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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Detection of Anti- Ovarian Antibodies and Anti-sperm Antibodies in Sera of Sub Fertile Women in Baghdad Farhan A Risan
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The study was  carried out through  the period  March/2017 to  October/2017,for   estimate the ant ovarian antibodies and anti sperm antibodies in  sera (fifty  nine) sub fertile women  compared with( twenty seven ) healthy women as control  group.  Their mean aged 28 years. The diagnosis of  anti ovarian antibodies concentration   were  a done  by enzyme linkage immunosorbent  assay(ELISA)  A high  significant in cement (p≤ 0.001 ) was observed  in the  sera of sub fertile women( 819 uL) compared  with  control  group( 476uL),while   the anti-sperm antibodies concentration  show high significant in cement (p≤ 0.0l) in the sera of sub fertile women(211 uL) compared with control group(42  UL).Keywords:  Anti-ovarian antibodies, Anti-sperm antibodies, Sub fertile women.
Variety of German Chamomile (Matricariarecutita l.) Secondary Compounds in Different Planting Dates in Iran Mohammadreza Naderidarbaghshahi
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

This study was conducted in the Research – Educational field of Isfahan Islamic Azad University (Khorasgan) Branch, Faculty of Agriculture, in the crop year 2014-2015, in order to evaluate the quantitative and qualitative aspects of German chamomile in different planting dates of chamomile. In this study, quantitative and qualitative characteristics of German chamomile were studied during three planting dates in mid-October, mid-November and mid-March in a Randomized Complete Block Design. In this study, the planting date of chamomile leads to relatively large changes in the chemical composition and chamomile yield and the amounts of Chamazulene and its Bisabolol oxide A, so that, along with delay in chamomile planting date, dry flower yield performance decreased, but Chamazulene and Bisabolol oxide A of that chamomile has increased. In line with the comparison between these three planting dates, in terms of the performance of produced chamomile, mid-October German chamomile planting with 1602 kg per hectare of chamomile dry flower had the most amount of dry flower yield and early-March planting with 1/9 kilograms per hectare of essential oil production and 0/14 kilograms per hectare Chamazulene had the highest amount of essential oil yield and Chamazulene and it can be recommended for the study region
Technical Factors Affecting to Production of Dried Roasted Pumpkin (Cucurbita) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Pumpkin seeds are covered by a white husk. Pumpkin seeds are subtly sweet and nutty with a malleable, chewy texture. The seeds of pumpkin are rich in oil and nutrients. Pumpkin seed has been considered as beneficial to health because it contains various biologically active components. It lowers cholesterol level in blood. Drying and roasting are the most important processes giving neccessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during infrared drying as well as storage. So the objective of the present study was to identify the effect of temperature in infrared drying, roasting condition, packaging and storage to antioxidant (tocopherol) in the dried Pumpkin (Cucurbita) seed. Results demonstrated that drying temperature (42 oC), roasting (155 oC in 4 min), vaccum packing in polyethylen (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 12 weeks. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted pumpkin seed.Keywords: Pumpkin, Drying, Roasting, ANTIOXIDANT, tocopherol, Vaccum.
Synthesis, Characterization and Biological Evaluation of Some 2-Azetidinones Derivative from Benzimidazole and Used as Anti-Fungicide Agents Ahmood Kh. Jebur Al-Joubory
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Reaction of benzimidazole with ethyl chloro acetate to give ethyl –N–benzimidazole acetate (M1) which was used the reaction with hydrazine hydrate to yield N- benzimid azole aceto hydrazide (M2). The reaction of compound (M2) with different aromatic aldehydes gave compounds hydrazone (M3, M4). (P-Hydroxy (or Chloro) benzylidine) -N- aceto hydrazide benzimidazole. Then the compounds (M3, M4) reacted with chloro acetyl chloride in presence of tri ethyl amine using DMF as solvent to obtain 2-azetidinones compounds (M5, M6). The structures of all the newly synthesized compounds were confirmed by elemental analysis and FT-IR, 1H NMR and 13C NMR as well as melting point. Some of these compounds showed good antimicrobial activity (M1-M6) and anti-bacterial activity (M1-M6) Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and E.coli (Gram negative). Some the compounds showed high inhibition activity against bacteria and two fungi (Candida albicans).Keywords: Benzimidazole, Schiff bases, Ester, Heterocyclic compounds.
Assessment of Pregnancy Complications among Internally Displaced Women in Karbala Governorate Ridha M. lefta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background Pregnant women face increased risks of complications as they exposure to displaced conflict zones with damaged and destroyed health facilities in out conflict zones. Objectives: To determine the pregnancy complications among displaced women, and to find out the relationship between dietary habits for displaced pregnancy and complication of pregnancy. Methodology: A descriptive analytic study has been conducted on non-probability purposive sample of (200) displaced pregnant women select AL-Hussein Teaching Hospital in Karbala governorate. This study has been conducted during the period of 1st December until (30)th December 2017. A questionnaire is used as a tool of data collection to fulfil the study. A content validity, which is carried out through 13 panels of experts .Validity is determined by a panel of experts while the reliability utilization its split half. A descriptive and inferential statistics are used to analyze the data. Results: This table shows that the study result for demographic data the majority of the study samples 21-25 years old are 32% and the most the sample related level of education  have secondary school 38% and housewife are 93% and resident in urban. The study results indicate that the economic status sufficient to some extend and living at camp are 53%. This table depict that the complication among pregnancy displaced that indicate majority of pregnancy suffer from anemia is 49%.This table depict that the there is a non- significant between complication among pregnancy displace women and diatery habit domain at p. value more than 0.05. While there is a significant between complication pregnancy displaced and (dental problems and prenatal vitamin) at p. value less than 0.05, also the correlation between foreign food and complication pregnancy displaced women is high significant at p. value less than 0.01. Conclusion: Anemia is the major pregnancy complication among IDPs women. Recommendations: A special education programs focused on improvement the women knowledge and practices about the prevention and management of pregnancy complications.Keywords: Internally displacement, Pregnancy complications, Anemia, Prenatal vitamins, Dental problems.
Study of the Effect of Carbopol and Chitosan on the Gelatin Water Solvation Process with the Method of Molecular Dynamics Mayorova AV
Journal of Global Pharma Technology .
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Abstract

Background: The purpose of the paper is the analysis of scientific and technical information concerning features of using microcapsules in dermal medicinal and cosmetic products, as well as a theoretical study of the effect of carbopol and chitosan on the process of gelatin solvation in microcapsules. An analysis of published data showed urgency of developing dermal medicinal and cosmetic forms using microencapsulation, as well as the prospects for studying the relationship between the material of microcapsules and chemical composition of the drug. Carbopol 940 and chitosan succinate were used as the basic carrier for the developed dosage forms. A statistically significant increase in the solvation level of gelatin in the presence of carbopol at the human body temperature compared to solvation with pure water was established by the molecular dynamics method with the use of the Bio Evrica software. In a similar way, an insignificant effect of the ionized form of chitosan on the level of gelatin solvation was found. Methods: The molecular dynamics simulation was performed with direct account of the solvent molecules, the charges of carbopol and chitosan atoms were calculated previously by abinitio method (6-311G**).Conclusion:  The obtained results show the expediency of using carbopol and chitosan as the basic carrier of external dosage forms with gelatinous microcapsules, since increasing the gelatin solvation level promotes the release of active substance of microcapsules.Keywords: Molecular dynamics, Solvation, Gelatin, Carbopol 940, Chitosan microcapsules, Gel.
The Effect of Extra Virgin Olive Oil to Decrease HSP-90, TNF-Α and ET-1, in Pre-Eclampsia Rat Model Wenny Rahmawati
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

ABSTRACTBackground: Preeclampsia characterised by new-onset hypertension with systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, measured on two occasions at least four hours apart, and proteinuria of > 0.3 g per 24 hours or ≥ 1+ proteinuria, detected by urine dipstick after 20 weeks of pregnancy, or in the absence of proteinuria. Objectived: This study aimed to determine effect of EVOO as a strong exogenous antioxidant to decrease TNF-α, HSP-90 and ET-1 level in preeclampsia rat model. Method: This research consisted of five groups; negative control, positive control (preeclampsia rat model), doses 1, 2, and 3 that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). After sacrificed, placentas were collected to determine HSP-90, TNF-α and  ET-1 level. Result: Result of this study showed that there was a reduction of HSP90 (p=0,00), TNF-α (p=0.011), ET-1 (p=0.02). Conclusion: Administration EVOO decreased HSP-90, TNF-α and ET-1 Level in preeclampsia rat modelKeywords: Preeclampsia, EVOO, HSP-90, TNF-α, ET-1,  Antioxidant, Oxidative stress.
Mixed Ligand Schiff Base Complexes of Some Metal (II) Salts: Preparation, Spectral Characterization and Antibacterial Screening Faeza Hasan Ghanim
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Schiff base ligand (E)-2-((3-hydroxyphenylimno) methyl)-6-methoxyphenol has been synthesized from m-aminophenol and o-vanillin. The geometry of Schiff base has been determined on the basis of Micro elemental analysis (C.H.N), molar conductance. Mass,  1HNMR, FT-IR and UV-Vis spectroscopic techniques. Metal mixed ligand complexes for manganese(II),cobalt(II),nickel(II),copper(II),zinc(II) and cadmium(II) for Schiff base ligand and paracetemol have been prepared in the molar ratio 1:1:1 (M:L: Para), (M= Metal, (L)= Schiff base ligand and (Para) = paracetamol) have been prepared and identified by using flame atomic absorption, FT.IR and UV-Vis spectral methods, on other than magnetic properties and conductivity measurements. Their electrical conductance values indicate that all complexes are electrolytes. From   obtained data octahedral geometry were suggested with all prepared complexes. Schiff base ligand, paracetamol as well as metal (II) complexes were assayed by antibacterial activity against some pathogenic bacteria using disc diffusion method.Keywords: Schiff base, Paracetamol, Mixed ligand complexes, Antibacterial screening.
A Quantitative PCR Approach for Recognizing the Functional Genes Involved in the Degradation of Naphthalene Dioxygenase and Polycyclic Aromatic Hydrocarbons in Contaminated Soils Hanan M. Ali
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Analysis of environmental pollutants is very important aspect; cheap and quick methods to clean-up the environment are required. Therefore, the polycyclic aromatic hydrocarbons (PAHs) and naphthalene dioxygenase (NAH-F/NAH-R) were separated from crude oil from north Al-Rumaila/ Iraq. These compounds were used in different concentrations as degraders that docking the functional genes of each of Aspergillus Niger strain AHBR3, Cladosporium ramotenellum and Penicillium brevicompactum isolate 66 small. The results were showed that the three microorganisms use these compounds as a source of food and energy to degrade the pollutants.Keywords: Pollutants, Polycyclic aromatic hydrocarbons, Aspergillus Niger, Cladosporium ramotenellum, Penicillium brevicompactum
Rapid Determination of Bi (III) and Al (III) in Pharmaceutical Formulations using Organic Reagent Spectrophotometrically Jumana W. Ammar
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

A new trend describes the development and validation of a simple, sensitive and selective spectrophotometric methods for the determination of Bi (III) and Al (III) in pharmaceutical formulations have been conducted. In this paper, 4-(4 acetamidophenylazo) pyrogallol was synthesized as a new organic compound, 4-APAP, by coupling pyrogallol with diazotized p- aminoacetanilide in medium of controlled pH. 4- APAP was characterized by techniques of FT-IR, H-NMR, GC-Mass, TG and DSC thermal analysis methods. Solvatochromic behavior in solvents of various polarities was also investigated.Keywords: Pharmaceutical applications, Pyrogallol, Bi (III), Al (III).

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