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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Self-Belief and Social Support Factors on the Emotional Response of Patients with Hypertension Riza Fikriana
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: Emotional responses that occur in patients with hypertension will affect the compliance of healthy life behaviors and treatment of hypertension. The study aims to analyze the effect of self-belief and social support on the emotional responses of patients with hypertension. Method: The study was analytic observational design with a cross-sectional study approach. Samples were taken by multistage random sampling as many as 225 people with hypertension who have systolic blood pressure above 160 mmHg and or diastolic pressure above 100 mmHg. Research instruments of the study are in the form of self-belief questionnaires, social support, and emotional responses. Data analysis performed using Pearson test and linear regression. Result: The results of the study describe all the variables of self-belief showing that more than 50% of sufferers have self-belief in the moderate category. Moderate social support variables describe more than 50% of sufferers have less social support. Pearson test found a significant relationship between self-belief and social support to emotional responses on patients with hypertension. Linear regression analysis found self-belief in the form of perceived severity, perceived threat and health worker's support affect the emotional response of patients with hypertension. Conclusions: The emotional response of patients with hypertension is influenced by health worker's support, perceived severity, and perceived threat.Keywords: Self-belief, Social support, Emotional response, Hypertension.
ND3 Mitochondrial Polimorphism G-10399-A and C-10401-T Significantly Associated with Elevated Serum 8-OHDG Concentration and Increased Risk of Malignant Behavior in Breast Cancer Wayan Tianing
Journal of Global Pharma Technology .
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Abstract

Introduction: ND3¬ gene polymorphisms had been associated with the risk of breast cancer. However, it association with cancer cell behavior and progression is yet to be evaluated and thus this research evaluate the relationship between ND3 gene polymorphisms with 8-OHdG concentration that represent oxidative DNA damage and with the risk of malignant cancer behavior. Method: A case-control study was conducted in Faculty of Medicine Udayana University and Sanglah General Hospital from January to December 2016. The case group was defined as sample with lymph vascular invasion and histological grade III. The blood samples were obtained to evaluate the polymorphism and serum 8-OHdG concentration. The polymorphisms were detected using PCR and sequencing while serum 8-OHdG concentration was determined using ELISA. Result: 70 subjects were enrolled in this study with 35 samples for each group. Increased serum 8-OHdG were associated with the presence of ND3 polymorphism [375.37±203.56ng/mL in wild type vs 610.65±271.9ng/mL (G-10399-A) and 636.18±287.75ng/mL (C-10401-T); p<0.05] and the number of polymorphism [391.45±210.97ng/mL for no polymorphism vs 487.52±227.18ng/mL in one polymorphism and 861.36±253.27ng/mL for two polymorphism; p<0.05]. Finally, the presence of polymorphism increased the risk of more malignant cancer behavior (OR: 4.792; 95%CI: 1.741 – 13.188). Conclusion: G-10399-A and C-10401-T ND3 polymorphism clearly increased oxidative DNA damage and the risk of malignant cancer behavior in breast cancer patients.Keywords: ND3 gene polymorphism G-10399-A and C-10401-T, 8-OHdG, malignant behavior, breast cancer
The Association between Toll-like Receptor 7 and Hepatitis C Virus in a Sample of Iraqi Rheumatoid Arthritis Patients Dunya Muyad Ahmed
Journal of Global Pharma Technology .
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Abstract

Background: Rheumatoid arthritis (RA) is one of the chronic inflammatory autoimmune diseases that included articular and joints infections. Viral infection and immunity had been suggested to play a role in the pathogenesis of autoimmune diseases. Objectives: The present study designed to estimate the association among RA, Hepatitis C virus (HCV) infections and the role of innate immunity expressed by toll-like receptor-7 (TLR-7) as a possible triggering factor in the sera and blood samples of 47 RA patients.  Results: The findings of the present study demonstrated that 18 of the 47th RA samples were positive for anti-HCV IgM and IgG antibodies, and 13 of the 18th HCV IgG and IgM seropositive samples were positive for HCV-RNA by using RT-PCR technique. Also, the findings revealed a significant association between RA, HCV infections and TLR-7 serum level in the studied groups. There was a significantly increased level of TLR-7 in the RA group (103.0±73.8 ng/ml) compared to controls (72.9±36.8 ng/ml). Conclusion: These findings concluded that hepatitis C virus infection and TLR-7 might have a role in RA pathogenesis.Keywords: Autoimmune disease, Rheumatoid arthritis, Hepatitis C virus, Innate immunity, Toll-like receptor-7.
Investigation of Immunomodulation Effects of Ethanolic Neem Seeds (Azadirachta indica) Extract on Induced Immune Response in BALB/C Mice with Vibrio alginolyticus Whole An Ihsan Dhari Awad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The Current study  was  studied the immunomoduatory  potentials  of Ethanolic Neem seed    extract in treated mice with Vibrio alginolyticus whole antigen through estimation the phagocytic activity of and lymphocyte proliferations as well as  estimation of  the serum fractions to evaluate the humoral immune response . The study was divided into 4 groups:  Group (I) was included treated mice with normal saline. Group II was included  mice treated with Vibrio alginolyticus  antigen only , Group,(III): included mice were treated with  (200 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen ,finally , Group IV included mice were treated with  (300 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen. The results of NBT index and MTT test were revealed group III and group IV showed highly significant increase (P≤ 0.05) comparison with other Groups .More further results of gel electrophoresis in current study were showed the level of Gamma globulin serum, Alpha-1 level, Alpha-2 level, Alpha-beta level were highly significantly in Group III and Group IV comparison with other groups. In other hands in this study the results were showed there is no significant difference between group III and group IV in NBT index and MTT test as well as Gel electrophoreses. Depending on the results of current study   the Ethanolic Neem extract had a positive immunomodutory effect on the induced immune response.Keywords: Neem Seeds extract, Immunomodulatory Effects, Vibrio alginolyticus whole antigen, Immune response.
Simple, Selective and Sensitive Spectrophotometric Method for Determination of Trace Amounts of Lead (II), Cademum (II), Cobalt (II) with Organomercury Compounds Fatima K. Aziz
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

A selective and sensitive reagent of 2-{[(2-mercurychlorid, 4-methylphenylImino] methyl} phenol (K) was synthesized and studied for the spectrophotometric determination of Lead, Cademum, and cobalt, in detail. At a pH value (7), which greatly increased the selectivity; lead, cademume, cobalt, reacted with (K)to form a 1:1, 1:1, and 1:1 complexes, with absorption peaks at 394, 394, 389 nm, respectively. Under the optimal conditions, Beer’s law was obeyed over the ranges (1X10-6, 1X10-5, 1X10 -4, 1x10-3 1X10-2) mg/L respectively. The apparent molar absorptivity and Sandell’s sensitivities were (0.3, 0.1, 0.2) L·mol-1·cm-1 respectively, and0.027, 0.05, 0.013) μg·cm-2respectively the detection limits were found to be be0.052, 0.036, 0.039) mg/L respectively.
Clinical Measures for the Cytokine Levels After and Before Hirudotherapy in Rheumatoid Arthritis Patients Dina A. A. AL-Roubaey
Journal of Global Pharma Technology .
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Abstract

Hirudotherapy is one of the oldest complementary medical methods using in treatment of disease like inflammatory disease, osteoarthritis, and after being surgery. The aim of this study was to identify what areroles of leech bioactive substances on the treating of rheumatoid arthritis disease. The study was carried out in Al-Najaf City/ Center of leech therapy, during the period from October 2016 to October 2017, the study involved (140) RA patients who attended the hospital, the majority of the study were women (64.29%), and the most effected age groups were from 61-70 years old in percentage (42.86%) followed by the age group 71-80 years old (25%), also the results showed a highly significant increased mean serum level of  hs-CRP  (9.35  vs. 1.19 mg/ ml), and cytokines including IL1β (59.87 vs.12.43 pg/ml), IL-6 (70.34vs. 13.33 pg/ml), IL-8 (53.25 vs. 11.61 pg /ml), IL-10(44.58 vs. 10.50 pg/ml), IL-17(77.45 vs. 10.42 pg/ml), and TNF-α(68.30 vs. 11.81 pg/ml) for RA patients as compared to controls group, in addition the study showed that the patients after hirudotherapy have a significant decreased mean serum level of  hs-CRP  and cytokines (IL1β, IL-6, IL-8, IL-10, IL-17, and TNF-α) as compared to the patients before hirudotherapy. It was concluded that leech therapy is a highly effective in treating RA patients by reducing the severity of disease. It was recommended to achieve more investigation for assassement the role of leech therapy and their bioactive substances in the treatment of RA disease.Keywords: Hirudotherapy, Cytokines, Rheumatoid Arthritis patients.
Morphological Features of Human Cerebellar Cortex in Old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

The objective of the study is to establish regularities of age changes in the structural organization of thecerebellar cortex in old age as compared to young age by using necropsy material. Craniometrical,organometric, histological, immunomorphological and morphometric studies of the cerebellar cortex in219 human corpses (108 men and 111 women) aged from 18 to 44 years and from 75 to 90 years.Comparative analysis of the parameters of Purkinje’s cells in these age groups revealed a decrease in theneurons’ height and width. It was found that the distance between the bodies of the neurons of ganglioniclayer increases with age, which is obviously due to the progressing disorganization and apoptotic death ofPurkinje’s cells. An increase in the number of astrocytes immunopositive to glial fibrillary acidic protein,S-100 protein and vimentin in the granular and molecular layers of the cerebellar cortex is observed, aswell as a decrease in the number of Purkinje’s cells immunopositive to neuron-specific enolase andimmunonegative to S-100 protein and vimentin, which can be considered as a manifestation ofneurodegeneration. Immunohistochemical techniques provide a more differentiated approach to themorphological assessment of the cerebellar cortex in old persons and make it possible to get moreobjective and complete information about the postnatal morphogenesis.
Influence of Blanching, Frying and Storage on the Physicochemical Properties and Shelf Life of Fried Taro (Colocasia Esculenta) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Taro (Colocasia esculanta) tubers have the great importance of functional foods. Taro tubers are important sources of carbohydrates as an energy source. Taro tubers provide a number of desirable nutritional and health benefits such as anticancer activity, phenolic acid and phytochemicals. Taro deteriorates rapidly as a result of its high moisture. The high perishability of taro during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. The major challenge for the food industry is to produce low fat fried product with desirable texture, color and flavor. This research has been focused on different parameters of blanching, drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and anthocyanin; extending product shelf life during packaging and preservation. Results revealed that blanching 95oC in 30 seconds with ascorbic acid of 0.15 g/100g taro, frying 2.0 cm of taro chip in soybean oil heating at 155oC in 2 minutes was appropriated. Fried taro chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried taro products. Frying of taro chips is carried out to convert the tubers to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Taro chip, Blanching, Frying, Shelf life, Anthocyanin, flavonoid.
Telmisartan Spongelike Particles as Oral Capsule II: Factors Affecting Formulation Hussam H. Tizkam
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Telmisartan  (TEL) is selective angiotensin II receptor blocker sued in the management of cardiovascular disorders. It is a class II drug according to Biopharmaceutics Classification System (BCS). The aim of current study is to prepare TEL sponge like particles (SP) as a drug delivery system and investigate the different variables that may affect the formulation in order to enhance the solubility and dissolution rate thereof. The TEL SP formulations were prepared by quasi-emulsion solvent diffusion method using Eudragit E100 as SP forming polymer at drug: polymer ratio of (5:1). The effect of solvent type of internal phase, internal phase volume, stirring rate, stirring time, plasticizer concentration, surfactant concentration, external phase volume, and drying temperature on the formulation of TEL SP were investigated. Twenty five TEL SP formulations were prepared and filled into hard gelatin capsule. They were investigated and characterized for production yield, loading efficiency and in vitro drug release in 0.1N HCl (pH 1.2). Results showed that the best TEL SP formula was F15 which was prepared using 5ml of dichloromethane (DCM) as an internal phase solvent, 0.05 g of polyvinyl alcohol (PVA) as a surfactant, 1 g of sodium chloride as a porogen, 1 ml of glycerol as a plasticizer, 200 ml of water as an external phase solvent, 1000 rpm for 1 hr as the stirring rate and time, and 40 0C as a drying temperature. The F15 showed good production yield (82%), loading efficiency (73%), and fast dissolution rate in 0.1 N HCl (more than 80% drug release in less than 15 min). The in vitro release study showed that F15 had significantly better release characteristic (p < 0.5) when compared to both the pure TEL and the reference commercial tablet Micardis®. Finally, one can conclude that the SP technology can be a promising alternative way for the formulation of poorly water soluble drugs, such as TEL, into immediate release formulation.Keywords: Telmisartan, Sponge like, solubility, Eudragit E100.
Estimation of C-Peptide, HSP60 and Anti-GAD Antibody Levels in Type 1 Diabetes Mellitus Duha T. Khalaf
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Type 1 diabetes, previously known as insulin-dependent diabetes or juvenile diabetes, is caused by the destruction of beta cells responsible for insulin secretion in the pancreas through a process in which T-cells play a central role. The study was conducted on 56 patients with type 1 diabetes, whose mean ages (12.68 ± 3.33) years, and 20 healthy people, as control group for comparison purposes at the National Center for Diabetes and Endocrine Research (Al-Mustansiriyah University) from February 2017 until July 2017. Venous blood samples were collected from patients and healthy individuals to evaluate the levels of Fasting Serum Glucose FSG, C-peptide, Heat Shock Protein 60 (HSP60) and Anti-Glutamic Acid Decarboxylase (anti-GAD) antibodies. The results of the study showed a highly significant increase in the level of FSG, HPS60 and Anti-GAD antibodies in patients compared to the control group (P <0.001),while C-peptide showed a highly significant decrease in patients when compared with the control group (p <0.001).Keywords: T1D – C-Peptide – HSP60 – Anti-GAD.

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