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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Genetic Study for the Role and Predictive Consequence of Certain Cytokines in Hepatitis B Iraqi Patients Ali Hussein Al-Marzoqi
Journal of Global Pharma Technology .
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Abstract

Hepatitis B virus (HBV) infection is a serious and common infectious disease of the liver, HBV infection is endemic, particularly in developing countries, and is a serious public health problem. Cytokines and regulatory molecules play a fundamental role in the immuno pathogenesis of HBV infection. The gene loci for cytokines are defined, and polymorphisms of these genes are suggested to influence the outcome of HBV infection. In our study we revealed that there are elevated in Aspartate transaminase (AST), Alanine transaminase (ALT) and Bilirubin (Bil) among HBV patient than control group. IL–4 rs2070874 SNP Genotypes among patients with HBV was ONLY 68 positive to PCR results while in contrast it is only 9 within control group. The highest ratio of genotype in both groups was in CC as 36 (52.9%) in patients and 5 (55.6%) in control. Allele frequency on other hands describe as follow;  in HBV and control group for C 72 (63.7%), 11 (61.1%) while for T 41 (26.3%) and 7 (38.9%) respectively. Genotypes of IL–10 rs1800872SNP among patients was in AA as 43 (62.3%) in patients and 13 (76.5%) in control. On other hands Allele frequency describe as follow; in HBV and control group for A 106 (76.8%), 29 (85.3%) while for G 32 (23.2%) and 5 (14.7%). IFN-γ (rs2069705 SNP) Genotypes among patients with HBV was in AG as 39 (28.8%) in patients and 10 (47.6%) in control with GG. Allele frequency. Moreover, describe as follow; in HBV and control group for A 61 (33.3%), 28 (66.7%) while for G 122 (66.7%) and 28 (66.7%)Keywords: Hepatitis, Cytokines, PCR, IFN, SNPs, IL-10, IL-2.
Diagnostic of Plasma Spectral and Development Ti6Al4V Alloy with Deposition Titanium Layer by R-F Sputtering Mustafa Abdulkareem
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Ti6Al4V became the most favourable Titanium alloy due to its attractive mechanical and physicochemical properties and is currently extensively used e.g. in biomedical industry this work studies surface modification of Ti6Al4V to use in the implant bone. RF- sputtering is used for coating Titanium on the material Ti6Al4V alloy. The aim of this work is the power parameter (different power), used the ration power (50 watt, 100 watt, 150 watt and 200watt) the experimental Diagnostic of the coated layers by spectroscopy, FESEM and the average particle size (8.3-13.11) .The result show different colour layers, the TiN layer was shown the relationship between the electron temperature with the different power and electron density of TiN layer on Ti6 Al4V alloy with the different power (50,100,150and 200) Watt And during see the same figure the average particle size is equal for all picture between (8.3- 13.11) in the range of 100nm. The cumulative mass loss of the deposited coating specimen was about 3.71649mg for optimization samples TiN layer. The average hardness of the coating is about (264 to 331), which is higher than that of the substrate. The increases of average hardness depend on the different power.Keywords: Sputtering, Titanium, Homogenies, Implant, FESEM, Distribution, Surface modification and power.
Anticancer Activity of Oecophylla smaradina against Dalton’s Lymphoma Ascites Induced Tumor Balamurugan K
Journal of Global Pharma Technology Volume 10 Issue 12 (2018) December 2018
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Abstract

Objective to evaluate Oecophylla smaragdina (OS) for antitumor activity against Dalton's Lymphoma Ascites (DLA) cells in Swiss mice. Materials and Methods Oecophylla smaragdina (OS)was successively extracted with ethanol for three times  and the treatment was started after 24 hours of the tumor inoculation continued once daily for 14 days and the antitumor efficacy of ant extract of Oecophylla smaragdina was compared with that of 5-Fluorouracil(10 mg/kg, i.p) and DLA control. After 14 days the mice was sacrificed and dissected for observation of antitumor activity. Results Oecophylla smaragdina extract treated group showed decrease in packed cell volume, viable cell count. The all the parameters were showed in normal levels. Conclusion the findings and indicate the ant extract to promote and preventing the tumor cells and also it is evident that these extract have natural anticancer effect.Keywords: Oecophylla smaragdina, Antitumor, Dalton’s lymphoma ascites.
Acupuncture Prevent Progression of Cachexia in Breast Cancer in Outpatients of Dr. Saiful Anwar General Hospital Malang East Java Indonesia Laily yuliatun
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: This study was aimed to assess effect of acupuncture in progression of cachexia in breast cancer patient. Indicator progression of cachexia in this study is level of BMI, FM and FFM was measured before and after eight session of acupuncture procedure.Methods:  Seven patients were diagnosed breast cancer provide eight acupuncture session before chemotherapy and radiotherapy procedure. Acupuncture procedure was done every 2 days, with duration 30 minutes for every session. Bioelectrical impedance analysis (BIA) measurements were taken at before and after eight acupuncture session to evaluate the body composition of patients. BIA is fast, inexpensive and noninvasive method for evaluating Body Mass Index (BMI), Fat Mass (FM) and Fat-Free Mass (FFM).Results and Conclusion: All patients were include in the analysis were complete the acupuncture intervention and BIA measurements. Average age was 54 years, with rang 47-58 years. Most of patients in advanced cancer, 28.5% stage 3 and 43% in stage 4. In this study acupuncture could prevent progression of breast cancer cachexia, with maintain body composition during procedure. BMI was relative constant after eight session of acupuncture (20.25±3.1; p>0.00). Similarly, from BIA measurement, FFM decrease only 0.4% (p>0.05) and FM increase 0.4% (p>0.05). The constant value of body composition mean acupuncture could maintain the metabolism rate in cachexia patients. This study indicate acupuncture could prevent progression of cachexia in breast cancer. Keywords: Acupuncture, Cachexia, Breast Cancer, Body composition.
Effect of Cross-flow Velocity and Temperature in Microfiltration of Wax Apple (Syzygium samarangense) Juice Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Wax apple (Syzygium samarangense) fruit has a good source phenolics, flavonoids and antioxidant constituents with great potential benefits for human health. Its pulp is crisp and watery, slightly acid flavor to a full and fruity apple flavour. Microfiltration is an emerging technology, a good alternative for the fruit juice processing with a significant interaction to sensory and nutritional attributes. Purpose of our research verified the feasibility of different variables of cross-flow velocity (3.2, 4.0, 4.8, 5.6, 6.4 m/s) and temperature (22, 26, 30, 34, 38oC) in microfiltration using hollow fibre membrane to permeate flux (L/m2h), total phenolic (mg GAE/g) and flavonoid (mg GE/g) in wax apple juice. Our results revealed that the microfiltration should be performed at cross-flow velocity 4.8 m/s at temperature 34oC to get the highest permeate flux, total phenolic and flavonoid.Keywords: Wax apple juice, Microfiltration, Cross-flow velocity, Temperature, Permeate flux, Total phenolic, Flavonoid.
Isolation and Identification of Some Pathogenic Bacteria from Otitis Media in Babylon Governorate Hawraa Jawad Kadhim
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

This study was conducted for the period from February to November 2016 in Babylon Teaching Hospital , during this period, 200 swab ear of people with otitis media in the city of Babylon were collected . 120 sample was diagnosed with bacterial isolates depending on morphology on the different culture media and some biochemical tests. The highest rate of infection in the age group (21-40)years , and the least in the age group (41-60)years as it was(46 %,15%)respectively. In this study were isolate five types of a bacteria (Pseudomonas aeruginosa,  Staphylococcus aureus , Escherichia coli, Streptococcus pneumonia and Klebsiella pneumonia) and the highest rate of infection has reached (35 %, Pseudomonas aeruginosa), ( 26%,Staphylococcus aureus). As for the results of examination of the sensitivity of the bacterial isolates to antibiotics was the highest rate of antibiotic resistance was (94%Tetracyclin, 92%Ampicilin and 91% Chloramphenicol), while the resistance decreased in the case of antibiotics (42%Amikacin, 42%Gentamicin and 31%Tobramycin). Streptococcus pneumonia were detected by PCR , 16 cases were PCR positive for Streptococcus pneumonia , there was no samples displayed culture positive and PCR negative for Streptococcus pneumonia .Keywords: Pathogenic bacteria, Otitis media, Sensitivity test, PCR.
The Effect of Special Exercises using Marcie Wedge Device Associated with the Laser Therapy in Rehabilitation of Elbow Joint Injured for Women Tahseen Abdulkarim Amin
Journal of Global Pharma Technology .
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Abstract

The importance of the research of reducing the duration of therapy and the importance of modern equipment used in the research, either in the therapy or in the exercises, the researcher used laser therapy, the latest method in the world, which provides therapy injury and infected return to practice daily work at a record speed, Marcy Wedge in the performance of strength exercises, flexibility and slow pace. The researcher also used the 200-EK3 electronic device to measure the muscle strength in Newton units. The problem of the research lies in the length of the therapy programs used in the rehabilitation centers, which are not in the interest of the infected, so the researcher considered reducing the duration of therapy through the use of modern and sophisticated equipment, And effort. The aim of the study was to prepare strength and flexibility exercises using the Marcy Wedge and Laser Therapy sessions in the rehabilitation of the injured elbow in women. Also, the impact of strength exercises and flexibility associated with laser therapy sessions in the rehabilitation of the injured elbow in women. The researchers also used the 200-EK3 electronic device to measure muscle strength in Newton units. The problem of the research lies in the length of the therapy programs used in the rehabilitation centers, which are not in the interest of the infected, so researchers considered reducing the duration of therapy through the use of modern and sophisticated devices, and effort. The aim of the study was to prepare strength and flexibility exercises using the Marcy Wedge and Laser therapy sessions in the rehabilitation of the injured elbow in women. Also, the impact of strength exercises and flexibility associated with laser therapy sessions in the rehabilitation of the injured elbow in women. The researchers used the experimental approach in the design of a single group and in the method of pretests and post measurement. The study was conducted on a sample of (20 patients) who were deliberately chosen from among the women who had a tennis injury. Their age ranged from 25-30 years. The sample was then subjected to laser therapy sessions and exercises to increase the strength and flexibility of the affected joint. The researchers concluded that the therapeutic laser had a positive effect on pain relief and the speed of wound healing. The strength and flexibility exercises using the Marcy wedge system increased the strength and flexibility of the injured joint. The researchers recommended the need to adopt laser in the therapy of various injuries for it to achieve good results and fast time.Keywords: Strength and flexibility exercises, Marcy Wedge and Laser.
Abrasion-Resistant Elastic Coatings Technology for Dental Implants Anatolij Utyuzh
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Development of coatings with the properties of resistance to mechanical loads of various kinds as abrasion, pressure remains an urgent issue in modern dentistry. A framework with a stable coating is less exposed to an aggressive biological environment - saliva, as well as the activity of microorganisms. To achieve the optimal result, it is necessary to search for the optimum in a combination of three factors: the actual structural properties of the implant, the properties of the coating of the implant, as well as the manufacturing technology of the coating and the implant itself. The work was performed on a clinical basis of Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University). Medical steel, grade BioDur 108 (Carpenter Technology Corp.) was used as the basis (or substrate) for production of dental implants for testing. Supporting coatings based on titanium oxide (TiO2) or based on titanium nitrides/oxynitrides (TiOxN1-x) were placed on the substrate. Roughness coefficient (Ra) was in the range of 0.30-0.55 μm. We have not recorded statistically significant differences between the Ra value and type of product (substrate). That is, dental implants with and without coating did not have a difference in the Ra coefficient.The same results were obtained for the hydrophilic properties of the surface of dental implants - regardless of the presence or absence of coating, hydrophilicity indices were observed within 84-87%. The surfaces of dental implants do not have a significant effect on any physiological indicators of platelet activity. Without contact with the substrate, the parameters of blood plasma were proved to remain unchanged for an hour at 37°C. On the contrary, in contact with the steel part of the dental implant, without coating, there was a significant increase in platelet activity. As our experiments showed, the presence on the dental implants of a coating consisting of titanium oxide, or with the inclusion of Ti-O-N, reduces the likelihood of a blood clot. The reason for this is reduced adhesion of blood cells to titanium oxide surfaces.Keywords: Magnetron sputtering apparatus, Titanium oxide, Spearman correlations.
Fabrication of palatable medicated chocolate of salbutamol and ambroxol for pediatric delivery Gayathri Rajaram
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Chocolate as a dosage form is the most adaptable and versatile form that attracts children of all age groups. The present research work is to design and fabricate a palatable medicated chocolate to deliver salbutamol and ambroxol for pediatric care or prescription. Preformulation studies such as DSC, FTIR, melting point and solubility were carried out to detect any incompatibility and purity of the drugs. Medicated chocolate was formulated by incorporating the drugs into the chocolate base, with desirable viscosity. Three formulations were prepared and evaluated for physical appearance, drug excipient compatibility, weight variation, thickness, drug content, in-vitro drug release, bloom strength, stability and release kinetics. The parameters were within official specifications for formulation F3. The in-vitro drug release for optimal formulations is 86.7% and 89.4% for salbutamol and ambroxol, respectively and followed zero-order kinetics and fickian transport from the dosage form. No significant changes in the physical and chemical properties were observed during stability studies, which indicate that the formulated medicated chocolate was stable and could ensure a good therapeutic effect with patient compliance. The fabricated chocolate was elegant, smooth and creamy in texture and was excellent for taste masking unpleasant flavors associated with the drugs and excipients. The formulated chocolate may improve patient compliance as it can be used easily by pediatric patients with high preference. Keywords: Ambroxol, Chocolate delivery, Mucolytic, Bronchodilator, Salbutamol, Pediatric
Efficacy of Anger Management Skills on Reducing Aggression and Improving Adjustment in Addicts Treating with Methadone in Sari-Iran Shahnam Abolghasemi
Journal of Global Pharma Technology .
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Abstract

Background: Aggression and lack of adjustment are important issues in incidence and recurrence of addiction. This study aimed to evaluate the effectiveness of anger management skills training on modifying these variables among addicts treating with methadone. Methods: In the present experimental study all patients referred to four private addiction treatment centers supported by Sari University of Medical Sciences in north of Iran in 2015, to receive methadone treatment, completed Bell Adjustment Questionnaire and Buss-Perry Aggression Questionnaire. Sixty-four men scored high on aggression questionnaire and low on the Bell were identified.  Among them forty were selected randomly and were replaced in two groups (twenty in case groups and twenty in control group). Nine sessions anger management skills training was performed in case group and both groups completed questionnaire again. Data were analyzed using covariance in SPSS-20.Findings: Training anger management skills reduced aggression and increased personal and social adjustment among addicts treating with methadone, significantly (p<0.001).Conclusion: Given the benefits of anger management skills as a non-pharmacological and effective approach, using this strategy as a part of a comprehensive treatment for addicts recommended.Keywords: Anger management therapy, Aggression, Personal-social adjustment, Methadone, Drug users.

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