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<![CDATA[Terapi Oral dan Tetes Mata Topikal pada Green Nail Syndrome ]]>
<![CDATA[Putti Fatiharani Dewi]]>;
<![CDATA[Ambar Aliwardani]]>;
<![CDATA[Nugrohoaji Dharmawan]]>
<![CDATA[ MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v34i3.81
<![CDATA[Background: Green nail syndrome is one of the chromonychia caused by infection of Pseudomonas aeruginosa, characterized by onycholysis and greenish-black discoloration of the nail. There were no reports regarding the incidence of green nail syndrome in Indonesia. Predisposing factors for the occurrence of green nail syndrome include onychomycosis, high activity in moist and wet conditions, diabetes mellitus, and immunosuppression. Case: A 51-year-old man complained about greenish-black discoloration on his fingernails. Dermatological examination in 1st and 3rd digit of the right hand, as well as 1st digit of the left hand, found multiple greenish-black discoloration with onychodystrophy. Dermoscopy examination of the affected nails showed greenish-black pigmentation in the distolateral nails with peripheral fading. Culture examination using MacConkey agar showed colonies of greenish-brown pigments. The patient was diagnosed with green nail syndrome and treated with ciprofloxacin 500 mg/day and topical polymixin B eye drops b.i.d. for 3 weeks, resulting in good outcome. Discussion: The diagnosis of green nail syndrome is made based on anamnesis, physical examination, and bacterial culture. showing a distinctive feature. The predisposition factor in this case, is the frequent washing hands habit of the patient up to more than ten times per day. Treatment using topical eye drops facilitates the absorption of active ingredients into the nails.]]>
<![CDATA[The Promising Therapeutic Effects of Nigella Sativa ]]>
<![CDATA[Rimenda Sitepu]]>;
<![CDATA[Kirsten Putriani Hartman]]>;
<![CDATA[Yessy Adhi Utami]]>
<![CDATA[ MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v34i3.83
<![CDATA[Medicinal plants can be potential source to improve general health and perhaps for the treatment of various diseases. However, despite the fact that herbal medicine has been used among various civilizations worldwide, scientific research regarding many herbal medicines was still limited. Nigella sativa (N. sativa), commonly known as fennel flower, black caraway, black cumin, jintan hitam, or kalonji, is a widely used medicinal plant that has been used for the treatment of various health problems. N. sativa contains some compounds that are potentially beneficial for health and wellness, particularly thymoquinone (TQ). Studies have shown some therapeutic benefits of N. sativa, however most them require further investigations to evaluate its efficacy and safety profile. This paper provides summary of available studies and reviews of N. sativa, including findings and limitations of the studies.]]>
<![CDATA[Tingkat Perbedaan Serum Nitric Oxide terhadap Derajat Keparahan dan Durasi Psoriasis ]]>
<![CDATA[Ambar Aliwardani]]>;
<![CDATA[Bobby Febrianto]]>;
<![CDATA[Fiska Rosita]]>;
<![CDATA[Putti Fatiharani Dewi]]>;
<![CDATA[Muhammad Eko Irawanto]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.84
<![CDATA[Psoriasis belongs to erythrosquamous dermatosis with uncertain etiology. Nitric oxide (NO) that acts as growth and differentiation regulator of keratinocytes is thought to play an important role in the pathogenesis of this disease. This study was aimed to determine the difference of nitric oxide serum level with the severity and duration of psoriasis patients. A cross-sectional study was conducted in 22 subjects with psoriasis vulgaris in the outpatient clinic of Dr. Moewardi Hospital Surakarta from May-September 2018 with 22 healthy individuals as control group. The severity of psoriasis was assessed using psoriasis area severity index (PASI), and serum NO is measured using Greiss method. Data then analysed using T-test and Kruskal Wallis tests (p<0.05). There was a significant difference in serum NO between the psoriasis patients and control group (p=0.020); there was no significant difference between serum NO patients and PASI score and duration of disease. It can be concluded that NO is an important factor in the inflammatory process in psoriasis, especially in active lesion.]]>
<![CDATA[Laporan Kasus Pyoderma Gangrenosum disertai Kandidiasis Kutis pada Wanita dengan Sindrom Metabolik ]]>
<![CDATA[Ambar Aliwardani]]>;
<![CDATA[Fiska Rosita]]>;
<![CDATA[Putti Fatiharani]]>;
<![CDATA[Endra Yustin Ellistasari]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.85
<![CDATA[Introduction: Pyoderma gangrenosum (PG) is a rare inflammatory disease characterized by sterile, predominantly neutrophilic infiltration of the skin and other organs. PG is found particularly in women aged between 40-60 years. Metabolic syndrome is reported to have a potential role to induce PG. Case: A 45-year-old woman came to Dr. Moewardi Hospital with chief complaints of ulcer in the chest and legs that was preceded by reddish fluid filled bump which then broke into painful wound. History of trauma, gastrointestinal, and joint pain was denied. Dermatological examination of anterior trunk region and inferior extremity showed erythematous patches with multiple ulcers with irregular border covered with hemorrhagic crusts and necrotic tissue. Pathergy test was negative. In the right and left axillary, inframammary and inguinal, there were hyperpigmented patches with scales and satellite lesions, KOH 10% examination obtained pseudohyphae and cell budding. The patient also has metabolic syndrome. Diagnosis of PG was made based on the presence of 2 major and 2 minor criteria. Patient was given intravenous methylprednisolone 93.75 mg/24 hours, analgesics, antibiotics, topical antifungals, debridement and breast reconstructive surgery after response to steroid therapy was seen. The patient was discharges from hospital with improvement. Discussion: Metabolic syndrome is considered to be a risk factor contributing to the development of systemic chronic inflammatory processes and has been described as one of the precipitating factors for PG and skin candidiasis. Management of metabolic syndrome as the known risk factor aims to minimize the recurrence of PG in the future.]]>
<![CDATA[Prosedur Pembedahan pada Hiperhidrosis Aksilaris dengan Teknik Tumesen Liposuction-Curettage ]]>
<![CDATA[Danu Yuliarto]]>;
<![CDATA[Wibisono Nugraha]]>;
<![CDATA[Moerbono Mochtar]]>;
<![CDATA[Ammarilis Murastami]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.86
<![CDATA[Hyperhidrosis is an excessive sweat production due to autonomic nerve dysfunction that occurs in areas with higher concentration of eccrine gland such as palms, soles of the feet, and axilla. Management of hyperhidrosis includes pharmacological and nonpharmacological approach. Patients with severe focal hyperhidrosis should consider surgical treatment or botulinum toxin injection. Tumescent liposuction with curettage is one of surgical technique option for the treatment of axillary hyperhidrosis. Case: A 32-year-old woman with complaint of excessive sweating, especially in the axillary area. The patient had received oral therapy from a dermatologist prior, but there was no improvement, so the patient was advised to undergo a surgical procedure. In this patient the tumescent liposuction-curettage procedure was performed. Discussion: Treatment of hyperhidrosis with both topical and systemic agents generally provides only temporary suppression of hyperhidrosis. In severe, disturbing cases, the treatment of choice for axillary hyperhidrosis is the surgical procedure. Combination of liposuction-curettage surgical method using tumescent anesthesia is relatively simple and safe. Reduction of apocrine gland secretion after liposuction-curettage takes a relatively long time. This surgical technique has many advantages, such as relatively minimal injury dan short recovery period. Follow-up after this combined liposuction-curettage procedure should be performed subjectively and objectively at 3, 6, and 12 months postoperative.]]>
<![CDATA[Peran Vitamin D dalam Aktivitas Penyakit Lupus Eritematosus Sistemik (LES) ]]>
<![CDATA[Sukamto Koesnoe]]>
<![CDATA[ MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i2.87
<![CDATA[Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that leads to various immune system dysregulation. SLE has complex pathophysiology involving interaction between factors that will produce abnormal immune response. This abnormal immune response results in inflammatory reactions throughout various organs, and this chronic process will lead to tissue and organ damage. Vitamin D has been studied for its’ role as an immunomodulator, therefore it is potential to be part of SLE management.The potential benefits of vitamin D supplementation to improve clinical conditions of SLE patients has been investigated. Some studies showed that there were positive effects after supplementation with vitamin D in SLE patients. This can be explained considering vitamin D deficiency is associated with disease activity and frequency of exacerbations in SLE. Vitamin D’s active form, calcitriol, was found to have an important role in the pathogenesis of SLE. Study found that vitamin D supplementation could help to reduce disease activity and improve clinical condition in SLE patients.]]>
<![CDATA[Pendekatan Diagnosis dan Tata Laksana Alopesia Androgenetik ]]>
<![CDATA[Ardhiah Iswanda Putri]]>;
<![CDATA[M Yulianto Listiawan]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.88
<![CDATA[Androgenetic alopecia (AGA) is the most common form of alopecia, and affects both men and women. It is described as a progressive reduction in hair diameter, length, and pigmentation. The early signs of AGA can begin in adolescence, where family history is the most predisposing factor. AGA interferes with physical appearance which is an important factor in human self-image. Patients suffering from AGA can experience a significant reduction in quality of life, so they tend to seek for effective hair loss treatments to prevent further thinning and stimulate optimal regrowth. Unfortunately, drugs that have been approved for the treatment of AGA are still limited, have some potential side effects, and do not always give satisfactory results. The limited efficacy of the therapeutic regimen, poor tolerance, and lack of information about the duration of treatment as well as possible side effects can affect adherence to medications, also lead to disappointment and early discontinuation of treatment. Therefore, comprehensive AGA management and proper education are essential to obtain optimal results in the management of AGA.]]>
<![CDATA[Ekstrak Daun Zaitun Olea europaea L. untuk Tata Laksana Hipertensi ]]>
<![CDATA[Swandari Paramita]]>;
<![CDATA[Fenny Yunita]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.89
<![CDATA[Hipertensi atau penyakit tekanan darah tinggi adalah kondisi medis yang dapat meningkatkan risiko penyakit kardiovaskular dan kerusakan organ target seperti penyakit jantung koroner, stroke, gagal ginjal, dan sebagainya. Kondisi hipertensi berkaitan dengan angka kematian yang tinggi di seluruh dunia. Sebagian besar pasien hipertensi memerlukan obat antihipertensi untuk mencapai target tekanan darah yang diinginkan, dengan profil keamanan yang baik dan biaya yang terjangkau. Oleh karena itu pengembangan obat herbal yang potensial untuk penanganan hipertensi dapat menjadi salah satu strategi yang dapat diupayakan untuk meningkatkan keberhasilan pengobatan hipertensi. Salah satu bahan alam yang mendapat perhatian adalah daun zaitun (Olea europaea L.). Kandungan utama dari daun zaitun antara lain adalah oleuropein yang telah diketahui memiliki efek sebagai penurun tekanan darah. Berdasarkan hasil penelitian preklinik dan uji klinik, ekstrak daun zaitun memiliki potensi untuk membantu mengendalikan tekanan darah sehingga akan menjadi pilihan terapi yang bermanfaat dalam tata laksana kasus hipertensi. Ekstrak daun zaitun juga terbukti dapat membantu memperbaiki profil lipid dengan profil keamanan yang baik.]]>
<![CDATA[Peran Analgesik Nonsteroidal Anti-inflammatory Drugs (NSAIDs) dan Analgesik Non-NSAIDs dalam Penanganan Nyeri ]]>
<![CDATA[Jan S. Purba]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.90
<![CDATA[Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. The experience of pain serves as one of the most important protective mechanisms of the body. Understanding the mechanisms of pain is important for any clinician since chronic pain is a global problem that transcends all medical specialties. Chronic pain describes pain that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments. There are a variety of treatment options for people with chronic pain. The goal of pain management is to provide symptom relief and improve an individual's level of functioning in daily activities. A number of types of medications have been used in the management of chronic pain.]]>
<![CDATA[Analysis of Mortality Risk Factors in Children with Pneumonia in RSUD Dr Soetomo Surabaya ]]>
<![CDATA[Tutwuri Handayani]]>;
<![CDATA[Retno Asih Setyoningrum]]>
<![CDATA[ MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS ]]>
Publisher : <![CDATA[PT Dexa Medica ]]>
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DOI: 10.56951/medicinus.v35i1.91
<![CDATA[Background: Pneumonia is one of the leading causes of under-five morbidity and mortality. We carried out a comprehensive study to identify risk factors contributing to both mortality and morbidity rate in children less than 5 years of age that were hospitalized with pneumonia. Objective: To evaluate mortality risk factors in children with pneumonia in RSUD Dr. Soetomo Surabaya. Methods: This is an analytic observational study using secondary data that was taken from medical record of hospitalized children with pneumonia between 2015-2018. Data was analysed using Chi-square test or Fisher’s exact test and logistic regression (p<0.05). Results: A total of 817 children with pneumonia were enrolled in this study. In children aged 2–59 months, the risk factors significantly associated with death included age, low birth weight, prematurity, breastfeeding status, pleural effusion, atelectasis, and comorbidity. Logistic regression revealed status of breastfeeding, pleural effusion, and comorbidities, influenced the mortality outcome of pneumonia. Conclusion: Nonexclusive breastfeeding, pleural effusion and comorbidities are the independent predictors of mortality in children with pneumonia. Thus, early identification and prompt management of these simple clinically recognizable predictors of death may help reduce mortality rate in such population.]]>
