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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Donor Site Morbidity after Anterior Iliac Bone Graft Harvesting Rahadyan Magetsari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Bone substitutes are being increasingly used especially in oncologic surgery, traumatology, revision prosthetic surgery and spine surgery. Bone substitute can be defined as a synthetic, inorganic or biologically organic combination which can be inserted for the treatment of a bone defect instead of autogenous or allogenous bone. Despite the improvement of research, human bone grafts persist to be the most effective bone substitutes to replace bone loss. This research was retrospective study conducted in consecutive sampling in Sardjito General Hospital Yogyakarta from January 2014 to Desember 2018. Patients underwent anterior iliac crest bone graft harvesting was included. 4 months after the procedure, the donor site morbidity was identified. The parameters used in this study are pain score using visual analog scale, paresthesia, problem in walking, wound infection, scar satisfaction and major morbidity. Anterior iliac bone graft harvesting resulted in minimal morbidity and neither pain or functional limitations. It also provides the optimal bone graft material, yields minimal morbidity, and is an acceptable choice in autologous bone graft harvesting.
Distribution of Fim A Genotypes among Porphyromonas Gingivalis associated with Chronic Periodontitis in Al-Najaf Al-Ashraf City Ahlam Kadhum Al-Yasseen
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

This research aims to detect the prevalence of fim A genotypes I, Ib, II, III, IV and V among Porphyromonas  gingivalis related with periodontitis. Amplification of 16S rRNA gene showed that out of 150 DNA samples that extracted from subgingival plaque specimens of patients with chronic periodontitis only 40 DNA specimens were belonged to P. gingivalis and DNA sequencing demonstrated 98% homologous with P. gingivalis strain CP38 16S rRNA gene, partial sequence. fimA type IV gene was the most predominance with 27.5% followed by fimA type III with12.5%  while fimA type II show up with the lowest percentage (5%) while fimA type Ib was not identified. This finding denoted that  P. gingivalis that possess  fimA type IV was the most importance pathogens associated with  chronic periodontitisKeywords: P. gingivalis, Fim A genotypes, Periodontitis.
Strategies, Management of Urban Transport and its Solutions, with Sustainable Development Approach (Case Study: Tehran) Maryam Esmaeili
Journal of Global Pharma Technology .
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Abstract

Sustainable transport concepts that are always changing the type of fuel and reduce fuel consumption car or use public transportation to the mind.In the meantime, pay attention to issues relating to sustainable development can be explained by causes instability and factors affecting transport in cities with a sustainable approach examined.In addition, it can transport needs and requirements to achieve sustainable urban design and planning presented. But in the meantime, variables such as dimensions of sustainable development and its axis can specify various aspects of this process.Therefore, the aim of the present study provide urban transport management strategies and solutions with a sustainable development approach, the analytical method.To achieve this goal, first to experience the world of transportation was different cities of the world, then transport axes Paydarmvrd was investigated. As well as transport and traffic studies Tehran was assessed, finally, urban transport planning and management strategies and solutions that were presented.The results show that most interest is the urban management policies, teaching and development of traffic culture as the main solution to the traffic problem in Tehran, which will help to urban planning.Keywords: Urban transportation, Transportation management, Sustainable development, Tehran city.
Sequential Injection Spectrophotometric Method for Determination Paracetamol in Pharmaceutical Formulations using N- bromosuccinimide and Methyl Orange as Oxidants Khdeeja Jabbar Ali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Sequential injection analysis (SIA) system is proposed for the determination of Paracetamol (PCT). PCT was determined by SIA based on the reaction between N-bromosuccinimide (NBS) and Methyl orange as  reagent in found  PCT in acid medium , yielding a red colour complex with absorption maximum at 507 nm., Under the optimum experimental conditions   such as the flow rate  and loading coil length  , the reaction coil length , hydrochloric acid  concentration, KBr concentration , the methyl orange concentration  and NBS concentration with both volume of mix PCT and volume Methyl orange, the determinable ranges were 1–10 mg /L, the detection limit was equal to 0.0135 mg /L, this technique is characterized by its  system was ease and speed, It was applied to the determination of PCT in different drug samples.Keywords: Sequential injection analysis (SIA) system, Paracetamol (PCT), N-bromosuccinimide (NBS).
Synthesis, Characterization and Preliminary Cytotoxic Study of Sinapic Acid and its Analogues Yasser Fakri Mustafa
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The use of natural products to treat human diseases especially cancer is an interesting trend in pharmaceutical research. Sinapic acid, being a member of hydroxycinnamic acid family and having well-established pharmacological properties, could have a potential antitumor activity that has not been investigated sufficiently. This work aimed to test the preliminary cytotoxic effect of sinapic acid and nine of its synthesized analogues utilizing MTT assay on four cancer cell lines; which are: HeLa, AMN3, SKG, and MCF-7. The chemical structures of the intermediates and of the synthesized products were approving by analyzing their IR, 1H-NMR, 13C-NMR, and MS-ESI spectra. Results of the cytotoxicity study indicated that sinapic acid analogues 3a, 3c, 3d, 3e and 3h have lower IC50 values  than that of positive control on the tested cancer cell lines, while sinapic acid itself and the other synthesized analogues did not have such cytotoxic effect.Keywords: Sinapic acid, Analogues, Gastrodigenin, MTT, Cytotoxicity.
Evaluation of Antibacterial Potential of the Crude Phenolic, Alkaloid and Terpenoid Extracts of Ricinus Communis L. against Gram-negative Pathogenic Bacteria Hussein J. Hussein
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

To uncover the effect of the crude extracts to the phenolic, alkaloid and terpenoid compounds of Ricinus communis L. against some gram-negative Pathogenic Bacteria. Antibacterial activity of the crude Phenolic, Alkaloid and Terpenoid of Ricinus communis L. was determined in vitro using agar well diffusion methods against some gram-negative pathogenic bacteria. Obtained results showed that active compounds of Ricinus communis L. possess wide ranges of antibacterial activity against gram-negative bacteria. This investigation exhibits that we can presume that the effect of active compounds in Ricinus communis L. has a distinctive effect on various pathogenic life forms in various concentrations. Alkaloid compounds extracted from Ricinus communis L. leaves had shown effective antibacterial activity against Escherichia coli, Salmonella and Enterobacter .While, terpenoid compounds   it was more effective to Enterobacter, Shegilla and Pseudomonas.Keywords: Antibacterial; Ricinus communis L; Pathogenic Bacteria; Gram-negative Bacteria.
Synthesis of Polymerization of New Derivative of 2-Decanoic Acid Extracted from Coriander Seed Fatimah Ali Hussein
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work, includes  preparation of the derivative of decanoic acid  was extracted  from conriander seeds by fractional distillation for four hours, then reacted with one groups of amin of  thio urea  the2nd group  amin in thioureia was  reacted  with maleic anhydride a  different drugs was used to obtain  novel  derivatives.  The compounds  written off as  by using some spectroscopic methods, H1NMR and  FT-IR used to characterization the derivatives, control drug release was studying of some derivatives, biological activity against bacterial was studying and thermal stability of the derivatives.Keywords: Decanoic acid, Conriander seeds, FT-IR, H1NMR
Effect of Health Education Intervention about Emergencies on the Knowledge and Ability of Parents in Handling Children with Emergency Condition Ni Luh Putu Inca Buntari Agustini
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Emergency is an unexpected and often dangerous situation requiring immediate action, accurate, and correct action to save lives. Delays in conducting emergency assistance often occur in children, adults and the elderly, where the consequences of the delay are permanent disability and even death. Emergency for children becomes an important concern because children are not used to expressing uncomfortable conditions in an emergency condition. Emergency conditions which often occur in children are febrile convulsion, choking and cardiac arrest. The purpose of this study was to identify the differences in parents’ knowledge before and after given education about febrile convulsion, choking, and cardiac resuscitation.  Method: This research employed Pre-Experiment with One Group Pre-test Post-test design. The sample of this research was 70 parents who have children under five years. The sampling technique was used total sampling technique. Univariate analysis was used to determine the demographic data of respondents. Bivariate analysis was used to determine the differences in parents’ knowledge before and after given the education.  Results: The research revealed that (Febrile convulsion P 0,000 <a = 0.05), (Choking P 0,000 <a = 0, 05), and (Cardiac arrest P 0.000 <a = 0.05). Conclusion: There is an effect of giving education toward parents' knowledge in handling children with emergency conditions. It is recommended that further activities and training on emergencies should be carried out steadily since emergencies can occur anywhere. So, it is important for parents to know the right guidance.Keywords: Emergency, Health education, Febrile seizures, Choking, Cardiac arrest.
COMPARISON OF OSTEOGENIC AND CHONDROGENIC DIFFERENTIATION POTENTIAL BETWEEN WHARTON’S JELLY AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS AS THE ALTERNATIVES OF BONE MARROW MESENCHYMAL STEM CELLS: A SYSTEMATIC REVIEW Petrus Aprianto
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Introduction. Currently, Bone Marrow is the most common source of Mesenchymal Stem Cell (MSC). The limitation of the source and pain post harvesting procedure make the next alternative of BM-MSC is needed. Wharton Jelly, offer a low cost and pain free collection method. Adipose tissue provide abundant amount stem cell and has a interestingly compatible osteogenic and chondrogenic activity. The objective of this study is to search alternative Bone Tissue Engineering (BTE) source other than BM-MSC.Materials and Method. Literature search was conducted using several search engines. This review used all In vitro experimental comparison of Adipose Tissue Mesenchymal Stem Cells (AT-MSC) and wharton’s jelly stem cell (WJ-MSC). We compared osteogenic and chondrogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, animal MSCs and human MSCs.Result and Discussion. The first study that compared osteogenic and chondrogenic differentiation from animal AT-MSC and WJ-MSC consists of 7 trials. Most of the result shows that AT-MSC has greater osteogenic differentiation potential compared to WJ-MSC and controversial result for chondrogenic differentiation between them. The second study consist of 3 trials. In these studies, the results were more homogenous and concluded that AT-MSC has higher osteogenic differentiation potential than WJ-MSC but the chondrogenic differentiation were not significantly different.Conclusion. AT-MSC may be more appropriate than WJ-MSC for osteogenesis and bone repair usage.Keyword: Osteogenic differentiation, Chondrogenic differentiation, Wharton’s jelly Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells
Knowledge on Cervical Cancer Prevention and Attitude towards Pap smear and HPV Vaccination among Women Attending a Health Clinic in IPOH, Malaysia Sandheep Sugathan
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objectives: Cervical cancer is the second most common cancer among women in Malaysia and is one of the leading causes of cancer mortality in women worldwide. This study was carried out to study the knowledge level regarding cervical cancer prevention and attitude towards Pap smear and HPV vaccination among women attending Greentown outpatient clinic in Ipoh, Malaysia. Methods: Data were collected using a structured questionnaire which included socio-demographic characteristics, knowledge of cervical cancer, Pap smear and HPV vaccination and attitude towards Pap smear and HPV vaccination from a sample of 100 women of age between 16 and 65 years, who were attending the Greentown outpatient clinic in Ipoh, Perak from 21st July to 8th August 2014.Results: Most of the participants were of the age group of 26 to 45 years (44%). Majority of the respondents had good knowledge of cervical cancer, Pap smear and HPV vaccination and showed good attitude towards Pap smear and HPV vaccination. Knowledge levels were significantly different in the different age groups. Attitude on Pap smear and HPV vaccination was significantly higher among higher education groups and employed groups. Conclusion: Age was significantly associated with knowledge levels on cervical cancer prevention and HPV vaccination. Education and occupation levels were significantly influencing the attitude of women regarding cervical cancer, Pap smear and HPV vaccination.

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