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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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Quantitative structure-cytotoxic activity relationship of phenylthiourea derivatives from ChemBL database on sirtuin-1 receptor by in silico Nasyanka, Anindi Lupita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 1 (2019): April
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.876 KB) | DOI: 10.22219/farmasains.v4i1.7745

Abstract

Rational drug design becomes a necessity amid the development of drugs that are inefficient and time-consuming. Hansch's QSAR helps reduce these shortcomings supported by the role of biocomputation. Some of the roles of biocomputation that can be used include in silico testing and the availability of databases for new drug-receptor and ligand candidates. This study aims to determine the QSAR through the search for the best equations analyzed by ANOVA statistics between cytotoxic activity in silico (Log 1/c) anticancer compounds derived from phenylthiourea stored in the ChemBL database with lipophilic parameters (ALPP and AlogP) , electronic (ACDpKa), and its sterics (PMW). The best equation is obtained Log 1/c = -46,194 - 0,152 PMW- 3,769 ALogP - 1,336 ACDpKa with a value of N = 28; F = 20,866; r = 0,850;  P = 0,000; SE = 5.82160. In the future, this equation can be used to find other new phenylthiourea derivatives that have better cytotoxic activity.
EFEK PEMACUAN APOPTOSIS FRAKSI ETIL ASETAT EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia Jack) TERHADAP SEL HeLa Nurkhasan, Isnaniati Romadhoni Indarwati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.549 KB) | DOI: 10.22219/far.v2i1.1151

Abstract

Pasak bumi is one of the Indonesian original plants having anticancer activity. Eurycomanone was isolated from Eurycoma longofolia, Jack  root was proven to have cytotoxic effect and induce apoptosis on Hela cells. The objective this study was to know the cytotoxic activity of ethyl acetate fraction of ethanolic extract of the Eurycoma longifolia, Jack root on Hela cells and the mode of death. Ethyl acetate fraction was obtained from  the ethyl acetate soluble fraction from residue of chloroform fraction of ethanolic extract of Eurycoma longifolia Jack roots. The cytotoxic assay was performed using MTT test method with concentration series used in this study were 1000; 750; 500; 400; 200; 100; 50; 12,5; 6,25; 3,125; and 1,5625 µg/ml. Absorbance was measured at wavelength of 550 nm using ELISA reader. Apoptosis assay were observed using Giemsa staining. MTT assay indicated that etil asetat fraction of ethanolic extract of the Eurycoma longofolia, Jack root showed cytotoxic activity againts Hela cells with IC50 value 3,70 µg/ml. The result of apoptosis assay indicated that the ethyl acetate fraction of ethanolic extract of the Eurycoma longofolia, Jack root induce apoptosis. The apoptotic cells was observed wrinkle, rounded and dark colors leading to chromatin condensation.
PEMANFAATAN BIJI Nigella sativa DALAM TERAPI PENYEMBUHAN KANKER DAN GANGGUAN METABOLISME Jamil, Ahmad Shobrun
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 1 (2010): April-September 2010
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (58.354 KB) | DOI: 10.22219/far.v1i1.422

Abstract

The seed of Nigella sativa has long time ago employed as medicinal remedy for numerous disorders. N.sativa has active compounds in its seed likes nigellisine, nigellidine, nigellimine-N-oxide, thymoquinone, dithymoquinone, thymohydroquinon, nigellone, thymol, arvacrol, oxy-coumarin, 6-methoxycoumarin, 7-hydroxy-coumarin, alpha-hedrin, steryl-glucoside, flavonoids, tannins, essential amino acid, ascorbic acid, and minerals. The seed has various curative activities. As body immunity stimulator by stimulating the formations of bone marrow and many kind of antibody cells, antihistamine, anti-hypertension, anti-inflammation, antimicrobial activities by protecting bodies from viruses and decreasing the risk of infections, anti-diabetic (metabolic syndrome), and anti cancer. These papers have to discuss deeper about the beneficial aspect of N. sativa seed against metabolic syndrome and cancer. Based on several research known that N. sativa has potential to decrease total cholesterol, low density lipoprotein and blood glucose level. This seed also has potential to maintain the homeostatic of blood vessels as the backbone of the circulatory system in the body. At the cancer case, this seed substances has potential to decreasing the development of cancerous cells, kills the cells by enhances its apoptotic programs and also lessening the metastasis of the cancer cells. Keywords: cancer, metabolic syndrome, Nigella sativa
STRUMA MULTI NODOSA NON TOKSIKA INTRATHORAKAL Apa pilihan approach operasinya? Haruskah dilakukan Median Sternotomy? Sander, Mochamad Aleq; CS, Fina
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.01 KB) | DOI: 10.22219/far.v1i2.1513

Abstract

Mochamad Aleq Sander, dr., M.Kes., SpB., FinaCSFakultas Kedokteran Universitas Muhammadiyah MalangJl. Bendungan Sutami 188A Malang 65145e-mail: aleq.sander@yahoo.comblog: bedahunmuh.wordpress.comAbstractIntrathoracal non toxic multi nodular struma is lumpy enlargement of thyroid glandwithout hypothyroidism that extend from cervical thyroid gland into thoracal cavity. Accordingto anatomy location of thyroid, their name were substernal, retrosternal, mediastinal,intrathoracal, plunging, anterior and posterior mediastinal, and aberrant mediastinal. Theorigin of blood supply of mediastinal struma was inferior thyroidea artery, especially casesfrom aorta, subclavia artery, internal mammary artery, or ima thyroidea artery. According toStudy got that seven patients with mediastinal struma had intrathoracal blood supply directly.Surgery could cervical approach and/or thoracotomy according to anatomic location andtype of intrathoracal struma.Keywords: intrathoracal strumaAbstrakStruma multi nodosa non toksika intratorakal adalah pembesaran kelenjar tiroid yang tampakberbenjol-benjol tanpa disertai tanda-tanda hipertiroidisme yang mengalami ekstensi kearahinferior dari kelenjar tiroid servikal hingga masuk ke dalam rongga thoraks. Jaringan tiroidyang berada di rongga toraks diberi nama sesuai tempat anatominya yaitu substernal, retrosternal,mediastinal, intrathorakal, plunging, anterior dan posterior mediastinum, serta mediastinumaberrant. Suplai darah untuk struma mediastinum biasanya dari arteri tiroidea inferior, padakasus tertentu suplai darah dapat berasal dari aorta, arteri subklavia, arteri mamaria interna,atau dari arteri tiroidea ima. Hasil penelitian didapatkan bahwa dari tujuh orang yang mengalamistruma mediastinum ternyata memiliki sumber perdarahan langsung dari intrathorakal. Tindakanoperasinya bisa melalui cervical approach dan/atau thoracotomy, hal ini tergantung dari lokasianatomis dan tipe struma intratorakal yang diderita oleh pasien.Kata kunci: struma intratorakal
FORMULASI SUSPENSI DOKSISIKLIN MENGGUNAKAN SUSPENDING AGENT PULVIS GUMMI ARABICI: UJI STABILITAS FISIK DAN DAYA ANTIBAKTERI Chasanah, Nur; Trisharyanti DK, Ika; Indrayudha, Peni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 1, No 2 (2011): Oktober 2010 - Maret 2011
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.779 KB) | DOI: 10.22219/far.v1i2.1165

Abstract

Suspension is a dosage contain solid drug material with insoluble form and smooth. Doxycycline is an antibiotic which difficult dissolve in water. Stable doxycycline suspension during 2 week if it kept at space temperature, stable on the air but will change to be dark if it influence sunshine. The aim of the research to evaluate physical stability and ability antibacterial stability doxycycline suspension with PGA as suspending agent. Research category are: Independent variable : concentration of suspending agent (PGA), suspension holding time. Dependent variable: physical stability (sedimentation volume, viscosity, redispersibility, easy to pour, and particle size) and antibacterial of doxycycline suspension, and variabel control is temperature suspension making, create of suspension. Data collecting with measuring physical stability and ability antibacterial of doxycycline suspension. The result shows doxycycline suspension with suspending agent PGA had physical stability and antibacterial ability is good. Physical Stability test show  formula 1 rate PGA 5% is formula had physical stability better than formula 2 with rate PGA 7,5% and formula 3 withrate PGA 10%. stability ability test antibacterial show formula 2 is the  best in pursues Staphylococcus aureus.
Factors affecting in the use of antihipertension drugs with the health belief model approach in Puskesmas Pandanwangi Malang Hidayati, Ika Ratna; Putri, Cikita
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.893 KB) | DOI: 10.22219/farmasains.v4i2.10071

Abstract

Hypertension is a condition where systolic blood pressure is 140 mmHg or higher, and diastolic blood pressure is 90 mmHg or higher. Generally, hypertension patients use captopril and Amlodipin as treatment of hypertension. It is necessary to take various efforts to improve the obedience of hypertensive patients during drug therapy. One theory studies that obedience behavior is the Health Belief Model. The HBM theory covers perceived susceptibility, severity, benefits, and barrier, along with self-efficacy. To investigate factors affecting the obedience of hypertensive patients during the antihypertensive captopril and amlodipine medications treatment in the Puskesmas Pandanwangi, Malang, this study using the approach of HBM theory and instrument. Sampling was done through a purposive and accidental sampling method. The data analysis was done through multivariate analysis, which used multiple regression to determine the effecting factors based on the HBM theory on the obedience of hypertensive patients during the antihypertensive captopril and amlodipine medications therapy. Factors of HBM theory that affect the obedience of hypertensive patients are self-efficacy, perceived severity, and perceived barrier. Whereas, the unaffected factor are perceived suspectibility and perceived benefits. Overall, factors of HBM theory affect obedience.
Isolation of terpenoid compound of n-hexane extract of Marsilea crenata Presl.. Ma'arif, Burhan; Agil, Mangestuti; Widyowati, Retno
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1419.172 KB) | DOI: 10.22219/farmasains.v4i2.10717

Abstract

Isolation, identification, and structure elucidation of terpenoid compounds from an n-hexane extract of Marsilea crenata Presl., had been done. The leaves of M. crenata was extracted using n-hexane solvent. The extract then separated with vacuum column chromatography and open column chromatography to obtain the isolate. Furthermore, the isolate was identified and elucidated using UV-Vis, FT-IR, 1H-NMR, 13C- NMR, and 2D-NMR (COSY, HMQC, and HMBC). The identification and elucidation of the isolated structure from an n-hexane extract of M. crenata leaves indicate the isolate was a pentacyclic triterpenoid. 
Benefit administration of vitamin B1, B6, and B12 on the depression symptom in hemodialysis patients Pinzon, Rizaldy Taslim; Ardiani, Birgitta Lisbethiara
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1279.788 KB) | DOI: 10.22219/farmasains.v4i2.8919

Abstract

Chronic kidney disease (CKD) is a disease that causes a decrease in kidney function, which can be seen from GFR (Glomerulus Filtration Rate) value, which is less than 60 ml/minute/1.73 m2 in minimum three months. Depression is a psychological problem in a patient with chronic kidney disease undergoing hemodialysis. The previous study has shown that giving vitamin B combination can improve depression symptoms. To measure the benefit of vitamin B1, B6, B12 parenterally for depression symptoms in chronic kidney disease patients undergoing hemodialysis. This study used an experimental design (one group pre and post-test) in 117 patient that obtained using a consecutive sampling method. Depression score was measured by the HADS questionnaire before given vitamin B (pre-test) and after given vitamin B (post-test). Data were statistically analyzed using a licensed SPSS program with paired t-test/Non-Parametric Wilcoxon. The relationship between the history of the use of the antihypertensive, antidiabetic, folic acid drug, and depression scores were not showing significant results (p > 0.05). The relationship between administration of vitamins B1, B6, and B12 and the patient's depression score showed a decrease but not significant (p = 0.522). There was no significant difference after the administration of vitamin B1, B6, and B12 on the depression score of patients with chronic kidney disease undergoing hemodialysis at Bethesda and Panti Rapih Hospital in Yogyakarta.
Transdermal delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): a mini review Nugraheni, Raditya Weka
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.334 KB) | DOI: 10.22219/farmasains.v4i2.11369

Abstract

The transdermal route has several advantages over the oral route, especially for the drugs which significantly experience the first-pass effect in the liver. Another advantage of drug administration via the transdermal route is its non-invasive way and can be used by patients themselves. Also, it allows long-term use, thereby increasing patient compliance and is generally inexpensive. The development of transdermal preparation itself is not easy because of the permeability factor of drug ingredients through the skin is relatively low compared to the gastrointestinal route or mucous membrane because the skin is part of the body's defense system and prevents foreign materials to entering the body. The biggest challenge for drug administration via the transdermal route is that the limitations of drugs can be administrated through this route. NSAIDs are drugs that are widely used in chronic conditions and can cause serious gastrointestinal side effects. Therefore the transdermal route is expected to be a promising alternative in the future. The drug-loaded nanoparticle delivered using the iontophoresis method can improve the bioavailability of NSAIDs via the transdermal route.
Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain Aditama, Agnis Pondineka Ria
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1183.384 KB) | DOI: 10.22219/farmasains.v4i2.10718

Abstract

Diabetes mellitus (DM) is a progressive metabolic disease that continues to increase every year. Treatment therapy using oral hypoglycemic drugs to treat DM has side effects, and alternative approaches must be taken. Abelmoschus esculentus has been known to be used as an alternative to DM because it has antioxidant activity due to its high flavonoid content. The purpose of this study was to determine the antidiabetic activity of 96% ethanol extract of Okra leaves against male mice of balb-c strain. Male mice were acclimatized for seven days and divided into five test groups and then fasted for 18 hours. Then the mice were induced with 150 mg / 20 g BW alloxan and measured on the 3rd day. Ethanol extract 96% okra leaves were then given in a dose of 5.6 mg / 20g BW; 11.2 mg / 20g BW; 22.4 mg / 20g BW, CMC Na 0.5% as negative control and glibenclamide 0.026 mg / 20g BBs as positive control for 14 days. The results of therapy with 96% ethanol extract of okra leaves can reduce blood glucose levels in mice so that the okra leaves contain flavonoid compounds that have antioxidant activity and can reduce blood glucose levels.

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