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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 201 Documents
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Serum Level of 25-Hydroxyvitamin D in Children with Epilepsy Receiving Long-Term Antiepileptic Treatment Ismail, Chasan; Irawan, Roedi; Saharso, Darto
MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.621 KB) | DOI: 10.56951/medicinus.v33i2.59

Abstract

Background: Long-term treatment with antiepileptic drugs (AED) requires monitoring of potential side effects, one of them is the decreasing in serum vitamin D level. Low serum vitamin D level is also a global health problem in healthy children. There are conflicting results regarding the low serum vitamin D level in epileptic children due to treatment with AED. Purpose: This study aimed to compare serum vitamin D level between healthy children and children with epilepsy receiving long-term AED treatment in Soetomo General Hospital. Methods: This was a cross-sectional study conducted in the pediatric neurology clinic of Soetomo general academic hospital from August 2018 to July 2019. Subjects are children ages 2-18 years with epilepsy receiving AED treatment for over 6 months (n=22), with healthy children as control (n=22). Peripheral serum 25-hydroxyvitamin D level were measured using enzyme-linked fluorescence assay (ELFA) method. The differences of those groups were analyzed by comparing the mean of 25-hydroxyvitamin D level of both groups using Anova and T-test (95% CI). Results: Low serum vitamin D level were identified in 27% children with epilepsy and 13% healthy children. The mean of serum 25-hydroxyvitamin D level in children with epilepsy and healthy children was 21.5 ng/ml (SD 8.41) and 34.3 ng/ml (SD 10.09), respectively. There was a significant difference between groups (p<0.05). Conclusion: Children with epilepsy receiving long-term AED treatment have lower level of serum 25-hydroxyvitamin D than healthy children.
Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.767 KB) | DOI: 10.56951/medicinus.v34i2.61

Abstract

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.
Hemangioma Verukosa Rinandari, Ummi; Yustin Ellista Sari, Endra
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.125 KB) | DOI: 10.56951/medicinus.v33i3.62

Abstract

Verrucous hemangioma (VH) is a localized verrucous venous malformation comprising a capillary or cavernous hemangioma with proliferation reactions such as epidermal hyperkeratosis, acanthosis or papillomatosis also vascular proliferation and widening in the dermis to subcutaneous tissue. This disorder is usually found in the lower extremities and unilateral. It is often misdiagnosed as venous or lymphatic malformations. An 11 year-old boy presented with rough patches and blackish-red lumps on the right leg since birth. Four months prior, the lesion bled after being hit by ball and became rougher, thickened and darker thereafter. He was initially diagnosed with hemangioma and cryotherapy was performed, but there was no improvement after 6 cryotherapy treatment. A diagnosis of VH should be considered in the presence of erythematous papules, nodules, and plaques, especially those that are hyperkeratotic, present at birth, located at the lower extremities, and progressively enlarge after trauma or infection. Based on patient history, physical examination and laboratory results, the patient was diagnosed with VH. Excision surgery is the gold standard of VH management. The excision of the lesion must be deep and wide with a margin of 1 cm, to minimize recurrence. Treatment consists of combination of clobetasol propionate 0.05% and salicylic acid 5% ointment before excision was performed.
Analisis In Silico Potensi Minyak Kedelai (Glycine max) dalam Terapi Dermatitis Atopik Primadhanty. R. S. Bhadra; Mardiana; Ahmad Fiqri; Ummi Rinandari; Didik H. Utomo; Muhammad Eko Irawanto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.375 KB) | DOI: 10.56951/medicinus.v34i2.63

Abstract

Soybean oil contains various bioactive phytochemicals such as phenolic acids, flavonoids, isoflavones, saponins, phytosterols and sphingolipids which might give benefit in the treatment of atopic dermatitis (AD). This study aimed to evaluate the soybean oil compounds using computational in silico analysis for the treatment of atopic dermatitis. The active compounds of soybean oil were extracted from the KNApSAcK database. Results showed that soybean oil might possess some potential bioactivity such as immunosuppressant, antiinflammatory, improves skin barrier function, antieczema and histamine inhibitor. The highest potential bioactivity of soybean oil was as antiinflammatory, with an average value of probable to be active (Pa) 0.684; while the high potency active compound is alpha-tocopherol (Pa: 0.956).
Acute Mesentric Venous Thrombosis with a History Recurrent DVT in Young Age: A Case Report Z. A. Haldis; B. A. Kuncoro
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (79.417 KB) | DOI: 10.56951/medicinus.v33i3.64

Abstract

Acute mesenteric ischemia (AMI) may be defined as a sudden interruption of the blood supply to a segment of the small intestine, leading to ischemia, cellular damage, intestinal necrosis, and eventually patient death if left untreated. Mesenteric venous thrombosis (MVT) is an emergency condition that is rarely found as a cause of AMI compared to arterial thrombosis, and accounts for only 16% of all mesenteric ischemia cases. The overall incidence is low (0.09-0.2% of all acute admissions to emergency department), prompt diagnostic and intervention are essential in order to reduce the high mortality rate (50-80%).
Closing the Gap of Unmet Needs in Inflammatory Pain Management: Case Series of Predimenol for Pain Rizaldy Pinzon
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.21 KB) | DOI: 10.56951/medicinus.v34i2.65

Abstract

Chronic inflammatory pain is major medical problem worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used medications to treat chronic pain. However, these agents have been associated with serious gastrointestinal, renal and cardiovascular adverse effects. This limitation indicates a clear unmet need in terms of safety of current treatment options for the management of chronic inflammatory pain. Those adverse effects may caused by overlapping roles of COX-1 and COX-2 in physiological and pathophysiological processes. Predimenol is a herbal medicine that can be used to treat pain. Recent findings showed that these phytochemicals may directly act upon several inflammatory processes and offer compelling evidence that predimenol could reduce pain and inflammation. We report two cases and short review of the use of predimenol for pain management. Our review showed that predimenol formulations could be a valuable alternative treatment to relieve symptoms of pain with good safety profile. Further researches through large, high quality RCTs to investigate the clinical benefit of predimenol for pain management are needed.
Pubertas Prekoks Perifer Isoseksual akibat Juvenille Granulosa Cell Tumor Santosa, Putu Adi; Widijanti, Anik; Susianti, Hani; Engli, Katherina Alfa
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.213 KB) | DOI: 10.56951/medicinus.v33i3.66

Abstract

A 16-month-old girl with peripheral isosexual precocious puberty due to juvenile granulosa cell tumor underwent unilateral salpingo-oophorectomy procedure to stop the symptoms of precocious puberty. The diagnosis was established based on the patient’s medical history, physical findings, laboratory and other examinations which demonstrated secondary sexual characteristics according to Tanner scale M3P2, presence of abdominal mass, elevated serum estradiol, and a histological finding of juvenile granulosa cell tumor. Karyotyping results was normal. Left salpingo-oophorectomy successfully reduced estradiol concentration and stop the menstruation, while the other secondary sexual characteristics is monthly assessed at the clinic.
Ulkus Marjolin yang Berkembang dari Ulkus Trofik Kronis pada Pasien Kusta Adniana Nareswari; Harijono Kariosentono; Nugrohoaji Dharmawan; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.255 KB) | DOI: 10.56951/medicinus.v34i2.67

Abstract

Marjolin’s ulcer is a malignant complication of chronic ulcer. Changes in ulcer lesions to malignancy can be caused by chronic irritation, infection, decreased vascular variation, and increased expression of proto-oncogene. The most common histopathological form of Marjolin's ulcer is squamous cell carcinoma. A 55-year-old man, complaining of a protruding wound on his left hand that has not healed since three years ago. The patient was diagnosed with leprosy 30 years ago with a history of incomplete treatment. On physical examination, the left palmar region showed solitary ulcer, ±10x8x1.5 cm in size, nodular surface, reddish, hard consistency, with bulging and irregular edge. Slit-skin smear (SSS) examination with Ziehl-Neelsen staining found abundant acid-fast bacilli. Histopathological examination of the ulcer edge shows appearance of epithelial tumor, with differentiated epidermal cells invading the dermis, tumor cells arranged focally and concentrically with a mass of keratin appeared as horn pearl cells. Fite-Faraco staining found abundant M. leprae acid-fast bacilli. Based on the patient’s medical history and clinical examination, patient was diagnosed with Marjolin's ulcer in multibacillary (MB) leprosy. Patient was treated with MB multidrug therapy for 12 months and below-wrist amputation.
Diagnosis dan Terapi Terkini Multiple Myeloma Savitri, Merlyna
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.672 KB) | DOI: 10.56951/medicinus.v33i3.68

Abstract

Multiple myeloma (MM) merupakan keganasan sel plasma yang ditandai oleh proliferasi klonal sel plasma ganas di sumsum tulang dengan protein monoklonal dalam serum dan/atau urine, serta disfungsi organ terkait disertai dengan morbiditas dan mortalitas substansial, berupa end-organ damage: gangguan ginjal, hiperkalsemia, lesi tulang litik, dan anemia. Dengan perkembangan terapi yang lebih baik, MM telah berubah dari penyakit yang tidak dapat diobati ke salah satu penyakit yang masih belum dapat disembuhkan, namun highly treatable dengan kebanyakan pasien dapat berobat rawat jalan. Kelangsungan hidup pada MM telah meningkat secara signifikan dalam 15 tahun terakhir. Hal ini disebabkan oleh adanya terapi terkini seperti bortezomib, thalidomide, dan lenalidomide. Dalam dekade terakhir, carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, daratumumab, isatuximab, dan selinexor juga telah disetujui oleh Food and Drug Administration (FDA) untuk pengobatan MM yang mengalami kekambuhan. Selain itu, adanya terapi autologous stem cell transplantation (ASCT) dapat meningkatkan median overall survival (OS) pasien MM sekitar 12 bulan dan sudah dapat dilakukan di Indonesia, khususnya di Surabaya (FK Unair- RSUD Dr. Soetomo-RS Unair).
Studi Kasus Covid-19 Akibat Kerja Anna Suraya; Zulfikli Dharma; Putri Tresnasari; Putri Dwi Ginanti; Fani Syafani
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.154 KB) | DOI: 10.56951/medicinus.v34i2.69

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) yang menjadi penyebab Coronavirus Disease 2019 (Covid-19) merupakan pajanan biologis di fasilitas kesehatan, di mana perawat, dokter, serta petugas medis maupun nonmedis lainnya menjadi kelompok pekerja yang rentan tertular Covid-19 saat bekerja. Studi kasus ini bertujuan untuk memberikan gambaran penerapan tujuh langkah diagnosis okupasi pada tiga kasus Covid-19 yang terjadi pada tenaga kesehatan. Kasus pertama adalah Covid-19 pada perawat ICCU yang terbukti mengalami kontak dengan pasien Covid-19 saat bertugas kurang dari 14 hari sebelumnya. Kasus kedua merupakan kasus Covid-19 pada dokter yang terjadi akibat penularan di rumah tangga, dan kasus ketiga adalah kasus Covid-19 pada dokter UGD yang merawat pasien Covid-19 beberapa hari sebelum munculnya gejala. Kasus ini merupakan kasus fatalitas yang mendapatkan kompensasi dari BPJS Ketenagakerjaan. Penegakkan diagnosis okupasi sangat penting karena dapat menjadi umpan balik atau evaluasi terhadap tindakan pencegahan yang sudah dilakukan di tempat kerja. Adanya penyakit akibat kerja (PAK) di kalangan pekerja merupakan sinyal diperlukannya peningkatan perlindungan bagi pekerja.

Page 3 of 21 | Total Record : 201

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