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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
Effect of Some Types of Doping Used by Athletes on Liver and Kidneys Functional Performance in Albino Male Rats Saher Mahmood Jwad
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

The studies and researches at the present time interested with doping especially the anabolic androgenic steroids (AAS) due to their commonly used by the athletes  and non-athletes , as well as study the effect of these doping on body organs and its tissues such as liver and kidneys, effectiveness of hepatic enzymes, the variations in the performance of liver and kidney functions, in addition to the hepatic pathological changes like cirrhosis, congestion, necrosis, increased collagen content in the liver parenchyma and disturbance in the glomerular filtration process of kidney. Therefore, this study aimed to use Nandrolone decanoate doping (ND) that has been possessed anabolic androgenic ability and diagnosis its influences on the tissues of some organs especially liver and kidneys. The current study was performed in the animal house return to the Biology department / Faculty of Education for Girls / Kufa University, in this study (30) male rats of Sprague-Dawley strain were used and divided into two main groups, the first group was the control group comprised (15) rats were also divided into three equal subgroups, a group was injected with normal saline solution (0.9%) once a week for one month, a group was also included (5) rats injected with (0.9%) normal saline solution one time weekly for two months and the last group was  also injected with normal saline (0.9%) once weekly for three months, while the second group was contained (15) rats and divided into three equal subgroups, a group was injected with Nandrolone decanoate doping (ND) at the concentration of (1 mg/kg) once weekly for one month, a group was injected with (1 mg/kg) of (ND) doping also one time at week for two months, concerning to the last group was injected with (ND) doping at the concentration of (1 mg/kg) once a week for the period of three months, the injection process of all treatments was intramuscular (in the hind limb muscle) for each rat.  The study was contained, body weight recording as well as the relative weights of liver and kidneys, estimation of some biochemical parameters of the blood as: Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphatase (ALP), the levels of total bilirubin, total protein, albumin, total cholesterol, triglycerides, creatinine and urea, whereas the histological study included, preparation of tissue sections for the liver and kidneys. The statistical analysis of study were revealed : a significant increase (p<0.05) in the body weight, relative weights of liver and kidneys, effectiveness of hepatic enzymes (AST, ALT, ALP), levels of total bilirubin, total protein, albumin, total cholesterol, triglycerides, creatinine an urea at the groups were treated with Nandrolone decanoate doping compared to the control groups . With regard to the microscopic examination of liver and kidneys sections for male rats that injected with Nandrolone decanoate doping were exhibited various patho-histological changes when compared with the control groups. The conclusion: the present study was conducted to, the treatment with Nandrolone decanoate doping for the periods (one, two and three months) caused observable deterioration in the functional performance of both hepatic and renal tissues.Keywords: Nandrolone decanoate doping, Hepatic and renal tissues functional performance, Patho-histological effects, Physiological and biochemical properties of the blood.
Job Performance and its Correlation with Decision-Making to Teachers of Physical Education in Najaf Governorate Jameel Hamid Kadhim
Journal of Global Pharma Technology .
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Abstract

There is no doubt that the professional performance of the teachers of physical education is the basis of their work, which is linked to their scientific specialization, and to the ability of the teacher and the school to perform their official duties and responsibilities, the extent to which they succeed in fulfilling their educational and scientific message to our children, namely the creation of education Psychologically, mentally, physically and socially balanced, the functional performance of a teacher and the school of Physical Education is the cornerstone and basis of the process of education and instilling the values, principles and good qualities of studentsThe Objectives of ResearchPreparation of the functional performance measures to identify the level of physical education teachers in the governorate of Najaf.Preparation of a decision-making scale by teachers of physical education in the Governorate of Najaf.To identify the nature of the relationship between the performance and decision-making of the teachers of physical education in the Governorate of Najaf.The researcher used the descriptive approach in the survey method and in the relational relationships method to see the relationship between variables and predictive studies. The research community is a teacher of male and female physical education in secondary, middle, intermediate and vocational schools in the governorate of Najaf, where there are 363 teachers and schools distributed to (310) schools for the 2016-2017 school year.In the light of the findings of the researcher, he concluded that:Research capabilities (functional and decision-making scale) in the measurement of search variables.Teachers of physical education in Najaf Governorate enjoy a positive level of performance and decision-making.There is a positive correlation between the research variables, the functional performance and the decision-making factors of the teachers of physical education in the Governorate of Najaf.Keywords: Job performance, Decision-making and physical education.
The Effect of Educational Exercises and Added Weights in Some Kinematic Variations of the Performance Angle of the Shudder Effect on the Horizontal Bar of Youngsters Nada Ibrahim Abdulreda
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The objective of the research was to prepare educational exercises and weights to improve and develop some kinetic variables for the performance angles of the skill of the generator on the young Horizontal bar machine and also to identify the kinetic variables for the performance angles of the skill either hypothesized. The research and training program had a positive effect on some kinetic variables for performance angles of the skill of the catalyst, Statistical significance between the results of the tribes and Posttests of the research sample in some kinetic parameters of the performance angles of the skill of the generator on the brain of young people. The researcher used the experimental method in designing a single group as well as the use of video imaging and determined the research community in a deliberate manner. The pilot experiment was conducted. The experiment was carried out by a group of six players, aged 10-13 years. And then the tests of the Pre group of research and then were applied educational exercises and exercises with weights added two (14) week and the existence of three training units per week and the number of educational units and training (42) training unit and when the program was completed tests dimensionality and processing the results statistically. The fourth part included presentation, analysis and discussion of the results. The researchers concluded that the educational exercises and the added weights contribute to the improvement of some kinematic variety of the performance angles of the skill of the skeletal system in the brain of young people and recommended the use of educational exercises and exercises in weights added to other skills in the gymnastic and other devices. The trainers should take into account the values of the biochemistry variables that have been achieved when training the performance angles of the skill of the generator on the brain of young people.Keywords: Educational Exercises, Weights Kinematic Variations, Performance Angle, Shudder Effect and the Horizontal bar.
Single Nuclear Polymorphisms of VEGF, TGF-β1, MMP9 Genes in Type 2 Diabetic Foot Ulcer Patients in Indonesian Population: A Case Control Study Dedy Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: Vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-β1) and matrix metalloprotein-9 (MMP9) are known to have roles in the process of diabetic foot ulcer (DFU) formation. VEGF rs2010963C>G rs1271283232T>C, TGF-β1 rs1982073C>T rs1800469C>T, and MMP9 rs3918242C>T rs367601348A>G genes polymorphism may result in differences in the quantity and quality of the proteins which influence the risk of DFU formation. This study aims to assess the difference in frequency distribution of certain VEGF, TGF-β1, and MMP9 genes polymorphism between diabetic patients with and without DFU.Methods: A case-control study was conducted among patients with type-2 DM with DFU (case) and without DFU (control) in Cipto Mangunkusumo Hospital Jakarta, with DNA analysis using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The confounding factors are also analyzed.Results: A total of 197 patients was assessed, 96 with DFU and 101 control. The genotype analysis by logistic regression found significant association of CT genotype in TGF-β1 rs1982073C>T  (OR:0.28;95%CI:0.13-0.60;p=0.001 compared with CC); TT genotype in TGF-β1 rs1800469C>T, (OR:2.37;95%CI:1.11-0.60;p=0.001 compared with CC); TC genotype in MMP9 rs3918242C>T (OR:0.19;95%CI:0.19-0.64;p=0.001 compared with CC). There are no significant association in any mutation in VEGF rs2010963C>G, rs1271283232T>C, and MMP9 rs367601348A>G.Conclusion: VEGF rs2010963C>G rs1271283232T>C, and MMP9 rs367601348A>G polymorphisms did not have significant association with DFU formation. CT in TGF-β1 rs1982073C>T and TC in MMP9 rs3918242C>T found as protective factor for DFU, and TT in TGF-β1 rs1800469C>T as risk factor for DFU.Keywords: diabetic foot ulcer, genetic polymorphism, VEGF, MMP9, TGF-β1, rs2010963C>G, rs1271283232T>C, rs1982073C>T, rs1800469C>T, rs3918242C>T rs367601348A>G
Evalution of the Effect of Gigaspora Margarita and Glomus Desriticola Fungi in Stimulating the Resistance of the Capsicum Annuum L. plant towards Chromium and Lead Thamer A. A. Muhsen
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The present study was conducted to evaluate the effect of fungi Gigaspora margarita and Glomus desriticola in stimulating the resistance of the capsicum annuum L. towards the chromium and lead after 60 days, planting and using the pots in the glass house. The highest concentration of chromium and lead in the root was found in the presence of the mycorrhizal mixture (194.93, 150.40) μg / g, respectively, compared to the lowest concentration (90.69, 79.37) μg / g respectively, while the highest concentration of chromium and lead in the shoot was found in the presence of the mycorrhizal mixture (94.63, 79.33) μg / g respectively, compared with the lowest concentration in the control treatment (72.58, 60.70) μg / g respectively. The results showed the highest uptake efficiency and low translocation and phytoextraction efficiency of chromium and lead (179.73, 0.49 and 19.56) μg / g respectively for chromium and (144.63, 0.53 and 15.29) μg / g respectively for lead. The highest percentage of mycorrhizal mixture was recorded in the Intensity of the Mycorrhizal Colonization in the root System and root Fragments reached to (23.61, 26.50) % respectively, while the lowest percentage in mixing (chromium+lead) was (13.22, 13.47) % respectively. The highest percentage of mycorrhizal dependency was found in the mycorrhizal mixture with mixing (chromium+lead) which was 193.16% compared with the least of mycorrhizal dependency in Gigaspora margarita reached 98.34%. The lowest magnesium content in the control treatment was 28.36 mg / dry weight while the mycorrhizal mixture recorded the highest content of 33.41 mg / dry weight. The highest activity of guaiacol peroxidase and glutathione reductas in the treatment of the mycorrhizal mixture and mixing to heavy metals was (50.93, 10.11) absorption unit / gw fresh roots respectively compared with the lowest activity of the enzyme in the control was (31.48, 3.55) absorption unit / gw fresh roots respectively, all the tables showed significant differences.Key words: Pepper plant, AM fungi, Heavy metals, Magnesium, Antioxidants enzymes.
Lipoprotein-Associated Phospholipase A2 Activity increase the Sensitivity of Framingham Score for detecting the incidence of Acute Myocardial Infarction in sub-population of Indonesian Male Patients Andi Wahjono; Saifur Rohman; Miryanti Cahyaningtias; Rina Yudha; Yanna Indrayana; Mifetika lukitasari; Rusdianto Rusdianto; Aditya Kurniawan; Djanggan Sargowo; Sasmojo Widito; Dadang Hendrawan; Jayarani Fatimah Putri; widodo Ph.D
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cardiovascular disease. Framingham score is currently a widely used risk stratification tool for detecting the incidence of acute myocardial infarction (AMI), although it is not very sensitive. Adding Lp-PLA2 to the Framingham score can raise the odds ratio (OR) for AMI, but requires further research.Objectives: In this study, we examine the role of Lp-PLA2 in increasing the sensitivity of the Framingham score for detecting the incidence of AMI.Methods: This study was a case-control study of 97 male patients, 60 of whom had AMI and were treated in the intensive care unit as test subjects, and 37 of whom were non-AMI patients with normal treadmill test used as controls.Results:Lp-PLA2 activity was found to be higher in the AMI group than that in the control group (83.97 ± 27.15 nmol/ml/min vs. 55.04 ± 31.99 nmol/ml/min). Eighteen patients (30%) with AMI were included in the high-risk category according to the Framingham score; this number increased to 36 patients after the addition of Lp-PLA2 activity to the Framingham score. Analysis using a receiver operating characteristic (ROC) showed a cut-off value for Lp-PLA2 activity associated with AMI of approximately 74.21 nmol/ml/min with an accuracy of 67%. The OR for detecting AMI incidence increased after the addition of Lp-PLA2 activity from 1:01 (CI 95%, 0.414–2.48) to 4.67 (CI 95%, 1.88-11.61).Conclusions:   The addition of Lp-PLA2 activity may increase the sensitivity of the Framingham score for detecting the incidence of AMI.
Synthesis Five and Seven Heterocyclic Compounds: from Starting Materials Furoic -2-Carboxylic Acid (Pyromucic Acid) Amal Abd Al-Rada
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work involves synthesis of different five and seven member heterocyclic ring starting from furoic-2-carboxylic acid(pyromucic acid) This part involved  synthesis of ethyl-2- chlorobenzoate  via reaction of 2-chlorobenzoic acid with sulfuric acid in ethanol absolute and the product reacts  with hydrazine hydrate in ethanol to get 2-chlorobenzohydrazide then reaction of different acide (aromatic)Keywords: Oxadiazoles, POCl3, 2- chlorobenzaoic acid, Furoic acid, Biological.
The Synergistic Effect of Aspirin and Brassinolide Hormone in Some Enzymatic and Non-enzymatic Antioxidants of Caraway Plant (Carum carvi) Exposed to Water Stress Hayder Nasser Hussain Al-Mentafji
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The experiment was conducted to study was the effect of  water stress (5,10,15) days and interaction with spraying Aspirin (ASA) (0,5,10) mg.L-1 and brassinolide (BL) growth regulator (0,0.5,1) mg.L-1 on some biochemical and enzymatic and non-enzymatic antioxidants (Salicylic acid concentration, Carotene concentration, Phytosterols, Glutathione Peroxidase (GPX) Enzyme Activity, Glutathione (GSH) concentration) and the and the Free radicals scavenging activity  for Caraway plant  Carum carvi, the experiment performed  with factorial Randomized Block Complete Design (RBCD), with three replicates and 81 experimental units the area of one of them 2m2.The Results Showed:The effect of   severe water stress for 15 days was negative effect and decreased the means of studying characters.Increasing in  the GPX activity and GSH means under Water stress and spraying with (Aspirin, Brassinolide)The means of free radicals scavenging activity decreased with water stress.The effect of aspirin and brassinolide was positive to increase of study characters with the influence of concentrations under water stress.The role of aspirin and brassinolide were positive to decrease of passive effect of water stress also the triple interaction between the severe stress at 14 days and then spraying the aspirin and hormone was positive to decrease the effect of severe stress.Keywords: (Water stress, Aspirin, Brassinolide, Carum carvi).
The Efficacy of Vinegar against Contaminated Bacterial Isolates from the Hospital Environmental Ashwaq MS Al-Jbouri
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Objective Hospital environment can represent an important source of pathogens which high risk for patients. Acquired antimicrobial resistances is the major problem .Aims of this study to detection the common contaminant bacteria among the hospital environment and determine the antimicrobials activity of agents (Apple vinegar, Garlic vinegar, Dates vinegar, Raisin vinegar) against pathogenic bacteria isolated from hospital environment. Method In the study 172 samples were taken by swabs from three hospitals in Hilla city, from October 2016 to march 2017.Antimicrobial activity test of (apple, palm, garlic and black raisins) vinegar was determined by  MIC and Agar-well diffusion assay, alsoantibiofilm Formation and ant adherence activity of vinegar against microbes were determined. Result In this study, 172 samples were taken from three Hospitals in Hilla city the result showed that 73 (42.44%) samples were positive cultured and 99 (57.55%) negative cultured from total samples. Staphylococcus aureus37 (33%) was highly isolated from other microbes followed by Bacillus anthrax. Conclusion Staphylococcus aureus is more common in Hospitals in Babylon Provence, vinegar is the most effective substance that killing bacteria that contaminate hospital environment.Keyword: Hospital environment, Vinegar, Antimicrobial agents, Adhesion, Biofilm production.
Template Synthesis of Hybrid Schiff Base Complexes of Zn2+, Cd2+, and Hg2+ Ions Abdul-Razak H. Al-Sudani
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Five Schiff base complexes of d10 metals were prepared via Template synthesis procedure. This procedure included the synthesis and isolation of intermediate diamine complexes derived from N,N-Diethylethylenediamine; (Et2ne), and appropriate metal salt; MCl2; (M= Zn2+, Cd2+, and Hg2+), followed by the condensation of either of Ortho-phathaldehyde (OPA) or Benzaldehyde with different intermediate diamine complexes of aforementioned metal ions. Moreover, the condensation reaction of the intermediate diamine complexes of the formula [HgCl2 (Et2ne) 2] with OPA failed to produce either the corresponding Schiff base – Mercury- or Organo - Mercury Complex. The identification of the reported Schiff base Metal complexes were  based on Elemental Analyses, Atomic Absorption; FT-IR, Vis-UV; and Molar Conductance. In addition to those techniques, 1H NMR and Mass Spec. were recorded for a couple of the reported complexes.Keywords: Template synthesis, Hybride Schiff Base, Schiff base-d10 metal complexes, Reduction of mercury diamine complex, N,N-Diethylethylenediamine,  Benzaldehyde, o- Phathaldehyde.

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