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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 179 Documents
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Modalitas Terapi Vitiligo pada Anak Nathania Amelinda; Endra Yustin Ellistasari; Indah Julianto
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.106

Abstract

itiligo is a pigmentation disorder characterized by depigmented patches on skin and hair due to functional loss of melanocytes. Vitiligo in children is generally associated with other autoimmune diseases and has serious cosmetic and psychosocial impact. Treatment modalities for vitiligo in children consist of topical therapy, phototherapy, systemic therapy, and surgery. Vitiligo in children has a relatively good prognosis compared to adult cases. Repigmentation in childhood vitiligo usually happen spontaneously and relapses are rare.
Pemeriksaan Aldosterone/Renin Ratio sebagai Prediktor Penyakit Ginjal Kronis pada Penderita Hipertensi Juliani Dewi
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.107

Abstract

The prevalence of chronic kidney disease (CKD) is increasing. Hypertension is an established risk factor of CKD, yet found prevalent in Indonesia. To date, there is no test that can be used as predictor of , especially hypertensive patients. Recently, the relationship between aldosterone level (plasma aldosterone concentration/PAC) with hypertension and CKD has been extensively studied. Advanced studies have found that aldosterone/renin ratio (ARR) can be a promising parameter to predict the occurrence of CKD. This result brings hope for hypertensive patients, as we are able to predict not only the occurrence of CKD, but also the probability of cardio- and/or cerebrovascular events. Particularly for East Asia ethnic groups that are known to consume a relatively high amount of salt, ARR could also be a marker of salt intake sensitivity that may lead to a proper salt restriction in daily diet.
Pendekatan Multiperspektif dalam Manajemen Penyakit Asma Dito Anurogo
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.108

Abstract

Asthma is a chronic inflammatory disorder of the respiratory tract. This scientific review aims to provide comprehensive explanation about asthma, including epidemiology, etiology, diet and nutrition, genetic and epigenetic factor, pathophysiology, asthma control evaluation, imaging, management, and trend toward novel therapy in the future, such as nanotechnology.
Potential Implication of Treatments for Alzheimer’s Disease: Current and Future Jan Sudir Purba
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.112

Abstract

Alzheimer’s disease (AD) is a long-term and progressive neurodegenerative disorder, characterized by both structural abnormalities and inflammation in the brain. Patients suffering from AD lose their ability to perform daily activities, gradually worsens cognitive function and communicating skills, often accompanied by visual disturbances, eventually leads to disability. Pathologic characteristics of AD are β-amyloid (Aβ) plaque and neurofibrillary tangles. Current therapy available only targets to reduce symptoms using various drugs and psychotherapy, but do not cure the disease itself. Unfortunately, few chemical drugs designed for clinical applications have only reached the expected preventive therapeutic effect, with some safety concerns. Traditional herbal medicine has accumulated many experiences in the treatment of dementia during thousands of years and modern pharmacological studies have confirmed the therapeutic effects of many active components derived from herbal medicines. Recently, herbal medicine is shown to be a potential approach for various diseases, including neurodegenerative disorders.
Terapi Sel Punca dan Tata Laksana Covid-19 Dito Anurogo; Zahradiva Putu Fitria Hermawan; Nur Rahmah Awaliah; Taruna Ikrar
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.113

Abstract

Covid-19 was first identified in Wuhan, China, and known as a disease that can damage the lungs, as well as other organs and system organs such as the heart and the immune system. To date, there is no specific treatment for this disease, however, scientists in China have conducted many clinical studies of cell-based therapies for patients with Covid-19 and other respiratory diseases, especially mesenchymal stem (stromal) cells (MSC), by utilizing MSC-derived conditioned media (CM) or extracellular vesicles and several other cell types. Recent preclinical data from respiratory viral infection models and clinical studies related to the use of MSCs by altering the expression of proinflammatory cytokines, and facilitate the repair of damaged tissue in Covid-19 patients. This research method uses descriptive case study method. The purpose of this study was to determine the effectiveness of therapy using stem cells or mesenchymal stem cells (MSCs) in the management of Covid-19. The results suggest that administration of allogeneic MSCs could accelerate the process of tissue repair in the lungs, thus reducing the need for further mesenchymal cell activation. Positive responses in subjects receiving UC-MSC treatment indicated a decrease in inflammatory cytokines, rather than a change in viral load. The high cost of cell therapy makes researchers only able to conduct limited clinical studies on cell therapy for Covid-19 patients.
Pneumothorax Spontan pada Pasien Penyakit Paru Obstruktif Kronis Davidtuan Andartua Sihombing
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.114

Abstract

Secondary spontaneous pneumothorax occurs due to underlying lung disease. Chronic obstructive pulmonary disease is the most common cause of secondary spontaneous pneumothorax. Secondary spontaneous pneumothorax can develop into a life-threatening tension pneumothorax. In this case, a 63-year-old man came with chief complaint of severe shortness of breath. The patient has a history of chronic obstructive pulmonary disease. Chest X-ray identified a pneumothorax on the right side. Then the needle decompression was immediately performed due to suspected tension pneumothorax. After needle decompression, shortness of breath was relieved, and then the patient was planned for water seal drainage insertion in the intensive care unit.
Kajian Interaksi Nanoemulsi Silymarin-Carbon-Dots secara In Vitro pada Sel 3T3/NIH, MCF-7, dan MDA-MB Menggunakan Mikroskop Konfokal Heni Rachmawati; Yogie Handoko; Juniar Kalpika Resmi
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.115

Abstract

Silymarin is a natural compound from Silybum marianum which has potential to treat various liver diseases, but it has low bioavailability. This study aimed to develop silymarin-carbon dot nanoemulsion, analyze its parameters, and its interaction with various cell lines. Nanoemulsion oil phase was prepared from castor oil: cremophore RH40 (surfactant): PEG400 (co-surfactant) with a ratio 1:8:1. Mild stirring method was applied for nanoemulsion preparation followed by characterization including, visual appearance, droplet size, polydispersity index, zeta potential, entrapment efficiency, and physicochemical stability under normal storage condition for 2 weeks. Toxicity determined by IC50 using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] method using NIH/3T3, MCF-7, and MDA-MB cells. Nanoemulsion penetration ability was compared to silymarin solution on MCF-7 cell using confocal microscope after 3 and 6-hours incubation. The results of droplet measurement, zeta potential, polydispersity index, and entrapment efficiency was 27,95 ± 4,31 nm, 0,296 ± 0,09, -11,81 mV, and 91,92 ± 0,04%, respectively. According to stability data, the nanoemulsion showed no significant changes in the entrapment efficiency as well as the physical characteristic. The IC50 value of silymarin nanoemulsion and solution was 30,67µg/ml and 45,40µg/ml for MCF-7, and was 37.50 µg/ml and 39.14 µg/ml for MDA-MB. The nanoemulsion containing silymarin is potential to penetrate MCF-7 cell line at concentration of 12.5 µg/ml both after three and six-hours incubation. The developed nanoemulsion is a promising system to improve the therapeutic value of sylimarin.
Kromoblastomikosis Penyakit Jamur yang Terabaikan Danu Yuliarto; Achmad Satya Negara; Harijono Kariosentono; Nugrohoaji Dharmawan; Nurrachmat Mulianto
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.116

Abstract

Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue caused by pigmented or dematiaceous fungi. This disease is endemic in tropical and subtropical regions such as Asia, Africa, and Latin America. Chromoblastomycosis is more common in adult men who work in agricultural areas, work as gardeners, or as carpenters. The diagnosis of chromoblastomycosis is confirmed by the finding of muriform cells or medlar bodies obtained from skin scrapings, microscopic culture, or tissue histopathological examination. The clinical feature varies, the initial lesion is a papule that spreads slowly over several months or years, and then this lesion will form a plaque with atrophic center. Many patients go undiagnosed at the early stage of the disease because this stage is rarely seen. Treatment of chromoblastomycosis includes surgery for the initial lesion and pharmacological therapy using antifungal agent such as itraconazole, the most commonly used drug for the treatment of chromoblastomycosis. The prognosis for chromoblastomycosis is poor, except on new lesions.
Sindrom Kindler Budi Eko Prasetyorini; Suci Widhiati
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.117

Abstract

Kindler syndrome (KS) is a very rare form of epidermolysis bullosa (EB) and is a disease with defective FERMT1 gene. The FERMT1 gene provides the information needed to produce a protein called kindlin-1 where this protein plays an important role in attaching cells to the extracellular matrix which functions to hold, organize and connect cells in the body. Abnormalities in KS cause cells in the extracellular matrix to weaken so that the skin becomes brittle, prone to blisters and sores. Symptoms of SK are characterized by blisters that most often form on the backs of the hands and the tops of the feet, and thin, fragile skin. Mucosa of the eyes, intestines, esophagus, mouth, urinary tract and genitals may be affected. SK sufferers have a high sensitivity to light. Other symptoms can include discolored skin, thickened skin on the palms and soles and skin thatis atrophied or thin, dry and wrinkled. These symptoms appear in infancy and continue into adulthood, the risk of gingivitis (inflammation of the gums) which can lead to periodontitis or gum disease, throat, eye problems, higher risk of developing skin cancer and intestinal bleeding. Kindler syndrome management is basically preventive and symptomatic. Good wound care including the use of topical and systemic antibiotics for infected and ulcerated bullous lesions can reduce morbidity. Educating the patient to avoid trauma can help prevent blister formation.
Neuroprotection in the Treatment of Glaucoma Astrianda Nadya Suryono
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.119

Abstract

Glaucoma is a neurodegenerative disease with certain characteristics of progressive damage to the optic nerve, loss of retinal ganglion cells (RGC) and their axons, accompanied by typical visual defect. Increased intraocular pressure (IOP) is the main risk factor for glaucoma. Some study stated that RGC death is still progressing despite the use of IOP-lowering medications. The main aim of glaucoma treatment remains to lower IOP, however neuroprotective agents have increased interests due to its effects to prevent or slow down the rate of RGC death other than IOP-dependent mechanisms. Production of glutamate and nitric oxide is known as one of the contributing factors of RGC death, and neuroprotective agents that work by targeting the production of glutamate and nitric oxide can be a valuable option to prevent further RGC death.

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