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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 25 Documents
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Search results for , issue "Volume 12 Issue 11 (2020) Nov. 2020" : 25 Documents clear
Efficacy, Safety, Quality Assurance of Isomers of Non-Steroidal Anti-Inflammatory Drugs: Dexketoprofen and Dexibuprofen Elena Litvinova; Mariya Zarichkova; Svitlana Kovalenko; Olga Posylkina; Olena Tkachenko; Anastasiia Lisna
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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The aim of this work is to analyze and systematize data on efficacy, safety, and quality assurance for NSAID isomers – dexketoprofen and dexibuprofen. Studies were conducted using databases on the Internet: PubMed; Food and Drug Administration, European Medicines Agency. It has used retrospective, logical, systematic and analytical methods. The results of a multifaceted analysis of sources of data of clinical use proved the high analgesic efficacy of dexketoprofen and dexibuprofen in acute and chronic pain of various etiologies, such as toothache, dysmenorrhea, pain after surgery, muscle pain, headache, back pain, pain from bone metastases, etc. To achieve the effect obtained with the use of 1 dose of racemic NSAIDs, half the dose of their active isomers is sufficient. The high clinical effectiveness of dexketoprofen, dexibuprofen combines with their relative tolerance, in particular from the gastrointestinal tract. In large part, the safety of dexketoprofen is due to the presence of only the active S (+) - enantiomer of ketoprofen, dexibuprofen is due to the presence of only active S (+) - ibuprofen, which eliminates the side effects associated with the influence of the R (-) - enantiomers. The results of the analysis of quality assurance of generic dexketoprofen (class 1 of biopharmaceutical classification system) and dexibuprofen (class 2 of biopharmaceutical classification system) during the biowaiver procedure are systematized. It has been shown that not only high permeability and high solubility, but also the composition of the drug excipients are important for pharmaceutical equivalence in vitro. Based on the results research findings presented, it is possible to optimize the technological process and analytical methods, which allows taking into account critical factors and ensuring the quality of the medicine and its bioequivalence to the reference drug.
The Effect of Moringa oleifera Extract as Candidate Prebiotic to Increase the Growth of Lactobacillus acidophilus and Lactobacillus plantarum Probiotics Widya Paramita Lokapirnasari
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Objectives: The potential of probiotics can be increased by adding prebiotics, which are substances that cannot be digested, but can be used by probiotics to increase their growth. Prebiotics generally consist of oligosaccharides. Moringa oleifera has potential as a prebiotic candidate. This study aims to prove the use of Moringa oleifera (M. oleifera) extract as a prebiotic candidate to increase the growth of Lactobacillus acidophilus (L. acidophilus) and Lactobacillus plantarum (L. plantarum) probiotics. Methods: This study consisted of 4 treatments and each treatment was repeated 5 times. The treatments consisted of: P0: 0% Moringa oleifera extract, P1: 0.1% Moringa oleifera extract (v/v), P2: 0.2% M. oleifera extract (v/v), P3: 0.3% M. oleifera extracts (v/v). The probiotic concentration is 1.5x108CFU/ml. Results: The results showed that there was a significant difference (p
Flood Mitigation in Malang City: The Perspective of Health Policy Mohammad Muhibbin; Umar Sahid Sugiharto; Budi Parmono
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Objective: The high intensity of rainfall in Indonesia causes some cities to experience flood, including Malang City. Malang is a mountainous city which is located on highlands, between 444 to 667 meters above sea level. Ironically, every year during the rainy season, many parts of Malang are hit by flood. This flood disaster causes severe health problems. This paper aims to describe the flood mitigation in Malang City. Method: The method used in this research is the socio-legal research. It uses the cultural socio-legal approach, with the background of the thought that the law cannot be separated from the lives of the people, in the form of values, attitudes, behaviors, and impacts which it causes. Results: The results of this research show that the main cause of the flood is influenced by human activities as the main factor. Conclusion: The government should make policies in preventing the health impacts caused by flood.
Antibacterial Activity of Bis (2-Ethylhexyl) Phthalate Leaves Fraction of Colocacia esculenta L against Enteric Gram Negative Bacteria Herwin Herwin; Siska Nuryanti; Muzakkir Baits; Sjafaraenan Sjafaraenan
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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This study is aimed at testing the antibacterial activity of the compound Bis (2-Ethylhexyl) phthalate leaves fraction of Colocacia esculenta L against enteric gram negative bacteria. The search for bioactive compounds employs the vacuum liquid chromatography method used for fractionation and purification, spectroscopic analysis (infrared, proton and carbon core magnetic resonance, chromatography-mass spectroscopy) gas, Minimal Inhibitory Concentration (MIC), Minimal Bactericidal Concentration (MBC), Agar diffusion and TLC-Bioautography for activity testing against Enteric Gram Negative Bacteria. The results of the fractionation shows that based on agar diffusion, the B fraction obtains the MIC value is 0.1%, and MBC value is 1%. Spectroscopic analysis of the secondary metabolites of the leaves fraction of Colocacia esculenta L obtains the chemical structure of Bis (2-Ethylhexyl) phthalate with the molecular formula C24H38O4 and molecular weight 390.5. The test on the compound Bis (2-Ethylhexyl) phthalate from the leaves fraction of Colocacia esculenta L L by TLC-Bio autography obtains an active Rf value of 0.7 against bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella thypi, Streptococcus mutans, and Vibrio cholerae, by diffusion Agar method, the largest inhibition zone in Salmonella thypi bacteria. Based on the results, the identification of secondary metabolites from the leaves fraction of Colocacia esculenta L obtains the chemical compound Bis (2-Ethylhexyl) phthalate and based on the results of the antibacterial activity test of the chemical compound Bis (2-Ethylhexyl) phthalate leaves of Colocacia Esculenta L is potential for the treatment of enteric gram negative bacteria infections. Keywords: Colocacia esculenta L, Bis (2-Ethylhexyl) phthalate, Antibacterial
Prevention of Oral Health in Persons with Tobacco Smoking of Steam Cocktails Elena Emelina
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Recently, tobacco smoking has an epidemiological character. The largest number of smokers, according to many studies, was found between the ages of 30 and 35. Studies conducted by the World Health Organization (WHO) indicated that if a young man smoked at least two cigarettes, 70 out of 100 would continue to smoke for life. Due to the increasing prevalence of tobacco smoking, WHO began to consider smoking not only as a bad habit, but also included tobacco dependence in the International Statistical Classification of Diseases and Health Problems (10th revision); Class V: Mental and behavioural disorders; group: Mental and substance use behavioural disorders; heading: Mental and behavioural disorders caused by tobacco use (code F 17). Keywords: Oral hygiene, Tobacco smoking, Hookah smoking, Health, Safety, Smoker.
Peripheral Neutrophil-to-Lymphocyte Ratio (NLR) and Breast Cancer Distant Metastasis: Analysis of a Simple Diagnostic Biomarker Ni Putu Yenny Kendarini
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Introduction: Neutrophils and lymphocytes serve as easily accessible indicators representing the immune landscape in breast cancer. Combination of such variables in the form of neutrophil-to-lymphocyte ratio (NLR) allowed for extensive analysis and better interpretation. The heterogeneity in predictive role of NLR to prognosticate breast cancer sruvivalcould be attributed to metastatic spread. Methods: Data from breast cancer patients attending Oncology clinic in Sanglah Hospital, Bali was collected retrospectively. Samples were selected by simple random sampling technique from a sampling frame of patients with available preoperative complete blood count in the registry. Bivariate and multivariate analysis was performed with NLR value stratification using optimal NLR cut-off value derived from receiver operating characteristic (ROC) curve analysis. Results: A total of 51 patients diagnosed within the period of January 2016 through November 2017 were investigated. The cut-off point of NLR value in this study was 3.1 (Area under ROC curve [AUC]: 0.826). A significant association between NLR value and distant metastasis was found consistentlyin bivariate (PR 5.4, 95%CI 2.5-11.8, p=0.001) and multivariate analysis (Adjusted PR 4.9, 95%CI1.53-16.1, p 0.01). The association was not affected bybreast cancer subtype, histological grading, lymphovascular invasion, and tumor-infiltrating lymphocytes level. Conclusions: The NLRvalue was found to be an independent factor for distant metastasis in breast cancer. Its added value on diverse NLR clinical prognostication utility warrants further prospective investigation. Keywords: Neutrophil to lymphocyte ratio, Neoplasm metastasis, Breast neoplasms, Biomarkers.
Prescription of Antihypertensive and Antianginal Medications within the Conditions of Outpatient Treatment of Patients with Ischemic Heart Disease Along with Hypertension Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract Cardiovascular morbidity leads the world in the morbidity rate structure. An arterial hypertension and a stable angina are widely occurring among the population and, in terms of medical and social significance, stand at the head of the circulatory system diseases. The combination of these diseases is observed in 2/3 of patients. An important challenge for cardiology is to ensure a rational approach to the choice of medications for effective antianginal and antihypertensive therapy, its compliance with accepted treatment quality standards, the development of clear and scientific-based criteria for the use of medications, improvement of the patients’ quality of life while reducing the economic costs for medications supply. Purpose. To develop an approach to the optimization of medications supply for patients with ischemic heart disease in combination with arterial hypertension in inpatient and outpatient practice, based on the use of pharmacoeconomic and pharmacoepidemiological researches. Materials and methods. To assess the prescription structure of the various groups of antihypertensive and antianginal medications, an analysis of the past medical history in patients with ischemic heart disease in combination with arterial hypertension was carried out. Variation statistics methods have been applied in mathematical data processing. Results. Beta-blockers prevailed, followed by angiotensin-converting enzyme inhibitors, calcium channel blockers, and diuretics were found in the structure of medicinal benefits when prescribing pharmacotherapy to patients with stable angina pectoris with arterial hypertension. Conclusions. As a result of the research, it was revealed that the combination therapy in most cases was based on beta-blockers, angiotensin-converting enzyme inhibitors, diuretics in various combinations with each other.
Synthesis, Characterization of 2-azido-4-(azido (2-azido-2-( azido carbonyl)-1,3-dioxoian-4-yl)methyl)– 5-((R-azido (hydroxyl) methyl-1,3-dioxole-2-carbonyl azide. ethanol. hydrate (L-AZD) with Some Metal Complexes Ala H. Hassn
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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The reaction of (L- AsCl2) : Bis [O,O – 2,3, O,O – 5,6 – (chloro(carboxylic)methylidene] – L-ascorbic acid with sodium azide in ethanol with drops of distilled water has been given a new product (L-AZD), was isolated and characterized by elemental analysis (C,H,N) , 1H-NMR, mass spectra and Fourier transform (Ft-IR). The reaction of the (L-AZD) with: [VO(II), Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)], has been investigated and was isolated as tri nuclear cluster and characterized by: Ft-IR, U. v-Visible, electrical conductivity, magnetic susceptibilities at 25 Co, atomic absorption and molar ratio. Spectroscopic evidence showed that the binding of metal ions were through azide and carbonyl moieties resulting in a six- coordinating metal ions in [Cr (III), Mn (II), Co (II) and Ni (II)]. The Vo (II), Cu (II), Zn (II), Cd (II) and Hg (II) were coordinated through azide group only forming square pyramidal for VO (II), square planar geometry for Cu (II) and tetrahedral for Zn (II), Cd (II) and Hg (II), - for Ni (II), Cr (III) complexes were calculated, the ratio of (L-AZD) to metal ions was (3:1) confirmed by metal ratio and atomic absorption spectrophotometer, magnetic moment values at (298 K) of VO (II), Cr (III), Mn (II), Co (II), Ni (II) and Cu (II) are lower than the total spin-only indicate a dominate of anti-ferromagnetic coupling between them. Keywords: Synthesis, Tri nuclear cluster, Azide.
Formulation and Evaluation of Oral Disintegrating Film Containing Lisinopril for the Effective Management of Hypertension and Cardiac Diseases Velayutham Pazhanivel
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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This study was aimed to develop oral disintegrating film (ODF) containing an anti-hypertensive drug Lisinopril. Five trial formulations (F1-F5) of Lisinopril ODF were prepared using Hydroxypropyl methylcellulose E15 (HPMCE15), Polyvinyl pyrrolidone (PVPK30), Polyethyleneglycol400, Polyplasdonexl, Mannitol, Peppermint oil, Propylparaben, Citric acid, and Allura red. The prepared formulations were evaluated for their Physico-chemical characters like weight, thickness, surface pH, folding endurance, and disintegration time. They were also evaluated for the content of Lisinopril. The above studies revealed that formulations trial F4 was better than other Formulations. Because, it has exhibited faster disintegration time (21.32 sec) when compared to the other formulation. So, F4 was selected for stability study (40ᵒC,75% RH) for six months and Scanning Electron Microscopy (SEM). The results of the above studies have shown that F4 was stable and has a uniform distribution of Lisinopril.
Antibiotics Treatment for Acute Respiratory Tract Infections (ARTIs): Evaluation of Doxycycline Resistance Cases at a Community Health Center in Urban Area of Indonesia. Danni - Ramdhani
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract. Acute respiratory tract infections (ARTIs) are a major health problem in developing countries. This infection can occur in the upper or lower respiratory tract which is accompanied by inflammation. Doxycycline is highly recommended for the treatment of ARTIs patients allergic to penicillin. This study aimed to evaluate the effectiveness of doxycycline in the treatment of ARTIs through its antibiotic resistance rates, and identify bacteria that have been resistant to doxycycline antibiotics. This study consists of the stages of rejuvenation of clinical isolates from ARTIs patients at a community health center in the Urban Tasikmalaya area, identification of bacteria, and testing for antibiotic resistance using the paper-disk method. The results of resistance tests from 116 single clinical isolates showed that there had been resistance to doxycycline antibiotics in the treatment of ARTIs in the urban area of Tasikmalaya with a category of 64.29% being resistant; 14.29% intermediates and 21.42% are still sensitive. The results of bacterial identification showed that doxycycline was resistant to the Corynebacterium, Streptococcus, Staphylococcus, Haemophillus and Bordetella bacteria groups. Doxycycline treatment for ARTIs infection is considered not very effective. Another class of drugs as a substitute for doxycycline for patients allergic to penicillin is needed.

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