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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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Pelepasan Flavonoid Gendarusa vulgaris Nees dari Matriks Sediaan Param Fraksi Etanol 60% dan Param Fasa Air Astuti, Engrid Juni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.333 KB) | DOI: 10.22219/far.v2i1.1157

Abstract

The aim of the research is to know the different release gendarusin A from the external tradisional dosage form named param 60% ethanol and param water phase. The release gendarusin A was detected using  Transdermal Delivery System equipment and cellophane membrane. Other conditions: Phosphate buffer pH 6,0 as a diffusion Liquid, temperature 37° C ± 0,5° C, sampling time 10, 20, 30, 40, 50, 60 minutes and sample were analysis by HPLC to get concentration of gendarusin A. The result shows that the release flux param at 60% ethanol fraction = 0,6065 µg/cm2/minute1/2 and flux param water phase = 0,3895 µg/cm2/minute1/2.   It means that the release gendarusin A from param ethanol 60% fraction more rapid than param water phase. Release gendarusin A percentage from param 60% ethanol fraction is bigger than param water phase.
Clinical study of the efficacy and safety of jamu for hyperuricemia Triyono, Agus; Novianto, Fajar
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1034.889 KB) | DOI: 10.22219/farmasains.v4i1.6628

Abstract

Hyperuricemia is a degenerative disease with a reasonably high prevalence and requires long-term treatment. Clinical research has been conducted to test the efficacy and safety of herbal medicine for hyperuricemia. The research involved 30 subjects who had fulfilled the inclusion and exclusion criteria and conducted with a pre-post test research design. Subjects were treated with herbal medicine for hyperuricemia three times a day for 28 days. From the research, jamu for hyperuricemia was effective in reducing blood uric acid levels from 7.43 mg/dL to 5.72 mg/dL, raising the quality of life score (SF-36) from 78.06 to 81.50, and disappeared of clinical symptoms. Use of herbal medicine for hyperuricemia for 28 days in subjects had no symptoms of severe side effects found and did not interfere with liver, kidney, and blood function.
STUDI BEBERAPA DOSIS INFUS DAUN SALAM (Syzygium polyanthum Wight Walp) SEBAGAI ANTIDIARE PADA MENCIT (Mus musculus) ., Sundari; ., Masruhen
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.976 KB) | DOI: 10.22219/far.v1i1.428

Abstract

Daun Syzygium pholyanthum Wight Walp masyarakat seringkali menyebutnya dengan sebutan daun salam biasanya digunakan masyarakat sebagai bumbu masak. salam merupakan salah satu tanaman obat yang memiliki banyak khasiat dalam mengobati berbagai penyakit,salah satunya sebagai obat diare.Penelitian ini bertujuan untuk mengetahui efek antidiare infus daun salam dengan pengamatan jumlah feses, konsistensi feses, serta lama diare. Daun salam diperoleh dari Lembaga Ilmu Pengetahuan Indonesia (LIPI) UPT Balai Konservasi Tumbuhan Kebun Raya Purwodadi di Pasuruan. Hewan coba dibagi secara acak menjadi 8 kelompok terdiri dari kelompk yang tidak didiarekan, kelompok kontrol positif, kontrol negatif serta kelompok diberikan infus daun salam secara oral dengan berbeda dosis yaitu 15%, 20%, 25%, 30%, dan 35% b/v. Waktu pengamatan dilakukan setiap 1 jam selama 4 jam, evaluasi hasil dilakukan dengan menghitung jumlah feses, skor kosistensi feses serta lama diare mencit. Analisis hasil penelitian yang digunakan adalah analisis varian ( ANAVA), dilanjutkan dengan uji Student Newman Keuls (SNK). Hasil analisis penelitian diperoleh data bahwa infuse daun salam dengan dosis 25% b/v, memberikan efek daya antidiare terbesar yaitu dengan rata rata jumlah feses 56%, konsistensi feses sebesar 51,77%, serta lama diare 36,66 menit. Infus daun salam dosis 15% rata rata jumlah 46,66%, konsistensi feses 43,26%, serta lama diare 46,66 menit. Salam. Dosis 20% rata rata jumlah feses 42,66%, konsistensi feses 36,18,serta lama diare51,67%. Dosis 30% rata rata jumlah feses 32%,konsistensi feses 33,33%,serta lama diare 53,33%.Dosis 35% rata rata jumlah feses 45,33%, konsistensi feses 41,14%, serta lama diare 51,67%. Berdasarkan hasil penelitian dapat disimpulkan daun salam dapat mengurangi jumlah feses, lama diare serta meningkatkan konsisitensitensi feses terhadap mencit. Semakin tinggi dosis infus daun salam yang digunakan untuk antidiare belum tentu daya antidiare infus daun salam semakin meningkat hal itu terbukti bahwa dosis 25% memiliki daya antidiare tertinggi dibanding dosis 15%, 20%, 30%, dan 35%. Dosis 25% memiliki efek yang sama seperti efek yang dihasilkan oleh loperamid dosis 0,052 mg. Berdasarkan hasil penelitian disarankan. Masyarakat menggunakan daun salam sebagai obat antidiare dosis 25%. Isolasi tannin yang terdapat dalam daun salam sehingga zat-zat lainya tidak ikut tersari sehingga memaksimalkan pengobatan diare. Dilakukan penelitian mengenai ED50. Senyawa kimia yang berkhasiat sebagai antidiare ini adalah tannin.  Kata kunci: daun Syzygium pholyanthum, diare, infus
EFEK SITOTOKSIK PROTEIN DARI DAUN Mirabilis jalapa l HASIL PEMURNIAN DENGAN KOLOM CM SEPHAROSE CL-6B TERHADAP KULTUR SEL HeLa Sudjadi, Sismindari, Ni Putu Ariantari, Zullies Ikawati,
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1282.332 KB) | DOI: 10.22219/far.v1i1.419

Abstract

Mirabilis jalapa l leaves have been known containing Ribosome Inactivating Proteins (RIPs) base on its N-glycosidase activity and cleavage of supercoiled double stranded DNA. The research aims to investigate cytotoxic activity of protein isolated from Mirabilis jalapa l leaves against HeLa cell culture. In this research, crude extract of Mirabilis jalapa l leaves was separated by gradual precipitation using sulphate ammonium followed by dyalisis. Further separation of protein fraction with cation exchange chromatography using CM sepharose CL-6B column and elution with sodium phosphate buffer 5 mM pH 6,5 for 30 minutes continued with sodium phosphate buffer 5 mM pH 6,5 containing 0-0,5 M NaCl by gradient elution for 90 minutes. Cytotoxicity activity testing of protein fraction that showed an ability to cleave supercoiled double stranded DNA revealed that RIPs eluated at NaCl gradient of 0,33-0,37 M and 0,38-0,41 M, concentration of 0,553 mg/mL relatively less toxic against HeLa cell culture with percentage of cytotoxicity of 29,53%. Keywords: Mirabilis jalapa l, RIPs, cytotoxicity
Uji Potensi Perlekatan Bakteri Asam Laktat Isolat TLA-15 Dan TLA-20 Pada Sel Epitel Usus Tikus (Rattus norvegicus) Wijayanti, Ernanin Dyah; Ardyati, Tri
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.32 KB) | DOI: 10.22219/far.v1i2.1171

Abstract

In Vitro probiotic potential test that had been conducted before, which consist of probiotic bacteria test  resistance toward the gastro-intestinal track pH and the bile salt concentration shows that the strain bacteria TLA-15 and TLA-20 had potential as probiotic bacteria. An advance test are required to fullfill the requirement as the probiotic bacteria. So that, the objective of this research are to study the viability of lactic acid bacteria strain TLA-15 and TLA-20 at the Rattus norvegicus GI track. At the first step of this research was added 4 106 cell/ml lactic acid bacteria TLA-15 and TLA-20 given orally.
Pengembangan Matrik Lepas Lambat Berbasis EC – PVP K30 Menggunakan Teknik Dispersi Solida Dengan Model Obat Natrium Diklofenak Arina Swastika Maulita, Yulistia Budianti Soemarie
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.74 KB) | DOI: 10.22219/far.v2i1.1162

Abstract

This research is a modification of controlled release which beneficially to optimize the medicine reaction and to minimize the fluctuation of blood level in a certain period of the release. The aim of research is to develop the matrix  system in ethylcellulose basic PVP K30 which applies dispersion solid method using sodium diclofenac as sample. Resulted four formulas consist of PVP K30 percentages as follow 0%, 5%, 10% and 20%. The different percentages of PVP K30 is aimed to know the formula which produces the releasing result of ND more optimal. This research produces in each formula significant differences (p<0,05). The formula whole percentages of PVP K30 10% has completed the requirements of control release better than the other one, shown the better resistance characteristics and release profile.
Correlation of illness perception, asthma control, and lung function value to the quality of life of asthma outpatients Mayzika, Nadia Aisah; Mukti, Asri Wido
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1247.427 KB) | DOI: 10.22219/farmasains.v4i1.10176

Abstract

Asthma is a heterogeneous disease and chronic inflammation of the respiratory tract that has an impact on the decreased quality of life. The design of this research is non-experimental cross-sectional. The variables of this study are illness perception, control of asthma, lung function values, and life quality of asthma patients. The relationship of asthma control, illness perception, lung function value, and life quality of asthma patients can be seen with structural equation modeling using Smart-PLS software. The results are only control of asthma affects life quality, where the coefficient value is 0.511, which is positive and significant (p = 0,000). Lung function value and asthma quality indicate that lung function has a positive relationship direction seen from the coefficient value of 0.306 but not significant (p = 0.061). The correlation between illness perception and life quality of asthma was negative, where the coefficient value was - 0.142 and not significantly different (p = 0.332). This means that the direction of the relationship is reversed; it means the quality of life of asthmatic patients, which affects illness perception by 14.2%. The conclusion is that the life quality of asthmatic patients is influenced by the control of asthma and lung function. But it’s different from illness perception, where there is a negative relationship between illness perception and life quality of asthma patients. Which means illness perception affects the life quality of asthma patients.
Pengaruh Konseling Apoteker Terhadap Hasil Terapi Pasien Hipertensi di Poliklinik Penyakit Dalam RSUD Kraton Kabupaten Pekalongan I Dewa Putu Pramantara, Anita Budi Mulyasih Djoko Wahyono
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.232 KB) | DOI: 10.22219/far.v2i1.1153

Abstract

Prevalence of Hypertension increased in line with changes of life style as smoking, obesity, non physical activity, psycho-social stress in many countries. Comprehensive and intensive treatment could be more control of blood pressure. Understood, knowledge and adherence of patient expected will improve along with act of distributed useful and correct information by pharmacist. The aim this study to determine the effect of counseling pharmacist on therapeutic outcomes and adherence and to know the correlation between therapeutic outcomes and adherence of outpatients hypertensive in the internal disease clinic at RSUD Kraton Pekalongan District. This research was experimental intervention with pre-post intervention with randomized without matching. Data was collected by prospective method. The control group given a leaflet at the first month, and the intervention group given a leaflet at the first month and counseling every early month, during 3 months.There was 75 patients, the intervention group (N=39) experienced a significant decrease in blood pressure at the end of the study, on systolic amounted 11.28±8.33 mmHg [P=0.000(P<0.05)] and diastolic amounted 7.18±6.86 mmHg [P=0.000(P<0.05)], whereas in the control group (N=36) did not experience a significant decrease in blood pressure is systolic amounted 2.22±10.45 mmHg [P=0.203(P>0.05)] and diastolic amounted 0.28±6.09 mmHg [P=0.782(P>0.05)]. Adherence of patients as measured by MMAS scale in the intervention group better adherence than the control group (33.33% : 2.78%). There was have correlation a means between MMAS score with change of systolic (P=0.019; r=0.270) and diastolic (P=0.001; r=0.372) which positive direction. It was concluded that counseling has an effect on adherence positively in the intervention group better than the control group and decreasing systolic and diastolic blood pressure until reach targets. There was a close correlation between decrease in blood pressure with MMAS score in hypertensive patients.
PENGARUH PEMBERIAN INFUS BUAH BELIMBING WULUH (Averrhoa bilimbi l) TERHADAP KADAR KOLESTEROL DARAH TIKUS ., Masruhen
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.609 KB) | DOI: 10.22219/far.v1i1.424

Abstract

Telah dilakukan penelitian tentang pengaruh infus buah belimbing wuluh terhadap kadar kolesterol darah tikus. Penelitian terdahulu membuktikan bahwa air perasan belimbing wuluh dengan volume 1ml, 1,5ml, 2ml, dan 2,5ml secara oral pada tikus putih dapat menurunkan kadar kolesterol dalam serum darahnya. Belimbing wuluh mengandung senyawa flavonoid, pektin dan vitamin C yang dapat menurunkan tekanan darah. Buah belimbing wuluh mempunyai rasa yang sangat masam, sehingga orang enggan memakan langsung atau diperas airnya. Dengan membuat infus dapat mengurangi rasa masam pada belimbing wuluh. Dengan cara penyarian infundasi zat aktif flavonoid, pektin dan vitamin dapat tersari, namun demikian perlu diuji efek menurunkan kadar kolesterolnya. Penelitian ini bertujuan untuk mengetahui pengaruh infus buah belimbing wuluh terhadap kadar kolesterol darah tikus. Penelitian dilakukan dengan menggunakan 15 ekor tikus putih yang dibagi dalam 5 kelompok percobaan. Masing-masing tikus diberi asupan kolesterol tinggi kuning telur ayam 54 mg/200 g BB, dan diukur kadar kolesterol darahnya menggunakan chip strip chek kolesterol. Berikutnya, kelompok I diberi infus belimbing wuluh dosis 1,8 g/200 g BB, kelompok II dosis 3,6 g/200 g BB, kelompok III dosis 5,4 g/200 g BB, kelompok IV diberi gemfibrozil dosis 10,8 mg/200 g BB sebagai kontrol positif, kelompok V diberi aquades sebagai kontrol negatif, dan diukur kadar kolesterolnya. Data dianalisis mengunakan analisis Kovariansi dan dilanjutkan uji SNK. Hasil penelitian menunjukkan bahwa pemberian infus belimbing wuluh menyebabkan penurunan kolesterol darah tikus secara bermakna. Analisis kovariansi menghasilkan nilai F hitung = 43,41 yang lebih besar dari F tabel = 6,55 (p > 0,01). Hasil uji SNK menunjukkan perbedaan yang tidak bermakna antara kontrol negatif dengan kelompok I, tetapi berbeda bermakna dengan kelompok II, III dan IV. Terdapat perbedaan bermakna antara kelompok I, II, dan III. Kontrol positif berbeda tidak nyata dengan kelompok III. Dari data penelitian dapat disimpulkan bahwa infus buah belimbing wuluh dosis 3,6 g, dan 5,4 g /200 g BB dapat menurunkan kadar klesterol darah tikus. Dosis 5,4 g memberikan efek yang setara dengan gemfibrozil 10,8 mg/200 g BB. Kata kunci : infus, buah belimbing wuluh, kadar kolesterol darah.
Studi Etnofarmasi Etnis Using Banyuwangi Indonesia Syifa, Nailis; Sihdianto, Apris Dwi; Herjuno, Adityo; Salash, Alvan Febrian
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (897.113 KB) | DOI: 10.22219/far.v1i2.1167

Abstract

Cultural studies about treatment methods and herbal plants in an ethnic important to understand in order to know the different methods of treatment and medicinal plants used from each ethnicity. In addition, this study is also useful to know the drugs from natural ingredients that have not been identified. In this study, as the object of research is ethnic Using, Kemiren village, District Glagah Banyuwangi. The method used in this study include interviews with local community and the people who play a role in traditional medicine in these ethnic. The results obtained information on 62 commonly used medicinal plants for traditional medicine. From 62 plants were then performed classification based on the bioactivity.

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