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International Journal of Health and Pharmaceutical (IJHP)
Published by CV. Inara
ISSN : -     EISSN : 2808845X     DOI : https://doi.org/10.51601/ijhp
Core Subject : Health,
Nursing Public Health
International Journal of Health and Pharmaceutical (IJHP) e- ISSN : 2808-845X is a communication media and scientific publication in the health and pharmaceutical fields published by Inara Publisher. International Journal of Health and Pharmaceutical (IJHP) contains articles from research focusing on basic medicine, clinical medicine, epidemiology, preventive medicine (social medicine), pharmacy, and other medical fields. International Journal of Health and Pharmaceutical (IJHP) is published periodically four times a year (February, May, August and November).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 426 Documents
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Differences In D-Dimer Levels of Moderate And Severe Covid-19 Patients Treated At Hajj Adam Malik Hospital, Medan Hadi, Denny; Siregar, Jelita; Novisari Soeroso, Noni; M. Nafchi, Asgar
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.396

Abstract

An outbreak of coronavirus disease 2019 (COVID-19), initially reported in December 2019 in Wuhan, Hubei Province, China, emerged as a mysterious pneumonia caused by the novel β-coronavirus, 2019-nCoV. Among hospitalized COVID-19 patients, elevated D-dimer levels and impaired hemostasis have been commonly observed, often associated with disease severity and mortality. This study aimed to assess differences in D-dimer levels among mild, moderate, and severe COVID-19 patients in a cross-sectional design involving 36 confirmed COVID-19 patients hospitalized at H. Adam Malik General Hospital Medan. Conducted from August to October 2021 at the Departments of Clinical Pathology and Pulmonology and Respiratory Medicine, the study used consecutive sampling. The participants had an average age of 50.92 years, with hypertension and diabetes mellitus being the most common comorbidities. The average D-dimer level was 1324.28 ng/mL (SD = 2360.45 ng/mL), ranging from 100 ng/mL to 13,420 ng/mL. A significant difference in D-dimer levels was observed between patients with moderate and severe COVID-19, highlighting its potential role in evaluating disease progression and severity.
Formulation and Physical Stability Testing of Exfoliating Gel and Moisturizing Gel From Sugarcane Bagasse Extract Suhesti, Iin; Dwi Antari, Ester; Chasna Nasrina, Syafa; Pancaya Putra, Marzela
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.397

Abstract

Sugarcane bagasse extract (Saccharum officinarum Linn.) has high antioxidant activity due to its phenolic compounds, which are beneficial for moisturizing dry skin, smoothing the skin, and combating free radicals. This study aimed to evaluate the physical stability of exfoliating and moisturizing gel formulations containing sugarcane bagasse extract at concentrations of 1%, 3%, and 5% using the cycling test method over six cycles (12 days) at temperatures of ±4°C and ±40°C. Parameters tested included organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesiveness. The results showed that the formulations without extract (control) and those with 1% extract concentration met the physical stability parameters and remained stable throughout the cycling test, with viscosity ranging from 13,665.7 to 20,180.6 cPs, pH between 4.76 and 5.43, spreadability from 3.25 to 5.64 cm, and adhesiveness from 0.42 to 1.52 seconds. In contrast, formulations with 3% and 5% extract concentrations exhibited physical instability, such as changes in pH, viscosity, and spreadability, failing to pass the stability test cycles.
Digital Transformation in Hospital Management: Building Readiness for Society 5. Handrean, I Gede Eka; Rian Pratama, Ivanda; Rahma Sumarna, Dita; Fakhrazi, Ricky; Rejauw, Saperyanus; Paramarta, Vip
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.398

Abstract

This study examines digital transformation strategies in hospital management and assesses organizational readiness for Society 5.0 implementation through a systematic literature review. The research employed a comprehensive narrative review methodology, analyzing peer-reviewed publications from 2014 to 2024 across major scientific databases including PubMed, Scopus, Google Scholar, and Science Direct. Our analysis identified four critical factors for successful digital transformation in healthcare settings: (1) robust technological infrastructure integrated with competent human resources and adaptive organizational culture; (2) transformative leadership and sustained management commitment; (3) systematic monitoring and continuous evaluation frameworks; and (4) enhanced patient engagement mechanisms that leverage digital technologies to improve healthcare service quality. These findings provide practical insights for healthcare institutions navigating digital transformation while preparing for Society 5.0 challenges. The study contributes to the growing body of knowledge on healthcare digitalization by offering an integrated framework for assessing and implementing digital transformation initiatives in hospital settings.
The Relationship Between Anxiety Levels and Family Support and UKMPPD Results at The Faculty of Medicine, University of Muhammadiyah Semarang Kamila, Kamila; Pandu Arfiyanti, Mega; Novitasari, Andra; Muslimah, Muslimah
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.399

Abstract

The Medical Profession Program Student Competency Test (UKMPPD) is a test and assessment on a national scale for students of the medical profession program, which emphasizes attitudes, knowledge, and skills as a basis for practicing medicine. Based on data from the UKMPPD National Committee and Institutional Feedback, the UKMPPD results at Muhammadiyah University Semarang, the percentage of UKMPPD pass in February 2021 and November 2021 were 75% and 81.25%, respectively. In general, the level of anxiety experienced while undergoing medical education has a negative impact, namely students having difficulty undergoing competency assessment and can reduce their level of confidence when they are about to face exams. In addition to anxiety, it was also identified that influenced the UKMPPD results, including family support. This study aims to analyze the relationship between anxiety levels and family support with UKMPPD outcomes. This study used a quantitative method in the form of analytic observational with a cross sectional approach. This study used the Hamilton Rating Scale for Anxiety questionnaire and the family support questionnaire. The sample in this study were medical professional education students at the Faculty of Medicine, University of Muhammadiyah Semarang who took part in UKMPPD for the November 2022 period. Sampling used a total sampling technique. The results of the univariate analysis with a total of 32 respondents, namely the majority had high family support (71.9%), a mild level of anxiety (50.0%), the majority were female (86.8%), and the majority of respondents graduated UKMPPD (87.5%). The results of the chi square analysis of the anxiety level variable had a value of p = 0.008 (p < 0.05), and the family support variable was p = 0.557 (p > 0.05). There is a significant relationship between the level of anxiety with UKMPPD results. Family support has no significant relationship with UKMPPD results.
Characteristics of Chemotherapy Side Effects in Patients with Nasopharyngeal Cancer Dilla Putri Deli, Fera; Purnamasari Juhamran, Reeny; Irmandha Kusumawardhani, Sri; Tenri Sanna, Andi; Ardhani Pratama, Ahmad; Poentoro, Poentoro
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.400

Abstract

This study investigates the characteristics of post-chemotherapy side effects in patients with nasopharyngeal cancer at Dr. Wahidin Sudirohusodo Hospital in Makassar during 2023. Utilizing secondary data, the research analyzes the prevalence of side effects based on gender and age. The findings reveal that male patients predominantly experience gastrointestinal (11.6%) and respiratory (16.8%) side effects, while female patients report higher rates of neuropathy (22.2%). In terms of age, adults exhibit the highest prevalence of gastrointestinal effects (12.1%) and combined effects (5.3%), whereas adolescents show significant rates of neuropathy (40.0%) and respiratory complications (60.0%). Elderly patients experience similar gastrointestinal and neuropathic toxicities (17.3% each), but at lower frequencies. Notably, no cases of nasopharyngeal cancer were reported in toddlers and children, indicating that this malignancy primarily affects older age groups. The study underscores the need for increased public awareness regarding nasopharyngeal cancer, particularly among vulnerable demographics, to promote early detection and prevention. Additionally, enhancing public knowledge about nasopharyngeal cancer and its risk factors is crucial for better understanding and management of the disease. Future research should focus on elaborating the specific side effects associated with each affected system to provide comprehensive insights into the impact of chemotherapy on nasopharyngeal cancer patients. Overall, this study contributes valuable information to the understanding of chemotherapy-related side effects in nasopharyngeal cancer, emphasizing the importance of tailored management strategies to improve patient outcomes and quality of life.
Inequality of Thought (IOT) on HIV-Aids and LGBT Through Social Media: A Case Study Gen Z in JPC Foundation Puspitaloka Mahadewi, Erlina; Reza Hilmy, Mohamad; Chairun Nisa, Puspita; Pamungkas, Ario; Purnama, Suryari; Ozays , Mehmet; Pantja Djati, Sundring
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.401

Abstract

The study focused on the purpose of finding out the effect and covering the views and acceptance of LGBT. Jakarta Indonesia is beginning to be seen clearly, especially the large amount of LGBT content both on television stations and on social media at home and abroad. This is very worrying because shows that LGBT is a risk factor for sexually transmitted infections (STIs) including HIV/AIDS. Unsafe sex, drugs, and many sexual partners, make LGBT people more susceptible to STIs. This study aims to determine the description of knowledge about STIs and attitudes towards the LGBT phenomenon in society, especially among young Gen Z people who still have the impact of inequality of thinking in social media. This study is a qualitative descriptive study conducted from October to December 2024. Data collection used a google form questionnaire. The sample consisted of 75 respondents who were members of the community fostered by the "Jakarta Plus Center (JPC)" Foundation. The sampling technique used was purposive sampling. The data is presented in a frequency table. The results of this study showed that most respondents had good general knowledge about STIs but lacked in more specific knowledge questions in medicine. The acceptance and views of the community in this community towards the LGBT phenomenon are quite low. People in the community consider LGBT to have a negative impact on life, although respondents agree that the human rights of LGBT people as humans must still be protected and respected, as they see on social media.
Stage-Specific Pathological Features of Chronic Kidney Disease: An Article Review Indriani, Intan; Dwi Nopriansyah, Wely; Ishak Hutasoit, Januar; Ikram Zakaria, M.
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.402

Abstract

Chronic Kidney Disease (CKD) is a major global health challenge, with increasing prevalence, particularly in developing countries. CKD is characterized by a gradual and irreversible decline in kidney function, often progressing to End-Stage Renal Disease (ESRD). The pathophysiology of CKD involves structural and functional deterioration in various renal compartments, including the glomerulus, tubules, interstitial tissue, and blood vessels. Histopathological changes play a critical role in disease progression, with interstitial fibrosis, glomerulosclerosis, and tubular atrophy being the hallmark lesions observed across different CKD stages. This review highlights the anatomical pathology of CKD at various stages, focusing on histopathological changes, diagnostic techniques, and factors influencing disease progression. Renal biopsy remains the gold standard for assessing kidney damage, utilizing special stains such as Periodic Acid-Schiff (PAS) to identify fibrosis and sclerosis. However, noninvasive biomarkers like Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have emerged as promising tools for early detection. Studies indicate that histopathologic findings, including interstitial fibrosis and glomerulosclerosis, often correlate with CKD progression more accurately than estimated glomerular filtration rate (eGFR) alone. This review underscores the need for integrating histopathological, clinical, and molecular biomarkers to improve CKD diagnosis and management. A better understanding of kidney pathology can facilitate early detection, refine prognostic assessments, and enhance treatment strategies. Future research should focus on noninvasive diagnostic alternatives and novel therapeutic targets to slow CKD progression and mitigate its global health burden.
Trends in Artificial Intelligence Research in Urology, Anesthesiology, Cardiology, and Otolaryngology: A Bibliometric Analysis (2019-2024) Sidharta Krisna, Muhammad; Alfi Reza, Muhammad; Ghiffary, Muamar; Satir Sayati, Muhammad; Awaluddin, Muhammad
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.403

Abstract

Background: The application of Artificial Intelligence (AI) in medicine is rapidly evolving, particularly in urology, anesthesiology, cardiology, and otolaryngology (ENT). AI is utilized in image-based diagnosis, patient monitoring, as well as the optimization of therapy and robotic surgery. However, research trends in AI within these fields have not yet been comprehensively mapped. Methods: This study employs bibliometric analysis to evaluate publication trends in AI across these four medical fields from 2019 to 2024. Data were collected from Google Scholar, PubMed, and Scopus, then analyzed using VOSviewer and R-Bibliometrix to identify the number of publications, keyword trends, institutional collaboration networks, and the most highly cited articles. Results: The number of AI-related publications in medicine has increased from 50 articles in 2019 to 130 articles in 2024. The United States, China, and the United Kingdom have the highest number of publications. Research trends indicate that deep learning and machine learning dominate, with broad applications in disease diagnostics and medical imaging. Cluster analysis reveals four main domains: anesthesiology (120 publications), cardiology (105 publications), urology (98 publications), and ENT (80 publications). Conclusion: AI has become an essential component in the advancement of modern medicine. With the increasing number of studies and multidisciplinary collaborations, AI is projected to continue expanding in data-driven diagnosis and therapy. However, challenges in clinical validation, regulation, and AI ethics must be addressed to ensure its safe and effective use.
Mapping the Future: A Content Analysis of the Evolution of Gene Therapy in Urological Cancer Sidharta Krisna, Muhammad; Alfi Reza, Muhammad; Aksanda Putra, Bobby; Muslim Siregar, Bukhari; Alif Adhani, Muhammad
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.404

Abstract

Background: Gene Therapy Has Emerged As A Promising Approach In The Treatment Of Urological Cancers, Including Prostate, Kidney, And Bladder Cancers. Over The Past Decade, Significant Advancements Have Been Made In Gene Editing Technologies Such As Crispr-Cas9, Rna-Based Therapies, And Viral Vector Systems. These Innovations Offer Precise Targeting Of Oncogenes And Tumor Suppressor Genes, Potentially Improving Treatment Efficacy And Reducing Adverse Effects Compared To Conventional Therapies. Methods: A Systematic Content Analysis Was Conducted On Peer-Reviewed Literature And Clinical Trial Reports From 2015 To 2025. Databases Such As Pubmed, Sciencedirect, And Scopus Were Used To Extract Relevant Studies. Inclusion Criteria Encompassed Original Research Articles, Systematic Reviews, And Clinical Trials Focused On Gene Therapy Applications In Prostate, Kidney, And Bladder Cancer. Studies Exclusively Conducted On In Vitro Or Animal Models Without Clinical Relevance Were Excluded. Results: Crispr-Cas9 Has Demonstrated High Precision In Gene Editing, Particularly In Prostate Cancer, Where Targeting Androgen Receptor-Related Genes Has Enhanced Hormone Therapy Sensitivity. Rna Therapy, Especially Using Sirna Targeting Vegf And Hif-1α, Has Shown Promise In Kidney Cancer Treatment By Inhibiting Angiogenesis. Viral Vectors Remain A Primary Method For Gene Delivery In Bladder Cancer, Although Immune Responses Pose A Significant Challenge. Clinical Trials Indicate That Gene Therapy Combined With Immunotherapy, Particularly Checkpoint Inhibitors Like Pembrolizumab, Enhances Treatment Efficacy. However, Regulatory Barriers, High Costs (Estimated At Over $500,000 Per Patient), And Safety Concerns Regarding Off-Target Effects Remain Major Obstacles To Widespread Clinical Implementation. Conclusion: Despite These Challenges, Gene Therapy Holds Great Potential For Revolutionizing Urological Cancer Treatment. Future Research Should Focus On Optimizing Gene Delivery Systems, Reducing Off-Target Risks, And Developing Cost-Effective Production Methods. Personalized Gene Therapy Approaches, Leveraging Advancements In Genomic Sequencing, Are Expected To Further Enhance Treatment Precision. With Continued Innovation And Regulatory Advancements, Gene Therapy Is Anticipated To Become An Integral Part Of Standard Urological Cancer Care In The Coming Decade.
The Association Between Gastroesophageal Reflux Disease (Gerd) And Sleep Quality Among Medical Students of The Indonesian Muslim University Class of 2021 Moh. Hamdhan Hamsa; Lestari Daeng Kanang, Indah; Aulia Namirah, Hanna; Iskandar, Darariani; Khaerina Amaliyah Bakhtiar, Ilma
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.405

Abstract

The Association Between Gastroesophageal Reflux Disease (Gerd) and Sleep Quality in Medical Faculty Students of Indonesian Muslim University Class of 2021. Gastroesophageal Reflux Disease (GERD) is a chronic gastrointestinal disorder characterized by the regurgitation of stomach contents into the esophagus, causing symptoms such as heartburn, regurgitation, sore throat, and cough. GERD can worsen sleep quality, contributing to sleep disorders. This study aims to examine the association between GERD and sleep quality among medical students at Indonesian Muslim University Class of 2021. This study emploved a descriptive analytics desing with a cross-sectional approach, and the sample was selected through total sampling. The chi-square test was applied to analyze the association between GERD and sleep quality with a significance level of p < 0.05. Among 274 respondents, 45 (16.4%) had GERD, while 229 (83.6%) did not. Additionally, 42 (15.3%) had good sleep quality, whereas 232 (84.7%) had poor sleep quality. Statistical analysis showed a p-value = 0.027, indicating a significant association between GERD and sleep quality (p < 0.05). The findings suggest that students with GERD are at a higher risk of experiencing poor sleep quality. These results highlight the need for preventive measures and interventions to improve sleep quality in students suffering from GERD.

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