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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 13 Documents
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Search results for , issue "Vol. 6, No. 1" : 13 Documents clear
Penelitian Bahan Pencerah dan Pelembab Kulit dari Tanaman Indonesia Wih, Wong Lip; Ranti, Anna S; Wasitaatmadja, S M; Suryaningsih, Suryaningsih; Junardy, F D; Maily, Maily
Majalah Ilmu Kefarmasian Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

The market of skin lightening product grows very fast. This is especially true in almost all Asian countries. Martha Tilaar Innovation Center has found natural ingredients which function as anti oxidant and anti tyrosinase in vitro. These ingre-dients are extracted from Indonesian plants namely Lansium domesticum (LE)*) and Phyllantus niruri (PE) *). Several aspects should be considered to utilize these ingredients in cosmetic, such as, the stability of the plant materials and their safety and efficacy on human skin. The objective of this research is to study whether these ingredients in cosmetic preparations have skin lightening and skin moisturizing effects clinically. This article will describe the safety and efficacy evaluation on natu-ral ingredients extracted with ethanol from the above Indonesian plants. The safety evaluation is conducted clinically using Repeated Opened Patch Test (ROPT) and followed by Single Closed Patch Test (SCPT) in more than 50 selected healthy volun-teers. Their irritation properties on mucous membrane were evaluated using HETCAM method. Then, their efficacies on lightening and moisturizing were conducted in more than 26 volunteers, using Mexameter MX 16 and Corneometer CM 820. These results revealed that both extracts are safe on human skin and mucous membrane and can function as skin lightening agent. Lansium domesticum extract also has skin moisturizing effect.
Antibakteri Ekstrak Kulit Batang Manggis Hutan (Garcinia rigida miq.) Elya, Berna; Soemiati, Atiek; Farida, Farida
Majalah Ilmu Kefarmasian Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

A research on the antibacterial activity of n-hexane extract and the ethyl acetate Garcinia rigida Miq. Bark against Salmonella typhosa ATCC 14028, Staphylo-coccus aureus ATCC 29213 dan Bacillus subtilis ATCC 6633 has been carried out. The research was included the determination of the growth inhibition zona with the cylinder diffusion method and the minimum inhibitory concentration with the petri dish dilution method. The result of this study showed that the n-hexane extract of Garcinia rigida Miq.bark did not give the growth inhibition zona to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633, but gave the minimum inhibitory concentration at 500 mg/ml for Sal-monella typhosa ATCC 14028, 250 mg/ml for Staphylococcus aureus ATCC 29213 and 125 mg/ml for Bacillus subtilis ATCC 6633. Whereas the ethyl acetate extract of Garcinia rigida Miq. bark gave the growth inhibition zona of concentra-tion 500, 250 and 125 mg/ml with average diameter to Salmonella typhosa ATCC 14028 were about 11.15, 9.05, 7.55 mm, to Staphylococcus aureus ATCC 29213 were about 14.25, 11.10, 8.95 mm and to Bacillus subtilis ATCC 6633 were about 20.97, 15.00, 10.07 mm. The minimum inhibitory concentration to ethyl acetate extract to Salmonella typhosa ATCC 14028, Staphylococcus aureus ATCC 29213 and Bacillus subtilis ATCC 6633 were about 250, 62,5 and 31,25 mg/ml respec-tively. As a conclusion, the ethyl acetate extract of Garcinia rigida Miq. bark had more better antibacterial activity than the n-hexane extract of Garcinia rigida Miq. Bark.
Pembuatan Mikroemulsi Dari Minyak Buah Merah Jufri, Mahdi; Djajadisastra, Joshita; Maya, Ledy
Majalah Ilmu Kefarmasian Vol. 6, No. 1
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Abstract

Red fruit oil (Pandanus conoideus) is a natural product typicaly from Papua used as a medication for some disease, as a food supplement, and for beauty skin care. But this advantages are not supported by an appropriate dosage form. Oils are difficult to dissolve in GIT and difficult to penetrate the human skin, slower the absorption then. Microemulsion is a dispersion system which can help to solve the problems by enhanc-ing the oil solubility in GIT and the oil penetration through the skin. The objective of this study is to formulate a clear and stabile microemulsion. Microemulsion will be physically evaluated for 2 months. The material composition is 5% glycerin and 15% sorbitol as the cosolvent, and 20% , 30%, and 40% tween -20 as the surfactants. The result showed that formula of 40% tween-20 gave a good microemulsion which is physically stable as long as 2 months stored at room temperature.
Vaksin DNA: Vaksin Generasi Keempat Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 6, No. 1
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Abstract

Vaccines have been developed for a range of different infectious diseases. The complex-ity of microbial infections requires novel approaches to vaccine design. The first-generation of vaccines were live attenuated pathogens. Because of safety concerns, the second-generation of vaccines, chemically or physically inactivated pathogens were later developed. Purified or synthetic proteins represent a third generation, and recent advances in molecular biology and genetic engineering have led to the development of the fourth vaccine generation, which includes DNA and virus vector-based vaccines. This review discusses on the genetic elements and construction of DNA vaccines, comparison of DNA vaccines and conventional vaccines, the benefits and limitations of DNA vaccines, and the advances of genetic vaccine development over the last decade.
Karakterisasi Ekstrak Etanolik Daun Asam Jawa (Tamarindus indica L.) Munim, Abdul; Hanani, Endang; Rahmadiah, Rahmadiah
Majalah Ilmu Kefarmasian Vol. 6, No. 1
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Abstract

Leaves of tamarind (Tamarindus indica L.) has been traditionally used to treat some diseases such as: constipation, dyspepsia, flatulence and urinary tract infection. The leaves extract also reported has antibacterial and antidiabetic activities. It is essential to determine its specific and non specific parameters in assesing the quality and safety. The samples collected from three different perferctures. Grounded samples were macerated with ethanol. The extracts were subjected to determine its characteristic parameters. Parameter of quality for the extracts consisted of water content, ethanol-extractive, water-extractive, loss on drying, total ash, acid-insoluble ash, solvent residue and heavy metal content. Phytochemical identification showed that the ex-tract contains flanovoid, tannin, glycosides, and saponin. TLC chromatogram using chloroform-methanol-water (80:12:2) as mobile phase, exhibited 4 spots after sprayed with iron(III) chloride. Total phenolic was determined pectrophotometrically using Folin Ciocalteu reagent, gave 0.35-8.24% total phenolic as gallic acid.
Kajian Narrative terhadap Profil Farmakokinetik Antibiotik pada Pasien Kritis: Implikasi terhadap Ketercapaian Target Farmakokinetik-Farmakodinamik Setiawan, Eko; Widyati,; Marpaung, Ferdy Royland; Sukandar, Edy; Susaniwati,; Lukas, Dwi Lily; Wijono, Heru; Warindra, Taufin; Kurniawan, Roni; Wibowo, Tjipto; Hendradi, Wahyu; Costa, Menino Osbert; Aziz, Mohd-Hafiz Abdu; Roberts, Jason
Pharmaceutical Sciences and Research Vol. 6, No. 1
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Abstract

The severity of diseases, the complexity of treatment, and the use of medical devices in the intensive care unit (ICU) may change the pharmacokinetics (PK) profile of antibiotics among critically ill patients.This narrative review aims to explain the PK profile of critically ill patients compared to other group of patients and to describe the pharmacokinetic-pharmacidynamic (PK-PD) target attainment among this group of patients. Only articles published less than 10 years ago were included in this narrative review. Evidences have indicated that critically ill patients have relatively larger volume distribution (Vd) of hydrophilic antibiotics compared to patients with stable conditions. The fluid shifting to interstitial space, hypoalbuminemia, and aggressive fluid treatment may contribute to the increase value of Vd in critically ill patients. The clearance (CL) of hydrophilic antibiotics in critically ill patients is highly determined by dynamic changing of renal function compared to patients in other wards. The phenomenon of augmented renal clearance and the use of high intensity of renal replacement therapy can increase the CL of hydrophilic antibiotics. The different PK profile of antibiotics may lead to the failure of attaining the PK-PD target if the dose of antibiotics is not adjusted according to such differences
Analisis Potensi Interaksi Obat Golongan Antidepresan pada Pasien Skizofrenia di Rumah Sakit Jiwa Dr. Soeharto Heerdjan Tahun 2016 Puspitasari, Atika Wahyu; Angeline, Loranda
Pharmaceutical Sciences and Research Vol. 6, No. 1
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Schizophrenic patients who used antidepressant combination drug therapy in their treatment can cause drug interaction. This study aimed to determine the potential drug interactions of antidepressant in schizophrenic patients. The study designed was cross-sectional by random sampling. The samples were secondary data from outpatient prescriptions and medical record of schizophrenic patients in Psychiatric Hospital Dr. Soeharto Heerdjan during 2016. From 743 drug prescriptions, it was found that 694 (91.41%) drug prescriptions having 1286 (61.24%) cases of drug interaction. The most common interaction were fluoxetine and risperidone in 376 cases (29.24%). The proportion based on interaction level was 1246 cases (96.89%) for severe, 34 cases (2.64%) for moderate, and 6 cases (0.47%) for minor. The study concluded that antidepressant prescribing needs to be closely monitored because of high incidence in drug interactions or modified when the negative impact was greater than the positive impact.
Improvement of Losartan Transdermal Permeation using Oleic Acid Pretreatment: in Vitro Observation and in Vivo Prediction Binarjo, Annas; Nugroho, Akhmad Kharis
Pharmaceutical Sciences and Research Vol. 6, No. 1
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The effect of oleic acid on losartan transdermal permeation has been observed to explore its ability as chemical enhancer. Potassium losartan solutions in citric buffer pH 5.0 were made in two levels of concentration i.e. 2 mg/mL and 10 mg/mL using propylene glycol 15% as solubilizing agent. Losartan transport from such solutions with and without oleic acid one hour pretreatment were tested using male Wistar rat skin as a membrane for 30 hours in vertical diffusion sel. The transport profiles were analyzed based on the lag time diffusion method. It is showed that oleic acid pretreatment did not effect on losartan permeation rate and efficiency of 2 mg/mL potassium losartan concentration. However, such pretreatment enhanced losartan permeation rate and efficiency 21 and 23-fold higher respectively for 10 mg/mL the potassium losartan concentration. It is predicted that losartan minimum effective plasma concentration can be achieved in transdermal administration through this transport improvement in normal application area.
The Effectiveness of Clinical Pharmacist Intervention in Reducing Drug Related Problems of Childhood Acute Lymphoblastic Leukemia Patient in Tangerang District General Hospital, Indonesia Budiastuti, Rizky Farmasita; Radji, Maksum; Purnamasari, Rini
Pharmaceutical Sciences and Research Vol. 6, No. 1
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This study aimed to evaluate the clinical pharmacist interventions in reducing drug-related problems (DRPs) in childhood acute lymphoblastic leukemia (ALL) patients in the Tangerang District General Hospital, Banten, Indonesia. This study used a prospective analysis of patients with a pre-post design between January-March 2017. The Pharmaceutical Care Network Europe (PCNE) (V6.2) pre-post study system was used to identify the DRPs of 138 patients. The Pharmacist interventions were addressed to physicians, patients, and other health professions to determine the effectiveness of pharmacist interventions before and after the intervention. The number of identified DRPs was 177 problems and the identified types of DRP was 164 types. The pharmacist interventions significantly decreased the DRPs from 177 to 10 DRPs (p < 0.05) and type of DRPs from 164 to 10 types of DRPs (p < 0.05). Risk factors for nutritional status, type of ALL, comorbidities, number of drug items, and type of treatments did not significantly affect (p > 0.05) to the decreased of the number and type of DRPs. Clinical pharmacist interventions able to reduce the number and type of DRPs and can improve treatment outcomes in childhood ALL.
Pengaruh Penggunaan Antikolinergik Terhadap Gangguan Fungsi Kognitif Pada Pasien Geriatri di Lombok Tengah, Indonesia Lupitaningrum, Dita Marina; Rahmawati, Fita
Pharmaceutical Sciences and Research Vol. 6, No. 1
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Geriatrics are more susceptible to the unwanted effects of drugs, such as potential cognitive impairment effects of anticholinergic drugs. This study aims to determine the effect of anticholinergic drug use on cognitive reduction in Central Lombok geriatric patients. This cross-sectional study was conducted by tracing a medical history and interview result using a Six-item Cognitive Impairment Tests (6-CIT) questionnaire to measure cognitive function. The sample size was 503 geriatric patients with 213 patients as users and 290 patients as non-users. Anticholinergic loads were determined in each patient using Anticholinergic Drug Scale (ADS). The data of the study were analyzed using Chi-square to see the effect of anticholinergic drug use on cognitive function reduction. A total of 168 patients (78.9%) used a single anticholinergic drug. Most of anticholinergic used were level 1 (95.8%). Patients who had a total anticholinergic load of 1 were 156 people (73.2%). In the user group, 191 patients (38%) experienced cognitive reduction. The most common disease experienced by drug user was circulatory system disease (50.9%) and the most widely used drug was furosemide (45.4%). Chi-square analysis showed that anticholinergic drug had significant effect on geriatrics impairment of cognitive function (OR 2.361; CI95% 1.399-3.983; P=0.002). The use of anticholinergic drugs had an effect on cognitive reduction in geriatric patient.

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