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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Iraqi Legal System of International Environmental Responsibility Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The domestic legal systems have shown an interest that varies from one system to another in the environment in which man lives. In the pursuit of progress and advancement, man has achieved great success in various fields, but on the other hand, he has contributed intentionally and unintentionally to harm the environment in which he lives, and the reaction of States when recognizing the dangers posed to the environment in an initiative to work to support their domestic laws to The adoption of programs and plans for the protection and preservation of the environment within the limits of its regional competence and the development of some laws and regulations in the field of the environment, which led to the flourishing support for domestic law in many countries, especially the developed world in the field of the environment, which led to the emergence of a series of national legislation However, efforts to protect and preserve the environment at the domestic level cannot lead to achieving their goals unless they are coupled with efforts at the other level, namely international relations, because the field of the environment highlights the close link between domestic and international law. The environment for natural and geographical considerations is ultimately only one integrated and connected in a natural format.Keywords: Environmental Law, Pollution.
Synthesis and Spectroscopic Studies of Some Metal Complexes of (4-Nitrobenzoyl) Carbarmothioyl) Histidine (NCH) Athraa Gazi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

(4-nitrobenzoyl) carbamothioyl) histidin (NCH) a new ligand was synthesized by reaction of Histidine with (4-Nitrobenzoyl isothiocyanate) by using acetone as a solvent. The prepared ligand (NCH) has been characterized by elemental analysis (CHNS), infrared (FT-IR), electronic spectral (Ultraviolet visible) and (1H, 13C-Nuclear Magnetic Resonance) spectra. Some Divalent metal ion complexes of (NCH) were prepared and spectroscopic studies by Fourier transform infrared (FTIR), electronic spectral (UV-Vis), molar conductance, magnetic susceptibility and atomic absorption.  The results measured showed the formula of six prepared complexes were [M (NCH) 2]    (M+2 =Manganese, Cobalt, Nickel, Zinc, Cadmium and Mercury), from the obtained data tetrahedral structure suggested for all complexes, except Copper complex has a square planer geometry.Keywords: Histidin, Metal Ion complexes, 4-Nitrobenzoyl isothiocyanate.
Encrusted Double-J Stents: Risk Factors Analysis Besut Daryanto
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction Since its introduction by Finney and Hepperlen in 1978, the double-J (DJ) stent has become a common armament that every urologist uses every day. The use of the DJ stent cannot be separated from the morbidity or complications that might occur, including discomfort arising from the insertion of stents, forgotten to remove, urinary tract infections, biofilm formation, and even encrustation of the stent. This research aims to determine the correlation between the risk factors in the formation of encrustation in patients with urinary tract stones. Materials & Methods This is a cohort study using the chi-square analysis and odds ratio calculation. We evaluated urine metabolite, urine culture, time of removal of the DJ stent, and encrustation formation in the DJ stent. Sixty patients with urinary tract stone and 60 without urinary tract stone participated in this research. Results The presence of urine bacteria and neglected DJ stent in the stone group and abnormal urine levels of magnesium in the non-stone group had significant correlation with encrustation formation of the DJ stent (P < 0.05). Conclusions various factors lead to encrustation formation in the DJ stent, and patients with a history of stones have more risk factors for encrustation formation.Keywords DJ Stent, Bacteria, Urine Metabolite, Neglected, Encrustation.
Bacterial Isolates Associated with Pelvic Inflammatory Diseases among Women of Reproductive Age in Babylon Province Moayad N. Mosleh Al-Kafajy
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Pelvic inflammatory disease (PID) is a common infection and inflammation of the reproductive tract that is lining (endometritis) and fallopian tubes (salpingitis), is a recurrent condition among young women .PID and its complications, such as infertility, ectopic pregnancy, and chronic pelvic pain, are preventable by screening asymptomatic patients for sexually transmitted infections (STIs). This study aimed at identifying the microorganisms isolated, as well as the evaluation of frequency distribution for Chlamydia trachomatis, Neisseria gonorrhea, and others aerobic and anaerobic bacteria which may be associated with PID. Materials and Methods: Endocervical swabs totalling 43 were aseptically collected from women of reproductive age with pelvic inflammatory disease (PID), attending in two hospitals of Babylon Province: Province: Babylon Maternity and Pediatrics Hospital, and Al-Mahaweel General Hospital; as well as the samples taken from private clinics, during the period from January to October 2018. Results: Out of the 43 samples analysed, 30 women (69.7%) yielded pure cultures of bacterial isolates, among these 30 women, 22 (73.3%) had mixed cultures while no bacterial growths were recorded from the remaining 30.3 % samples. Organisms encountered were Escherichia coli the most encountered frequency (37.2%) followed by Staphylococcus aureus with (27.9%). Enterococcus faecalis (23.2%), Gardnerella vaginalis (16.2%), and Candida spp (11.6%) were less common, while Chlamydia trachomatis, Klebsiella pneumonia, and Neisseria gonorrhoe had the lowest occurrence frequency of  (6.9%) , (6.9 %), and (3.2 %). Conclusions: Pelvic inflammatory disease is a major health problem in developing countries of the world; the micro-organisms frequently responsible for acute PID were genital tract Escherichia coli. Thus, measures should be taken regarding early diagnosis in order to provide treatment before the complications develop of PID.Keywords: Acute pelvic inflammatory disease (PID), Female patient, Clinical presentation, Microbial isolates.
Incidence of Neonatal Phenylketonuria in Hormozgan Province, Southern Iran, 2014-2016 Farzaneh Dehghan
Journal of Global Pharma Technology .
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Abstract

Background and Aim: Phenylketonuria is a hereditary, autosomal recessive disease characterized by deficiency of hepatic phenylalanine hydroxylase. Dietary PKU treatment and regular monitoring of blood Phe are responsible to prevent symptoms. Therefore, present research was performed with the objective of determining incidence of PKU in the Hormozgan Province, South of Iran. Material and Method: This cross sectional study was carried out in Bandar Abbas, Hormozgan among 71677 neonates, who were born from March 21, 2014 to March 21, 2016. The newborns were screened during the days 3 to 5 after birth. Finally, the incidence rate was calculated and statistical analysis conducted by Statistical Package for Social Sciences (SPSS) version 22 (SPSS Inc, Chicago, IL, USA). Results: Among study population, 36705 (51.2%) of cases were male and 34972 (49.8%) were female and 15 cases (12 in first year and 3 in second year) were ELISA positive (considered as suspected PKA) and referred for confirmatory HPLC test. Finally, three neonates were confirmed as PKA positive cases by HPLC test. Overall incidence rate of neonatal PKA in two studied years was 1:23866. Conclusion: We can conclude that the incidence rate of phenylketonuria in southern Iran is reduced to 1:16987 in 2015 and 1:37736 in 2016, which is probably due to improved knowledge of general population of Iran about controllable determinants of PKU.Keywords: Phenylketonuria, Newborn, Incidence, Iran.
Synthesis and Characterization of Some New D-mannose Derivatives Containing 1, 2, 3-Triazole Moiety and Screening Their Action as Urease Inhibitors Zeyad Kadhim Oleiwi
Journal of Global Pharma Technology .
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Abstract

Williamson etherification of (1) with propargyl bromide afforded the 1-O-propargyl-2, 3:5, 6-Di-O-isopropyli-dene α-D-mannofuranoside (2) in a very good yield. 1, 3-Dipolar cycloaddition of (2) with four different aryl azides derivatives using click conditions gave four new 1, 2, 3-triazole derivatives containing sugar moiety. The biological activity of synthesized compounds were tested against urease activity by immobilize this enzyme on the synthesized compounds. All of these compounds show inhibition activity of enzyme. Some of these compounds (T1) show high inhibition action on the enzyme activity, while (T2, T3, T4) show moderate effect on the activity.Keywords: Mannose, Derivatives, 1, 2, 3-triazole, Urease, Inhibitors.
Assessment of Drug Utilization Pattern in Chronic Kidney Disease Patients in A Tertiary Care Hospital Based on Who Core Drug Use Indicators Sharad Chand; C. S Shastry
Journal of Global Pharma Technology Volume 11 Issue 09 (2019) September 2019
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Abstract

Introduction: Chronic kidney disease (CKD) is defined as any decrease in the glomerular filtration rate (GFR) with an abnormality in the kidney structure or its function. CKD patients are presented with multiple co-morbidities and compromised pharmacokinetics resulting in compromised quality of life and considerable economic burden. Aim: To study the drug utilization pattern in Chronic Kidney Disease (CKD) patients by using the World Health Organization (WHO) core drug use indicators. Materials and Method: A prospective observational drug utilization study was carried out in out-patients of Department of Nephrology of Justice K S Hegde Charitable Hospital, Mangaluru, for period of 8 months. CKD patients with an age of 18 years and above were included with consent. Data was collected using data collection forms, patients case notes, prescriptions sheet and personal interviews. Result: A total of 256 patients were recruited. Of which, 192 (75%) patients were males and 64(25%) were females with a mean age of 54.5 years. Average consultation time was 6.5 minutes. A total of 1374 drugs were prescribed to these patients with an average of 5.3 drugs per prescription. The most common prescribed class of drugs were for the cardiovascular system (42.6%) followed by the hematopoietic system (16.7%). Further, 65% of the drugs were prescribed from the National list of essential medicines (NLEM) whereas 8.7% of drugs were prescribed by generic name. Conclusion:  Utilizing the WHO’s core drug use indicators in this special patient population will strengthen the current hospital drug use policies and improve the drug usage pattern, saving the precious life years and monetary resources.
Electronic Cigarettes Use Characteristics Among Smokers in Indonesia Susi Ari Kristina
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Vape also known as an electronic cigarette that included a set of battery-operated equipment that smoker used to breathe an aerosol, typically conceiving nicotine, flavorings, and other chemicals, and becoming one of the types of a developed cigarette. This study aims to explore the risks and benefits of using electronic cigarettes and investigate factors affecting smokers' use of electronic cigarettes. Methods: This research was a cross-sectional model for Yogyakarta adults using a validated self-administered questionnaire. The questionnaire is divided into three parts: sociodemographic characteristics, smoking, perception of risk-benefit. Data were descriptively and inferentially analyzed using the Chi-square test to investigate factors affecting risk and benefit perception of smokers using electronic cigarettes. Results: Results showed that 133 (66.5 percent) were vape users, and 67 (33.5 percent) were tobacco smokers. Most tobacco smokers and vape users in Yogyakarta province have a high perception of electronic cigarette risk-benefit. Respondent characteristics (age, last education, smoking status) significantly influenced the benefit perception of electronic cigarettes, and smoking status on respondent characteristics also significantly influenced the risk perception among smokers of electronic cigarettes (p
The Effect of Sensory Kinetic Exercises in the Development of Some of the Functional Abilities and the Accuracy and Strength of Serving Skill in Tennis Hameed Hammad Khalaf
Journal of Global Pharma Technology .
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Abstract

The problem lies in the apparent decrease in the accuracy and strength of the serving performance of theAnbar University team in tennis and the lack of focus on the mental abilities and linking them to thephysical and skillful aspects, which necessitated the researchers to go into this problem through thedevelopment of sensory - kinetic exercises to address this decline. The research aims at identifying theeffect of sensory-kinetic exercises in the development of the functional abilities, and the accuracy andstrength of serving in tennis. The researchers hypothesized that the impact of exercises has a statisticalsignificance on the functional abilities and the accuracy and strength of the skill of serving in tennis.They used the experimental approach to design the two equal groups and on a sample of (12) players.The field procedures of the research were by conducting the pretests on Wednesday, 4/10/2017 at 11amon the outdoor tennis court and the closed hall at the college. The sensory-kinetic exercises were carriedout over 6 weeks at three units per week. On Sunday, 12/11/2017 at 11 am the post-tests were conductedin the same court and conditions similar to the conducting of the pretests. The researchers concludedthat the controlling and experimental groups developed but the experimental group that used sensorykineticexercises was more advanced in the post-tests. They recommend the emphasis on using thesensory-kinetic exercises to develop the skill of serving, other tennis skills, and other individual andteam sports.Keywords: Sensory, Kinetic exercises, Functional abilities, Accuracy and Serving skill.
Studying Relationship between (Outer-Inner) Control Source and (Role–Personality) Conflict by Second Level High School Headmasters of Township Khorramabad Fazallah Mirderikvand
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

The aim of this study was to investigate the relationship between control source and role-personality conflict by the second level high school headmasters of township Khorramabad. The Statistical population consisted of all the second level high school headmasters of township Khorramabad in the academic year 2014-15; among them 65 headmasters (35 men and 30 women) were selected as sample. In this research the Rotter's control scale (1966) role-personality conflict questionnaire of Rizzo, House and Lirtzman (1970) were used. The results of the data analysis showed there is a significant and positive relationship between outer control source and role-personality conflict by the second level high school headmasters of township Khorram Abad (0/01). This relationship was also confirmed for male and female headmasters separately (0/01). There was not resulted any significant difference between the average scores of headmasters' control source by male headmasters and the average scores of control source by female headmasters. Also there was not observed any significant difference between the average scores of headmasters' role-personality conflict by male headmasters and the average scores of role-personality conflict by female headmasters.Keywords: Managers, Control source, Role-personality Conflict.

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