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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Gender inequalities in caries experience among primary school-children. A cross-sectional study in a rural area of Indonesia Sri Widiati; Al. Supartinah Santoso
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Abstract

OBJECTIVES Dental caries is known as one of the most prevalent chronic diseases among school-children, especially those with lower socioeconomic status and higher sugar consumption. The purpose of the study is to compare caries prevalence between female and male school-children aged 11-13 years, adjusting for socioeconomic status. METHODS A cross-sectional study was carried out in a rural area of Sleman, Indonesia, to estimate the effect of gender, parental education and family income. A sample of 1,144 children at fifth grade were selected from 45 elementary schools in Sleman, Indonesia. Information concerning paternal education, demographic data of the school-children and family income were obtained from parents or guardians of the children. Caries status (DMF-T) of the schoolchildren was examined according to WHO dental health survey guidelines. RESULTS The results of the study showed that female students had on average 0.39 higher DMF-T than male students (p=0.001) and 28% less odds for caries-free status (p=0.009) adjusting for paternal education and family income. University education of fathers was associated with 0.53 lower DMF-T compared to the lowest education category and 79% increase in odds for caries-free status. There is no difference in restorative index between male and female students reflecting similar experience in dental care. CONCLUSIONS Female school-children aged 11-13 years were consistently at a greater risk for dental caries adjusting for parental education, an issue for further research and school-based oral health promotion program.
Anti-Cancer Potential of Vateria Indica L. Stem Bark Enriched Fractions in EAC and C6 Cell lines-an In-Vitro Study Richard Lobo
Journal of Global Pharma Technology Volume 09 Issue 08
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Abstract

The western Ghats of India present Pharmacognosists and botanist a rich source of biological diversity to explore their unearthed potential. V. indica, one among the thousands of such plant growing in the southern states of India especially in Kerala, Karnataka and Tamil Nadu, at about 750 m altitude is a slow growing plant of Dipterocarpaceae family. The present study was aimed to investigate the anticancer potential of stem bark of Vateria indica by trypan blue exclusion method and Sulphorhodamine B assay against C6 and EAC cell lines respectively. From the studies it was found that the acetone fraction of V. indica demonstrated high activity whereas ethanolic and petroleum fraction were moderately active against C6 cell lines respectively. It was also observed that the ethanolic and ethyl acetate fraction of V. indica were highly active whereas petroleum ether extract was moderately active against EAC cell lines.Keywords: Vateria indica, Anticancer potential, SRB assay.
Application of Some Effects on the Degradation of the Aqueous Solution of Fuchsine Dye by Photolysis Luma Majeed Ahmed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

This manuscript was focused on to how can utilize from UV-A light in order to decolorize the basic fuchsine dye from the aqueous solution at pH 6.4. The produced results from this study were indicated that the acidic medium is favor to decolorize this dye at pH equal to 4.6 and the efficiency of photoreaction increases from 73.75 % to 89.63 % at 70 min. The effect of temperature was done in ranged from (288.15 -333.15) K and occurred that the photoreaction of basic fuchsine dye increases with the increasing the temperature. The activation energy was calculated by depending on Arrihnes equation and found to be 10.286 kJ mol-1. Moreover, the thermodynamics parameters such as ΔH#, ΔS#and ΔG# were measured and given values equal to 7.714 kJ mol-1, -0.00362 kJ mol-1 and 8.923 kJ mol-1 respectively. The positive value of ΔH# enhances the photoreaction of photo-decolorization of this dye. A statistic study was performed by using t-test and F-test, and noticed that there was no significant difference between these methods.Keywords: Basic Fuchsine dye, Photolysis, Rosaniline hydrochloride dye,  PDE and Decolonization.
Technical Factors Affecting to Durian (Durio Zibethinus Murr) Drink Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Durian (Durio Zibethinus  Murr) fruit possesses high nutritional value and has rich bioactive properties. The ripe durian fruit has unique taste and aroma. It is usually used for fresh consumption. During the durian havesting season, excessive supply of the fruit causes the price of durian decreasing dramatically. Therefore we have our tried to add value to the durian fruit. One method of adding value to fresh durian is processing it into drink. We carried out the investigation of extraction (ratio of water: durian, temperature and time of blanching); juicy mixture; preservation. Our result showed that the durian drink having the best quality when extracting with water: durian pulp ratio (70:30) at 85 oC in 3 minutes. The sample was then cooled to 37°C before the addition of pectinase enzyme at 0.06%. The juice was then incubated in a water bath at 37°C in 45 minutes. After the incubation process, the juice was heated in a water bath at 100°C for 2 minutes to inactivate all enzymes present. The hydrolyzed durian juice will be formulated with sugar 2%, citric acid 6%, gellan gum 0.03%. Durian drink shelf-life could be maintained for 12 months.Keywords: Durian, Durio zibethinus Murr, Drink, Gellan gum, Pectinase, Shelf-life.
Fluorimetric Determination of Mefenamic Acid using Sodium Per Sulfate as a Precipitating Agent and Low Pressure Mercury Lamp; Via the use of ISNAG Continue Flow Fluorimeter Nagam Shakir Turkie
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A new, simple, sensitive and fast method for the determination of Mefenamic acid in pure form and drugs (tablets) by continuous flow injection analysis via measurement of diverged beam of light by ISNAG_-fluorimeter. The method based on the reaction of the Mefenamic acid with sodium persulfate to form yellow precipitate. Optimum parameters have been studied to increase the sensitivity for the developed method. The linear dynamic range for the instrument response versus Mefenamic acid concentration was 0.01-5 mmol/L while the L.O.D was 215.955 ng/sample from the step wise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The correlation coefficient (r) was 0.9968 while percentage linearity (R2%) was 99.35%. RSD% for the repeatability (n=8) was lower than 0.2% for the determination of Mefenamic acid, with concentration of 1, 3 mmol/L respectively. The: developed method was applied successfully for the determination of Mefenamic acid in pharmaceutical tablets. A comparison was made between the newly developed methodology and the classical method (turbidometry) of analysis using the standard addition method via the use of paired t-test. It shows that there was no significant difference between the quoted values of each individual company with calculated t-value at 95% confidence interval from developed method.Keyword: Mefenamic acid, Flow injection analysis, Diverged beam of light, Homemade instrument.
Studying Inhibitory Effect of William Pear and Propolis against Alernaria Alternate with Diagnosis of Some Active Compounds Mohammed Allawi
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Alternaria alternate was isolated from orange juice, using potato dextrose agar (PDA) media, incubated for 5 days at 27 co, the evaluating anti fungal effects were seven different concentration (1.25, 2.5, 5, 10, 15, 20, 25) mg / ml of the extract alcohol: (William pear extract = WPE) and (Propolis extract = PE), the inhibitory efficacy of each extract against the fungus was increased by increasing its concentration. Also observed that the inhibitory activity of (PE) was greater than (WPE).The separation process of (PE) showed a presense: Flavone, 3-hydroxy flavone and Quercetin and absense these compounds in (WPE).Keywords: Propolis, Wiliam pear, A. alternate, TLC.
Study the Functional VNTR Polymorphism of Monoamine Oxidize a (maoa) Gene in Violent Criminal Behavior for Iraqi Prisoners Suhad Redah AL-Tayie
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Monoamine oxidise A (MAOA) enzyme activity is changed in mood disorders and lower activity associated with criminal and aggressive behaviours. The monoamine oxidise-A (maoa) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, nor epinephrine, and dopamine, contains a polymorphism in its promoter region that affects transcriptional efficiency. maoa -VNTR genotype has been related with both psychological and physical measures.   Blood samples were provided from 200 prisoners (case group) who convicted with terrorism (150 sample), murder (30 sample) and drug trading (20 sample) issues selected from Al –Hila prison reformist central for men and women / Babylon city and from position and deporting division /Karbala, this sample include (160 male and 40 female).Additionally, control subject (100) sample were provided included (54 male and 46 female). DNA was extracted and the mentioned polymorphism (VNTR) was genotyped by PCR. The results were confirmed by using sequencing technique.   The maoa VNTR polymorphism was analyzed in male and female separately due to the gene location on X-chromosome .The results demonstrated that there was non- significant  difference  observed  between all genotypes and alleles frequencies between case and control male (p> 0.05),whereas in female a significant association in 3.5/3.5 and 5.5/4.5 genotypes (p<0.01) ,additionally the 3.5 R alleles was associated with higher risk of violent criminal behavior in female (p= 0.004; OR=2.62; 95% CI=1.36-5.05). The maoa genotype 3.5/3.5 and the risk allele were a significantly associated   within female  and  they might be associated with increased risk of engaging in violent crimes.Keyword: Monoamine Oxidase- A, Maoa- VNTR, Genotype, Violent criminal behavior.
Studying the Pattern of Phenotypic Resistance to some Antibiotics for Local Isolates of Enterobacter Cloacae and its Evolutionary Relationship with Global Isolates Safaa M. Salman
Journal of Global Pharma Technology .
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Abstract

26 isolates of Enterobacter cloacae from 264 specimens from different clinical sources and from inpatients for ages ranged from one Week to 73 years from 15/12/2016 to 18/7/2017collected from two hospitols of AL-Diwaniyah city. The isolation and diagnosis process was based on the results of phenotypic and biochemical tests and the Vitek system .The sensitivity of the isolates for antibiotics were tested against 15 antibiotic using disk diffusion  method , The results showed an absolute resistance (100%) for Amoxicillin, Cephalothine and Doxycycline, while their sensitivity to Amikacin , Gentamicin, Tetracycline, Nitrofurantoin and Nalidixic acid were various, they resisted it at percentage of 11.53 %, 34.61% , 73.07% , 34.61% and 23.07% respectively . For the rest of the Cephalosporin group (Cefoxitin, Cefotaxim and Ceftriaxone) , the isolates were resisted  them with percentage 65.38%, 57.69% and 34.61%, respectively , While   all isolates (100%) were sensitive to Chloramphenicol, Ciprofloxacin, Impenem and Meropenem . Twenty-four isolates (92.30%) were able to produce β-lactamase. PCR was used to amplify HSP60 gene which used to determine the sequence of nucleotides and draw the phylogenic tree and find the relationship between the current isolates of this study with global isolates.Keywords: Enterobacter cloacae, HSP60 gene, PCR, evolutionary relationship.
Influence of Li Doping in NiO Thin Films Prepared by Simple Chemical Method Ahmed N. Abd
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

This study deals with the study of the structural and visual properties of NiO and Li Doped NiO films in different percentages (0.02, 0.04, 0.06, 0.08% mol).Thin films of NiO were deposited on glass substrates at 300 ° C and 150 nm using droplet casting technique. X-ray diffraction (XRD) showed that multi-crystalline films had a cube structure with a preferred orientation along the length of (111). The tonic stimulator did not change between 0.02, 0.04, 0.06 and 0.08% Grammy% of the preferred trend. The average grain sizes of crystals classified from XRD data were found in the range of 15.62 - 37.52 nm. Atomic Force Microscope (AFM) data shows that the film surface is extremely smooth. The photovoltaic permeability of pure NiO membranes is 72% in the visual and x-ray regions (NIR), which is important for their applications as window layers in solar cells.Keywords: Nickel oxide, XRD, AFM, grain sizes, thin film.
Asymptomatic Tremendous Lung Shadow in a Young Man: A Case Report Li Min Wang
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The study is devoted to a unique asymptomatic case of pulmonary sequestration with no infection detected and offers an appropriate treatment solution.The study was carried out in the Surgery Department of the polyclinic No.47011661433010211A1001, Hangzhou, China, in 2019. The patient diagnosed with pulmonary sequestration was 26 years old. No associated symptoms were detected. CT Angiography (CTA) was applied to diagnose pulmonary sequestration, whereas Digital Subtraction Angiography (DSA) was conducted before operation in order to localize abnormal vessels. CT Angiography (CTA) suggested thickening and tortuous regional arteries in the right lower lung, with obvious increasing in branches. The 12th thoracic level aorta branched out into the right lower lobe of the lung, the vein drained back into the pulmonary vein. The surgical treatment of pulmonary sequestration was performed with the embolic thread and involved embolization with an embosphere of 0.5 mm diameter and a spring coil. The post-surgical angiography revealed the disappearance of distal blood flow, indicating success of the therapy. After the intervention, the patient developed a recurrent fever. After the oral administration of low-dose glucocorticoids, the patient’s body temperature dropped to the normal level. The final CT scan of the chest conducted a year after treatment showed shadow absorption.The embolization therapy turned out to be effective and hence is suitable for the treatment of pulmonary sequestration. It was established that lung malformations may manifest as an asymptomatic condition. This finding expands what we know about the pulmonary sequestration. Keywords: Pulmonary sequestration; Interventional embolization, Angiography, Clinical case.

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