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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,093 Documents
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Flood Mitigation in Malang City: The Perspective of Health Policy Mohammad Muhibbin; Umar Sahid Sugiharto; Budi Parmono
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The high intensity of rainfall in Indonesia causes some cities to experience flood, including Malang City. Malang is a mountainous city which is located on highlands, between 444 to 667 meters above sea level. Ironically, every year during the rainy season, many parts of Malang are hit by flood. This flood disaster causes severe health problems. This paper aims to describe the flood mitigation in Malang City. Method: The method used in this research is the socio-legal research. It uses the cultural socio-legal approach, with the background of the thought that the law cannot be separated from the lives of the people, in the form of values, attitudes, behaviors, and impacts which it causes. Results: The results of this research show that the main cause of the flood is influenced by human activities as the main factor. Conclusion: The government should make policies in preventing the health impacts caused by flood.
Production of Dried Roasted Watermelon (Citrullus Lanatus) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Watermelon seeds are a source of protein, B vitamins, and minerals. The watermelon seeds are often discarded while the fruit is eaten. Watermelon seeds are considered as a good source of food for human nutrition and health. Drying and roasting are the most important processes giving necessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during infrared drying as well as storage. So the objective of the present study was to identify the effect of temperature in infrared drying, roasting condition, packaging and storage to tocopherol, total phenolic and antioxidant activity in the dried roasted watermelon (Citrullus lanatus) seed. Results demonstrated that drying temperature (45 oC), roasting (165 oC in 3 min), vaccum packing in polyethylene (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 16 weeks. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted watermelon seed.Keywords: Watermelon seed, Drying, Roasting, Antioxidant, tocopherol, Phenolics, vaccum.
An Analysis of the Quality of Patient Development Integrated Records as System Information Among Healthcare Professionals Muhammad Hadi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Patient Development Integrated Records (CPPT) is the documentation for health personnel in conducting the assessment of hospitalized patients according to the Hospital Accreditation Committee Standard (KARS). The CPPT is a tool for all health professions to convert the data and treatment plan for the patient. This would lead to a collaboration and communication between healthcare professionals at the hospital. This study aims to analyze CPPT as the information system between healthcare professionals at the hospital. This design study used a mixed-method with quantitative research as a source of primary data and qualitative research as secondary data. This research used cross-sectional approach as the quantitative tool, involving 76 health workers, most of whom were nurses. The sample was done by systematic sampling. Data collecting was done using questionnaires chi-square bivariate analysis and multivariate logistic regression. Qualitative research was done through interviews, focus group discussions and documentation with the status of 140 documents. The results of this quantitative study showed that the quality of study documentation in hospitals is still 80,3%, good category, and based on documentation study shows 52.9%. Meanwhile, as an information system between professionals was influenced by education, length of work, understanding of the Standard Operating Procedure (SOP) and concern of health professionals who write Patient Development Integrated Records, with the most dominant factor is the knowledge of SOP with (p=0.003). These factors should be a concern for the hospital management as the evaluation in order to improve care to patients, patient safety and protect health care workers from lawsuits.Keywords: Influential factor, Inter-professional information system, Patient development integrated records.
Application of Electronic Medical Record at Intensive Care Unit in Maternity and Children Hospital Moustafa Ali Ghazi Al-Shammari
Journal of Global Pharma Technology .
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Abstract

Background: Electronic medical record implementation within the PICU to measure the system effectiveness with analysis the user's attitude toward the system use based on TAM3. Methods: A controlled before and after study, started from 29th Sep 2016 to 11th May 2017, were conducted in the PICU of Children Hospital. A convenience (probability) sample of pediatric patients was selected before and after EMR use. And a purposive (non-probability) sample of PICU staff was selected after 3 months of EMR application. The data were gathered from sheets in the before and after period by stopwatch and an excel spreadsheet tool. In addition to, the electronic questionnaire developed based on TAM3 by using (google forms) used to collect data from the respondent survey, for the period from (14th March - 30th April 2017). Data were analyzed using SPSS®, through applying descriptive and inferential analysis as; frequency, percentage, mean, Cronbach's alpha test, and paired-samples T test. Results: The results were the documentation time was faster using electronic recording, (10.25 min 0.38sc vs 23.9 min 0.43 sc; p < 0.001). And documentation completeness was enhanced significantly after application. All PICU users enrolling in the afterward time accomplished analyses were having highly scored of attitude toward EMR system use.  Conclusion: The EMR system implemented in the PICU overall succeed, electronic charting was faster, as well as the documentation completion recording was significantly improved. The healthcare members were having a positive attitude toward adoption of the system.Keywords: Documentation completeness, EMR, Implementation process, PICU, Technology acceptance model 3, Time.
METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TICARGRELOR IN BULK AND COMPARISON WITH OTHER PUBLISHED METHODS BS Muddukrishna
Journal of Global Pharma Technology .
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Abstract

The following article consist of highly sensitive and easy RP-HPLC method to estimate Ticagrelor in bulk. Ticagrelor was separated using Shimadzu LC-20-AD with auto sampler and PDA/UV detector. The separation was achieved using a C18 Vydac Monomeric 120A (5.0 micron, 250 x 4.6mm) column. Acetonitrile: Water Milli Q (60:40 v/v) at a flow rate of 1.0 ml/min was used as the mobile phase. The method was linear having line equation f(x)=1.90442e-005*x-0.302059 with correlation coefficient (R2) of 0.997. The method was precise having  RSD as 0.27% (intraday precision). The LOD & LOQ were 0.083μg/mL and 0.25μg/mL respectively. The developed method was validated for precision, linearity, system suitability and robustness; hence proves that it is highly applicable to estimate Ticagrelor in day to day analysis.
Molecular Detection and Prevalence of, Cryptosporidium Parvum, Entamoeba Histolytica and Giardia Lamblia among Patients with Diarrhea at Al- Rifea city/Thi-Qar Province Bassad Akrab Al- Aboody
Journal of Global Pharma Technology .
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Abstract

Diarrhea  is defined as having extra stools than are usual for that individuals or as passage of watery stool for more than three times in 24 hours, caused by various pathogens such as  bacteria, viruses and parasites and protozoa consider as important causes of diarrhea and other gastrointestinal infections in humans they include mostly Cryptosporidium parvum, Entamoeba histolytica and Giardia lambella, this study aimed to determined the prevalence of parasitic agents in stool samples  of diarrheic  patients , this study is carried out in Thi –Qar Province / Al-Refaie district in Al-Refaie general Hospital which included collection of stool samples from diarrheic patients at a period extended from October / 2017 – January / 2018 , (96) stool samples taken from patients with different ages to both sexes examined by PCR technique. The results showed The percentage of positive samples were 63.5% while 36.5% was negative C. parvum (11.9%), E. histolytica (22.6%) and G. lamblia (65.5%), no significant statistical differences between males, females and between Urban and Rural areas while there was significant statistical differences between age groups (the highest rate in less than 1 – 10 years and lowest age group was (11 – 20 years).Keywords: Cryptosporidium parvumm, Entamoeba histolytica and Gardia lamblia, Polymerase chain reaction (PCR), Protozoa.
The Accuracy of Brachial Artery Volume Flow as a Predictor of Brachiocephalic Arteriovenous Fistula Maturation Patrianef Darwis
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: This study aims to investigate brachial artery volume flow accuracy in predicting AVF maturity. Methods: This was a cross-sectional study involving 80 patients that underwent AVF creation in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Parameters recorded include demographic data, ultrasound parameters in six weeks after AVF creation, and complications. Diagnosis tests were performed to determine the area under the curve (AUC), cut-off, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Of 80 patients that underwent brachiocephalic AVF, we found that 64 (80%) successfully mature, and 16 (20%) failed to mature. Receiver operating characteristic (ROC) for brachial artery volume flow in predicting brachiocephalic AVF had AUC of 97,6 %. With cut-off brachial artery volume flow of 700 ml/minute, the sensitivity, specificity, PPV, NPV, and accuracy were 98.44 % (95 % CI 91.6-99.7%), 87.5 % (95 % CI 63,9 % - 96.5 %), PPV 96.9 % (95% CI 89.4-99.15%) NPV 84.6 % (95 % CI 66.5 % - 93.8 %) 93.33 % (95 % CI 70.1-98.8%), respectively. Conclusions: Brachial artery volume flow six weeks after AVF creation is an accurate parameter in predicting brachiocephalic AVF maturity. Keywords: brachial artery volume flow, maturity, arteriovenous fistula
The Effect of Educational Tools Exercises on Certain Joints’ Angles in Javelin Performance and Achievement Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

The study included a number of axes that concentrated on selecting the exercises used in the educational process by the physical education professors and mixing them using wires and plastic nets. These methods help achieving the goals of the educational exercises. The educational exercises included all the technical stages of the Javelin, and have simultaneously concentrated on its difficult aspects, since some of the stages require more than spears and medical balls, but rather tools that help the students learn the initial applications from holding the javelin to the release step, and help the students be precise with the track of the spear through the movement of the plastic, spear-like sticks in certain measurements through parallel-fixed wires, and curved-fixed as well. These tracks well help the students focus on how to perform in the technical stages without much thinking about carrying the tools or the gravity, and concentrate on struggling with steering the spear while running. After mastering the fixed tracks, the Javelin is now performed on the plastic nets. Then, the students do the Javelin using the legal tools on the legal field. The educational exercises along the helping tools were applied on the experiment group for four weeks, an average of two educational units per week. Then it was compared with the original group, and as the statistics show, the experimental group has exceeded the original group.Keywords: Educational exercises, Educational tools, Kinetic variables, Learning to perform.
Association between Hypothyroidism and Herpes Simplex Virus with Interleukin-23 Sahar H. Al-Hindawi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Hashimoto’s thyroiditis and Hypothyroidism play a distinct role in the suppression and reactivation of herpes viruses. Herpes simplex virus infections have been assumed as one of the factors that may trigger autoimmune thyroid diseases; however, IL-23 has an important role in the pathogenesis of several inflammatory and autoimmune conditions. Objective: This study aimed to investigate the association between thyroid hormones in hypothyroid state and the Herpes simplex virus status in such patients; besides detecting the role of IL-23 in these cases. Materials and Methods: The present study included 65 Iraqi female hypothyroid patients with age ranged between 26-54 years and 25 healthy controls with age ranged between 25-50 years. Serum samples were collected from the study groups. Levels of thyroid hormones (TSH, T4, and T3) were determined by using automated Chemiluminescence Immunoassay (CLIA) analysis system. The detection of herpes simplex virus IgG and IL-23 levels in the serum samples were determined by an enzyme linked immunosorbent assay (ELISA) kits. Results: The current study results revealed that serum IL-23 and HSV levels are increased significantly (P<0.001) in the hypothyroid patients group as compared with control. There was a significant positive correlation between TSH and (IL-23, HSV); also between IL-23 and HSV (P<0.01). Moreover, there was a significant negative correlations (P<0.01) between IL-23 with (T4, T3) and between HSV with (T4, T3).  Conclusion: The present study pointed to the association between thyroid hormones deficiency in Hashimoto thyroiditis cases and IL-23 levels through disruption of the patient’s immune system; and with Herpes simplex viruse-1by their role in the replication.Keywords: Hashimoto Thyroiditis, Hypothyroidism, Herpes Simplex Virus, IL-23.
Quantitative Estimation of Gallic Acid in Triphala Churna by HPTLC Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

A simple, reliable and rapid HPTLC method was developed for qquantitative estimation of gallic acid in the methanol extract of Triphala churna. The method was validated as per ICH guidelines for linearity, accuracy, precision, and specificity. Silica gel 60 F254 pre-coated aluminium plates were used as the stationary phase. Toluene: Ethyl acetate: Formic acid: Methanol (12: 9: 4: 0.5) constituted the mobile phase.  Percentage of gallic acid was estimated through densitometry scanning using a TLC Scanner III (Camag, Switzerland) with winCATS software. The amount of gallic acid present in the sample was found to be 0.41 ± 0.08 % w/w with respect to dried plant material. Thus, the developed method can be applied in quantifying the amounts of gallic acid in Triphala churna and results of this work will support in the standardization process of Triphala churna using gallic acid as the biomarker.Keywords: Triphala churna, Methanol extract, HPTLC, Gallic acid.

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