natural products from various endophytic microbes have been investigated. Some examples of natural products observed from endophytic microbes are antibiotics, antiviral compounds, anticancers, antimalarial compounds, antioxidants, antidiabetics, and immunosuppressive compounds.
Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia SP Dari Kepulauan Seribu Hanani, Endang
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 µg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group.
Pengobatan Sendiri Sakit Kepala, Demam, Batuk Dan Pilek Pada Masyarakat Di Desa Ciwalen, Kecamatan Warungkondang, Kabupaten Cianjur, Jawa Barat Supardi, Sudibyo; Notosiswoyo, Mulyono
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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The self-medication is an effort conducted by the community to cure theirselves using medicine, traditional medicine or others without health proffesional advice. The aims of this study are to know healthy – illness concept, to know local language, symptoms, cause, prevention and curation of headache, fever, cough and common cold, and the self- medication practice on the village community. This study using qualitative design and data was collected by depth interviewing from 12 key informans at Ciwalen village, Warungkondang sub-district, Cianjur district, West Java, in 1998. Key informans are the chief of RT, the chief of RW, the teachers of elementary school, the health cadres, and the housewives. Data were analyzed using triangulation methode and confirmating the interview result to the key informans. The conclussion of this study are The healthy-illness concept does not only physical aspect, but also social culture aspect. The light illness - heavy illness concept depends on the physical condition of patient, the daily activity and the medication. The community use generally local language nyeri sirah for the headache, muriang for the fever, gohgoy for the cought and salesma for the common cold. The cause of illness is commonly their physical environment, include bacteria for the cought. The prevention of illness is generally conducted by avoiding its cause. The self-medication practice generally use the medicine that were bought from the retail at their village, some of them use the traditional medicine. Reason of self-medication practice are light illness, inexpensive, time eficiency, and as a first aid before going to the health proffesional or health center. The self-medication practice is improperly done, because the community mostly bought a small amount of medicine, so that the brochure of the medicine can not be read.
Perbandingan Pelepasan Propranolol Hidroklorida Dari Matriks Kitosan, Etil Selulosa (EC) Dan Hidroksi Propil Metil Selulosa (HPMC) Sutriyo, Sutriyo; Djajadisastra, Joshita; Indah, Rosari
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Chitosan is a polycatonic biopolymer that can form gel in acidic environment so that can be used as a hydrophilic matrix in controlled release drug delivery system. In this research, propranolol hydrochloride controlled release granule was made in chitosan matrix. Granules were made by wet granulation method with variety of matrices, i.e. chitosan, hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC). HPMC and EC were used as a comparing matrix. The release rates of propranolol HCl from matrix were determined by using dissolution apparatus type I with 50 rpm stirring rotation in acidic media of pH 1,2 and base media of pH 7,5 for 8 hours. Sample was taken at certain time and the samples were analyzed by spectrophotometer. The result showed that the release of propranolol hydrochloride from chitosan matrix was the slowest compared to the other matrices.
Optimasi Penetapan Kadar Akrilamida Yang Ditambahkan Ke Dalam Keripik Kentang Simulasi Secara Kromatografi Cair Kinerja Tinggi Harahap, Yahdiana; Harmita, Harmita; Simanjuntak, Binsar
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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A method by high performance liquid chromatography for the analysis of acrylamide in potato chips, is reported. The retention time for the elution of acrylamide from the C18RP column ranged from 3 to 3,2 minutes, and the eluate was analyzed by UV-VIS detector. A linear response was found for the acrylamide standard tested within the concentration range of 0,8 – 10µg/ml and the corelation coefficient (r) greater than 0,999, with detection limit 0,06 ppm and quantitative limit 0,19 ppm. Sample preparation was performed by means of solvent extraction using dichlormethane and subsequent re-extraction of the organic solvent with water. This aqueous sample solution was found to be free of any interferences and gave acrylamide and recorveries higher than 90%.
Evaluasi Pelaksanaan Prosedur Pelayanan Obat Pelengkap Oral Di Ruang Rawat IRNA B Perjan RS Dr. Cipto Mangunkusumo Jakarta Harianto, Harianto; Lestari, Itet; B, Laswety
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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A research had been performed in order to get general description of the service of an oral complementary drug in the nursing ward of IRNA B of Perjan RS Dr. Cipto Mangunkusumo and it evaluated the operation of the oral complementary drug service was, and also found out the correlation of the orderly medication instruction writing of the oral complementary drug, the orderly operation of the process of the oral complementary drug procurement, drug preservation, drug preparation, the hand-over the oral complementary drug to a patient, and Communication, Information and Education (CIE) in the nursing ward of IRNA B relation to the orderly operation of oral complementary drug service procedure. The research used the cross sectional method of survey which was descriptive and analytic in its nature. The research showed that 74,81% of the patients medication instruction writing in prescription did not fit the requirements in administration writing and medication information completely. 67,94% of the patients bought the prescription (76%-100%) form the drug store in RSCM, 42,75% of patients kept the 76%-100% of their drug in the pharmacy depot, 42,75% of patients prepared the 76%-100% of patient prepared the 76%-100% of their drug in unites of doses by the pharmacy depot. 64,12% of the patients were given their drug by nurses directly, and finished to swallow the drug according to its use direction, and there was none of the patients who got CIE service from a pharmacist. The operation of the oral complementary drug service in the nursing ward of IRNA B was evaluated as less appropriate to the procedure. It could be concluded that there is significant correlation between medication instruction writing, the orderly operation of the process of the oral complementary drug preservation, the drug preparation, the hand-over the oral complementary drug to a patient in the nursing ward of IRNA B with the orderly operation of oral complementary drug service procedure; and there is no correlation between the procurement of the oral complementary drug, the orderly operation of CIE in the nursing ward of IRNA B with the orderly operation of oral complementary drug service procedure.
Evaluasi Kadar Kurkumin dalam Jamu Tradisional Kunir Asam yang Dijual di Pasar Kota Gede Bulan Februari 2015 Yusuf, Fitrilya Mustikahati; Nurkhasanah, Nurkhasanah
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Abstract

Javanese women often consume kunir asam to relieve dysmenorrhea symptom. It is a traditional herbal medicine which is conventionally prepared from curcuma domestica. One of the active compound of curcuma domestica is curcumin. The purpose of this research is to determine the amount of curcumin available in kunir asam selling in daily market of Kota Gede. Curcumin level in daily batches consistency was also evaluated. Curcumin analysis was conducted by qualitative and quantitative tests by TLC densitometry method. A total of 50.0 ml kunir asam was extracted with 25.0 ml of chloroform, and then the mixture was dried by evaporation. The dried residue of extract was then reconstituted in 5.0 ml of 96% ethanol. 5 μl of sample supernatant and standard solutions spotted on the plates of silica gel 60 F254 that has been activated previously. The organic solvent mixture comprise of chloroform: ethanol: glacial acetic acid (94:5:1) was used as the mobile phase for elution, and the spots were then analyzed by using densitometry at wavelength of 425 nm. Curcumin levels was calculated by inputting the size of spot area data into the standard curve linear regression equation of curcumin concentration versus the size of spot area. The data analysis was performed by normality test Kolmogorov-Smirnov test, Levene test of homogeneity followed by Post Hoc / Test LSD (Least Significant Difference) or Mann Whitney. TLC analysis conducted on four samples of “kunir asam” displayed a disparities on the curcumin level between the three days of sampling in a row. Statistical analysis of the curcumin content in traditional herbal medicine of “kunir asam” samples showed that the levels were not consistent in the three days of the examination. Curcumin levels in all four samples were also shows a significant difference in variations.
Toksisitas Ekstrak Etanol Mangifera foetida L. sebagai Pengkelat Besi Ditinjau dari LD50 dan Komponen Sel Darah Wahyuni, Tri; Sari, Santi Purna; Estuningtyas, Ari; Freisleben, HJ
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Abstract

Ethanolic extract of bacang mango leaves (Mangifera foetida L.) decreased iron concentration in blood Sprague dawley rats that had been induced iron overload. The aim of this experiment was to determine acute toxicity (LD50) value of ethanolic extract of M.foetida by weil method and its effect to blood component. This study was conducted by employing a complete random design using 25 male and 25 female mice of DDY strain which devided into 5 groups. The first group until fourth group were administered ethanolic extract of M.foetida with dose variation which suspension in aquadest orally. The fifth group was control that administered aquadest. The LD50 was determined by the total of death on all group. LD50 value of the extract showed no death in the biggest doses (13.013 g/kg). The examination was continued with measured blood count (erythrocites, trombocytes, leukocytes, and haemoglobin concentration). It was shown that the extract at dose 1.626; 3.253; 6.506 and 13.013 g/kg unchanged the blood count measurement.
Pengaruh Kandungan Komponen Minor dari Minyak Kelapa Sawit (Elaeis guineensis Jacq.) Terhadap Aktivitas Antioksidan pada Proses Pemurnian Karotenoid Sinaga, Ahmad Gazali Sofwan; Siahaan, Donald
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Abstract

Palm oil contains carotenoid and vitamin E which possess antioxidant properties. A long exposure of heat and chemical substances during the purification process may lower antioxidant activity. This research was conducted to compare antioxidant activity of carotenoid and vitamin E obtained from each stage of three continuous purification process (transesterification, solvolytic micellization, and saponification). Total carotenoid concentration was analyzed by UV-visible spectrophotometer at λ 446 nm and total vitamin E concentration was analyzed by high-performance liquid chromatography, while ester and triglyceride concentration were analyzed by gas chromatography. Antioxidant activity was measured by DPPH assay with incubation time in 60 minutes. The highest concentration of carotenoid (229,968 mcg/ml) was extracted from saponification process, yet the highest concentration of vitamin E (97.64 mcg/ml) was extracted from transesterification process. The highest antioxidant activity of carotenoids and vitamin E was obtained from the transesterification process, while other processes had lower antioxidant activity, so it can be concluded that exposure to heat and excessive chemical substances couldimpact on antioxidant activity.
Evaluasi Aktivitas Antioksidan Senyawa 4-[(E)-2-(4-okso-3-fenilkuinazolin-2-il)etenil]-benzensulfonamida dan Analognya Jatmika, Catur; Maggadani, Baitha Palanggatan; Hayun, Hayun
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Abstract

Quinazolinone derivative compounds exhibit a broad spectrum of biological activity, including antioxidant. Quinazolinone derivative compound 4-[(E)-2-(4-oxo-3-phenyl quinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs (2a-f) have been synthesized and demonstrated its activity as a selective inhibitor of cyclooxygenase-2. The aim of this research was to evaluate the antioxidant activity of compound 4-[(E) -2-(4-oxo-3-fenilkuinazolin-2-yl)ethenyl]-benzensulfonamida and its analogs with DPPH radical scavenging method, ferric reducing activity potential (FRAP), and phosphomolybdenum method. The experiment revealed that the % inhibition and antioxidant capacity of compound 2c, 2e and 2f were higher compared to compound 2a, 2b and 2d. The DPPH radical scavenging analysis found that the % inhibition of compound 2c, 2e and 2f at high concentration of compound solution (1000 µg/mL) were 4.8 %, 3.46 %, and 3.68 %, respectively. While the total antioxidant capacity of compound 2c, 2e and 2f were recorded 37.93, 33.4, and 46.3 µg ascorbic acid equivalence/mg of compound, respectively. However the antioxidant activity of all synthesized compounds (2a-f) were lower than the standard ascorbic acid.

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