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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 16 Documents
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Search results for , issue "Vol. 7, No. 1" : 16 Documents clear
Penelitian Antiimplantasi Ekstrak Etanol Daging Buah Burahol (Stelechocarpus burahol Hook F. & Thomson) Pada Tikus Putih Sunardi, Clara; Sumiwi, Sri Adi; Hertati, Ai
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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We examined antiimplantation effect of ethanol extract from ripening burahol flesh (Stelechocarpus burahol Hook f. & Thomson) using doses 1g and 0.5g per Kg Body Weight (BW) on White Female Rats Wistar Strain. The ethanol extract was given orally on daily basis from diestrus phase until 7th day of pregnancy. Two parameter used in this investigation were number of implants and number of born fetus. The fetus were examined by observing their morphology to identify the existence of teratogenic effect. The result showed that the two doses reduced both the number of implants and born fetus significantly. In addition, the burahol flesh as an antifertility agent has two functions: as antiimplantation and abortifacient. Lastly morphological examination on the fetus did not show any teratogenic effect.
Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Ningtyas, Zimy Fianti
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution rate of piroxicam Orally Disintegrating Tablet prepared by direct compression method was observed in this research. Concentration of Avicel PH 102 used were 5%, 10%, 15% and 0% as a control. Physical characteristics of the powder blend including flow rate and angle of repose showed good attributes. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The physical characteristic of piroxicam orally disintegrating tablet including hardness, friability, disintegration time, and dissolution rate were examined. The hardness of all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%, disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes were between 32,71%– 88,63%. The results showed that increasing the concentration of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the friability and disintegration time of piroxicam orally disintegrating tablet . From statistical analysis (µ = 0,05), it could be seen that there was significant difference in physical characteristics and dissolution rate of all formulas. Among all formulas, it could be concluded that formula with 10% concentration of Avicel PH 102 was the optimum formula
Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Aktivitas Antioksidan dan Penetapan Kadar Fenol Total Ekstrak Metanol Dedak Bebeapa Varietas padi (Oryza sativa L.) Sugiat, Dede; Hanani, Endang; Mun’im, Abdul
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Antioxidant has been known to have an important role in the prevention and treatment of diseases. In recent years, many plants have been explored to obtain new antioxidants from natural products. Rice has been known rich in antioxidative compounds. However, there is little attention to the co- or by- products from rice (Oryza sativa) milling plant. One of the products is rice bran. In this study ten varieties of rice bran, which are commonly cultivated varieties in Indonesia were studied their antioxidant activity and total phenolic content. The antioxidant activity was examined by DPPH scavenging assay and total reducing power, while total phenolic content was determined by Folin-Ciocalteu reagent. The results of this study showed that the methanolic extract of IR-64 variety demonstrated the strongest DPPH radical scavenger activity with IC50 350.64 ppm, while in reducing power activity was exhibited by methanolic extract of IR-42 variety. However, the highest total phenolic content (71.85 mg gallic acid equivalent/gram) was found in methanolic extract of OM-4495 rice bran. These result indicated that the methanolic extract of rice bran might potentially be natural antioxidants.
Uji Efek Antiartritis Ekstrak Etanol 80% Kulit Buah Delima Merah (Punica granatum L) Terhadap Udem Pada Telapak Kaki Tikus Putih Jantan yang diinduksi oleh Complete Freund’s Adjuvant Sari, Rusmalita Pebriana; Amin, Juheini; Sari, Santi Purna
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Rheumatoid arthritis is a chronic inflammatory disease that can degrade the quality of patient survival. Conventional treatments of this disease have potentially dangerous side effects. Therefore, many patients are turning to alternative medicine using medicinal herbs, one of which is the fruit of Punica granatum L. The aim of this research was to determine antiarthritis effect of 80% ethanolic extract of Punica granatum L. fruit peel which had been given orally on 17-30th day based on decreased edema volume and percentage indexes of arthritis. The method was adjuvant induced arthritis by using the complete freund’s adjuvant 0,1 mL by subplantar and allowed to arthritis until day 16. The animals test were used 33 male rats of Sprague Dawley strain that were divided into six groups: normal control, positive control, negative control, and three groups had received suspension of 80% ethanolic extract of Punica granatum L. fruit peel in 0,5% CMC at doses 20, 40, and 80 mg/200 g body weight. The Edema volume was measured by pletismometer on days 17, 20, 23, 26, 29, 31 and indexes of arthritis determined on days 17 and 31. The Results showed that they were not significant difference in the decreased edema volume and the percentage indexes of arthritis, although the percentage inhibition of edema elevated with increasing dose.
Formulasi Tablet salut Teofilin Menggunakan Eksipien Koproses Pregelatinisasi pati Singkong- Metilselulosa sebagai bahan Penyalut Pradana, Rangga; Chaidir, Chaidir; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Pregelatinized cassava star ch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient were characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis. Theophylline tablet that coated by PCS, MC, and co-processed PCSMC ratio (4:1) characterized and in vitro drug release were made in chloride medium of pH 1,2 and phosphate medium of pH 7,2. The characterization result of co-processed PCS-MC showed the improvement of functionality from PCS and synergism PCS with MC. Meanwhile, the result of in vitro drug release showed theophylline tablet that coated by MC 1%, co-processed PCS-MC (4:1) 4% and 2% could retard the drug release in both medium.
ACE Inhibitory Activity and Functional Group Analysis of Solvent- Partitioned Fractions of Eleusine indica Cometa, Jade Celon; Mancol, Liahona Faith Roldan; Yen, Anthony Nalzaro; Manlusoc, Joanne Katherine Talens
Pharmaceutical Sciences and Research Vol. 7, No. 1
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Eleusine indica Linn. Gaerth or Indian goose grass has been widely used as an alternative natural anti-hypertensive agent. However, the rationale behind this mechanism is still unknown. The purpose of this study is to confirm the presence of functional groups that may be responsible for its ACE inhibitory activity and its possible synergism. Each solvent-portioned fraction was analyzed by FTIR, individual ACE inhibitory activity, and combination of fractions. FTIR results of solvent- partitioned fractions revealed that O-H and C-H stretches were present in all fractions. In addition to this, C-O and C=O groups were also present in all fractions except in ethyl acetate. S=O groups were also present in chloroform, ethyl acetate, and n-butanol fractions. Other function groups such as N-O and C=C groups were present in ethyl acetate and n-butanol fractions, respectively. The highest % inhibition obtained among the individual fraction is n-butanol at 96.031 % ± 0.004 at 500 ug/ml. The lowest % inhibition obtained among the individual fraction is chloroform at 32.544 % ± 0.011 at 500 ug/ml. The highest % inhibition among the combined fractions is ethyl acetate:butanol at 95.727% ± 20.847, while the lowest % inhibition in combination is hexane:chloroform at 89.626 % ± 19.577. The fraction with the lowest IC50 is hexane at 15.357, while the highest IC50 is chloroform at 168.207 ug/ml. Functional group present may be associated with the antihypertensive activity of the E. indica extracts. The more polar solvent-partitioned fractions of E. indica has a higher ACE inhibitory activity compared to its less polar solvent- partitioned fractions. The higher ACE inhibitory activity may be associated with the secondary metabolites present in the more polar fractions. There is also possible synergism present in the combined solvent-partitioned fractions as their % inhibition is higher than their individual effects.
Anti-proliferative Effects of a Coumarin Benjaminin on Four Human Cancer Cell Lines Mah, Siau Hui; Teh, Soek Sin; Ismail, Ahmad Azri Fitri; Ee, Gwendoline Cheng Lian
Pharmaceutical Sciences and Research Vol. 7, No. 1
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Cancer is a major health issue around the globe. Chemotherapy and radiation therapy are no longer the standard treatments for patients as these remedies lead to many adverse effects. Thus, the development of alternative effective drugs from lead compounds, especially natural products is necessary. This study aimed to isolate cytotoxic phytochemical constituents from a plant Calophyllum inophyllum, which has been used as traditional medicine since ancient time. The root of C. inophyllum was extracted and subjected for phytochemical constituent isolation. A coumarin, benjaminin (1) was isolated successfully from the chloroform extract and its structural elucidation was performed by spectroscopy analyses of MS, IR and NMR. The anti-proliferative effect of 1 on four cancer cell lines, leukemia (K562), stomach (SNU-1), liver (Hep-G2) and lung (NCI-H23) cancers were evaluated by using colorimetric MTT assay. Benjaminin (1) exhibited cytotoxic effects towards all cancer cells and showed the strongest inhibition towards SNU-1 cell proliferation with an IC50 value of 70.42 μM. The outcome of this study revealed that 1 is a potential cytotoxic lead compound that could be further developed into anti-cancer drug. Thus, the study on the structure-activity relationship of 1 is highly recommended in due course to improve its anti-proliferative effects on cancer cells.
Interaction of thymidine with sodium bis(2-ethylhexyl) sulfosuccinate in alcohol and water: Studies with UV-Vis technique Paudel, Indu M; Bhattarai, Ajaya
Pharmaceutical Sciences and Research Vol. 7, No. 1
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The accurate measurement of thymidine absorbance in the presence of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) in ethanol and water systems at room temperature by UV-vis technique has been reported. The AOT concentrations varied from 0.0005 to 0.014 [mol/L] in ethanol whereas from 0.0002 to 0.042 [mol/L] in water. The concentration of thymidine was 0.0073 [mol/L] during UV-vis spectrum registration. The thymidine spectrum was examined in the presence of AOT concentration. Using a statistical method of non-linear regression (NLREG), thymidine binding and thymidine distribution constants were evaluated. A noticeable decrease in thymidine absorbance in the presence of AOT concentration was shown in the water system; whereas, in the ethanol system, just the opposite trend has been found. The results are discussed in the context of binding and distribution constants in the studied systems.
An Exploration of Electrospun Fibers Containing Drug-Cyclodextrin Inclusion Complexes Fatimah, Fatimah; Aytac, Zeynep; Uyar, Tamer; Pasparakis, George; Williams, Gareth R
Pharmaceutical Sciences and Research Vol. 7, No. 1
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A series of new core-shell fibers were developed containing anticancer drugs (5-fluorouracil or ferulic acid) and their cyclodextrin inclusion complexes, with a gadolinium-based magnetic resonance imaging (MRI) contrast agent. These were prepared by electrospinning, a simple method for producing ultra-fine fibers through the application of a strong electrostatic force on a polymer solution. The shell of the fibers was formed from Eudragit S100, and the drugs were loaded in the core. Scanning electron microscopy images showed the formation of smooth ribbon-like fibers, with diameters ranging from 1.4 to 5.1 μm, and transmission electron microscopy reveals a transparent interface between the core and shell compartments. X-ray diffraction and differential scanning calorimetry data confirmed the encapsulation of the drug into the cyclodextrin cavity and the formation of amorphous solid dispersions in the fibers. Drug release from the systems at pH 1 and 7 showed that all the drug loading was released within one hour at pH 1. Based on these results, it is proposed that the relatively low molecular weight drugs were able to diffuse out of the system into the release medium at acidic pH, despite the insolubility of the shell polymer under these conditions. These findings have important implications for the design of electrospun drug delivery systems.

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