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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Multi Objective Optimal Operation of Micro Grid Mahdi Mozaffari Legha
Journal of Global Pharma Technology Volume 08 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

In recent years, the utilization of renewable energy sources in supplying electricity energy has resulted in more reliable and efficient operation with better power quality and flexibility especially distribution network. However, from the operation and management points of view, the high utilization of the distributed generation can cause unexpected challenges which a part of them is addressed by microgrids (MGs) problem. In this paper, for analysis some of unexpected challenges such as uncertainty in wind and sun power, the optimal operation of grid-connected MG during a specific day and with considering a proper mathematical model for simplifying the optimization program, is investigated. The considered MG consisted of wind turbines, Photovoltaic (PV) systems, battery energy storage, diesel generator and local loads. The wind speed and sun irradiation data are obtained for a rural village which is located in 470.5'N and 350.59'E in Kurdistan province in Iran. By applying the demand response (DR) strategy to the optimal operation program, the results are compared with typical operation condition (non-DR) of the MG. In addition, the impacts of uncertainties such as wind speed and sun irradiations variations on the optimal operation of the MG are investigated. The optimal sizes of the MG components are obtained with HOMER software.Keywords: Component; Optimal operation; Micro grid; Renewable energy, Demand response; Uncertainty.
Removal of Malachite Green from Aqueous Solution by PMUC: Equilibrium and Thermodynamic Studies Muneer A. Al-Daamy
Journal of Global Pharma Technology .
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Abstract

Removal of Malachite green dye has been carried out by using (Porcelanite- Melamine –Urea) (PMUC) as an adsorbent. The characterization of (PMUC) was done by using FTIR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and Atomic force microscopy (AFM) . Different experimental data such as contact time, pH, adsorbent dosage and ionic strength were studied. The equilibrium experimental data were analyzed by Langmuir, Freundlich and Temkin isotherm models. Thermodynamic parameters such as change in free energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°) were also determined.Keywords: Adsorption, Porcelanite rocks, Malachite green, Isotherms, Langmuir, Freundlich, Temkin.
Pulmonary Arterial Hypertension and Risks of Progression Evgeniya Malashenko
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Pulmonary arterial hypertension is an increase in blood pressure above 140 and/or 90 mmHg, caused by irreversible changes in arterioles, either by an unknown reason (essential), or as a secondary condition.  691 people under the age of 7 to 14 years (343 males and 348 females) were examined. They divided into two groups: 1st-with high blood pressure; 2nd-control group with normal blood pressure. The study results show that 19.5% of the total number of patients had high blood pressure, where 46.7%-7-10 years old children and 53.3%-11-14 years old. Almost equal ratio of boys and girls was noted in both age subgroups. Thus, there were 24.4% of boys and 22.2% of girls among children with high blood pressure aged 7-10 years and 24.4% of boys 28.9% of girls aged 11-14 years. The gender differences were found in blood pressure, heart rate and pulmonary arterial hypertension, accordingly. The systolic blood pressure (SBP) and heart rate (HR) of 7–10 years girls were significantly lower than that of male peers (96.8 and 93.2%, respectively). The most of physical development indicators of males with hypertension significantly exceeded peers with normal blood pressure. The average body weight of males with PAR significantly exceeded the control groups of the corresponding age by 16 and 25.2%, respectively, in the studied age periods. The thoracic region of the younger subgroup boys with PAH was significantly greater than that of boys with normal blood pressure by 6.5%; in the middle age subgroup - by 11.3%. The hypertension in childhood and adolescence is associated with an increase in height, weight, BMI, BFM, MM, and LBM. Hypertension occurred much more often because of overweight and obesity than with normal body weight and protein-energy malnutrition.Keywords: Pulmonary arterial hypertension (PAH), Absolute muscle mass (MM), Body mass index (BMI), lean body mass (LBM), Body fat mass (BFM).
Development of Behavior Models of Pregnant Women towards High Risk Pregnancy Conditions Based on Social and Culture Capital Evi Pratami; Sukesi Sukesi; Ervi Husni
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: A person behavior in acting is influenced by social and cultural aspects. Someone has a wide stretch throughout the activities carried out namely: walking, working, thinking and another. Aim: To analyze the effect of social capital and culture capital on behavior, prove the model of social capital and culture capital on improving the behavior of high-risk pregnant women. Methods: The study was conducted in 2 stages: First, using a cross sectional design, the population of pregnant women in the Surabaya City Health Service area. Sample size was calculated by the ROT formula, a number of 314 respondents. The sampling technique used non probability sampling. The data were analyzed using PLS. Second stage, tests the model obtained. Results: Social capital affects behavior in the regularity of antenatal care, the accuracy of taking drugs or vitamins, diet, monitoring of fetal movements (T> 1.97), but in the pattern of activity (T
Electrochemical Determination of Tetracycline at SPCE modified with Nanocomposite Sundus H. Merza
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

An electrochemical sensor based on manganese dioxide nanorodMnO2and Graphene oxide (GO) functionalized with 4-amino, 3-substituted 1H, 1, 2, 4 Triazole 5(4H) thion  (FGO)/MnO2Nanocompositewas developed for voltammetric determination of Tetracycline (TET).The working electrode WE of SPCE was modified bya drop casting method. X-ray powder diffractometer (XRD), scanning electron microscopy (SEM) and FT-IR were employed to characterize the synthesized FGO/MnO2.  The determination of TET at the modified electrode was studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in the phosphate buffer solution (PBS).TET  show sharp increase in the oxidation peaks  in the pH 2.Voltammetric characteristics of TET (Epa, Ipa) were estimated. From effect of scan rate, the average surface coverage ( ) of TET on the surface of  SPCE modified with FGO/MnO2 nanocomposite, the electron transfer coefficient and electron transfer constant rate ket was obtained as  10.56×1014 molecule cm-2, 0.5, and 10.41 cm.s-1respectively.  Under the optimal conditions, the peak current shows  linear relationship with concentration of Tetracycline (TET) ranges 1–9 µM with the detection limit of 0.2  M. The modified SPCE was successfully used to detect TETKeywords: SPCE, Functionalize graphene oxide, Cyclic voltammetry.
The Effect of Fluctuations in Climate Parameters on Wheat Market Mahmoud Daneshvar Kakhki
Journal of Global Pharma Technology .
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Abstract

The great dependency of agricultural sector on climate conditions and high attribution of this sector to the economy of developing countries shows the importance of agricultural sector and its impressions from climate change phenomenon. One of the important questions that occur in mind is the effect of fluctuations in climate parameters on market of agriculture sector products. Since production in agriculture sector is important because of food provision of society members, studies in this field are so important for policy making and planning aspects. This issue is more important in countries and regions in more vulnerability of climate changes. Therefore, dry and semi-dry climates of Iran and Khorasan Razavi province were mentioned to study the production and demand for strategic product, wheat, by consideration of climate changes condition. To reach this goal, first an index to study climate parameters fluctuations was designed and calculated. Then, wheat economic model was made by aim of reaching balanced price by making supply and demand sides. The demand and supply functions were estimated as panel data for 30 provinces of country in 2005-2015 in Stata software. Then, optimization model was made in GAMS software to reach product equilibrium in the studied region. Results of calculations displayed that permanent risks have a negative and significant effect on product and wheat balanced price in Khorasan Razavi province whose price was obtained 12863 Rial in 2015. It is suggested to policy makers and planners to use simulation of various parts of the model and the obtained results from scenario for prediction in order to select the adapted policies with climate changes or reduce negative effects of this phenomenon in regions such as studied region.Keywords: Price, Permanent risk, Recurrent risk, Partial equilibrium.
Use of Iraqi Attapulgite (ATP) and Surfactant-modified Iraqi attapulgite for Adsorption of Crystal Violet from Aqueous Solutions Dhafir T.A. Al-Heetimi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Iraqi attapulgite (ATP) mineral clay was modified using anionic surfactant (Sodium dodecyl sulfate (ATP-SDS)) to improve its adsorption capacity for crystal violet (CV+) dye. Different techniques were used to characterize the ATP and ATP-SDS such as FTIR spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The adsorption properties of crystal violet (CV+) from aqueous solutions by ATP and ATP-SDS were further evaluated. Many parameters like adsorbent dosage, contact time, pH and temperatures were investigated and discussed. The adsorption kinetics were described using pseudo-first-order and pseudo-second-order models. The CV+ dye uptake process obeyed the pseudo-second-order kinetic. The experimental data were examined using Langmuir, Freundlich and Temkin isotherms models. The results showed better fit to Freundlich and Temkin models than Langmuir model. Thermodynamic values (∆Go, ∆Ho and ∆So) showed that adsorptions of CV+ onto ATP and ATP-SDS were endothermic, spontaneous and randomness increasing for both sorbents. The results indicate that this natural and modified Iraqi attapulgite could be employed as low-cost alternative for removal of cationic dye CV+ from wastewater.    Keywords: Adsorption, attapulgite, Sodium dodecyl sulfate, crystal violet, Thermodynamic parameters.
Sequencing of GTFD Gene among Biofilm Genes (GTF) in Streptococcus Mutans Isolated from Dental Caries Hala Hussein
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Objectives: Streptococcus mutans has been implicated as a primary etiologic agent of humans dental caries. An important virulence properties of this bacterium is its ability to form biofilm known as dental plaque on tooth surfaces, these bacteria also produces glucosyltransferases, multiple glucan-binding proteins, collagen-binding protein, and protein antigen c, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. This study aimed to detect gtfB, gtfC and gtfD genes in Streptococcus mutans isolated from dental caries patients in Babylon Province, Iraq. Methods: Out of 150 samples were collected from patients with dental caries35 isolates were diagnosed as Streptococcus mutans. The bacterial isolates were identified by standard laboratory protocols. Polymerase chain reaction (PCR) was used for detecting gtfB, gtfC and gtfD genes and Sequencing of gtfD genes confirmed of the results. Results: Out of, 35isolatesof Streptococcus mutans, 30(85.7%) isolates had gtfB encode GtfB with 80 bp, 27 (77.14%) had gtfC encode GtfC with 81 bp, and 31 (88.57%) had gtfD with 324 bp which explain their potential of biofilm formation. Conclusion: Our study results showed presence of High frequency of gtf genes among the clinical isolates of S. mutans isolates in Babylon Province, Iraq.
Efficacy of Edible Coatings on Enhancing the Shelf-Life of Fresh and Frozen Tilapia (Oreochromis niloticus) Fish N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Tilapia (Oreochromis niloticus) is generally processed to fresh and frozen fillets for domestic consumption. Deterioration of fish quality in refrigerator storage has great impact on the nutritious value of fish and the health of consumers. Freezing and cold storage is an efficient method which preserves taste and nutritional value. Glazing is a process used to reduce undesirable drying or dehydration of fish during frozen or cold storage. Objective of the current research studied the feasibility of edible coating in maintaing and preserving the chemical, microbial and sensory attributes of fresh and frozen tilapia fillet. The fresh and frozen tilapia fillets were treated with different formulas (N0: control; N1: 1.5% w/w chitosan and peracetic acid; N2: 1.5% w/w chitosan and gelatin; N3: 1.5% w/w whey protein isolate and ethanol; N4: 1.5% w/w xanthan gum). The chemical quality was based on the analyzed results of ammonia (µNH3/g) and pH; biogenic amines such as putrescine (mg/kg), cadaverine (mg/kg), histamine (mg/kg), spermine (mg/kg), spermidine (mg/kg); lipid oxidation or malondialdehyde value (mg/kg); microorganism such as Total plate count (cfu/g), Enterobacteriaceae (cfu/g), Coliform (cfu/g), E. coli (cfu/g), Staphylococus (cfu/g), Listeria (cfu/g), Salmonella (cfu/g), Vibrio (cfu/g); sensory score. All treated fresh tilapia fillets were tested after 21 days of cool storage (4oC). All treated frozen tilapia fillets were tested after 12 months of cold storage (-18oC). Results revealed that the incorporation of 1.5% w/w chitosan and peracetic acid could inhibit microbial spoilage and lipid oxidation and therefore maintain the freshness of tilapia fillet for 21 days at 4oC and 12 months at -18oC storage. The study indicated that the combination treatment with edible coating could be commercially utilized to maintain the freshness and prolong the shelf‐life of fresh and frozen tilapia fillet effectively.Keywords: Frozen, Tilapia fillet, Chitosan, Peractic acid, Gelatin, Whey protein isolate, Ethanol, Xanthan gum.
Domperidone Maleate Orodispersible Tablet Formulation Using Primojel® Superdisintegrant with the Wet Granulation Method D. Gozali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Orodispersible tablets are a solution for people who have problems swallowing drugs because they will break down instantly in the mouth without having to be swallowed. Objective: The aim of this research was to formulate orodispersible tablets using Primojel® as a superdisintegrant and domperidone male ate as an active compound to achieve the best disintegration time in the oral cavity by a wet granulation method had been carried out. Method: The tablet of 180 mg in weight was made with variation of concentration as followed 7, 2 mg (F1); 9 mg (F2); 10,8 mg (F3); 12,6 mg (F4); 14,4 mg (F5). F1, F3, F4, and F5 were qualified based on uniformity of weighing. Results: All of the formulas (F1, F2, F3, F4, and F5) were qualified based on the disintegrating time of orodispersible tablets (below three minutes). F2 has a quickest disintegration time and F1 has the longest disintegration time. Statistical analysis at α = 0, 05 showed that the concentration variation of Primojel® affected the disintegration time of the tablet. Hedonic test with five parameters included likeness, flavor, taste after taste showed that F5 was the most favorite formula. Conclusion: All formulas met the requirements of the Indonesian Pharmacopoeia IV crush time that was no more than 3 minutes. The results of the statistical analysis stated that F5 was the most preferred formula of domperidone maleate orodispersible tablets.Keyword: Orodispersible tablets, Primojel®, Wet granulation, Domperidone maleate, Tablet formulation.

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