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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Simultaneous Determination of Furosemide, Carbamazepine, Diazepam and Carvedilol in Quaternary Mixture via Derivative Spectrophotometry Nahla. A. Alassaf
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

Quick and accurate quaternary mixture resolution of furosemide (FURO), carbamazepine (CARB), diazepam (DIAZ) and carvedilol (CARV) by using derivative spectrophotometric method was performed. FURO and CARV were determined by means of first (D1), second (D2), third (D3) and fourth (D4) derivative spectrophotometric methods,  CARB was determined by using D1, D2, D3 derivatives, while D1 and D2 were used for the determination of DIAZ. The recommended methods were verified using laboratory prepared mixtures and then successfully applied for the pharmaceutical formulations analysis of the cited drugs. The results obtained revealed the efficiency of the proposed methods as quantitative tool of analysis of the quaternary mixture with no requirements for sample neither pretreatment nor preliminary separation of analytes from the pharmaceutical preparations.Keywords: Derivative spectrophotometry; Furosemide; Carbamazepine; Diazepam; Carvedilol.
Thermal Resistance of Epoxy Resin and Phenol Formaldehyde Compound Mixed with Mixed Inhibitors Mustafa A. Rajab
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The properties of flammability and the effect of zinc oxide with antimony trioxide were examined on the thermal corrosion testing of epoxy resin and formaldehyde. Zinc borate was added to the resin and then reinforced with silica fiber and woven glass fibers (90 ° -0º) with thickness (4 mm). Then expose the system to Acetylene Oxide flame (3500 ° C) directly with different exposures of flame (10 mm, 20 mm), to study flame retardant resistance and protection of the substrate. Animein trioxide was then added to zinc porcine in different quantities (10%, 20% and 30%) to form hybrid flame retardants for hybrid exposure to the same flame temperature and exposure distances. The method of measuring the surface temperature of the flame was used to determine the temperature transferred to the composite material. The results showed that the best exposed distance and a large proportion of protective layer of zinc boron with antimony trioxide was at 30%. Keywords: Hybrid Flame Retardants, Composite Material, Inorganic Retardants.
Chemistry in Forensics and Crime Solving: Review Dina B. Abbas AL-Saedi
Journal of Global Pharma Technology .
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Abstract

Chemistry is one of the most important forensic sciences beside of the other evidence sciences, and it is focus on the chemical examination of chemical waste by different methods of analytical chemistry and instrumental analytical methods. In addition to the quantitative and qualitative analyzes, it is possible to perform a comparative and comparison between the different samples and the connection between them in different fields associated with crimes. Forensic chemistry includes organic and inorganic analysis, toxicology, arson investigation, and serology. Each method of analysis uses specialized techniques and instrumentation. The process may be as simple as setting up a density gradient column to compare soil samples or as complicated as using a mass spectrometer or neutron activation analysis to characterize an unknown substance.Keywords: Analytical chemistry, Forensic sciences, Toxicology, Finger print.
WATER EXCTRACT OF PURPLE SWEET POTATO INCREASE SUPEROXIDE DISMUTASE, CATALASE GENES AND DECREASE MDA LEVEL IN MULTIPLE ORGANS OF DIABETIC WISTAR RATS Bagus Komang Satriyasa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Objective: The purpose of this study was to prove the water extract of purple sweet potatoes can increase superoxide dismutase (SOD) gene expression and catalase (CAT) and decrease malondialdehyde (MDA) in vital organs of diabetic rats. Method: This study was randomized experimental design with posttest only control group design. Sample divided into 2 groups: control and treatment groups, respectively 18 diabetic Wistar rats. The control group will be given streptozotocin. The treatment group was given streptozotocin and water extract of purple sweet potato 4 cc/day. This treatment is carried out for 2 months. Result: Water extract of purple sweet potato was proven significantly increased mRNA expression of aorta and kidney SOD but decreased SOD mRNA expression in the liver (p <0.05). This water extract also increases SOD mRNA expression in cardiac but not statistically significant (p> 0.05). Water extract of purple sweet potatoes also found significantly increased renal and cardiac expression of CAT mRNA (P <0.05), but not statistically significant (p> 0.05). Conclusion: Purple sweet potatoes extract to decrease the expression of liver CAT mRNA non-significantly, and decrease MDA in liver and kidney of diabetic Wistar rats significantly (P <0.05).
Several Parameters of Blanching and Drying Influencing to Quality of Dried Pumpkin Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Is one such plant that is frequently being used as food as well as traditional medicine for long days. It is a large climbing herb, annual or perennial, for use as vegetable as well as medicine. It contains several phytochemicals including alkaloids, flavanoids, phenols, carbohydrates, tannins, saponins, terpenoids and proteins.  The presence of these phytochemicals has been found to possess various medicinal functional functions which are essential in the management of various diverse ailments.  Pumpkin has gained a considerable attention in recent years for its nutritional and health promoting values. Drying is a relatively simple process in which water activity in food is reduced, minimizing or inhibiting the chemical and enzymatic reactions and microbial growth that are responsible for its deterioration. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to β-caroten (mg/100), vitamin C (mg/100g), rehydration capacity (kg moisture/kg d.s.), sensory score of the dried pumpkin (Cucurbita spp.). Results showed that pumpkin (Cucurbita spp.) should be blanched in hot water 95oC at 10 seconds in the present of citric acid 4g/l and then beeing dried by heat pump dryer at 50oC until 12% moisture. Blanching is carried out to improve food quality by inactivating enzymes, reducing microorganisms and preserve the natural color when pumpkin after blanching is subjected to drying. The final dried pumpkin was shelf-stable for a period of 12 weeks at ambient temperature without any appreciable adverse changes in physico-chemical as well as sensory quality characteristics of the dried products.Keywords: Pumpkin, Blanching, Drying, β-caroten, Vitamin C, Rehydration capacity.
Optical Conduct of Nanostructure Co3O4 rich Highly Doping Co3O4: Zn Alloys Sami Salman Chiad
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The spray pyrolysis technique (SPT) was used because it is simple, low cost and less equipment. Structural, morphological and optical properties of pure Co3O4 and doping 1% and 3% Zn: Co3O4 were anayzed by X- Ray diffraction (XRD), Atomic force Microscope (AFM) and UV-visible Spectroscopy. XRD indicate a polycrystalline structure  with AFM images shows that the films was discontinuous surface with spherically  grains increase from (70 to 84 nm) with increase doping from 1% to 3%. The energy gap Eg was decreased from 2.75 to 1.64 eV when doping increase. Keywords: Co3O4, Zn: Co3O4 thin films, XRD, AFM and optical characterizations.
Acceleration the Liver Regeneration by Hyperbaric Oxygen Therapy in Model Rabbit Zainab J. Malik
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

In this study, we were investigating the importance of therapy of the hyperbaric oxygenon the regeneration of liver. Sixteen mature rabbits of Iraqi breed were used. The animals divided equally into two groups (control and treated). The anesthetizing of animals was done byatropine sulphate (1mg /Kg B.W) intramuscularly; as premedication and 15 minutes later a mixture of xylazine hydrochloride (20mg /Kg B.W) and Ketamine hydrochloride (40 mg /Kg B.W) are giving intramuscularly. In control group the rabbits were anesthetized and preparation the site of operation was done in the upper part of abdomen.  Surgical incision made and exposure of fourth lobe of the live. The liver handling by thump forceps and the stitches was done on the lobe. Three knots were tied and we used dissecting scissors in order to cut the tied lobe just distal to the suture. After that the wall of abdomen was re approximated with a running 3-0 Polyglactinsuture, then the skin closed with a running 2-0 polyamide suture. While in treated group the same procedure that mentioned above with hyperbaric oxygen therapy was done. The clinical parameters included temperature, respiratory, and heart rates, were within acceptable limits post operatively in all animals in two groups. The intra-abdominal adhesions in different degrees of evaluations and occurred among liver, different organs and abdominal wall that more frequency in control group when compared with treated group. Histopathological Examinations was done by taken the liver biopsies on 15rd, and 30th, day postoperatively. The histopathological results of this study revealed that the liver regeneration more maturity in treated group than in control group.Keywords: Hyperbaric oxygen therapy, Liver, Rabbit, Regeneration.
Synthesis Conditions of AgCore@Au Shell System by Laser Ablation with (1064, 532, 355) nm Wave lengths Ghaleb Al-Dahash
Journal of Global Pharma Technology .
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Abstract

Laser ablation in liquid technique (PLA) has become a more important for the preparation of NPs. Metal targets were laser ablated in liquid for preparation of spherical Ag @ Au core @ shell NPS colloidal solution for refractive index sensing. In our research was prepared Core-shell Nano colloid system of Ag @ Au by using pulses of Nd-YAG laser with (1064, 532, 355) nm wavelength and (80 @ 60) mJ energy in ethanol liquid. The Surface texture, topography and morphology studied by Transmission Electron Microscopy (TEM) and Scanning Electron Microscope (SEM).Our structural analysis indicated the grains show spherical shape, where TEM images showed formation of Core-Shell clearly, UV-Visible spectroscopy has been employed for the optical properties measurements, Absorption peaks shifted to lower wavelength (blue shift) (UV). The effect of (Ag -core) was more effective than the (Ag - shell), and so by the sliver core effect (Ag -Core), and this confirms clear evidence that the effect of the (Core) influential, which dominates the effect of (shell).
Hidden Trends in Modern Sickness Rate Dynamics in Children Yuri Arkadievich Tyukov
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The health state of children in Russia has a number of unfavorable trends, i.e. chronic diseases increase, and infectious diseases increase. Objective: To obtain an objective characteristic of the overall sick rate in children of the regional center and the role of urgent pathology in its level and dynamics. Methods: The study base was ‘Children's City Clinical Hospital #8’, serving the entire child population of the Metallurgical District, Chelyabinsk. The number of children for the period from 2008 to 2017 raised from 23.4 thousand to 26.5 thousand children. Results: The total disease appealability decreased from 2195.0 per 1,000 children to 1,733.2 in 2017. At the same time, the total urgent morbidity, according to the emergency department, ambulance and hospital wards increased to 1,025.3 cases per 1 000 children Conclusion: A disease appeal ability decrease is counterbalanced by an increase in urgent morbidity, which means the absence of a real improvement in children's health indicators.Keywords: Sick rate, Child population, Urgent morbidity, Disease appeal ability, State of health.
Effect of Special Exercises in the Development of Special Endurance (Endurance Strength and Speed Endurance) for the Effectiveness of Running 400 Meters Class (CP 36) Hind Walid Kalaf
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The sport of the disabled is one of the most important sports that have witnessed remarkable development in recent years, especially after the London Paralympic Games 2012, especially on athletics. In view of the close relationship between modern training theories and its practical, scientific and training aspects to achieve the best levels, Athletes in category (CP 36) The researcher noted the lack of interest in this category of training, which depends on the scientific basis in terms of physical tests that fit the possibilities and capabilities of the category (CP 36).Where the objectives of the research were determined:Prepare special exercises in the development of your endurance.Identify the impact of special exercises in developing the endurance force for an effective 400 meters.Identify the effect of special exercises in the development of endurance speed for the effectiveness of 400 meters for class (CP 36).Research HypothesesThere were statistically significant differences between the pre and posttests of the two experimental groups in carrying power for the effectiveness of running 400 meters.There were statistically significant differences between the post-test of the two experimental groups in carrying the speed of running 400 meters for the class (CP36).The researcher used the experimental approach to suit the nature of the research with two equal groups.The research community was selected from the elite players (ages 18-23) category (CP 36) with a running efficiency of 400 m. The number of players (10) was divided into two experimental groups randomly and with (5) players for each group.The Researcher ConcludedThe special exercises showed a clear development in the endurance of disabled players in the category of CP 36)The wide development was the result of the prevailing quality of the effectiveness of the speed of 400 meters.Keywords: Special exercises, Special endurance, Endurance strength and speed endurance.

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