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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Dual Role of Gentamicin in Gene Expression of Fibronectin Binding Proteins in Staphylococcus Aureus Hind Tahseen Ibrahim
Journal of Global Pharma Technology .
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Abstract

Objectives: The current work aimed to reveal the impact of gentamicin on the fibronectin binding proteins (fnbp) gene expression and its relation to biofilm and agr type in Staphylococcus aureus.  Materials and Methods: A total of 25 S. aureus isolates were enrolled in this study previously isolated from different specimens. Identification confirmation and methicillin resistance were achieved by amplification of 16SrRNA and mecA. Multiplex polymerase chain reaction (PCR) based assay was employed to evaluate the agr typing. The gene expression of fnbA and fnbB genes was tested by real-time PCR technique. Minimum inhibitory concentration was estimated by micro broth dilution methodology. Microtiter plate method was performed to determine the adhesiveness of to human fibronectin, with and without gentamicin. Results: Here we revealed a weak inverse correlation was observed between gene expression of either fnbA or fnbB with each of biofilm forming capacity and agr type. Whereas there was a strong correlation between fnbA and fnbB gene expression. Furthermore, gentamicin affected the bacterial genome in a way that down-regulates one of the genes in question; meanwhile, up-regulates the other one. Moreover, the current study found that polysaccharides production in 48% of isolates significantly (P<0.05) reduced by increasing fibronectin concentration. Conclusion: gentamicin has dual impacts on fnb genes expression. Albeit much work is needed; however, it is strongly suggested that gentamicin should be omitted from antibiotic regimen in treating S. aureus isolates.Keywords: Gentamicin, Fnba, Fnbb, Biofilm, Staphylococcus arueus.
Efficacy of Ultrasound on Pre-fermentation Maceration in Red Dragon Fruit Winemaking Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Ultrasound has recently been applied to evaluate the possible effect on color and flavor extraction at different stages of the winemaking process. Red color and aromatic compounds are localized in the skin cells and their release is facilitated by mechanical actions, disruption of tissues and cells, temperature and alcohol. Red dragon fruit has various nutrients, vitamins and minerals and medicinal values. Our present research focused on the effect of power and time of ultrasound as pretreatment maceration in red dragon fruit winemaing. Results revealed that using ultrasound power 270 w in 20 minutes as a pre-treatment on crushed red dragon fruit for the extraction of polyphenol, aromas. The application of ultrasounds allowed a significant reduction of the maceration duration and to get high-quality wine with high alcohol content, total phenolic, and good sensory characteristics.Keywords: Red dragon fruit, Ultrasound, Maceration, Power, Duration, Winemaking.
Myristica fragrans and Chronic Toxoplasmosis; In Vivo Parasitological, Histopathological and SEM Study Noha Madbouly Taha; Maysa Mohamed Kamel Sobhy; Rabab Sayed Zalat; Mohamed Sherif Ismail Negm; Eman Ahmed EL-wakil; Dina M. H. El Akkad
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Toxoplasma gondii (T.gondii) is one of the most important protozoa causing abortion in pregnant women and fatal manifestations in immunocompromized individuals. The present study was conducted to assess the effect of Myristica fragrans (M.fragrans) alone and loaded on Chitosan nano particles (CS NPs) on chronic toxoplasmosis as a more effective safe candidate in comparison with spiramycin. One hundred and ten laboratory bred Swiss albino mice were infected by oral inoculation of T.gondii tissue cysts, treated for 14 days starting from the 4th week post infection (p.i) and sacrified at the 10th week p.i. The effect of drugs was assessed by counting the number of tissue cysts in homogenized brain tissues, histopathological examination and SEM of brain tissue. There was a significant decrease in the number of tissue cysts detected in the brain between the control group and all treated groups (P<0.001). Histopathological examination revealed marked improvement of inflammation in all treated groups and the SEM of brain tissues revealed remarkable changes in the shape and structure of the T.gondii tissue cysts.
An Overview: Nipah Virus Infection in Humans Ashwini Jadhav; Shubham Choudhary; Aishwarya Mandhare; Sagar Adak; Sandip Kshirsagar
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Nipah viruses (NiV) are emerging zoonotic viruses that cause severe and often lethal respiratory illness and encephalitis in humans. Henipaviruses can infect a wide range of species and human-to-human transmission has been observed for NiV. Nipah virus is an emerging zoonosis with the potential to cause significant morbidity and mortality in humans and major economic and public health impacts. According to World Organization for Animal Health (Office International des Epizooties: OIE), Nipah virus is a notifiable disease of importance to international trade.Keywords: Nipah virus, respiratory tract, CNS.
Histopathological and Some Hematological Analysis in Iraqi Patients with Osteoarthritis Nabaa S. Abdul Sahib Abdul Sahib
Journal of Global Pharma Technology .
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Abstract

Osteoarthritis (OA) is a biomechanical process in which the joints respond pathologically to mechanical stress, leading to articular cartilage damage and changes in other knee tissue. The present study focuses on some haematological and biochemical test in both patients and control and histopathological change with knee OA patients. Tissue samples (Synovial membrane and Cartilage) obtained from 50 knee OA patients (35 females and 15 males) during total knee replacement for histological study. Blood sample were obtained from 50 knee OA patients and 25 control. The tissue sample and blood were collected during the period from October 2015 to June 2016. In the present study, the Histological study of knee OA tissues (Synovial membrane and Cartilage) expressed many histopathological changes such as fibrin deposition, congestion blood vessels and infiltration of inflammatory cells.Assessment of differential white blood cell (WBC) level in blood revealed that both neutrophils and monocytes levels elevated significantly in total knee OA patients (male and female) in compared with that of healthy controls, but there was no significant difference in neutrophils and monocytes levels of knee OA male patients compared with that of female patients. Also, no significant difference in WBC level of knee OA patients compared with healthy control, but there was a significant difference in WBC level between male and female knee OA patients. On the other hand, no significant difference in lymphocyte level of knee OA patients compared with healthy control for both male and female. Our results showed significant elevation in erythrocyte sedimentation rate (ESR) in females as compared with males with in the patients group. Also there was significant elevation difference in ESR between total patients and controls in males and females. While, no significant difference in platelets level of female with knee OA compared with healthy, but there was highly significant elevation difference in level of platelets in knee OA male compared with control, and between knee OA female and control but there was a significant elevation in platelets level of knee OA patient male as compared with knee OA female. On the other hand, no significant difference in Hemoglobin (Hb) level between male and female knee OA patients as compared with control, and between both males and females.Keywords: Osteoarthritis, Synovial Membrane, Cartilage, Knee joint.
Study the Effect of Some Heterocyclic Compounds on the Cholinesterase Enzyme in Human Blood Serum Meaaad Nasser
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

This research involve synthesis  of three  type of heterocyclic derivatives (thiadiazole, thiadiazole-shiff base, thiadiazole-azo) by three step, the first step react p-hydroxybenzoic acid with thiosemicarbazide to get compound (1), the second step include react (1) with (p-chloro benzaldehyde, p-hydroxy benzaldehyde) to get thiadiazole-shiff base derivatives (2,3) respectively, in other side the third step involve react (1) with 1-naphthol and salicylaldehyde to get, thiadiazole-azo derivatives (4,5) respectively, all these derivatives were characterize  by FT-IR, 1H-NMR, 13C-NMR  spectra .After that the effect of these compounds was studied  on the activity of the enzyme acetyl cholinesterase in the human serum. Compounds that have the donated  groups in the ring  showed a high inhibition ratio, either the compounds containing the withdrawing groups in the ring showed a low inhibition ratio because  the effect of resonance.Keywords: Thiadiazole, thiadiazole-shiff base, thiadiazole-azo, cholinesterase
Analytical Method Development and Validation for the Determination of Riociguat in Their Formulations by Lc-Ms/Ms Meyyanathan SN
Journal of Global Pharma Technology Volume 10 Issue 12 (2018) December 2018
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Abstract

Objective: The purpose of this study was to develop a simple, sensitive, precise, and rapid LC-MS/MS method for quantitative determination of anti-hypertensive drug Riociguat in its formulation using electrospray ionization in positive mode. Method: In this method, a zorbax (50mm x 4.6mm x 5µm) column with mobile phase 0.1% Formic acid: Acetonitrile (15:85, v/v) was used in the flow rate of 0.5mL/min. Results: The linearity range of Riociguat ranged from 10 to 110 ng/mL with the correlation coefficient of 0.9994. The method was validated as per the ICH guidelines. The limit of detection and quantification was found to be 3.5ng/mL and 10ng/mL, respectively. The recoveries of Riociguat at different concentration levels were found to be in the range of 97.34 % to 99.76 %. Conclusion: The proposed method was found to be simple, fast, accurate, and precise and can be applied for routine quality control analysis of Riociguat in formulations. The method proved to be selective, specific, sufficiently sensitivity, highly reproducible and robust for the analysis of formulation in Riociguat.Keywords: Formulation, Riociguat, LC-MS/MS, Validation.
Effects of Soursop (Annona muricata ) Lea f Water Extract (SLWE) on Body Weight, Leptin and TNF α Plasma Levels of Rats with High Fat and High Fructose (HFHF) Diet. Dini Sri Damayanti
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Abstract Background: Soursop leaves believed to be able to lose weight. The aim of the study was to prove that SLWE had an effect on body weight, leptin and TNF α plasma level in mice with the HFHF diet . Methods:The study used post test group design only. Male Wistar rats aged 8-10 weeks weighing 175-200g, healthy, 25 were divided into 5 groups by simple random sampling. Normal groups (N) , Positive groups (P) were given a HFHF 10% diet, treatment group  (T1), T2, and T3 ( HFHF diet + SLWE at dose of 100 mg / kg bw, 200 mg / kg bw, and 400 mg / kg bw). The diet and extract were given for 10 weeks. Measurement of body weight and weighing the amount of food consumed were carried out every week. Measurement of plasma leptin and TNF α levels using the ELISA method. Statistical analysis using ANOVA and Kruskal Wallis test with a confidence level p <0.05. Results : SLWE at all doses increased the amount of intake compared to P and N groups (p <0.05).Giving SLWE at dose of 400 mg/kgbw causes a slowdown in weight gain (p> 0.05),  increase levels of plasma leptin than P group. There was a tendency to decrease TNF α plasma levels with an increase in the dose of the extract (p>0.05). Conclution : Giving SLWE in HFHF diet-induced mice increased appetite, increased Leptin levels, and tendency to decreased weight gain and TNF α levels.Keyword : Soursop leaf, Weight gain, Leptin, TNF α, High Fat-High Fructose Diet
Synergistic Hurdle Effect of Physical and Chemical Treatments for Non-thermal Pasteurization of Guava (Psidium guajava) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Guava (Psidium guajava) is commonly known for its food and nutritional values throughout the world. It has high fermentable sugar composition when mature and ripe .It’s known for its sweet and tangy flavor and many uses. It is a fruit with good nutritional attributes but has short shelf-life under the ambient conditions. Dimethyl dicarbonate is a microbial control agent inhibitor widely applied in the food industry. Various current and potential applications of ultrasound in the fruit processing have been identified. Consumers prefer to safe, nutritious, high quality guava juices without thermal treatment. In our research, synergistic or hurdle effectiveness by ultrasound combined dimethyl dicarbonate was studied on guava juice. Different parameters of ultrasonic duration (10, 15, 20, 25, 30 min), dimethyl dicarbonate addition (10, 15, 20, 25, 30 µL/100mL) was examined on guava juice in respect of microbial inactivation. Log10 reductions of total plate count and coliform were evaluated to define the optimal variables. Our results revealed that microbial loads in guava juice would be decreased dramatically by ultrasonic treatment in 25 minutes at frequency 37 kHz with 20 µL/100mL supplementation of dimethyl dicarbonate to create a synergistic hurdle effect for a significant microbial reduction. It could be considered as an excellent non-thermal pasteurization for a better fruit juice quality, not only for guava but also for other tropical fruits to enhance their added value.Keywords: Guava juice, Synergistic, Hurdle, Ultrasound, Dimethyl dicarbonate, Microbial reduction.
Determination of Benzene in Iraqi Soft Drinks Mohammed B. Alqaraguly
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

In this study the trace level amounts of benzene was determined in the available soft drinks(locally produced having sodium benzoate as preservatives and ascorbic acid ) in Iraqi markets, Capillary gas liquid chromatography was used in this determination which was found to give accurate results in addition to its simplicity , results was found that benzene amounts were less than 10 µg/L (which is  less than the  WHO level) in most samples while few others recorded little bit higher results which means reconsideration  of using sodium benzoate in soft drinks should be taken into account.

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