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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Physical Effort due to Increased Intensity in Biochemical Variables in Blood and Some Basic Skills of Volleyball Players Arif Abdul Jabbar Hussain
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

AbstractThe object of research is to know effects of physical exercise on treadmill focused on enzymes, creatine, Phosphokinase, Cholesterol, Hemoglobin (H b), dehydrogenase (HDL) in blood and effect on performance of basic skills of volley ball.  Researcher presumed existence of significant differences between before and after examinations focused on Hemoglobin (H b), Cholesterol, and Enzymes like creatine, phosphokinase (CPK), lactate dehydrogenase (HDL) in performance of some basic skills of volley ball.  The tests proved differences. Total 18 persons physically suitable for the research were made to undergo in this trial.  The main experiment was applied which included biochemical values before the skill test and later physical exercise by running on treadmill for 12 minutes with change in its angle of elevation, then biochemical values recorded post skill test.  The result of research revealed positive effects for change in biochemical values related to this experiment and its enzymes like creatine, phosphokinase (HDL) (CPK) and at the performance of skill in volleyball like hitting ball within trial revealed said biochemical effect negative. It is also recommended in the research that biochemical tests bring traces of variation in blood within level related to each player at different level of their function.Keywords: Physical effort, Intensity, Biochemical, Blood and volleyball.
Young Papaya Seeds Ethanol Extract (Carica Papaya Seed) Inhibit Testosterone Hormone and Leydig Cells of Male Mice (Mus Musculus) Bagus Komang Satriyasa
Journal of Global Pharma Technology .
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Currently, the effort to invent ideal natural male contraceptives still faces many obstacles, especially due to the fact that ideal contraceptives should meet certain requirements such as: be able to cause total azoospermia; easily used; cause no untoward or toxic effects; not disturbing libido or sexual behavior; and be reversible. As male contraceptives are very limited in types, efforts to develop ideal male contraceptive drugs is crucial; particularly the effort to find alternative effective substances derived from natural resources. The purpose of this study is to investigate whether of young papaya seeds extract has a to inhibit the testosterone. The study used 30 male mice strain Balb-C which were allocated by simple random sampling into two groups: Control Group (P0) consisted of 17 male mice and Treatment Group 1 (P1) consisted of 17 male mice. After 36 days of treatment, control group and treatment group were taken for their blood. The blood was taken for testosterone hormone test using Radioimmunoassay (RIA) technique and the scrotum was taken for obtaining the Leydig cells. The result of t-test analysis showed that the level of testosterone in control group was 104,27 ± 25,79 ng/dl and Leydig cells 129,41±30,92, in treatment group 91,76 ± 30,45 ng/dl and Leydig cells 122,94±20,85.  The difference between control group and treatment group was the decrease of testosterone and Leydig cells. Young papaya seeds extract reduces testosterone and Leydig cells insignificantly.Keywords: Papaya seeds extract, Testosterone hormone, Leydig cel, Male Mice balb/C
The Activity Test of Ethanol Extract in Hibiscus Leaves (Hibiscus Tiliaceus L.) as the α-Glucosidase Enzyme Inhibitor by Using ELISA (Enzyme Linked Immunosorbent Assay) Reader Sukmawati .
Journal of Global Pharma Technology Volume 11 Issue 01.
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Hibiscus leaves (Hibiscus tiliaceus L.) was a plant from the family of Malvaceae, which contained triterpenoid, saponins, flavonoids, and polyphenols compounds that functioned as antidiabetic mellitus. The purpose of this study was to determine the activity of α-glucosidase enzyme inhibitor from the ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.). The test was carried out through in vitro by using α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida (PNPG) substrate, and measured by ELISA reader. The simplicia was macerated with alcohol 96%. The reaction of α-glucosidase enzyme and p-nitrofenil-α-D-glukopiranosida substrate produced yellow p-nitrofenol. The reaction product was measured at a wavelength of 405 nm. The results showed that ethanol extract of hibiscus leaves (Hibiscus tiliaceus L.) had activity as an inhibitor of α-glucosidase enzyme with Inhibitor Consentration IC50 37.98 µg / mL and could be categorized as active.Keywords: Hibiscus tiliaceus L., Hibiscus leaves, Α-glucosidase enzyme inhibitor.
Asthma Exercise Enhanced IL-10 Secretion but Had No Effect on IFN-ɣ in Patients with Persistent Atopic Asthma Rahmaya Nova Handayani
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Asthma is a chronic respiratory disease which is considered as a frequent non-communicable disease that could affect the quality of life. It is widely known that Th1 and Th2 imbalance is one of the underlying pathogenesis of asthma and many approaches had been devised to interfere this process. One of the well-known non-pharmacological approaches in asthma is asthma exercise. Therefore, this study aimed to investigate the role of asthma exercises on the balance of Th1 (IFN gamma) and T-regulator (IL-10). Methods: A pre-post-test group quantitative study was conducted using 39 subjects with persistent atopic asthma. All subjects participated on asthma exercise program that was conducted twice a day, 60 min per session. Atopic status was determined by skin prick test while IFN-Ɣ and IL-10 was determined by ELISA. Results: Median level of IL-10 was increased from 1.6 pg/ml before intervention to 2.2 pg/ml after intervention (p=0.000). However, the exercise program failed to produce any effect on IFN-Ɣ level which only showed a slight median increase from 9.374 pg/ml before intervention to 10.238 pg/ml in the post-test analysis (p=0.07). Conclusion: Asthma exercises significantly increased IL-10 level, but not significantly affect serum IFN-Ɣ in patients with persistent atopic asthma.Keywords: Asthma exercise, IL-10, IFN-Ɣ, T-h1/T-h2 balance.
Mathematical Design of the Experiment in the Development of Technology of Beeswax obtaining from Propolis Oleg Shpychak
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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In present material the development of the technology of purified beeswax obtaining from propolis, which meets modern physical-chemical and therapeutic requirements, using a various models of mathematical design of the experiment has been shown.In this work a petroleum-ether fraction of propolis containing a beeswax products was used. While analyzing of the obtained fraction, lipids and some other high-molecular compounds of unqualified structure are extracted in parallel, as well as an insignificant number of the γ-pyrone derivatives.In this connection, the development of the condition of beeswax obtaining from this fraction, which is maximally purified from the related substances was reasonable. For this purpose a series of classical methods of fractionally differentiated extraction followed by fractions evaporation in a vacuum was used. In addition, methods of precipitation using a some organic solvents were used.The optimal conditions of the technology of purified beeswax obtaining from propolis have been determined by methods of mathematical design.Keywords: propolis, beeswax, technology, methods of fractionally differentiated extraction, precipitation, methods of mathematical design.
Human Pabilloma Virus (HPV) and Cervical Cancer in Al-Najaf Governorate Musa Nima Mezher
Journal of Global Pharma Technology Volume 9 Issue 10
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Background: Human Papilloma virus causes benign and malignant tumours of squamous cells, many different types of HPV well known to infect a different portion of the body, also many HPV strains cause carcinoma of cervix.Objective To find the role of the virus in the cervical tumour and the extend of the effect of some tumour markers in the virus and its absence.Methods Seventy three  cases of cervical  cancer were obtained from Histopathological archival of central laboratory of AL-Sadder Hospital  and out laboratory in Najaf AL-Ashraf Governorate. Clinical data were analysed from  the medical records and formalin fixed, paraffin embedded tumour tissue were examined by Immunohistochemistry technique to the detection of  the L1 protein of HPV in cervix tissue blocks. Results The expression of HPV in tissues ,women patients with cervical cancer in the present study was 69.86% (51out of 73), where strong correlation was found between expression of HPV and women patients with cervical cancer. Also found relationship between women state, residency and differential ratio between five years ago (2012-2016) in AL Najaf City. ConclusionBased on the results of the current study, Human Papilloma virus  infection plays a major role in the pathogenesis of cervical cancer.Keywords: Cervical cancer, Human Papilloma virus, Human Papilloma virus  L1 protein, Immunohistochemistry technique.
Automated Pattern Classification for PCG Signal as a Novel Method for Clinical Decision Support System Ali Hussein F. Al-Nasraui
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Auscultation pattern recognition also known as PCG Pattern classification was one of the efficient computer-based methods applied to medical decision making. PCG Pattern recognition generally is interpreted in two ways.  This work reports robust results with phonocardiogram PCG-signal pattern classification. Linear prediction analysis with basic agglomerative clustering techniques was applied to extract the spectral pattern from phonocardiogram signals, a relatively new technique. In this test, 35 PCG samples are classified correctly, except for seven samples; and 24 PCG samples correctly, except for three samples.  The efficiency of PCG spectral features classification has been confirmed experimentally to be integrated in automated auscultation computer aided diagnosis (Au CAD) systems. The more specific interpretation algorithms are limited to finding patterns in PCG signals or other related bio-signal activities. This work covers the new technique applied in basis of pattern classification for mitral regurgitation PCG signals to investigate different hemodynamics turbulences and stochastic blood flow patterns associated with cardiac circulation.Keywords: Phonocardiography, Clinical Decision making, Pattern classification, Cardiovascular arrhythmia, Auscultation.
Comorbidity of the Metabolic Syndrome: Hyperuricemia, Gallstone Disease, Hormonal Disorders Raisa A. Aringazina
Journal of Global Pharma Technology Volume 11 Issue 04 (2019) April 2019
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This article presents relationships between metabolic syndrome and gallstone disease, hyperuricemia, hormonal disorders and point out the most relevant picture for today. In the review the general pathogenetic mechanism of endothelial dysfunction formation in metabolic syndrome and hyperuricemia is revealed and described. Shown, that hyperuricemia is a marker of the metabolic syndrome. The symptoms of metabolic syndrome increase with increasing levels of hyperuricemia. The review found that it is obesity and insulin resistance are common leading risk factors for progression metabolic syndrome and gallstone disease. No association between gallstone disease and dyslipidemia unlike metabolic syndrome. Obesity is a common factor in the relationship between metabolic syndrome, gallstone disease and hormonal disorders. Insulin resistance is a common factor metabolic syndrome and polycystic ovary syndrome, the leading factor in the course of metabolic syndrome in menopause, hypopituitarism, and gallstone disease. Also, insulin resistance is a common factor in the comorbidity of gallstone disease and postmenopausal conditions. Obesity and insulin resistance are common factors of metabolic syndrome and benign prostate hyperplasia. Keywords: Metabolic syndrome, Uric acid, Gallstone disease, Hyperuricemia, Hormonal disorders.
Doppler Study and Cell Free DNA Biomarkers by using PCR in Hypertensive and Diabetic Pregnant Iraqi Wom Dhelal Qasim
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Doppler ultrasonography has been used to assess both the fetal and placental circulation, to facilitate the diagnosis and monitoring of important conditions. Circulating cell-free (cf-DNA) in plasma is considered a novel biomarker with promising clinical applications. This biomarker was reported in prenatal diagnosis and in adverse pregnancy outcomes. Hypertensive disorders of pregnancy and both type 1 diabetes and type 2 diabetes in pregnancy represent a significant cause of maternal and perinatal morbidity and mortality. The aim of the study is to relate the Doppler study of the umbilical cord and uterine artery to the presence of different primers in hypertensive and diabetic pregnant women. Ninety women had been enrolled in this study. Thirty (33%) of them with diabetes mellitus and the other 60 (67%) women were with hypertension. The mean age of study sample was (29.7 ±6.33 years (. Careful history was taken from all women. Uterine blood flow for women below 28 weak gestational age, and umbilical artery blood flow for 28 weak pregnancies and more was done by Doppler Ultrasound. Blood samples were taken from all women and cf-DNA was measured using PCR technique. There is significant association (P ≤ 0.05) between Autism primers 3 with the Doppler study in hypertensive pregnant women. Also there is significant association between Sirti primers 3, 4 with the Doppler study in diabetic pregnant women, and there is significant association between Trisomy primers 3 with the Doppler study in hypertensive pregnant women. There is no difference between the negative and positive results in relation to Doppler study regarding hypertensive and diabetic pregnant women except for the above primers.  Keywords: Doppler study, Cf-DNA biomarkers, PCR, Hypertension, Diabetes.
Personalized Medicine: Can Indian Patients Afford it? Sreedhar D
Journal of Global Pharma Technology Volume 10 Issue 04: (2018) April 2018
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Abstract

Keywords: Personalized Medicines, Pharmacogenomics, Healthcare, Ayurveda, Pharmacoeconomics.

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