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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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DECOMPRESSION BY THINNING-OUT A BEAK-TYPE OSSIFICATION OF THORACIC POSTERIOR LONGITUDINAL LIGAMENT, A CASE REPORT S. Dohar A.L. Tobing; Ade Martinus
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

Introduction: Ossification of posterior longitudinal ligament (OPLL) is commonly caused dysfunction of the spinal cord. The conservative therapy has been proved to be ineffective and surgical treatment is often needed. Accessing the anterior border of OPLL for anterior decompression while ensuring safe decompression of spinal cord are technical challenges for the treatment. The objectives of this case report is to introduce a surgical technique of decompression and decided whether it is an effective surgical technique to treat a beak type thoracic OPLL, especially in T9-10.Methods: We reported a male, 38 years old, who were admitted to Cipto Mangunkusumo hospital in 2016 and was diagnosed as paraparesis due to OPLL at the level of   T9-10.Results and Discussion: Surgical decompression was performed from a posterior approach. The left facet, pedicle of T9, and  the distal part of T9 vertebral body were removed using highspeed burr until the interval of calcified area was reached distally. Thinning of the calcified area was done until paper thin and expansion of the dura and spinal cord can be observed. The decompression procedure was followed by stabilization of T7-11 using pedicle screws and rods. No worsening of the neurological symptoms was observed post operatively. The patient could stand and assisted walk in day 3 post operation.Conclusion:. This surgical procedure has been shown to be an effective therapy and achieves satisfactory clinical outcomes for patients.Keywords: thoracic ossification of posterior longitudinal ligament, beak type thoracic OPLL, Surgical Treatment, decompression with posterior approach. 
Quantitative Estimation of Gallic Acid in Triphala Churna by HPTLC Gouri Kumar Dash
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

A simple, reliable and rapid HPTLC method was developed for qquantitative estimation of gallic acid in the methanol extract of Triphala churna. The method was validated as per ICH guidelines for linearity, accuracy, precision, and specificity. Silica gel 60 F254 pre-coated aluminium plates were used as the stationary phase. Toluene: Ethyl acetate: Formic acid: Methanol (12: 9: 4: 0.5) constituted the mobile phase.  Percentage of gallic acid was estimated through densitometry scanning using a TLC Scanner III (Camag, Switzerland) with winCATS software. The amount of gallic acid present in the sample was found to be 0.41 ± 0.08 % w/w with respect to dried plant material. Thus, the developed method can be applied in quantifying the amounts of gallic acid in Triphala churna and results of this work will support in the standardization process of Triphala churna using gallic acid as the biomarker.Keywords: Triphala churna, Methanol extract, HPTLC, Gallic acid.
Thiamine, Riboflavin and Magnesium Level Correction in Improving the Quality of Life of Patients with Chronic Heart Failure Fatima Dzalaeva
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Data are presented on the effectiveness of treating patients with chronic heart failure (CHF) with vitamins B1, B2 and magnesium (Mg) added to the standard complex therapy. The group of patients with cardiovascular diseases (CVDs) consisted of 143 patients with CHF I-III functional class according to NYHA (New York Heart Association Functional Classification), as a complication of coronary heart disease (CHD). To determine the preferred doses of vitamins B1 and B2, we studied the dynamics of the concentration of thiamine (B1) and riboflavin (B2) in blood plasma and their daily excretion with a single intake of vitamins by healthy volunteers at doses of 10, 20 and 30 mg. To determine the preferred magnesium-containing drug, Mg concentration dynamics in the blood plasma of healthy volunteers were studied when taken orally in an equal dose in the form of Mg oxide and in the form of Mg orotate. The study involved 80 healthy volunteers. In order to improve the quality of life for patients with CHF and increase tolerance to physical exertion, it is advisable to add Mg in combination with vitamin B1 and B2 in the standard complex therapy. When Mg salts are added to the standard complex treatment of CHF, it is preferable to use Mg orotate. When using vitamin B1 (thiamine), it is not advised to increase the daily dose of more than 10 mg/day, since this leads to a progressive increase in the excretion of this vitamin B1 and vitamin B2.Keywords: Chronic heart failure, Therapy, Mg salts, Thiamine (B1), Riboflavin (B2).
Synthesis, Characterization and Biological Study of the Ligand 2-methyl-5-[(2E)-2-(4-Nitrobenzylidene) Hydrazinyl]- 1, 3, 4-Oxadiazole with some of its Transition Metal Complexes Zainab M. Kareem
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

A new series of transition metal ions (Cr (III), Co (III), Cu (II) and Ni (II) complexes with the ligand 2-methyl-5-[(2E)-2-(4-nitrobenzylidene) hydrazinyl]-1, 3, 4-oxadiazole were synthesized. A ligand was synthesized by reaction hydrazine hydrate with ethyl acetate in ethanol as solvent , the product reaction with potassium hydroxide and carbon disulphide to give 5-methyl-1,3,4-oxadiazole-2-thaiol, the product was reacted with hydrazine hydrate again to produce 2-hydrazinyl-5-methyl-1,3,4-oxadiazol. The resultant was mixed with parnitro-benzldehyde to produce the ligand (L2). The newly synthesized compounds were characterized by Fourier transform infrared (FTIR) Spectroscopy, Nuclear Magnetic Resonance Spectroscopy (1H NMR), elemental analyses (C, H, N), Mass Spectra data. The program Hyperchem 7.51 have been used for theoretical calculation using PM3 method to study the electrostatic potential, electron density, heat of complexation. It has been shown through all the above diagnostic measures that ligand is formed with the (Cu, Co and Ni) ions tetrahedral complexes and with the Cr formed octahedral complex. The biological study of ligand and its complexes showed that all prepared compounds have antibacterial against three types of bacteria and there was high percentage of hemolysis. Keyword: 1, 3, 4-Oxadiazole derivative, Antibacterial, Hyperchem, Hemolysis.
Forensic Systematic Fungal Infection Identification by PCR-DGGE in Human and Chicken Blood Samples Mohammad J. Al-Jassani
Journal of Global Pharma Technology .
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Abstract

PCR can act as a key clue in court after fungus infection is determined that give an indication of the source of infection in order to determine either a zoonotic infection and/or a possible bio-terror action in a disease outbreak or poisoning bio-crime. Total of 30 blood samples were collected in the EDTA tube that include (10 healthy (asymptomatic) human blood samples, 10 chicken blood samples and 10 human blood of poultry workers. The PCR-DGGE analysis showed multi-banding pattern for some ‎samples, which means that they are infected with more than one fungal ‎species. Some of these bands (OUT) are shared between human (asymptomatic), Chicken and poultry workers. Periodic fungal infections follow up, using PCR-DGGE technique, for fungal population variation and ‎detection of any new emerging strain, are highly recommended.Keywords: Forensic, Fungal infection, PCR-DGGE.
The Effect of Drying Our International Wetland on the Economic and Social Situation of Fishermen Sistan Hussein Keykha
Journal of Global Pharma Technology Volume 08 Issue 04
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Abstract

Wetland ecosystem is a complex ecosystem and its components great impact chains are accepted and man as part of the ecosystem in the event of any change, it is affected. Therefore, in this study, wetland drying Sistan plain is the result of several years of drought on the lives of fishermen Sistani is studied.Start the Sistan region since 1998 and has been prolonged drought continues. Sistani's 3500 household survey of fishers who were selected sample of 346 questionnaires. Economic and social science experts validity and reliability with Cronbach's alpha and number 747/0 respectively.Data analysis using descriptive statistics including frequency, mean and standard deviation were used. Inferential analysis compared the mean, t-test was performed using spss software and excel% 100 reduction mat weaving in the region, reducing the 82 percent increase in the 64 percent floor multi-job and unemployment is the result of drying wetlands in Sistan fishermen.By reducing fishing areas prone to drying out of wetlands to agricultural and animal husbandry respectively 45 and 40 percent that this reduction is multi-job employment system. Increased eye diseases, respiratory, neurological, psychological, increased insecurity, drug addiction and youth support organizations to increase the number of families covered 76 percent of our wetlands are drying other effects.Keywords: Sistan fishermen, Economic factors, Social factors, Our wetlands.
Study of the Genetic Diversity in Three Species Belonging to Family: Daphniidae (Crustaceae, Cladocera) Collected from different Regions in Baghdad Province /Iraq Bdoor Satar Albhadly
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Molecular methods were used to study three species belonging to the family of water fleas Daphniidae (Crustaceae, Cladocera), one belongs to the genus Daphnia and two species belonging to the genus Simocephalus. Collected from different places in the Baghdad province / Iraq (Al-Adhamiya Cornish, Al-Shula neighborhood, Brahim Bin Ali area, Al-Zawra Park, Lake of games city). The results showed that there are two species: D. magna, S. vetulus, were registered in Iraq, while the species S.congener recorded in Iraq for the first time. The genes COI, 16s, that of mtDNA, and 18s of the nucleus studied for the purpose of obtaining genetic diversity among species and for detecting the differences in the studied genes. This included DNA extraction from a group of individuals resulting from an adult female reproduction that carries the same genetic features of the mother (Monoclonal) produced from Parthenogenesis to get Iso- female line. DNA sequencing analysis of the three species of the water flea family was carried out using the forward primers that used with the reverse primers in magnification of parts of the genes 18s, 16s and COI. It was observed that there were variations in the sequences of the nitrogen bases of both genes when comparing the study samples with Standard reference sequences from around the world, and recorded sequences of nitrogen bases for study samples at the NCBI site and there was a genetic diversity of the same species by different sampling sites in the form of substitutions in the sequences of the nitrogen bases of the studied samples of the COI and 18s genes, while for 16s gene, no differences were observed for the same species, The genetic relationships tree among the studied species was drawn and compared to standard samples from results of the same studies in other countries that registered in NCBI for each of the three genes and the study results showed that the maximum likelihood of changing in nucleotides among the three species was that there were genetic differences between Simocephalus and Daphnia ,while the two species of the Simocephalus were found to be common in the same branch, and there was a similarity between them, While there were no significant differences among the species.Keywords: Daphnia, Simocephalus, RFLP, mtDNA, COI.
Antimicrobial Resistance Patterns and Metallobeta-lactamases Producing of Imipenem Resistant Pseudomonas aeruginosa Isolated from Clinical Samples of Iraqi Patients Marwa Lafta Jebur
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

In this study, a total of 160 clinical samples (72 burned skin, 25 wound, 18 sputum, 24 urine and 21 ear samples) were collected from five hospitals in Baghdad during the period December 2017 - April 2018. The samples were cultured on MacConkey agar and blood agar plates to isolate Pseudomonas aeruginosa in order to estimate its prevalence rate, which was 65% (104/160) of the total clinical samples. It was found that 37.5% (39/104) of P. aeruginosa isolates were resistant to imipenem (IRPA). A phenotypic detection of beta-lactamases showed that all IRPA isolates did not produce extended spectrum beta-lactamases, while 89.7% (35/39) of these isolates produced metallo-betalactamases (MBLs). Antibiotic susceptibility test against 11 antibiotics using the disk diffusion method showed that all metallo-betalactamases producing IRPA isolates were sensitive to polymyxin B, while resistance rates were 100% to both cefotaxime and ceftazidime, 94.3% to both netilmicin and amikacin, 91.4% to each of meropenem, gentamicin and tobramycin, 88.6% to cefepime, 82.9% to aztreonam and 77.1% to piperacillin/tazobactam. The resistance of metallo-betalactamase producing IRPA isolates for antibiotics according to MIC values was 100% to both tigecycline and cefazolin, 91.4% to meropenem, 85.7% to tobramycin, 80% to both cefepime and gentamicin, 71.4% to each ceftazidime, amikacin and levofloxacin, and 51.4% to ciprofloxacin.Keywords: Pseudomonas aeruginosa; Metallobeta-lactamases; and Antimicrobial Resistance.
The Prevalence of Tooth Wear in the Adult Population TONG MINH SON
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Objective: To evaluate the prevalence of tooth wear in the Vietnam adult population in different age groups, for both genders, in different socioeconomic classes, and for different types of teeth. Methods: A total of 800 patients of either gender, ages 18 – 60 years were placed into group A (acid-directly exposed) and group B (acid-indirectly exposed). We recorded the prevalence and severity of tooth wear (TW). TW was measured clinically by Smith and Knight Index. This study included a dentine hypersensitivy (DH) testing device (Yeaple Probe) in addition to the current visual analog scale (VAS) methods of dentine hypersensitivy testing.  Results: A total of 400 patients of group A, out of which 366 patients were diagnosed with tooth wear giving an overall prevalence of 91.5 %. In group B a total 400 patients were investigated out of which 344 (86.0 %) patients showed signs of tooth wear. From a total of 32247 teeth (400 faces) examined 4677 (14.5 %) showed dentine hypersensitive on tooth surface in group A. In group B total 32460 teeth (400 faces) were investigated out of which 1720 (5.3 %) teeth showed signs of dentine hypersensitive. Conclusion: Tooth wear is the prevalent condition in this population. Further investigations and continuous follow-up of cases may allow the mapping of the relationship of biological factors with the occurrence of tooth wear.Keywords: Tooth wear, Dentine hypersensitive, Visual analog scale.
The Processing of Information According to the Linguistic Neural Programming and its Relation to the Level of Skills Performance of the Monument and Undermine the Scout Tent Aqeel Yahya Hashim Abdulaziz
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Recently, the interest of trainers and teachers has increased to study the mental and physiological aspects of the player and the learner. The interest in the study of information processing and treatment levels has been highlighted as being one of the types of learning that has to do with the learner himself, directing and self-driving towards learning, and there is a close link between the representative systems owned by the learner whether (audio, visual, sensory) and the level of information processing on the one hand and between these systems and the level of learning skill on the other hand, the problem of this research is that there is a fluctuation among the students in the performance of the skills of erecting and undermining the scout tent. This may be due to the difference in their representation systems of the linguistic programming of the nervous system (auditory, visual and sensory) and related to the process of information processing within the brain.The researchers followed the following steps in the research procedures:The descriptive approach was used in the method of interconnectivity.The research was conducted on the students of the first stage in the Department of Physical Education College of Education for Girls - University of Kufa for the academic year 2016-2017 The sample (30)The sample was divided according to the Neural programming test into three groups representing the first group (the auditory system), the second group represented the visual system and the third group represented the sensory system.The research requires the use of several tests included the followingInformation processing test.Testing neural programming for representative systems (auditory, visual, and sensory).Skill tests of skill (erecting the tent, undermining the tent).The results of the researchThe level of information processing and accurate performance of the skill of setting the tent for those with the visual system is better than the audio and sensory system.The level of processing information undermines the tent for people with a visual system better than the system of audio and sensory.The processing of information is an important and essential role for the people of the visual system and the performance of the skills of the monument and undermines the tent.Keywords: Information Processing, Neural programming, Monument and undermine the scout tent.  

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