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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Investigating the Genetic Change in BRAF Gene Causing Manifestation of Prostate Cancer in a Sample of Iraqi Patients Jaleel I. Asaad
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

This study included 100 patients suffering prostate cancer, 15 persons with family history of cancer served as positive control, and 30 healthy men served as negative control.  Prostate cancer tissues were collected from surgical room and subjected to DNA extraction for further processing.  Four primers were designed to investigate lethal changes at BRAF location related to this disease. Six pathogenic mutations were found among patients included in this study. These were rs1131692058, rs180177042, rs397507484, rs121913364, rs121913377, rs113488022, and rs1131692058. These represented ingle nucleotide polymorphism except for rs1131692058 which was found a deletion mutation. More data showed that positive control were less specific to associate with BRAF primer suggesting they bear variations susceptible for lethal change that may developed to cancer.
Study of Feeding Preference and the Effect of Some Hosts of Aphid on Some Biological Aspect of the Coccinella Septempunctata (Coleoptera: Coccinellidae) Esraa Fadel Wathah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The current study included a food preference test for C.septempunctata in a modified McDonald's way inpreferring a type of aphid than the other, as well as to know the effect of the host species of prey inattracting predators. In which the type of aphid had been studied and they are Schizaphisgraminum,Aphis Nerii and thrioaphistrifolii. The results show that adult predators are attracted towards S.graminum followed by A. nerii and T. trifolii. When the adults were exposed to plants without aphid,they showed an attraction towards the Triticumspelta, followed by Nerium oleander and Medicago sativaplants successively. The study also included the testing of aphid species at different stages of life for thementioned type. The results of the study showed that the growth rate of predator larvae differedaccording to the insect host. The longest duration of the larval stage was (16091) day when feeding on S.graminum and the shortest (12.01) day when feeding on T. trifolii. As for the pupae role, the longestduration was (5.85) day when feeding on A.nerii insect. As for adults, the duration of pre-laying eggs, thenumber of eggs, incubation and the proportion of hatching differed depending on the host insect. Thehighest pre-egg laying time was (7.95) day when feeding on Nerium oleander aphid and the least (4.77)day in feeding on T. trifolii and the highest rate of eggs lying was (800.30) and the lowest (386.00) infeeding on S. graminum. The highest egg incubation period reached (4.00) day in feeding on A. Nerii andthe lowest (2.00) day in feeding on T. trifolii. The highest percentage of egg hatch is (88.82) in feeding onS. graminum and the lowest is (60.33) % in feeding on A. neriiKeywords: Hosts, Biological aspect, Coccinella Septempunctata.
Outpatient Educational Environment of Dental Medical Colleges of Bangladesh Utilizing Acleem Questionnaire Mainul Haque
Journal of Global Pharma Technology Volume 09 Issue 09
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Abstract

Background: The learning environment as: ‘a social system that includes the learner (including the external relationships and other factors affecting the learner), the individuals with whom the learner interacts, the setting(s) and purpose(s) of the interaction, and the formal and informal rules/policies/norms governing the interaction’ [2]. Educational environment both academic and clinical, are substantial elements carrying out medical students’ attitudes, knowledge, skills, progression, behaviors and achievements Methods: This was a cross sectional study. The study participants were Dental students of Dhaka Dental College and Mandy Dental College, Dhaka, Bangladesh. Data were collected in early 2017. The universal sampling method was adopted. ACLEEM validated instrument was utilized for the data collection. Data were using SPSS Version 21. Results: The response rate was 100%. The total study population was 134. Among the current SP 32.8% (44) and 67.2% (90) were male and female respectively. The reliability and Validity of the Questionnaire regarding local context were Cronbach’s alpha 0.939 and convergent validity -0.013-0.682 There were no statistically significant (p>0.05) differences observed between sex and dental colleges in the domain of Clinical Teaching, Clinical Training and Total when analyzed with an independent t-test. Conclusions: The ACLEEM instrument was valid and reliable to measure ambulatory educational environment for Bangladeshi for Dental School. Most of the study participants had positive perception regarding their education environment.Keywords: Acleem, Dental colleges, Bangladesh.
Synthesis and Characterization of New Schiff Bases Ligands and Studies It’s Complexes with Some Elemintes Mohmmed Hamid Said
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Preparation a new Schiff base ligand derived from reaction of terephthaldehyde with 2- aminobenzothiozol at (1:1) molar ratio and characterized by Uv-Vis, FT-IR, proton NMR and mass spectrometer and elemental analysis. The ligand mixed with Co (II), Ni (II), Cu (II), and Zn (II) chloride solutions at (2:1) molar ratio to form complexes. These complexes are characterized by elemental analysis, FT-IR, Uv-Vis, molar conductivity and magnetic sensitivity. This study concluded, the ligand acted as bidentate ligand, and all complexes have octahedral structuresKeywords: Terephthaldehyde, 2- aminobenzothiozol, Schiff base, Bidentate Ligand.
The Utility of Homemade ELISA Based Outer Membrane Proteins (OMP) of Salmonella Typhi in Diagnosis of Chronic Typhoid Carrier Thanaa R. Abdulrahman
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Typhoid fever is an extreme multi-systemic infection, constitutional symptoms is a major findings with classic prolonged fever. The simplicity, sensitivity, specificity and cost effective of diagnostic test which will be used in diagnosis of typhoid fever in human carriers, would give a compelling apparatus in controlling and preventing typhoid. The aims of this investigation were to determine the proportion of typhoid carriers by using homemade ELISA test based on OMP extraction. This study included fifty febrile patients and thirty age and sex matched apparently healthy individual as control with no history of immunization in the recent past, they were 24 (48%) males and 26 (52%) females, the age was ranged between 18-40 year with mean (33.6) .Blood and stool samples were collected from each participant and these samples underwent culturing on special media, after OMPs extraction from Salmonella typhi. Sandwich homemade ELISA were developed for detection of anti typhoid IgG and IgM using crud OMPS as antigen .The results showed that 18 (36.0%) out of 50 patients were stool culture positive, while blood culture results confirmed typhoid fever in 7 (14.0%) patients. Out of 50 serum samples were tested by homemade ELISA kit, which prepared in this study for IgG /IgM detection, there were 35(70.0%) IgG positive and only 8 (16.0%) was IgM positive. For IgG and/or IgM, as tested by ELISA positive results in accordance with stool and blood culture assays .For stool positive culture, IgG ELISA (26%) 13/50, showed positive results, while IgM (6.0 %) 3/50.Keywords: Salmonella typhi, Outer membrane protein, Homemade ELISA, Anti-typhoid antibodies, Roc test.
Different Parameters in Coconut (Cocos Nucifera) Wine Fermentation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Coconut (Cocos Nucifera) juice is an ancient tropical beverage whose popularity on the international market has been continuously increasing in recent years. The coconut (Cocos nucifera L.) is an important fruit tree in the tropical regions and the fruit can be made into a variety of foods and beverages. Coconut water is the clear liquid inside young coconuts. Coconut water (coconut liquid endosperm) is one of the world’s most versatile natural products. This refreshing beverage is consumed worldwide as it is nutritious and beneficial for health. An attempt explored a wine fermentation from coconut juice by examining the effect of different parameters such as soluble solid content (14.0oBrix, 14.5oBrix, 15.0 oBrix, 15.5 oBrix), fermentation temperature (28.5oC, 29oC, 29.5oC, 30.0oC), yeast Sacchromyces cerevisiae ratio (1.0%, 1.5%, 2.0%, 2.5%) to coconut wine quality. Our results proved that 15.0oBrix of coconut juice; fermentation temperature 29.5oC with 2.0% Sacchromyces cerevisiae was adequate for coconut juice wine fermentation. Using coconut juice having medicinal and nutritional value as a substrate for wine production, its health benefits can be improved effectively.Keywords: Coconut juice, Wine, Fermentation, Sacchromyces cerevisiae.
Implementation of Integrated Nursing Model towards the Quality of Services and Patients’ Satisfaction Deli .
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Abstract

Introduction: The lack of nursing quality indirectly can be seen in patients dissatisfactory. Today society demands service that focuses on patients need, and the correct approach will be determined by the selection of the nursing model. To increase the quality of service in nursing, require a redesigned model through implementing integrated healthcare services. Methods: This is a quasi experimental study to implement an integrated nursing model using an intervention group and a control model. A total of 154 samples were chosen using consecutive sampling technique and equally distributed to each group. T-test were used to analyze the patients satisfaction level of the nursing service. Results: The result shows in the intervention group, there were 60 people (78%) that are satisfied, while in the control group, there is only four-person (5%). The increase might be caused by the nursing that is more consistent, cooperative, and responsive. The nurse understand problem identification and actively collabore in search of solution in the integrated model. Constructive integrated structure model about responsible is essential in increasing professional nurse performance. Conclusion: In conclusion, there are significant differences; higher patient satisfaction level on the model implementing integrated model than without implementing integrated model.Keywords: Integrated model, Service Focus on Patients.
Influence of Immune Engines in Iraqi Patients with Acute Myeloid Leukemia Muhammed A.H. Aldabagh
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Acute myeloid leukemia (AML) is heterogeneous disorders originated from the abnormalities in the proliferation and maturation of myeloid progenitors in bone morrow. There is a clinical correlation between immunity engines and disease progression, but this relationship is not completely clear yet. This study was designed to assess the full immune response in Iraqi patients diagnosed with AML. Patients and healthy volunteers were divided into three groups: newly diagnosed untreated, under chemotherapy treatment patients and control group. A significant reduction were seen in C4 and IFN-γ levels in both untreated and treated groups with no significant difference between untreated and treated groups. On the other hand, IL-2 and IL-8 levels increased in untreated and treated groups, whereas IL-4 elevated only in untreated group. Additionally, IL-1α levels were decreased in treated group. Moreover, no differences in IL-10 and GM-CSF levels were found between studied groups. Levels of IGG significantly elevated after treatment. However, no differences in IGA and IGM levels were found. In conclusion, immune engines may have substantial effects on the development of AML disease, and chemotherapy may negatively or positively affect the levels of immune components.Keywords: Acute myeloid leukemia, innate and adaptive immune engines, IL-8, INF-γ, IgG.
The Use Two Methods of Presentation Clarity and Individual Competition to Develop of Mental Energy Mobilization and Learn Some Basic Skills for Students in Football Khalil Hamid Mohammed Ali
Journal of Global Pharma Technology .
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Abstract

Through the follow-up of field researchers to teach football in the lesson of physical education, he noted that many of the learners have difficulty in learning the basic skills as a result of their teaching methods, and that teaching requires other methods that lead to the best possible learning in accordance with the development of the game This is reflected in the upgrading of this game. The researchers' interest in this problem began in an attempt to reveal the use of methods to develop psychic energy and to learn the basic skills of football for students better. The objective of the research is to:Preparation of an educational program using the method of clarity of presentation in the development of mental energy mobilization and learn some basic skills for students of footballPreparation of an educational program using the method of individual competition in the development of mental energy mobilization and learn some basic skills for students of football.Identify which method (s) used best in the development of mental energy mobilization and learn some basic skills for football students.The Main Conclusions WereA clear improvement in the development of (experimental groups in the measure of mental energy mobilization and learn some of the basic skills of football.The first experimental group (individual competition mode) is superior to the second experimental group (the method of presentation clarity) in the development of the mental energy mobilization scale.The second experimental group (the clarity of presentation) has learned to teach the first experimental group (the style of individual competition) in the basic skills of football.Keywords: Two methods clarity of presentation and individual competition and the mobilization of psychological energy.
Nephrotoxicity: protection of silica nanoparticles loaded sodium salicylate and ginger in experimental rats Eman Refraat Youness
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: Ultrasound-assisted sol−gel method was used to prepare hollow structured porous silica nanoemulsion loaded with sodium salicylate as a model drug. Objective: This work was extended to achieve the target of the current work via investigating the protective role this nanoemulsion model as anti-inflammatory drug or ginger for its antioxidant effect against cisplatin-induced nephrotoxicity in male albino rats. Results: The results clarify that the nanoemulsion model was synthesized using ultrasonic assisted with small size and well stabilization as proved by TEM and DLS analysis.  Additionally, blood urea and serum creatinine were increased after cisplatin injection with disorders in oxidative stress and rising of homocysteine levels. Also, histopathological changes of the kidney tissue were observed.  These changes back to normal via treatment with silica nanoparticles loaded sodium salicylate (Si-Sc-NPs), ginger or both. Oil /water nanoemulsion of (Si-Sc NPs) and ginger showed a protective and promising preventive strategy against nephrotoxicity due to their antioxidant and anti-inflammatory effects.

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